Olive leaf extract inhibits gout enzymeOlea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase.
Directly addresses olive leaf effects
We explored the effectiveness of olive leaf, specifically the Olea europaea L. leaf extract, in treating gout. This investigation aimed to understand how this traditional remedy, commonly used in Mediterranean regions, affects an enzyme known as xanthine oxidase (XO), which plays a significant role in gout development.
In our analysis, we utilized an 80% ethanolic extract of olive leaves and examined several phenolic compounds found within. The research revealed that the olive leaf extract and certain phenolic constituents inhibited the activity of XO, potentially offering relief for gout sufferers.
Notably, we observed that the flavonoid apigenin showed remarkable potency against XO, with a considerably low inhibitory concentration compared to the well-regarded synthetic medication allopurinol. While another important component, oleuropein, also demonstrated a noteworthy effect, it was less potent than apigenin.
Furthermore, some other phenolics, such as caffeic acid and luteolin, contributed to the beneficial effects of the olive leaf extract on XO inhibition. This brings an exciting perspective to the use of olive leaves in folk medicine against gout, supporting traditional uses with scientific evidence.
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