Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Read More
8
DHA-derived protectins against influenza
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
Read More
7
We investigated the effects of docosahexaenoic acid (DHA), an essential omega-3 fatty acid, on B cell activity during influenza infection, particularly in the context of obesity. Our focus was on understanding how obesity might impair the immune response, especially regarding B cell function.
The study revealed that in obese mice consuming a Western diet, the production of antibodies was significantly reduced compared to those not on the diet. However, when we added DHA to the diet, we observed improvements in antibody levels. This is important because higher DHA levels often correlate with better immune responses, potentially due to its ability to generate specialized pro-resolving lipid mediators, which enhance antibody production.
While the research showed promising results for DHA, it's worth noting that it does not seem to work directly on B cells. Instead, it appears to improve immunity through these mediators, which help bolster B cell function during influenza infections. This insight is valuable as it adds to our understanding of nutrition’s role in immune health, especially in individuals dealing with obesity.
The study revealed that in obese mice consuming a Western diet, the production of antibodies was significantly reduced compared to those not on the diet. However, when we added DHA to the diet, we observed improvements in antibody levels. This is important because higher DHA levels often correlate with better immune responses, potentially due to its ability to generate specialized pro-resolving lipid mediators, which enhance antibody production.
While the research showed promising results for DHA, it's worth noting that it does not seem to work directly on B cells. Instead, it appears to improve immunity through these mediators, which help bolster B cell function during influenza infections. This insight is valuable as it adds to our understanding of nutrition’s role in immune health, especially in individuals dealing with obesity.
Read More
Most Useful Reviews
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
Read More
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
Read More
7.5
Nervous system support
This supplement is often prescribed for preventing and treating cardiovascular diseases, including atherosclerosis. Taking Omega-3 during influenza and colds is an effective method to strengthen the nervous system, enhance immunity, and improve overall health. It also supports skin rejuvenation, both on the face and body.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.8
- All Researches
9
Our study focused on understanding how 17-HDHA, a compound derived from docosahexaenoic acid (DHA), affects the immune response to influenza vaccination. We used both an OVA immunization model and a mouse model for influenza vaccination to investigate its potential benefits.
We found that when mice were immunized with either OVA plus 17-HDHA or H1N1-derived HA protein plus 17-HDHA, there was a notable increase in antibody titers. This means that the presence of 17-HDHA helped these mice produce more antibodies against the viruses involved. Additionally, the treatment boosted the number of antibody-secreting cells in vitro and in the bone marrow of the mice.
Importantly, the enhanced antibody production linked to 17-HDHA showed greater protective effects against live H1N1 influenza infection. This insight is particularly significant as it highlights a new connection between proresolution molecules and the adaptive immune response, suggesting exciting possibilities for developing new vaccine adjuvants.
Overall, our findings indicate that DHA-derived compounds like 17-HDHA could play a vital role in improving immune responses against influenza, a pressing global health challenge.
We found that when mice were immunized with either OVA plus 17-HDHA or H1N1-derived HA protein plus 17-HDHA, there was a notable increase in antibody titers. This means that the presence of 17-HDHA helped these mice produce more antibodies against the viruses involved. Additionally, the treatment boosted the number of antibody-secreting cells in vitro and in the bone marrow of the mice.
Importantly, the enhanced antibody production linked to 17-HDHA showed greater protective effects against live H1N1 influenza infection. This insight is particularly significant as it highlights a new connection between proresolution molecules and the adaptive immune response, suggesting exciting possibilities for developing new vaccine adjuvants.
Overall, our findings indicate that DHA-derived compounds like 17-HDHA could play a vital role in improving immune responses against influenza, a pressing global health challenge.
Read More
8
Eicosapentaenoic Acid and Influenza Study
We examined the potential effects of eicosapentaenoic acid (EPA) on influenza infections, focusing on how the gut bacteria Clostridium butyricum contribute to this relationship. Our exploration revealed that when Clostridium butyricum is taken orally, it can bolster resistance to influenza by boosting levels of a signaling molecule called interferon-λ in the lungs.
This process is facilitated by gut-produced EPA, specifically a version called 18-hydroxy eicosapentaenoic acid (18-HEPE), which encourages the production of interferon-λ through a specific receptor pathway in lung cells. What's fascinating is that the presence of Clostridium butyricum also enhances the sensitivity of lung tissues to the benefits of EPA by increasing receptor levels that recognize the molecule.
Overall, this study sheds light on a gut-lung connection, offering new insights into potential treatments for viral infections like influenza. However, while we noticed positive outcomes with the involvement of Clostridium butyricum and EPA, arriving at the isolated effects of EPA on its own requires further examination.
This process is facilitated by gut-produced EPA, specifically a version called 18-hydroxy eicosapentaenoic acid (18-HEPE), which encourages the production of interferon-λ through a specific receptor pathway in lung cells. What's fascinating is that the presence of Clostridium butyricum also enhances the sensitivity of lung tissues to the benefits of EPA by increasing receptor levels that recognize the molecule.
Overall, this study sheds light on a gut-lung connection, offering new insights into potential treatments for viral infections like influenza. However, while we noticed positive outcomes with the involvement of Clostridium butyricum and EPA, arriving at the isolated effects of EPA on its own requires further examination.
Read More
8
We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Read More
8
DHA-derived protectins against influenza
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
Read More
7
We aimed to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects the organization of lipid rafts in alveolar macrophages and its potential role in reducing inflammation during influenza. To investigate this, we used MH-S cells, an alveolar macrophage line, and treated them with DHA, comparing the results to a vehicle control group.
Through various advanced techniques, we observed that DHA seems to drive sphingomyelin and cholesterol into larger lipid rafts, which may help lower inflammation signals in these immune cells. Additionally, in a murine model of influenza, we examined pulmonary inflammatory markers from mice that had been fed DHA, revealing its anti-inflammatory properties that could be beneficial in the context of lung health.
Overall, our findings suggest that targeting alveolar macrophages with DHA could provide a new avenue for managing inflammation linked to respiratory infections like influenza. While the results highlight DHA's potential, further research is necessary to fully understand its impact and mechanisms in clinical settings.
Through various advanced techniques, we observed that DHA seems to drive sphingomyelin and cholesterol into larger lipid rafts, which may help lower inflammation signals in these immune cells. Additionally, in a murine model of influenza, we examined pulmonary inflammatory markers from mice that had been fed DHA, revealing its anti-inflammatory properties that could be beneficial in the context of lung health.
Overall, our findings suggest that targeting alveolar macrophages with DHA could provide a new avenue for managing inflammation linked to respiratory infections like influenza. While the results highlight DHA's potential, further research is necessary to fully understand its impact and mechanisms in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
Read More
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
Read More
7.5
Nervous system support
This supplement is often prescribed for preventing and treating cardiovascular diseases, including atherosclerosis. Taking Omega-3 during influenza and colds is an effective method to strengthen the nervous system, enhance immunity, and improve overall health. It also supports skin rejuvenation, both on the face and body.
Read More
Frequently Asked Questions
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
7.5
Nervous system support
This supplement is often prescribed for preventing and treating cardiovascular diseases, including atherosclerosis. Taking Omega-3 during influenza and colds is an effective method to strengthen the nervous system, enhance immunity, and improve overall health. It also supports skin rejuvenation, both on the face and body.
7
We investigated whether docosahexaenoic acid (DHA), a type of long-chain n-3 polyunsaturated fatty acid, could influence the body's response to influenza in young children. In our research, we found that children exposed to higher levels of DHA tended to have increased IgG antibody levels against the influenza A virus. This suggests that DHA might play a supportive role in enhancing the immune response to this particular virus.
However, it is important to note that while we observed this positive association, the study did not isolate the effects of DHA specifically on influenza. This points to a more complex relationship between DHA and the various viral infections that children may encounter.
Furthermore, our findings indicate that while certain fatty acids, including DHA, can impact the immune response, the overall benefit of DHA in protecting against influenza requires further exploration. Understanding these dynamics can help parents make informed dietary choices for their children and highlight the potential importance of omega-3 fatty acids in early nutrition.
However, it is important to note that while we observed this positive association, the study did not isolate the effects of DHA specifically on influenza. This points to a more complex relationship between DHA and the various viral infections that children may encounter.
Furthermore, our findings indicate that while certain fatty acids, including DHA, can impact the immune response, the overall benefit of DHA in protecting against influenza requires further exploration. Understanding these dynamics can help parents make informed dietary choices for their children and highlight the potential importance of omega-3 fatty acids in early nutrition.
8
DHA-derived protectins against influenza
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
2
We explored the effects of eicosapentaenoic acid, a key component of fish oil, on the immune response to influenza virus infections in mice. By feeding male C57BL/6 mice either a fish oil-rich diet or a control corn oil diet for two weeks, we sought to understand how such dietary choices might influence their resilience against the virus.
Our findings revealed a concerning trade-off. While the fish oil diet resulted in lower lung inflammation, it also significantly increased mortality rates, lung viral loads, and extended recovery times for the mice infected with the influenza virus. Notably, the fish oil-fed mice exhibited a 40% higher death rate and a 70% higher build-up of the virus in their lungs compared to those on the corn oil diet.
Additionally, we noted suppressed immune functions in the fish oil group, especially regarding splenic natural killer (NK) cell activity. Infected mice on the fish oil diet had fewer CD8+ T cells and showed reduced levels of key inflammatory markers, suggesting that the anti-inflammatory properties of eicosapentaenoic acid may impair the body’s immediate immune response necessary to fight off acute viral infections like influenza.
Overall, this study raises important questions about the balance between anti-inflammatory benefits during chronic conditions and the potential negative impact of fish oil on fighting off acute viral illnesses like the flu.
Our findings revealed a concerning trade-off. While the fish oil diet resulted in lower lung inflammation, it also significantly increased mortality rates, lung viral loads, and extended recovery times for the mice infected with the influenza virus. Notably, the fish oil-fed mice exhibited a 40% higher death rate and a 70% higher build-up of the virus in their lungs compared to those on the corn oil diet.
Additionally, we noted suppressed immune functions in the fish oil group, especially regarding splenic natural killer (NK) cell activity. Infected mice on the fish oil diet had fewer CD8+ T cells and showed reduced levels of key inflammatory markers, suggesting that the anti-inflammatory properties of eicosapentaenoic acid may impair the body’s immediate immune response necessary to fight off acute viral infections like influenza.
Overall, this study raises important questions about the balance between anti-inflammatory benefits during chronic conditions and the potential negative impact of fish oil on fighting off acute viral illnesses like the flu.
References
- Hagihara M, Yamashita M, Ariyoshi T, Eguchi S, Minemura A, et al. Clostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation. Cell Rep. 2022;41:111755. doi:10.1016/j.celrep.2022.111755
- Schwerbrock NM, Karlsson EA, Shi Q, Sheridan PA, Beck MA. Fish oil-fed mice have impaired resistance to influenza infection. J Nutr. 2009;139:1588. doi:10.3945/jn.109.108027
- Pennington ER, Virk R, Bridges MD, Bathon BE, Beatty N, et al. Docosahexaenoic Acid Controls Pulmonary Macrophage Lipid Raft Size and Inflammation. J Nutr. 2024;154:1945. doi:10.1016/j.tjnut.2024.04.006
- Hakola L, Oikarinen M, Niinistö S, Cuthbertson D, Lehtonen J, et al. Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study. Clin Nutr. 2022;41:2729. doi:10.1016/j.clnu.2022.10.017
- Lagarde M, Guichardant M, Bernoud-Hubac N. Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX. Biochimie. 2020;179:281. doi:10.1016/j.biochi.2020.09.008
- Kosaraju R, Guesdon W, Crouch MJ, Teague HL, Sullivan EM, et al. B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection. J Immunol. 2017;198:4738. doi:10.4049/jimmunol.1601031
- Imai Y. Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection. Biochim Biophys Acta. 2015;1851:496. doi:10.1016/j.bbalip.2015.01.006
- Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?. J Immunol. 2014;193:6031. doi:10.4049/jimmunol.1302795
- Bassaganya-Riera J, Guri AJ, Noble AM, Reynolds KA, King J, et al. Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. Am J Clin Nutr. 2007;85:824.
