Last update
5/28/2026
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.7
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
MSM (Methylsulfonylmethane)
2 g (2,000 mg)
*
📅 Last updated:

Top Medical Research Studies

8
MSM linked to lower migraine impact
We dived into how adherence to acute migraine medications influences migraine severity and patient satisfaction. Over three months, participants diligently recorded their migraine experiences in daily diaries.

With 337 adults participating, the findings showed that those using migraine-specific medication (MSM), especially when pain was milder, reported the best outcomes. This included less daily disability and greater satisfaction with their medication.

Our results suggest that starting treatment with MSM may lead to a better quality of life for migraine sufferers.
Read More
9
Erenumab reduces migraine medication use
We explored how erenumab impacts the use of acute headache medication, especially migraine-specific medications (MSM). The study analyzed data from two major clinical trials involving patients with episodic migraine (EM) and chronic migraine (CM). Participants received either erenumab or placebo over a set period, allowing us to compare medication usage accurately.

Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.

Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.
Read More

Most Useful Reviews

9
Helped headaches
A friend of mine has constant headaches, and this medication helps her tremendously. I will be ordering more for her benefit!
Read More
0
Migraine worsened
15 people found this helpful
Migraine Alert! I wanted to warn others prone to migraines that this product triggered a three-day migraine after I began it. I took the recommended dosage initially but found that those sensitive to headaches should introduce it slowly. After stopping for two days, my head improved, and I resumed with a single pill (1mg). The bottle suggests 2mg three times daily. I plan to take 1mg daily for a week to see if the headache returns. It helped my knee joint pain but caused severe exhaustion and persistent headaches. After discontinuing, I felt much better. Not a good experience at all for me.
Read More
2
Worsening condition
2 people found this helpful
Careful! Ordered by her rheumatologist, my daughter used this alongside Boswellia, leading to alarming swelling and poor circulation. This resulted in severe inflammation and crippling stiffness. Though she didn’t connect the pills to her declining condition, after stopping cold turkey, she felt unwell for a week with a bad headache before improvement began. Now, she no longer has stiffness or swelling, and her circulation has improved.
Read More

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Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
  • All Researches
9
Erenumab reduces migraine medication use
We explored how erenumab impacts the use of acute headache medication, especially migraine-specific medications (MSM). The study analyzed data from two major clinical trials involving patients with episodic migraine (EM) and chronic migraine (CM). Participants received either erenumab or placebo over a set period, allowing us to compare medication usage accurately.

Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.

Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.
Read More
8
MSM linked to lower migraine impact
We dived into how adherence to acute migraine medications influences migraine severity and patient satisfaction. Over three months, participants diligently recorded their migraine experiences in daily diaries.

With 337 adults participating, the findings showed that those using migraine-specific medication (MSM), especially when pain was milder, reported the best outcomes. This included less daily disability and greater satisfaction with their medication.

Our results suggest that starting treatment with MSM may lead to a better quality of life for migraine sufferers.
Read More

User Reviews

USERS' SCORE
Medium or Average
Based on 6 Reviews
6.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Helped headaches
A friend of mine has constant headaches, and this medication helps her tremendously. I will be ordering more for her benefit!
Read More
0
Migraine worsened
15 people found this helpful
Migraine Alert! I wanted to warn others prone to migraines that this product triggered a three-day migraine after I began it. I took the recommended dosage initially but found that those sensitive to headaches should introduce it slowly. After stopping for two days, my head improved, and I resumed with a single pill (1mg). The bottle suggests 2mg three times daily. I plan to take 1mg daily for a week to see if the headache returns. It helped my knee joint pain but caused severe exhaustion and persistent headaches. After discontinuing, I felt much better. Not a good experience at all for me.
Read More
2
Worsening condition
2 people found this helpful
Careful! Ordered by her rheumatologist, my daughter used this alongside Boswellia, leading to alarming swelling and poor circulation. This resulted in severe inflammation and crippling stiffness. Though she didn’t connect the pills to her declining condition, after stopping cold turkey, she felt unwell for a week with a bad headache before improvement began. Now, she no longer has stiffness or swelling, and her circulation has improved.
Read More
7.5
Headache improved
I purchased this product for its sulfur content, knowing its benefits, and I have not regretted it. It has significantly reduced my headaches.
Read More
7.5
Less shoulder headaches
After suffering from stiff shoulders for many years, I started taking this supplement. My headaches, related to the stiff shoulders, have decreased significantly since I began using it.
Read More

Frequently Asked Questions

7.5
Less shoulder headaches
After suffering from stiff shoulders for many years, I started taking this supplement. My headaches, related to the stiff shoulders, have decreased significantly since I began using it.
9
Erenumab reduces migraine medication use
We explored how erenumab impacts the use of acute headache medication, especially migraine-specific medications (MSM). The study analyzed data from two major clinical trials involving patients with episodic migraine (EM) and chronic migraine (CM). Participants received either erenumab or placebo over a set period, allowing us to compare medication usage accurately.

Our findings indicate that treatment with erenumab led to a significant decrease in the number of days patients used acute headache medications, particularly in those relying on MSM. This reduction was observed in both episodic and chronic migraine patients, suggesting that erenumab not only helps manage migraines but may also help mitigate the need for additional acute treatment.

Overall, these results highlight the potential benefits of erenumab in addressing not just the frequency of migraines but also reducing dependence on medications traditionally used for acute migraine relief.
8
MSM linked to lower migraine impact
We dived into how adherence to acute migraine medications influences migraine severity and patient satisfaction. Over three months, participants diligently recorded their migraine experiences in daily diaries.

With 337 adults participating, the findings showed that those using migraine-specific medication (MSM), especially when pain was milder, reported the best outcomes. This included less daily disability and greater satisfaction with their medication.

Our results suggest that starting treatment with MSM may lead to a better quality of life for migraine sufferers.

References

  1. Tepper SJ, Ashina M, Reuter U, Hallström Y, Broessner G, et al. Reduction in acute migraine-specific and non-specific medication use in patients treated with erenumab: post-hoc analyses of episodic and chronic migraine clinical trials. J Headache Pain. 2021;22:81. 10.1186/s10194-021-01292-w
  2. Seng EK, Robbins MS, Nicholson RA. Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study. Cephalalgia. 2017;37:955. 10.1177/0333102416663459
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