Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.4
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
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8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
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Most Useful Reviews
9
Improves arthritis mobility
1 people found this helpful
Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!
Read More
9
Prophylactic use
The capsules are odourless and tasteless with no aftertaste. They contain adequate fish oil to support brain function, reduce inflammation in arthritis, and maintain retina health. I take Omega-3 for preventative measures.
Read More
9
Reduces arthritis pain
Wonderful! The products are of high quality. Omega-3 fatty acids help prevent osteoporosis and maintain joint health, relieving pain during flare-ups. They combat bone loss, reduce inflammation, and alleviate symptoms of arthritis, slowing the damage to joint cartilage during arthrosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
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9
Docosahexaenoic acid reduces arthritis
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
We observed a fascinating case involving a 22-year-old woman with juvenile idiopathic arthritis who was put on a very low calorie ketogenic diet (VLCKD). This diet included high-biological-value protein preparations that featured docosahexaenoic acid (DHA), an omega-3 fatty acid known for its potential health benefits.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves arthritis mobility
1 people found this helpful
Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!
Read More
9
Prophylactic use
The capsules are odourless and tasteless with no aftertaste. They contain adequate fish oil to support brain function, reduce inflammation in arthritis, and maintain retina health. I take Omega-3 for preventative measures.
Read More
9
Reduces arthritis pain
Wonderful! The products are of high quality. Omega-3 fatty acids help prevent osteoporosis and maintain joint health, relieving pain during flare-ups. They combat bone loss, reduce inflammation, and alleviate symptoms of arthritis, slowing the damage to joint cartilage during arthrosis.
Read More
7.5
Reduces arthritis pain
32 people found this helpful
Omega-3 is exceptional! It significantly alleviates arthritis symptoms, helps with inflammation, and promotes joint mobility. I've also noticed improvements in my overall health, with added benefits for skin and digestion. I recommend taking three capsules daily with meals. If you find this review helpful, please click "YES" below and check out my other reviews. Wishing you good health!
Read More
7.5
Supports arthritis treatment
4 people found this helpful
This fish oil offers great value. It helps with arthritis and improves overall health by regulating metabolism and protecting against inflammation. It's essential to check the EPA and DHA levels, not just the total fish oil content.
Read More
Frequently Asked Questions
7.5
Eases arthritis pain
3 people found this helpful
Excellent product! There are no fishy burps, and these capsules are easy to swallow. I've noticed a significant improvement in my arthritis pain since I started taking them daily.
7.5
Relieves arthritis pain
1 people found this helpful
Omega-3s are excellent! They help maintain joint health, reduce inflammation, and relieve arthritis symptoms. They also aid in slowing down osteoporosis.
7.5
Arthritis support
14 people found this helpful
Omega-3 is crucial for preventing atherosclerosis and aiding arthritis. Recommended doses vary from 1g for prevention to up to 8g for severe cases like rheumatoid arthritis. It's essential to read labels for EPA and DHA content, as higher quality supplements will have greater concentrations.
9
Improves arthritis mobility
1 people found this helpful
Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!
7.5
Reduces arthritis pain
32 people found this helpful
Omega-3 is exceptional! It significantly alleviates arthritis symptoms, helps with inflammation, and promotes joint mobility. I've also noticed improvements in my overall health, with added benefits for skin and digestion. I recommend taking three capsules daily with meals. If you find this review helpful, please click "YES" below and check out my other reviews. Wishing you good health!
7.5
Joint health support
1 people found this helpful
Omega-3 capsules are a beneficial supplement for overall health. They support cardiovascular health, enhance brain function, and may improve mental well-being. I find that they reduce inflammation, which is great for managing arthritis and alleviating joint pain. Additionally, Omega-3 helps maintain skin health and can complement diets lacking these essential fatty acids.
9
Reduces arthritis pain
Wonderful! The products are of high quality. Omega-3 fatty acids help prevent osteoporosis and maintain joint health, relieving pain during flare-ups. They combat bone loss, reduce inflammation, and alleviate symptoms of arthritis, slowing the damage to joint cartilage during arthrosis.
8
We investigated the link between fatty acid profiles and the activity of rheumatoid arthritis (RA) in early-stage patients. By analyzing blood samples from 669 individuals, we found that a higher level of omega-3 fatty acids is associated with significantly lower disease activity after six months.
Additionally, a profile rich in omega-6 fatty acids also showed benefits in reducing disease activity. This suggests that incorporating omega-3 and omega-6 into our diets may help manage RA symptoms effectively.
Additionally, a profile rich in omega-6 fatty acids also showed benefits in reducing disease activity. This suggests that incorporating omega-3 and omega-6 into our diets may help manage RA symptoms effectively.
4
Omega-3 has limited arthritis impact
We investigated the effects of omega-3 fatty acid supplements on rheumatoid arthritis using data from 23 randomized placebo-controlled trials. Our analysis showed only a small effect in reducing pain, joint tenderness, and swelling.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
References
- Marushack GK, Savadipour A, Tang R, Garcia-Castorena JM, Rashidi N, et al. Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes. FASEB J. 2025;39:e70290. doi:10.1096/fj.202400544RR
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. doi:10.1017/S0007114524002721
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0
- Scherer D, Leite BF, Morimoto MA, Oliveira TL, Klemz BNC, et al. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. Adv Rheumatol. 2024;64:47. doi:10.1186/s42358-024-00389-5
- Liu Y, Song F, Liu M, Huang X, Xue S, et al. Association between omega-3 polyunsaturated fatty acids and osteoarthritis: results from the NHANES 2003-2016 and Mendelian randomization study. Lipids Health Dis. 2024;23:147. doi:10.1186/s12944-024-02139-4
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. doi:10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. doi:10.1007/s00394-024-03397-9
- Doucet MR, Laevski AM, Doiron JA, Boudreau LH, Surette ME. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLoS One. 2024;19:e0291399. doi:10.1371/journal.pone.0291399
- Xiong T, Huang S, Wang X, Shi Y, He J, et al. n-3 polyunsaturated fatty acids alleviate the progression of obesity-related osteoarthritis and protect cartilage through inhibiting the HMGB1-RAGE/TLR4 signaling pathway. Int Immunopharmacol. 2024;128:111498. doi:10.1016/j.intimp.2024.111498
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. doi:10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. doi:10.1016/j.biopha.2022.113608
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. doi:10.3390/nu14142947
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
- Jannas-Vela S, Candia AA, Peñailillo L, Barrios-Troncoso P, Zapata-Urzúa J, et al. Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial. F1000Res. 2023;12:942. doi:10.12688/f1000research.138392.1
- Deng C, Presle N, Pizard A, Guillaume C, Bianchi A, et al. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. Int J Mol Sci. 2024;25. doi:10.3390/ijms25031810
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. doi:10.26355/eurrev_202308_33310
- Wadell AT, Bärebring L, Hulander E, Gjertsson I, Landberg R, et al. Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial. Front Nutr. 2023;10:1209787. doi:10.3389/fnut.2023.1209787
- Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, et al. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023;28. doi:10.3390/molecules28020717
- Kuang X, Shao X, Li H, Jiang D, Gao T, et al. Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial. J Sci Food Agric. 2023;103:2970. doi:10.1002/jsfa.12346
- Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, et al. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021;19. doi:10.3390/md19100542
- Ceotto BH, Figueroba SR, Ferreira LEN, Amorim KS, Sánchez JB, et al. The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis. Ann Anat. 2022;239:151812. doi:10.1016/j.aanat.2021.151812
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. doi:10.3389/fimmu.2021.680073
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. doi:10.1093/jn/nxaa156
- Brown Z, Metcalf R, Bednarz J, Spargo L, Lee A, et al. Modifiable Lifestyle Factors Associated With Response to Treatment in Early Rheumatoid Arthritis. ACR Open Rheumatol. 2020;2:371. doi:10.1002/acr2.11132
- Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, et al. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38:2157. doi:10.1002/jor.24688
- Gowler PRW, Arendt-Tranholm A, Turnbull J, Jha RR, Onion D, et al. Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience. 2025;28:111862. doi:10.1016/j.isci.2025.111862
- Franks SJ, Gowler PRW, Dunster JL, Turnbull J, Gohir SA, et al. Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Math Biosci. 2024;374:109228. doi:10.1016/j.mbs.2024.109228
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. doi:10.1016/j.biopha.2024.116153
- Rondanelli M, Patelli Z, Gasparri C, Mansueto F, Ferraris C, et al. Very low calorie ketogenic diet and common rheumatic disorders: A case report. World J Clin Cases. 2023;11:1985. doi:10.12998/wjcc.v11.i9.1985
- Jeong M, Shin JI, Cho J, Jeon YJ, Kim JH, et al. DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients. Int J Mol Sci. 2023;24. doi:10.3390/ijms24021734
- Xie R, Zhang Y. Association between 19 dietary fatty acids intake and rheumatoid arthritis: Results of a nationwide survey. Prostaglandins Leukot Essent Fatty Acids. 2023;188:102530. doi:10.1016/j.plefa.2022.102530
- Oppedisano F, Bulotta RM, Maiuolo J, Gliozzi M, Musolino V, et al. The Role of Nutraceuticals in Osteoarthritis Prevention and Treatment: Focus on n-3 PUFAs. Oxid Med Cell Longev. 2021;2021:4878562. doi:10.1155/2021/4878562
- Chang CK, Chen PK, Chen CC, Chang SH, Chen CH, et al. Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors. Nutrients. 2021;13. doi:10.3390/nu13093050
- Christmann U, Hancock CL, Poole CM, Emery AL, Poovey JR, et al. Dynamics of DHA and EPA supplementation: incorporation into equine plasma, synovial fluid, and surfactant glycerophosphocholines. Metabolomics. 2021;17:41. doi:10.1007/s11306-021-01792-5
