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SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
USERS' SCORE
Good
Based on 25 Reviews
8.6
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Critical exploration of 12-HEPE
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Read More
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Directly addresses EPA for allergies
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
Eicosapentaenoic acid reduces inflammation
Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.
Direct insight into EPA's effects
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
Most Useful Reviews
9.5
Preventing allergies
Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.
Read More
9.5
Relieved allergies
My family and I take good Omega-3, especially during school as it helps relieve allergies.
Read More
9.5
Essential for health
Don't hesitate to take Omega-3; it's essential for our health. There's a significant deficiency of Omega-3 in our diet. This product meets the minimum daily requirement for these crucial fatty acids. I’ve experienced improvements in my health, including reduced allergies, after a year of use.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Study examines DHA's anti-asthmatic effects
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
9.5
New hypoallergenic formula shows promise
Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.
Impact of DHA on allergies unclear
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Read More
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Directly addresses EPA for allergies
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
9
Eicosapentaenoic acid reduces inflammation
Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes.
Direct insight into EPA's effects
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
9
Eicosapentaenoic acid and allergies
Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review.
Focused on EPA's allergy impact
We focused on understanding how the levels of eicosapentaenoic acid (EPA) at birth relate to allergies in children. Through a systematic review, we analyzed multiple studies, narrowing it down to 14 key articles that matched our criteria. The findings suggested that lower levels of EPA in cord blood were linked to a higher likelihood of allergic conditions later in childhood.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
When we looked deeper, we discovered that not only high levels of EPA, but also docosahexaenoic acid (DHA) and total n-3 long-chain polyunsaturated fatty acids were associated with a significant drop—at least 38%—in the risk of developing allergies in various studies. Additionally, we noted that the higher the levels of EPA, DHA, and docosapentaenoic acid in cord blood, the lower the laboratory measurements indicating allergic traits.
This paints a promising picture for the potential of these fatty acids in managing allergy risks. Overall, our findings can guide recommendations for the fatty acid intake that pregnant women should consider for better health outcomes for their children.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.6
10
Fish allergy alternative
This is GREAT for people with fish allergies! Being allergic to fish, I cannot have typical fish oil. This was a tremendous find; it has no aftertaste and provides the Omega-3 I need, courtesy of my allergies.
9.5
Preventing allergies
Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.
Read More
9.5
Relieved allergies
My family and I take good Omega-3, especially during school as it helps relieve allergies.
9.5
Essential for health
Don't hesitate to take Omega-3; it's essential for our health. There's a significant deficiency of Omega-3 in our diet. This product meets the minimum daily requirement for these crucial fatty acids. I’ve experienced improvements in my health, including reduced allergies, after a year of use.
Read More
9.5
Dryness relief
I've been taking Omega-3 for two winter seasons now. It has stopped the dryness and cracking of my skin, which I discovered was related to my cold allergies. After three weeks, my skin improved significantly, and I've noticed increased energy levels.
