I've been taking 3,000 to 8,000 mg a day for Rheumatoid arthritis in my hands in addition to Celebrex, and recently Allopurinol and Colcrys until I see a rheumatologist in a couple of weeks and a better treatment can be determined. In the mornings it takes a couple of hours for the drugs to kick in for the swelling (which never quite goes away) and the pain. My husband also takes one each morning. Initially my primary care physician had me on steroids which worked immediately but as I weaned off the steroids, the more the pain and swelling returned. Now, I hope I am keeping some of the swelling at bay and allowing my body to produce more synovial fluid in the joints. All of the 4 and 5-star reviews have given me hope. The rather large capsules are surprisingly easy to swallow. If the rheumatologist agrees that the MSM is a good treatment, then I will stick with it. Meantime, it can't hurt.
UPDATE January 13, 2015: I've come back to add two more stars to make this a 5-star product. While my rheumatologist, oncologist, and primary care physician are talking over what medication I can safely take for my particular arthritis in addition to the medications I already take, I have been taking the MSM. I have taken as much as 8,000 mg in one day. I have found that 3,000 mg is about right for me. My rheumatologist asked me if I was allergic to sulfa drugs and while it didn't occur to me at the time (two weeks ago) that the MSM has sulfa in it and I forgot to mention it to her. I told her I was not allergic to sulfa drugs. So while they are dilly dallying around I am medicating myself with this wonderful supplement
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