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SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
4
Fish oil's limited effect on gout
Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial.
Relevant to gout treatment research
We conducted a pilot study to examine how omega-3 supplementation from fish oil affects gout in individuals with elevated serum urate levels. Our research involved 40 participants who were split into two groups: one group received 6.2 grams of omega-3 fish oil daily, while the other group did not receive any fish oil for a period of 24 weeks.
Throughout the study, we measured serum urate concentrations, weight, and body mass index (BMI) monthly. Unfortunately, we found that there was no significant difference in serum urate levels or body weight changes between those who took fish oil and those who didn’t.
Interestingly, we discovered a notable correlation between higher omega-3 levels in the blood and a reduction in gout flare-ups among participants in the fish oil group. However, despite this link, the primary measures regarding serum urate and weight did not show meaningful improvement. Some participants reported mild gastrointestinal issues related to the omega-3 supplements, but overall, these supplements were well-tolerated.
This study shows that while omega-3 fish oil does not significantly affect serum urate levels or BMI, there may be potential benefits in reducing the frequency of gout flares. Based on these findings, further large-scale trials are encouraged to explore the role of fish oil as a preventive treatment for gout.
Throughout the study, we measured serum urate concentrations, weight, and body mass index (BMI) monthly. Unfortunately, we found that there was no significant difference in serum urate levels or body weight changes between those who took fish oil and those who didn’t.
Interestingly, we discovered a notable correlation between higher omega-3 levels in the blood and a reduction in gout flare-ups among participants in the fish oil group. However, despite this link, the primary measures regarding serum urate and weight did not show meaningful improvement. Some participants reported mild gastrointestinal issues related to the omega-3 supplements, but overall, these supplements were well-tolerated.
This study shows that while omega-3 fish oil does not significantly affect serum urate levels or BMI, there may be potential benefits in reducing the frequency of gout flares. Based on these findings, further large-scale trials are encouraged to explore the role of fish oil as a preventive treatment for gout.
Read More
8
DHA reduces gout-related inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Significant evidence of DHA benefits
We explored the effect of docosahexaenoic acid (DHA), a key component of fish oil, on inflammation caused by monosodium urate (MSU), which can lead to acute gouty attacks. The researchers conducted experiments both in lab cells and in mice to understand how DHA helps in managing this painful condition.
The results were promising. We found that DHA significantly reduced the production of two major inflammatory markers—interleukin-1β and tumor necrosis factor-α—in immune cells exposed to MSU. Moreover, DHA was effective in lowering the levels of reactive oxygen species, which contribute to oxidative stress and inflammation.
Additionally, DHA appears to help the body bolster its antioxidant defenses. It promoted the movement of a protein called Nrf2 into the cell nucleus, which then activated various antioxidant enzymes. Interestingly, DHA also aided in restoring mitochondrial function that is often impaired during inflammation.
Furthermore, when mice were given DHA-rich microalgal oil, their immune responses improved, showing less infiltration of inflammatory cells and reduced secretion of cytokines. Overall, these findings suggest that incorporating DHA into our diet could offer a natural approach to managing gout and its associated inflammation, chiefly by reducing oxidative stress.
The results were promising. We found that DHA significantly reduced the production of two major inflammatory markers—interleukin-1β and tumor necrosis factor-α—in immune cells exposed to MSU. Moreover, DHA was effective in lowering the levels of reactive oxygen species, which contribute to oxidative stress and inflammation.
Additionally, DHA appears to help the body bolster its antioxidant defenses. It promoted the movement of a protein called Nrf2 into the cell nucleus, which then activated various antioxidant enzymes. Interestingly, DHA also aided in restoring mitochondrial function that is often impaired during inflammation.
Furthermore, when mice were given DHA-rich microalgal oil, their immune responses improved, showing less infiltration of inflammatory cells and reduced secretion of cytokines. Overall, these findings suggest that incorporating DHA into our diet could offer a natural approach to managing gout and its associated inflammation, chiefly by reducing oxidative stress.
Read More
Most Useful Reviews
8.8
Health improvement
My husband previously suffered from gout, but his recent health check scores are nearly excellent. Drinking this has contributed, though it’s not a sole solution.
Read More
4.8
Caution advised
The company’s products are good, yet those suffering from gout should be cautious with omega-3. High daily doses can irritate gout severely; I recommend a low concentration once daily after meals.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
8
DHA reduces gout-related inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Significant evidence of DHA benefits
We explored the effect of docosahexaenoic acid (DHA), a key component of fish oil, on inflammation caused by monosodium urate (MSU), which can lead to acute gouty attacks. The researchers conducted experiments both in lab cells and in mice to understand how DHA helps in managing this painful condition.
The results were promising. We found that DHA significantly reduced the production of two major inflammatory markers—interleukin-1β and tumor necrosis factor-α—in immune cells exposed to MSU. Moreover, DHA was effective in lowering the levels of reactive oxygen species, which contribute to oxidative stress and inflammation.
Additionally, DHA appears to help the body bolster its antioxidant defenses. It promoted the movement of a protein called Nrf2 into the cell nucleus, which then activated various antioxidant enzymes. Interestingly, DHA also aided in restoring mitochondrial function that is often impaired during inflammation.
Furthermore, when mice were given DHA-rich microalgal oil, their immune responses improved, showing less infiltration of inflammatory cells and reduced secretion of cytokines. Overall, these findings suggest that incorporating DHA into our diet could offer a natural approach to managing gout and its associated inflammation, chiefly by reducing oxidative stress.
The results were promising. We found that DHA significantly reduced the production of two major inflammatory markers—interleukin-1β and tumor necrosis factor-α—in immune cells exposed to MSU. Moreover, DHA was effective in lowering the levels of reactive oxygen species, which contribute to oxidative stress and inflammation.
Additionally, DHA appears to help the body bolster its antioxidant defenses. It promoted the movement of a protein called Nrf2 into the cell nucleus, which then activated various antioxidant enzymes. Interestingly, DHA also aided in restoring mitochondrial function that is often impaired during inflammation.
Furthermore, when mice were given DHA-rich microalgal oil, their immune responses improved, showing less infiltration of inflammatory cells and reduced secretion of cytokines. Overall, these findings suggest that incorporating DHA into our diet could offer a natural approach to managing gout and its associated inflammation, chiefly by reducing oxidative stress.
Read More
8
Omega-3 fatty acids reduce gout inflammation
Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.
Study offers relevant insights
We explored the effects of omega-3-carboxylic acids, commonly found in fish oil, on gout and other crystal-related inflammation. The study utilized human THP-1 macrophages and primary blood cells to test the anti-inflammatory capabilities of these substances in a lab setting. We also examined the effectiveness of omega-3 carboxylic acids in animal models, specifically focusing on how they respond to various inflammatory crystals associated with gout.
The results were quite encouraging. We found that treatment with docosahexaenoic acid, a type of omega-3 fatty acid, significantly reduced the production of interleukin-1β, a key player in inflammation, in response to different crystals. When tested in rats with monosodium urate crystals—often a culprit in gout—omega-3 carboxylic acids not only lessened cell migration to the inflammatory site but also lowered both exudate volume and levels of inflammatory markers like IL-1β and prostaglandin E.
Comparatively, when we treated the rats with omega-3 carboxylic acids versus the traditional anti-inflammatory drug indomethacin, we observed similar levels of pain and swelling reduction. This suggests that omega-3 carboxylic acids could serve as a viable option for reducing gout symptoms.
In complex mixtures containing omega-3 fatty acids, however, higher levels of palmitic acid were found to diminish these anti-inflammatory effects, pointing to the importance of formulation. Overall, this study highlights that omega-3 carboxylic acids have a strong potential as an effective anti-inflammatory agent in gout treatment and possibly other conditions that involve elevated IL-1β levels.
The results were quite encouraging. We found that treatment with docosahexaenoic acid, a type of omega-3 fatty acid, significantly reduced the production of interleukin-1β, a key player in inflammation, in response to different crystals. When tested in rats with monosodium urate crystals—often a culprit in gout—omega-3 carboxylic acids not only lessened cell migration to the inflammatory site but also lowered both exudate volume and levels of inflammatory markers like IL-1β and prostaglandin E.
Comparatively, when we treated the rats with omega-3 carboxylic acids versus the traditional anti-inflammatory drug indomethacin, we observed similar levels of pain and swelling reduction. This suggests that omega-3 carboxylic acids could serve as a viable option for reducing gout symptoms.
In complex mixtures containing omega-3 fatty acids, however, higher levels of palmitic acid were found to diminish these anti-inflammatory effects, pointing to the importance of formulation. Overall, this study highlights that omega-3 carboxylic acids have a strong potential as an effective anti-inflammatory agent in gout treatment and possibly other conditions that involve elevated IL-1β levels.
Read More
8
Eicosapentaenoic acid influences urate
Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber.
Study highlights EPA's potential
We set out to explore how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, affects the body’s ability to manage urate levels, which is crucial for individuals dealing with gout. Gout is often a result of high serum urate, and the kidney plays a significant role in regulating this through a specialized transporter called URAT1.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Read More
8
Exploration of DHA and gout
Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.
Study supports DHA's potential effects
We investigated the connection between gut microbiota, docosahexaenoic acid (DHA), and urate metabolism to see how they interact and affect conditions like gout. The study utilized extensive data from a large number of participants, pulling information from various databases focusing on microbiota taxa, gout prevalence, and urate levels.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
8.8
Health improvement
My husband previously suffered from gout, but his recent health check scores are nearly excellent. Drinking this has contributed, though it’s not a sole solution.
4.8
Caution advised
The company’s products are good, yet those suffering from gout should be cautious with omega-3. High daily doses can irritate gout severely; I recommend a low concentration once daily after meals.
