Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.6
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
Read More
9
We delved into how folate treatment, specifically through folate-chicory acid liposomes, affects ulcerative colitis (UC). This study involved both laboratory models that mimic inflammation caused by LPS and a mouse model of UC induced by dextran sulfate sodium (DSS). Our goal was to see whether these specialized liposomes could help target macrophages and improve symptoms associated with UC.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Read More
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
Most Useful Reviews
7.5
Improved ulcers
1 people found this helpful
I often suffer from mouth ulcers, so I purchased this lozenge, which I can take without water even when I'm out. Since I started using it, I've noticed an improvement in my mouth ulcers and dizziness. I hardly get mouth ulcers now, which I believe indicates its efficacy.
Read More
10
No more ulcer
After researching, I discovered this product is effective for canker ulcers, and I found it to be fantastic! I no longer suffer from ulcers, and the sweet taste makes it enjoyable to use—usually, I just bite into it, and no water is necessary.
Read More
9
Faster healing
My mouth ulcers have healed faster since I started this treatment.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.6
- All Researches
9.5
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Golden kiwifruit aids gastric healing
We examined the effects of hydro-alcoholic extracts from golden kiwifruit flesh and peel on ulcers caused by indomethacin in rats. The study involved several groups, including a control that received just water and one that received indomethacin to induce gastric ulcers.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Read More
9
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
Read More
9
We delved into how folate treatment, specifically through folate-chicory acid liposomes, affects ulcerative colitis (UC). This study involved both laboratory models that mimic inflammation caused by LPS and a mouse model of UC induced by dextran sulfate sodium (DSS). Our goal was to see whether these specialized liposomes could help target macrophages and improve symptoms associated with UC.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Read More
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved ulcers
1 people found this helpful
I often suffer from mouth ulcers, so I purchased this lozenge, which I can take without water even when I'm out. Since I started using it, I've noticed an improvement in my mouth ulcers and dizziness. I hardly get mouth ulcers now, which I believe indicates its efficacy.
Read More
10
No more ulcer
After researching, I discovered this product is effective for canker ulcers, and I found it to be fantastic! I no longer suffer from ulcers, and the sweet taste makes it enjoyable to use—usually, I just bite into it, and no water is necessary.
Read More
9
Faster healing
My mouth ulcers have healed faster since I started this treatment.
Read More
7.5
Effective remedy
These small pills are easy to place on the lower back and have a pleasant taste, making it convenient to take while engaged in other activities. I felt that my mouth ulcers improved noticeably. I wholeheartedly recommend it!
Read More
7.5
Solid supplement
Having used NOW Foods B-12 for some time, I believe it's a reliable supplement. It helps boost my energy levels, and I've also observed that my mouth ulcers heal more swiftly after taking it. The lozenges dissolve easily and have a mild flavour, making them easy to consume. Overall, I'm pleased with its quality and will continue to use it.
Read More
Frequently Asked Questions
7.5
Improved ulcers
1 people found this helpful
I often suffer from mouth ulcers, so I purchased this lozenge, which I can take without water even when I'm out. Since I started using it, I've noticed an improvement in my mouth ulcers and dizziness. I hardly get mouth ulcers now, which I believe indicates its efficacy.
9
Faster healing
My mouth ulcers have healed faster since I started this treatment.
7.5
Solid supplement
Having used NOW Foods B-12 for some time, I believe it's a reliable supplement. It helps boost my energy levels, and I've also observed that my mouth ulcers heal more swiftly after taking it. The lozenges dissolve easily and have a mild flavour, making them easy to consume. Overall, I'm pleased with its quality and will continue to use it.
10
No more ulcer
After researching, I discovered this product is effective for canker ulcers, and I found it to be fantastic! I no longer suffer from ulcers, and the sweet taste makes it enjoyable to use—usually, I just bite into it, and no water is necessary.
7.5
Effective remedy
These small pills are easy to place on the lower back and have a pleasant taste, making it convenient to take while engaged in other activities. I felt that my mouth ulcers improved noticeably. I wholeheartedly recommend it!
9
Golden kiwifruit aids gastric healing
We examined the effects of hydro-alcoholic extracts from golden kiwifruit flesh and peel on ulcers caused by indomethacin in rats. The study involved several groups, including a control that received just water and one that received indomethacin to induce gastric ulcers.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
Results indicated that golden kiwifruit extracts reduced stomach damage and improved healing compared to controls. Notably, the extracts elevated vitamin B levels and showcased antioxidant properties. While Lansoprazole also helped, golden kiwifruit extracts showed even greater potential benefits for ulcer treatment.
9
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
7
We observed a case involving a 27-year-old male with a challenging condition known as pyoderma gangrenosum, a type of ulcer that can develop after surgeries like gastric bypass. In treating his non-healing leg ulcer, the medical team combined various approaches, including systemic immunomodulators and surgical intervention.
As part of his management, he received vitamin B complex, vitamin D supplements, and zinc sulfate, along with folic acid. While we noted the inclusion of folate in his treatment regimen, the overall effectiveness of folate alone on ulcer healing remains unclear due to the multifaceted treatment approach used.
The healing process was significantly aided by administering multiple doses of Infliximab, which is important to highlight. Therefore, while we recognize the role of folate in supporting overall health, the study does not isolate its specific impact on the ulcer’s healing.
As part of his management, he received vitamin B complex, vitamin D supplements, and zinc sulfate, along with folic acid. While we noted the inclusion of folate in his treatment regimen, the overall effectiveness of folate alone on ulcer healing remains unclear due to the multifaceted treatment approach used.
The healing process was significantly aided by administering multiple doses of Infliximab, which is important to highlight. Therefore, while we recognize the role of folate in supporting overall health, the study does not isolate its specific impact on the ulcer’s healing.
References
- Aleid IS, Alfheeaid HA, Aljutaily T, Alhomaid RM, Alharbi HF, et al. Gastroprotective Effects of , Golden Kiwifruit Flesh, and Golden Kiwifruit Peel Extracts Individually or in Combination against Indomethacin-Induced Gastric Ulcer in Rats. Nutrients. 2021;13. 10.3390/nu13103499
- Li F, Huang F, Tang Y, Zhang F, Jiang H, et al. Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study. Br J Nutr. 2024;132:1348. 10.1017/S0007114524002368
- Sawant R, Chaudhari P, Bardiya NA, Acharya S, Kumar S. From Treatment to Tragedy: Severe Methotrexate Toxicity With Mucocutaneous Ulcers, Myelosuppression, and Nephropathy. Cureus. 2024;16:e57797. 10.7759/cureus.57797
- Yang S, Li Y, Zheng X, Zheng X, Lin Y, et al. Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse. Phytomedicine. 2024;128:155415. 10.1016/j.phymed.2024.155415
- Albeladi AM, Busbaih Z, Almohammed Saleh AA, AlAlwan AQ, Aljughayman MA, et al. Successful Management of a Young Patient Suffering From Pyoderma Gangrenosum Following Gastric Bypass Surgery: A Case Report. Cureus. 2023;15:e34305. 10.7759/cureus.34305
- Shah A, Khuba S, Kumar C S, Shanmukhaiah C, George M, et al. Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations. J Hum Genet. 2025;70:207. 10.1038/s10038-025-01320-6
- Mousavi T, Jalali H, Moosazadeh M. Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis. BMC Oral Health. 2024;24:339. 10.1186/s12903-024-04072-5
- Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, et al. Vitamin B is a limiting factor for induced cellular plasticity and tissue repair. Nat Metab. 2023;5:1911. 10.1038/s42255-023-00916-6
- Sitaula S, Kharel S, Sherpali A, Shrees V, Mainali A. Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report. Ann Med Surg (Lond). 2023;85:528. 10.1097/MS9.0000000000000253
