Last update
3/13/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
8
Nattokinase aids cold recovery
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
Most Useful Reviews
6
Improves respiratory function
2 people found this helpful
I ordered this proteolytic enzyme for my mother because it helps break down mucus that clogs the airways. She is still coughing after severe pneumonia, and we hope this medication will enhance the cleanliness of her respiratory tract. Additionally, this drug is used in treating viral infections, so we plan to take it in combination during a cold. Wishing everyone good health and high spirits.
Read More
9
Effective immune support
Hello everyone! I truly trust this brand's supplements! I've tried various ones, all of excellent quality! Reasonable price, great ingredients, and good formulation. I bought this product as immune support during colds. It fulfils this role perfectly. The packaging is convenient, and the lid closes securely. The capsules are of standard size, making them easy to use.
Read More
8
Effective for colds
Nattokinase is suitable for complex treatment of colds.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Nattokinase aids cold recovery
We conducted a study to explore how a single dose of nattokinase (NK) influences recovery of skin temperature after exposure to cold water. This double-blind, placebo-controlled crossover study involved nine healthy men who took either NK or a placebo before submerging their hands in ice-cold water at 10 °C for one minute.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Our findings showed that participants who took NK experienced a quicker recovery of skin temperature in their middle finger, palm, and back of the hand compared to those who took the placebo. Although cold exposure initially caused a significant drop in skin temperature, the NK appeared to accelerate the warming process afterward.
Interestingly, we did not observe any changes in heart rate, cardiac output, or sympathetic nervous activity as a result of taking NK. This is noteworthy because it suggests that while NK may help with temperature recovery, it does not impact certain cardiovascular responses typically associated with cold exposure.
Overall, our study highlights the potential benefits of nattokinase, especially for individuals who are more sensitive to cold, such as women and the elderly. It could offer a new avenue for managing cold sensitivity and minimizing excessive vasoconstriction during chilly conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
6
Improves respiratory function
2 people found this helpful
I ordered this proteolytic enzyme for my mother because it helps break down mucus that clogs the airways. She is still coughing after severe pneumonia, and we hope this medication will enhance the cleanliness of her respiratory tract. Additionally, this drug is used in treating viral infections, so we plan to take it in combination during a cold. Wishing everyone good health and high spirits.
Read More
9
Effective immune support
Hello everyone! I truly trust this brand's supplements! I've tried various ones, all of excellent quality! Reasonable price, great ingredients, and good formulation. I bought this product as immune support during colds. It fulfils this role perfectly. The packaging is convenient, and the lid closes securely. The capsules are of standard size, making them easy to use.
Read More
8
Effective for colds
Nattokinase is suitable for complex treatment of colds.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nara N, Kurosawa Y, Fuse-Hamaoka S, Kuroiwa M, Endo T, et al. A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study. Heliyon. 2023;9:e17951. 10.1016/j.heliyon.2023.e17951
Data last updated:
