Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We explored the potential of a folate-aminopterin construct, known as EC2319, in treating multiple sclerosis (MS) using a focal model in rats. Our study involved 40 Lewis rats, with some receiving the treatment and others serving as controls. This design allowed us to assess how effectively EC2319 could reduce inflammation and lesion development associated with a chronic progressive form of MS.
Interestingly, we found that EC2319 was well tolerated by the rats and significantly reduced both inflammation and lesion development, indicating a promising therapeutic avenue for MS. In our investigations, we also used a specific imaging method (Ga-FOL) to assess the inflammatory lesions, enhancing our understanding of the treatment’s effects.
Furthermore, we examined postmortem brain samples from MS patients and discovered that they contain FR-β-positive cells in areas of chronically active plaques. This finding suggests that the approach we tested in rats may have relevance for human patients, opening doors for future research into targeted treatments for MS.
Interestingly, we found that EC2319 was well tolerated by the rats and significantly reduced both inflammation and lesion development, indicating a promising therapeutic avenue for MS. In our investigations, we also used a specific imaging method (Ga-FOL) to assess the inflammatory lesions, enhancing our understanding of the treatment’s effects.
Furthermore, we examined postmortem brain samples from MS patients and discovered that they contain FR-β-positive cells in areas of chronically active plaques. This finding suggests that the approach we tested in rats may have relevance for human patients, opening doors for future research into targeted treatments for MS.
9
We delved into the relationship between dietary patterns and multiple sclerosis (MS) to uncover the potential influence of folate on the condition. The study utilized genetic data from large-scale genome-wide association studies, particularly focusing on dietary habits and their connection to MS risk and severity.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
8
We explored the connection between folate receptor alpha autoantibodies (FRAA) and relapsing-remitting multiple sclerosis (RRMS). The study involved 54 patients with RRMS and 58 healthy individuals, intending to understand if these autoantibodies could play a role in the disease. Our analysis revealed that patients with RRMS had significantly higher serum levels of FRAA, averaging 67.20 ng/ml, compared to 37.32 ng/ml in healthy controls.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
Most Useful Reviews
9.5
Improved mood
I have been taking B12 for six months and have noticed I am more balanced, less aggressive, less anxious, and much cheerier. I sleep better now, all thanks to B12, which strengthens the nervous system. It is vital for individuals with autoimmune diseases. I have multiple sclerosis and will need it for life! Cheers to Ayherb for this vitamin.
8.8
Improved well-being
Excellent. Useful for individuals with neurological conditions like multiple sclerosis. I take B12 alongside magnesium. The best method is sublingually, as it is absorbed poorly when swallowed. It's an inexpensive supplement that lasts a long time, although it dissolves over 15-20 minutes. I feel it enhances my overall well-being; especially during hot weather, there is no weakness. If this review is helpful, a plus would be appreciated.
8
Pain management
Great! Vitamin B12 is crucial as it helps alleviate pain and prevents pernicious anaemia, heart attacks, and strokes. Alone, it aids in treating nervous diseases, anaemia, depression, hypertension, and multiple sclerosis. Usage: Adults should take one tablet daily with meals for a month. If needed, the dose can be repeated after a month. Vitamin B12 serves as 'food' for the nerves, ensuring proper nervous system function and aiding nerve growth and repair, while also supporting energy metabolism and preventing fatigue.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.7
- All Researches
9
We delved into the relationship between dietary patterns and multiple sclerosis (MS) to uncover the potential influence of folate on the condition. The study utilized genetic data from large-scale genome-wide association studies, particularly focusing on dietary habits and their connection to MS risk and severity.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
9
We explored the potential of a folate-aminopterin construct, known as EC2319, in treating multiple sclerosis (MS) using a focal model in rats. Our study involved 40 Lewis rats, with some receiving the treatment and others serving as controls. This design allowed us to assess how effectively EC2319 could reduce inflammation and lesion development associated with a chronic progressive form of MS.
Interestingly, we found that EC2319 was well tolerated by the rats and significantly reduced both inflammation and lesion development, indicating a promising therapeutic avenue for MS. In our investigations, we also used a specific imaging method (Ga-FOL) to assess the inflammatory lesions, enhancing our understanding of the treatment’s effects.
Furthermore, we examined postmortem brain samples from MS patients and discovered that they contain FR-β-positive cells in areas of chronically active plaques. This finding suggests that the approach we tested in rats may have relevance for human patients, opening doors for future research into targeted treatments for MS.
Interestingly, we found that EC2319 was well tolerated by the rats and significantly reduced both inflammation and lesion development, indicating a promising therapeutic avenue for MS. In our investigations, we also used a specific imaging method (Ga-FOL) to assess the inflammatory lesions, enhancing our understanding of the treatment’s effects.
Furthermore, we examined postmortem brain samples from MS patients and discovered that they contain FR-β-positive cells in areas of chronically active plaques. This finding suggests that the approach we tested in rats may have relevance for human patients, opening doors for future research into targeted treatments for MS.
9
We conducted a study to see how vitamin B12 and folate supplementation affects patients with relapsing-remitting multiple sclerosis (RRMS), particularly focusing on homocysteine levels and overall quality of life. A total of 50 patients participated, with half receiving the vitamins and the other half getting a placebo. Our findings were quite promising!
We observed a significant decrease in mean homocysteine levels and an improvement in anemia status among those taking the vitamins. Specifically, their hemoglobin levels rose, and the size of red blood cells decreased, which indicates better blood health. More impressively, the vitamin group reported substantial improvements in both their physical and mental quality of life scores, highlighting how these nutrients might help MS patients feel better overall.
Interestingly, while the placebo group also experienced some mental health improvements, our study underscores the potential benefits of vitamin B12 and folate supplementation for patients struggling with MS. It appears that these vitamins could play a vital role in enhancing the quality of life by addressing both physiological and psychological aspects of the disease.
We observed a significant decrease in mean homocysteine levels and an improvement in anemia status among those taking the vitamins. Specifically, their hemoglobin levels rose, and the size of red blood cells decreased, which indicates better blood health. More impressively, the vitamin group reported substantial improvements in both their physical and mental quality of life scores, highlighting how these nutrients might help MS patients feel better overall.
Interestingly, while the placebo group also experienced some mental health improvements, our study underscores the potential benefits of vitamin B12 and folate supplementation for patients struggling with MS. It appears that these vitamins could play a vital role in enhancing the quality of life by addressing both physiological and psychological aspects of the disease.
9
We explored the impact of high doses of B vitamins—specifically B1, B6, and B12—on patients with relapsing-remitting multiple sclerosis (MS) who experienced persistent visual difficulties after acute optic neuritis. In a pilot study involving sixteen patients, each participant took 300 mg of vitamin B1, 450 mg of vitamin B6, and 1,500 mcg of vitamin B12 daily for a period of 90 days, alongside their existing disease-modifying therapies.
The results were encouraging. We observed significant improvements in visual acuity and foveal sensitivity threshold after treatment. For example, visual acuity showed a notable enhancement (p = 0.002), while foveal sensitivity also improved substantially (p = 0.006). Additionally, correlations between age and visual outcomes indicated that younger patients tend to benefit more in terms of visual function recovery.
Importantly, our findings suggest that high-dose vitamin B12, in conjunction with other B vitamins, can positively affect visual function in MS-related visual disability. However, it's essential to note that while vitamin B12 is part of this promising combination therapy, its isolated effects warrant further investigation.
The results were encouraging. We observed significant improvements in visual acuity and foveal sensitivity threshold after treatment. For example, visual acuity showed a notable enhancement (p = 0.002), while foveal sensitivity also improved substantially (p = 0.006). Additionally, correlations between age and visual outcomes indicated that younger patients tend to benefit more in terms of visual function recovery.
Importantly, our findings suggest that high-dose vitamin B12, in conjunction with other B vitamins, can positively affect visual function in MS-related visual disability. However, it's essential to note that while vitamin B12 is part of this promising combination therapy, its isolated effects warrant further investigation.
8
We explored the connection between folate receptor alpha autoantibodies (FRAA) and relapsing-remitting multiple sclerosis (RRMS). The study involved 54 patients with RRMS and 58 healthy individuals, intending to understand if these autoantibodies could play a role in the disease. Our analysis revealed that patients with RRMS had significantly higher serum levels of FRAA, averaging 67.20 ng/ml, compared to 37.32 ng/ml in healthy controls.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved mood
I have been taking B12 for six months and have noticed I am more balanced, less aggressive, less anxious, and much cheerier. I sleep better now, all thanks to B12, which strengthens the nervous system. It is vital for individuals with autoimmune diseases. I have multiple sclerosis and will need it for life! Cheers to Ayherb for this vitamin.
8.8
Improved well-being
Excellent. Useful for individuals with neurological conditions like multiple sclerosis. I take B12 alongside magnesium. The best method is sublingually, as it is absorbed poorly when swallowed. It's an inexpensive supplement that lasts a long time, although it dissolves over 15-20 minutes. I feel it enhances my overall well-being; especially during hot weather, there is no weakness. If this review is helpful, a plus would be appreciated.
8
Pain management
Great! Vitamin B12 is crucial as it helps alleviate pain and prevents pernicious anaemia, heart attacks, and strokes. Alone, it aids in treating nervous diseases, anaemia, depression, hypertension, and multiple sclerosis. Usage: Adults should take one tablet daily with meals for a month. If needed, the dose can be repeated after a month. Vitamin B12 serves as 'food' for the nerves, ensuring proper nervous system function and aiding nerve growth and repair, while also supporting energy metabolism and preventing fatigue.
8.8
Pain relief
Super vitamin B12! It helps alleviate pain and prevents pernicious anaemia, heart attacks, and strokes. It can aid in treating nervous diseases, anaemia, depression, hypertension, and multiple sclerosis.
8
Essential vitamin
Vitamin B12 is essential as it helps eliminate pain and prevents pernicious anaemia, heart attacks, and strokes. It can assist in treating nervous diseases, anaemia, depression, hypertension, and multiple sclerosis.
Frequently Asked Questions
9.5
Improved mood
I have been taking B12 for six months and have noticed I am more balanced, less aggressive, less anxious, and much cheerier. I sleep better now, all thanks to B12, which strengthens the nervous system. It is vital for individuals with autoimmune diseases. I have multiple sclerosis and will need it for life! Cheers to Ayherb for this vitamin.
8
Pain management
Great! Vitamin B12 is crucial as it helps alleviate pain and prevents pernicious anaemia, heart attacks, and strokes. Alone, it aids in treating nervous diseases, anaemia, depression, hypertension, and multiple sclerosis. Usage: Adults should take one tablet daily with meals for a month. If needed, the dose can be repeated after a month. Vitamin B12 serves as 'food' for the nerves, ensuring proper nervous system function and aiding nerve growth and repair, while also supporting energy metabolism and preventing fatigue.
8.8
Improved well-being
Excellent. Useful for individuals with neurological conditions like multiple sclerosis. I take B12 alongside magnesium. The best method is sublingually, as it is absorbed poorly when swallowed. It's an inexpensive supplement that lasts a long time, although it dissolves over 15-20 minutes. I feel it enhances my overall well-being; especially during hot weather, there is no weakness. If this review is helpful, a plus would be appreciated.
9
We delved into the relationship between dietary patterns and multiple sclerosis (MS) to uncover the potential influence of folate on the condition. The study utilized genetic data from large-scale genome-wide association studies, particularly focusing on dietary habits and their connection to MS risk and severity.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
Our findings indicated that an increased intake of folic acid may play a beneficial role in reducing both the risk and severity of MS. Specifically, genetically predicted higher folic acid intake was associated with a lower risk of developing MS and a decline in its severity. This suggests that incorporating more folate-rich foods into our diets could help with MS management.
However, it’s essential to note that the study didn't isolate folate from other dietary components. As a result, while we observed a positive correlation between folate and MS outcomes, we can’t confidently conclude that folate alone is the deciding factor in these improvements. Nevertheless, these insights could guide future dietary recommendations for those at risk of or managing MS.
We explored how dietary interventions, specifically the low-saturated fat Swank diet and the modified Paleo Wahls diet, along with folate and vitamin B supplements, influence mood in individuals with relapsing-remitting multiple sclerosis (RRMS).
In a clinical trial that included 77 participants, we measured mood using the Hospital Anxiety and Depression Scale (HADS) and the Mental Health Inventory (MHI) over a 24-week period. Blood samples taken at four different points during the study allowed us to analyze serum levels of homocysteine, vitamin B, and folate to see if these factors were linked to mood improvements.
While both dietary approaches demonstrated significant positive effects on mood, we found that changes in serum levels of homocysteine, folate, and vitamin B did not contribute to these improvements. This suggests that the enhanced mood may not be directly connected to the biochemical changes we measured in the blood.
Overall, while we observed positive mood changes in participants following the Swank and Wahls diets, the specific contribution of folate and vitamin B supplementation by itself remains uncertain.
In a clinical trial that included 77 participants, we measured mood using the Hospital Anxiety and Depression Scale (HADS) and the Mental Health Inventory (MHI) over a 24-week period. Blood samples taken at four different points during the study allowed us to analyze serum levels of homocysteine, vitamin B, and folate to see if these factors were linked to mood improvements.
While both dietary approaches demonstrated significant positive effects on mood, we found that changes in serum levels of homocysteine, folate, and vitamin B did not contribute to these improvements. This suggests that the enhanced mood may not be directly connected to the biochemical changes we measured in the blood.
Overall, while we observed positive mood changes in participants following the Swank and Wahls diets, the specific contribution of folate and vitamin B supplementation by itself remains uncertain.
9
We conducted a study to see how vitamin B12 and folate supplementation affects patients with relapsing-remitting multiple sclerosis (RRMS), particularly focusing on homocysteine levels and overall quality of life. A total of 50 patients participated, with half receiving the vitamins and the other half getting a placebo. Our findings were quite promising!
We observed a significant decrease in mean homocysteine levels and an improvement in anemia status among those taking the vitamins. Specifically, their hemoglobin levels rose, and the size of red blood cells decreased, which indicates better blood health. More impressively, the vitamin group reported substantial improvements in both their physical and mental quality of life scores, highlighting how these nutrients might help MS patients feel better overall.
Interestingly, while the placebo group also experienced some mental health improvements, our study underscores the potential benefits of vitamin B12 and folate supplementation for patients struggling with MS. It appears that these vitamins could play a vital role in enhancing the quality of life by addressing both physiological and psychological aspects of the disease.
We observed a significant decrease in mean homocysteine levels and an improvement in anemia status among those taking the vitamins. Specifically, their hemoglobin levels rose, and the size of red blood cells decreased, which indicates better blood health. More impressively, the vitamin group reported substantial improvements in both their physical and mental quality of life scores, highlighting how these nutrients might help MS patients feel better overall.
Interestingly, while the placebo group also experienced some mental health improvements, our study underscores the potential benefits of vitamin B12 and folate supplementation for patients struggling with MS. It appears that these vitamins could play a vital role in enhancing the quality of life by addressing both physiological and psychological aspects of the disease.
4
We looked into how dietary intake, specifically focusing on folate, might influence fatigue levels in people living with multiple sclerosis (MS). Fatigue is a common and often debilitating symptom for those with MS, affecting up to 90% of patients at some stage. Given the limited effectiveness of current medication options for relieving this symptom, many individuals are seeking alternative strategies, including dietary changes.
Our investigation used a systematic approach to gather studies that examined the effects of holistic dietary patterns on fatigue perceptions among adults with MS. While we found that dietary intake has the potential to contribute to reducing fatigue, the evidence surrounding folate's specific impact remains inconclusive. Some findings suggest that adequate intake of magnesium and folate could possibly lead to decreased fatigue levels, but we must emphasize that clear and solid conclusions cannot be drawn from the existing studies.
Ultimately, while there is a hint that folate could play a role in lessening fatigue, we cannot isolate its effect definitively based on the current body of research.
Our investigation used a systematic approach to gather studies that examined the effects of holistic dietary patterns on fatigue perceptions among adults with MS. While we found that dietary intake has the potential to contribute to reducing fatigue, the evidence surrounding folate's specific impact remains inconclusive. Some findings suggest that adequate intake of magnesium and folate could possibly lead to decreased fatigue levels, but we must emphasize that clear and solid conclusions cannot be drawn from the existing studies.
Ultimately, while there is a hint that folate could play a role in lessening fatigue, we cannot isolate its effect definitively based on the current body of research.
8
We explored the connection between folate receptor alpha autoantibodies (FRAA) and relapsing-remitting multiple sclerosis (RRMS). The study involved 54 patients with RRMS and 58 healthy individuals, intending to understand if these autoantibodies could play a role in the disease. Our analysis revealed that patients with RRMS had significantly higher serum levels of FRAA, averaging 67.20 ng/ml, compared to 37.32 ng/ml in healthy controls.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
Notably, 85.18% of RRMS patients tested positive for these autoantibodies, in contrast to just 46.55% of those in the control group. This indicates a strong association between high FRAA levels and RRMS, suggesting that these autoantibodies may hinder folate transport to the brain, potentially impacting myelin stability and health.
While our findings highlight a notable prevalence of FRAA in RRMS patients, they do not specifically evaluate whether folate treatment itself improves patients' conditions. Thus, while understanding how folate mediates effects in these patients is crucial, we can’t conclude that folate treatment alone is effective without further focused studies.
8
We aimed to explore how nutritional intake, particularly folate, influenced daily function and quality of life in individuals with mild-to-moderate multiple sclerosis (MS). In this cross-sectional pilot study, we included 20 adult volunteers who were ambulatory and had varying degrees of disability due to MS. By assessing their dietary habits alongside various physical and self-reported performance measures, we gathered valuable insights into the role of folate and other nutrients.
Our findings indicated positive correlations between dietary fat, folate, iron, magnesium, and the overall quality of life as reflected in the Short Form Health Survey. Increased fat intake and lower carbohydrate intake were associated with better performance in the 6-Minute Walk Test, while micronutrients like folate showed significance in relation to physical functioning. However, we did not isolate the effects of folate specifically; rather, we observed it in conjunction with other dietary factors.
This pilot study suggests a potential connection between diet, including folate, and improved function in individuals with MS. It encourages further exploration of how specific nutrients may play a critical role in managing the challenges posed by this condition.
Our findings indicated positive correlations between dietary fat, folate, iron, magnesium, and the overall quality of life as reflected in the Short Form Health Survey. Increased fat intake and lower carbohydrate intake were associated with better performance in the 6-Minute Walk Test, while micronutrients like folate showed significance in relation to physical functioning. However, we did not isolate the effects of folate specifically; rather, we observed it in conjunction with other dietary factors.
This pilot study suggests a potential connection between diet, including folate, and improved function in individuals with MS. It encourages further exploration of how specific nutrients may play a critical role in managing the challenges posed by this condition.
References
- Nan H. Causal effects of dietary composition on multiple sclerosis risk and severity: a Mendelian randomization study. Front Nutr. 2024;11:1410745. doi:10.3389/fnut.2024.1410745
- Mashayekhi F, Hadipour E, Shabani S, Salehi Z. Folate receptor alpha autoantibodies in the serum of patients with relapsing-remitting multiple sclerosis (RRMS). Clin Neurol Neurosurg. 2024;237:108161. doi:10.1016/j.clineuro.2024.108161
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. doi:10.1016/j.msard.2023.104743
- Elo P, Li XG, Liljenbäck H, Gardberg M, Moisio O, et al. Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis. J Neuroinflammation. 2021;18:30. doi:10.1186/s12974-021-02073-7
- Bromley L, Horvath PJ, Bennett SE, Weinstock-Guttman B, Ray AD. Impact of Nutritional Intake on Function in People with Mild-to-Moderate Multiple Sclerosis. Int J MS Care. 2019;21:1. doi:10.7224/1537-2073.2017-039
- Nozari E, Ghavamzadeh S, Razazian N. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis. Clin Nutr Res. 2019;8:36. doi:10.7762/cnr.2019.8.1.36
- Pommerich UM, Brincks J, Christensen ME. Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review. Mult Scler Relat Disord. 2018;25:282. doi:10.1016/j.msard.2018.08.017
- Hesamian MS, Shaygannejad V, Golabi M, Mirmosayyeb O, Andalib A, et al. The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis. Iran J Allergy Asthma Immunol. 2022;21:332. doi:10.18502/ijaai.v21i3.9806
- Mandić M, Mitić K, Nedeljković P, Perić M, Božić B, et al. Vitamin B Complex and Experimental Autoimmune Encephalomyelitis -Attenuation of the Clinical Signs and Gut Microbiota Dysbiosis. Nutrients. 2022;14. doi:10.3390/nu14061273
- Taherian N, Vaezi G, Neamati A, Etemad L, Hojjati V, et al. Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis. Iran J Basic Med Sci. 2021;24:256. doi:10.22038/IJBMS.2021.51469.11681
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. doi:10.5582/ddt.2020.03031
- Pan L, Yin Y, Chen J, Ma Z, Chen Y, et al. Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis. Mult Scler Relat Disord. 2019;36:101395. doi:10.1016/j.msard.2019.101395
- Motte J, Kneiphof J, Straßburger-Krogias K, Pitarokoili K, Fisse AL, et al. Hereditary defect of cobalamin metabolism with adolescence onset resembling multiple sclerosis: 41-year follow up in two cases. Ther Adv Neurol Disord. 2019;12:1756286419872115. doi:10.1177/1756286419872115
