Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
Read More
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
Read More
8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
Most Useful Reviews
7.5
Reduced nausea
2 people found this helpful
I previously tried various vitamin B12 types, but none suited me. This Now brand has an incredibly delightful taste and doesn’t cause stomach pain or nausea. After using it for a week, I noticed a reduction in muscle pain. Thank you, Iherb, for your usual creativity.
Read More
10
No nausea
It has a sweet taste and does not cause nausea, plus its price is excellent. The round pills are chewable, unlike jelly.
Read More
10
No nausea
Excellent and easy to chew. I will purchase it again as it does not cause nausea and lacks a strong smell. It is very beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
- All Researches
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
Read More
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
Read More
8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
8
We observed how the B12-Ex4 conjugate may be a game-changer in managing type 2 diabetes. It effectively improved glucose tolerance in male rats without causing the nausea and malaise commonly associated with its unconjugated counterpart, Ex4.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
Read More
8
We examined a case of a 28-year-old man who experienced persistent headaches, nausea, and vomiting, ultimately diagnosed with cerebral venous thrombosis (CVT). This condition was linked to a mutation in the MTHFR gene and resulted in elevated homocysteine levels.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced nausea
2 people found this helpful
I previously tried various vitamin B12 types, but none suited me. This Now brand has an incredibly delightful taste and doesn’t cause stomach pain or nausea. After using it for a week, I noticed a reduction in muscle pain. Thank you, Iherb, for your usual creativity.
Read More
10
No nausea
It has a sweet taste and does not cause nausea, plus its price is excellent. The round pills are chewable, unlike jelly.
Read More
10
No nausea
Excellent and easy to chew. I will purchase it again as it does not cause nausea and lacks a strong smell. It is very beneficial.
Read More
10
No nausea
I always take this vitamin B12 in courses; I really enjoy it, and I experience no nausea.
Read More
10
Pleasant taste
It has a delightful strawberry flavour and does not cause nausea like some other types.
Read More
Frequently Asked Questions
7.5
Reduced nausea
2 people found this helpful
I previously tried various vitamin B12 types, but none suited me. This Now brand has an incredibly delightful taste and doesn’t cause stomach pain or nausea. After using it for a week, I noticed a reduction in muscle pain. Thank you, Iherb, for your usual creativity.
9
Energy boost
I'm very pleased with the fast delivery and high-quality packaging. The capsules are slightly large, but easy to swallow and taste citrusy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. After ten days, I’ve noticed benefits; before starting, I suffered from frequent headaches, nausea, and fatigue. Now, I've more energy, headaches have ceased, and my mood is excellent. I highly recommend it for those into sports or on a diet.
10
Pleasant taste
It has a delightful strawberry flavour and does not cause nausea like some other types.
9
Improved energy
A friend asked me to order this drug for neurological issues. She is pleased, mentioning that it worked well, causing no nausea or hot flashes. She has experienced an increase in energy.
10
No nausea
It has a sweet taste and does not cause nausea, plus its price is excellent. The round pills are chewable, unlike jelly.
10
No nausea
I always take this vitamin B12 in courses; I really enjoy it, and I experience no nausea.
4
Manage nausea
2 people found this helpful
The medication is effective, dissolving swiftly and tasting like candy. However, I realised I require a lower dosage; after frequent use, I experienced dizziness and nausea. Despite this, the medication is good, and I noticed results after adjusting my usage schedule.
7
We explored the impact of vitamin B12 deficiency on symptoms, including nausea, through a case study of a 60-year-old woman. When she presented with weakness, dizziness, and abdominal pain, lab tests revealed severe vitamin B12 deficiency linked to pernicious anemia.
After receiving treatment with intramuscular cyanocobalamin injections, her overall health improved significantly. This case highlights the importance of diagnosing vitamin B12 deficiency not only for its hematologic effects but also for alleviating symptoms like nausea. Early recognition is key to effective management.
After receiving treatment with intramuscular cyanocobalamin injections, her overall health improved significantly. This case highlights the importance of diagnosing vitamin B12 deficiency not only for its hematologic effects but also for alleviating symptoms like nausea. Early recognition is key to effective management.
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
8
We examined a case of a 28-year-old man who experienced persistent headaches, nausea, and vomiting, ultimately diagnosed with cerebral venous thrombosis (CVT). This condition was linked to a mutation in the MTHFR gene and resulted in elevated homocysteine levels.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
References
- Salimiaghdam N, Jumaah O, Acob T, Hakobyan K, Chen E. Vitamin B12 Deficiency in Pernicious Anemia: A Hemolytic Anemia Mimic. Cureus. 2025;17:e79176. doi:10.7759/cureus.79176
- Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. doi:10.7759/cureus.64676
- Meyers TM, Reeves PT, Lombardo JL, Anisowicz SK, Larson NS, et al. Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report. J Med Case Rep. 2023;17:342. doi:10.1186/s13256-023-04039-0
- Albai O, Timar B, Paun DL, Sima A, Roman D, et al. Metformin Treatment: A Potential Cause of Megaloblastic Anemia in Patients with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:3873. doi:10.2147/DMSO.S270393
- Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, et al. Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis. Cell Rep. 2020;31:107768. doi:10.1016/j.celrep.2020.107768
- Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, et al. A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes Obes Metab. 2018;20:1223. doi:10.1111/dom.13222
- Dikici S, Saritas A, Besir FH, Celbek G, Arslan G. May headache be the first sign of mutation in the MTHFR gene?. World J Emerg Med. 2013;4:69.
- Adu-Afarwuah S, Arnold CD, Lartey A, Okronipa H, Maleta K, et al. Prevalence of morbidity symptoms among pregnant and postpartum women receiving different nutrient supplements in Ghana and Malawi: A secondary outcome analysis of two randomised controlled trials. Matern Child Nutr. 2023;19:e13501. doi:10.1111/mcn.13501
