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SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 68 Reviews
8.9
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
MSM (Methylsulfonylmethane)
2 g (2,000 mg)
*
Top Medical Research Studies
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Highly relevant to MSM and arthritis
In a well-structured randomized, double-blind, placebo-controlled trial, we explored how methylsulfonylmethane (MSM) affects those experiencing mild knee pain. The study involved 88 healthy Japanese participants, split evenly into two groups where one received 200 mg of MSM while the other received a placebo for 12 weeks.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
Read More
8
MSM reduces gouty arthritis symptoms
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Direct relevance to treatment explored.
We explored the therapeutic potential of Modified Simiaowan (MSM), a six-herb formula, specifically for its effects on gouty arthritis (GA). To understand how MSM influences the condition, we conducted a thorough investigation using mouse macrophages that were exposed to inflammatory stimuli and then treated with MSM.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Read More
9
MSM and mobilee support cartilage health
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway.
Relevant but challenging to isolate effects
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
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Most Useful Reviews
9.5
Miraculous improvements
They should add this to the tap water like fluoride, allowing everyone to heal. I can't express how much this supplement has improved my life. I was recently diagnosed with rheumatoid arthritis in both shoulders, and I've resolved to manage my pain without narcotics. This has been miraculous. The pain diminished, my gastric problems are easing, my skin appears better, and I feel progressively healthier each day. Amazingly, there are no adverse reactions or known drug interactions. It seems incredible that more people aren't aware of its benefits, leading me to share this information with all who will listen.
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8.8
Reduces joint pain
Very good additive! MSM is an organic sulphur compound with anti-inflammatory effects. I purchased it for my mother, who suffers from arthritis, and she has experienced some relief in her joint pain and sinus issues. I also tried it for my allergies, and it has significantly reduced my morning cough and improved my breathing. I even found relief from severe bloating that previous medications couldn't alleviate.
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9.5
Life-changing product
I absolutely love MSM; it’s a lifesaver for my stage 4 arthritis in my knees. I take high doses daily along with other supplements and cannot imagine being without it. Before my regimen, my pain was a 9 on a scale of 10. Now, while it's not completely gone, it's down to a manageable 3. My MSM regimen enables me to work out and engage with life without feeling overwhelmed by pain. I recommend it to anyone suffering from inflammation related to arthritis.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
9
MSM and mobilee support cartilage health
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway.
Relevant but challenging to isolate effects
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
Read More
9
MSM improves knee OA treatment
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Evaluates MSM's combined benefits
We conducted a thoughtful investigation into how Methylsulfonylmethane (MSM) impacts the treatment of knee osteoarthritis (OA) when paired with glucosamine and chondroitin sulfate. In our study, 147 patients diagnosed with Kellgren-Lawrence grade I-II knee OA were randomly divided into three groups. One group received a combination of glucosamine and chondroitin sulfate, the second group received the same combination with MSM, and the third group was given a placebo.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
Read More
9
ARTRA MSM improves knee OA treatment
[Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug].
MSM is significant in joint treatment
We aimed to explore how the combined medication ARTRA MSM FORTE could help patients suffering from knee osteoarthritis (OA). This study involved 100 individuals who were experiencing noticeable pain while walking.
We divided participants into two groups: one group took ARTRA MSM, while the other received a similar combination without the MSM. Over the course of four months, we conducted monthly evaluations to track improvements in pain levels, mobility, and overall quality of life.
Notably, we observed that those taking ARTRA MSM experienced quicker reductions in pain and improvements in functional tests compared to the other group. In fact, 72% of patients taking ARTRA MSM reported feeling relief from pain more rapidly than those on the standard treatment. Based on these findings, we can comfortably recommend ARTRA MSM for managing knee OA in clinical settings.
We divided participants into two groups: one group took ARTRA MSM, while the other received a similar combination without the MSM. Over the course of four months, we conducted monthly evaluations to track improvements in pain levels, mobility, and overall quality of life.
Notably, we observed that those taking ARTRA MSM experienced quicker reductions in pain and improvements in functional tests compared to the other group. In fact, 72% of patients taking ARTRA MSM reported feeling relief from pain more rapidly than those on the standard treatment. Based on these findings, we can comfortably recommend ARTRA MSM for managing knee OA in clinical settings.
Read More
8
MSM improves mild knee pain
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Highly relevant to MSM and arthritis
In a well-structured randomized, double-blind, placebo-controlled trial, we explored how methylsulfonylmethane (MSM) affects those experiencing mild knee pain. The study involved 88 healthy Japanese participants, split evenly into two groups where one received 200 mg of MSM while the other received a placebo for 12 weeks.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
By measuring the total score on the Japanese Knee Osteoarthritis Measure (JKOM) at the end of the trial, we found that the MSM group showed a significant improvement compared to the placebo group. Specifically, total JKOM scores changed markedly, with an improvement in knee and systemic health reported by participants who took MSM.
Our findings suggest that MSM might be beneficial for individuals with mild knee pain, marking it as a useful supplement for enhancing joint health. The positive outcomes underscore the potential of MSM as a supportive treatment option for managing mild arthritic conditions.
Read More
8
MSM reduces gouty arthritis symptoms
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Direct relevance to treatment explored.
We explored the therapeutic potential of Modified Simiaowan (MSM), a six-herb formula, specifically for its effects on gouty arthritis (GA). To understand how MSM influences the condition, we conducted a thorough investigation using mouse macrophages that were exposed to inflammatory stimuli and then treated with MSM.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Our findings showed that MSM effectively reduces inflammation and oxidative stress, which are key contributors to gouty arthritis. We measured the expression of inflammatory markers and the NLRP3 inflammasome pathway to see how MSM interacts at a biological level. This included utilizing techniques like western blotting and ELISA to gather essential data.
Furthermore, we validated MSM’s anti-inflammatory and antioxidant activities in rat models of GA. The treatments pointed to MSM alleviating symptoms through the Nrf2/HO-1/ROS/NLRP3 signaling pathway, indicating a promising mechanism of action. Overall, our results highlight MSM’s significant potential as a natural solution for managing gouty arthritis symptoms successfully.
Read More
User Reviews
USERS' SCORE
Good
Based on 68 Reviews
8.9
10
Finger relief
When I take NOW MSM, I immediately feel relief in my arthritic fingers. I take one capsule in the morning and one at night; I couldn't manage without these.
10
Chronic pain solution
I have experienced foot and ankle pain for years, likely due to my weight. Taking two pills at least three times daily has eliminated the pain! Even my shoulder joints no longer cause excruciating discomfort when putting on or taking off a blouse. It's astonishing that doctors don't inform patients about this incredible pain relief option.
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10
Amazing joint relief
Great stuff! I've been in significant pain for several weeks, unable to manage daily tasks. Suddenly, my lower back and hips became incredibly stiff and painful. After starting MSM with turmeric and glucosamine, the results have been astounding! Though I still struggle with socks, today I managed to tie my shoes, which was unthinkable just a week ago! Spending time outdoors doing yard work for four hours today felt great. I believe the MSM is the key factor in my improvement, and I highly recommend it for arthritis pain and stiffness.
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10
Remarkable recovery
I have arthritis in my left knee and fibromyalgia, leading to constant pain and stiffness. After two weeks on MSM, I experienced fantastic relief. I found it surprisingly easy to navigate stairs, which I dreaded before. My sleep has improved and I feel rejuvenated after just one week on two capsules daily. I'm sold on this product and won’t go back!
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9.5
Inflammation reduction
My husband has taken MSM for nearly nine years, as recommended by a knowledgeable rheumatologist. It has significantly helped with his rheumatoid arthritis, alleviating both swelling and pain. This has allowed him to remain medication-free despite having osteoarthritis. We're pleased that alternatives like MSM are available, and Now Foods offers excellent products.
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