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NOW Supplements P-5-P
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%

Top Medical Research Studies

9
Vitamin B6 mitigates food symptoms
The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome.
Supports link to food reactions
We explored an intriguing connection between vitamin B6 and something called the Chinese Restaurant Syndrome, often linked to the consumption of monosodium L-glutamate (MSG). This study involved a group of 155 students who had not taken extra vitamin B6. By analyzing an enzyme called aspartate transaminase in their blood cells, we identified 27 individuals with notably low levels, which suggested they might have a vitamin B6 deficiency.

Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.

We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
Read More
9
Pyridoxal phosphate may aid recovery
Ginkgo seed poisoning.
Indicates potential vitamin B6 effectiveness
We explored the effects of vitamin B6 treatment in a fascinating case of ginkgo seed poisoning. A 2-year-old girl suffered from vomiting and diarrhea after consuming a large quantity of ginkgo seeds. The symptoms escalated to convulsions a few hours later, and blood tests revealed high levels of 4-metoxypyridoxine, a byproduct related to vitamin B6.

Reports indicate that ginkgo seed poisoning can lead to severe complications, particularly in children who may have repetitive seizures that can be fatal. However, in this case, the quick administration of pyridoxal phosphate, a form of vitamin B6, seemed to potentially prevent further seizures. This case also marks the first time that 4-metoxypyridoxine levels were measured in the context of ginkgo seed poisoning in an English-language report.

Overall, while the study did not conduct a formal evaluation of vitamin B6’s isolated effects, the results suggest that prompt treatment with pyridoxal phosphate can play a critical role in recovery from this type of food poisoning. Our findings highlight the importance of being aware of the risks associated with eating certain traditional foods and the potential benefits of timely medical intervention.
Read More
7
Vitamin B6 effects on mercury poisoning
Early indices of methyl mercury toxicity and their use in treatment evaluation.
Limited relevance for food poisoning
We explored the effects of vitamin B6 in conjunction with D-penicillamine (DPA) as a treatment for methyl mercury poisoning in a study involving female rats. The research aimed to understand how this vitamin might support recovery during food poisoning caused by mercury exposure.

The study observed changes in food consumption and body weight as early indicators of methyl mercury toxicity, noting a significant 75% decrease in food intake within the first day. Interestingly, while DPA effectively prevented neurological symptoms and enhanced recovery, vitamin B6's specific impact on food poisoning was less clear. It appeared that DPA's positive effects could be counterbalanced by vitamin B6, as it sometimes reduced food consumption and body weight.

Overall, while DPA showed promise in mitigating the effects of methyl mercury, the role of vitamin B6 was not distinct enough to draw firm conclusions regarding its effectiveness. Therefore, we found that vitamin B6 did not significantly enhance treatment outcomes, emphasizing the complexity of using multiple interventions in managing food poisoning.
Read More

Most Useful Reviews

8
Effective protocol
Just what I need to combat trigger finger and carpal tunnel. The magnesium is beneficial as well. The protocol I follow requires 50mg three times a day with food, as advised by the doctor who examined my hands. So far, it seems effective in addressing these issues.
Read More
8.8
Steady improvement
I began taking NOW Foods P-5-P upon my nutritionist's recommendation to support my B6 metabolism. It has been effective in alleviating some symptoms like fatigue and irritability. The capsules are a convenient size, and I have not noticed any side effects. While I have not experienced dramatic changes, there has been a steady improvement. It is a good product, but it is crucial to maintain realistic expectations about the outcomes.
Read More
8.8
Improved energy levels
Excellent! NOW Foods P-5-P has been invaluable for my overall nervous system health. The Vitamin B6 in the P-5-P form has high bioavailability, ensuring effective absorption. After several weeks of regular use, I observed improved energy levels, reduced fatigue, and better concentration. The capsules are easy to swallow and do not cause any side effects.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
  • All Researches
9
Pyridoxal phosphate may aid recovery
Ginkgo seed poisoning.
Indicates potential vitamin B6 effectiveness
We explored the effects of vitamin B6 treatment in a fascinating case of ginkgo seed poisoning. A 2-year-old girl suffered from vomiting and diarrhea after consuming a large quantity of ginkgo seeds. The symptoms escalated to convulsions a few hours later, and blood tests revealed high levels of 4-metoxypyridoxine, a byproduct related to vitamin B6.

Reports indicate that ginkgo seed poisoning can lead to severe complications, particularly in children who may have repetitive seizures that can be fatal. However, in this case, the quick administration of pyridoxal phosphate, a form of vitamin B6, seemed to potentially prevent further seizures. This case also marks the first time that 4-metoxypyridoxine levels were measured in the context of ginkgo seed poisoning in an English-language report.

Overall, while the study did not conduct a formal evaluation of vitamin B6’s isolated effects, the results suggest that prompt treatment with pyridoxal phosphate can play a critical role in recovery from this type of food poisoning. Our findings highlight the importance of being aware of the risks associated with eating certain traditional foods and the potential benefits of timely medical intervention.
Read More
9
Vitamin B6 mitigates food symptoms
The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome.
Supports link to food reactions
We explored an intriguing connection between vitamin B6 and something called the Chinese Restaurant Syndrome, often linked to the consumption of monosodium L-glutamate (MSG). This study involved a group of 155 students who had not taken extra vitamin B6. By analyzing an enzyme called aspartate transaminase in their blood cells, we identified 27 individuals with notably low levels, which suggested they might have a vitamin B6 deficiency.

Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.

We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
Read More
7
Vitamin B6 effects on mercury poisoning
Early indices of methyl mercury toxicity and their use in treatment evaluation.
Limited relevance for food poisoning
We explored the effects of vitamin B6 in conjunction with D-penicillamine (DPA) as a treatment for methyl mercury poisoning in a study involving female rats. The research aimed to understand how this vitamin might support recovery during food poisoning caused by mercury exposure.

The study observed changes in food consumption and body weight as early indicators of methyl mercury toxicity, noting a significant 75% decrease in food intake within the first day. Interestingly, while DPA effectively prevented neurological symptoms and enhanced recovery, vitamin B6's specific impact on food poisoning was less clear. It appeared that DPA's positive effects could be counterbalanced by vitamin B6, as it sometimes reduced food consumption and body weight.

Overall, while DPA showed promise in mitigating the effects of methyl mercury, the role of vitamin B6 was not distinct enough to draw firm conclusions regarding its effectiveness. Therefore, we found that vitamin B6 did not significantly enhance treatment outcomes, emphasizing the complexity of using multiple interventions in managing food poisoning.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8
Effective protocol
Just what I need to combat trigger finger and carpal tunnel. The magnesium is beneficial as well. The protocol I follow requires 50mg three times a day with food, as advised by the doctor who examined my hands. So far, it seems effective in addressing these issues.
8.8
Steady improvement
I began taking NOW Foods P-5-P upon my nutritionist's recommendation to support my B6 metabolism. It has been effective in alleviating some symptoms like fatigue and irritability. The capsules are a convenient size, and I have not noticed any side effects. While I have not experienced dramatic changes, there has been a steady improvement. It is a good product, but it is crucial to maintain realistic expectations about the outcomes.
Read More
8.8
Improved energy levels
Excellent! NOW Foods P-5-P has been invaluable for my overall nervous system health. The Vitamin B6 in the P-5-P form has high bioavailability, ensuring effective absorption. After several weeks of regular use, I observed improved energy levels, reduced fatigue, and better concentration. The capsules are easy to swallow and do not cause any side effects.
Read More
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