Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 13 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
Top Medical Research Studies
9
Vitamin B6 shows antioxidant effects
We explored the effects of vitamin B6 on liver damage caused by chromium-related oxidative stress in a study involving adult male Wistar rats. The rats received potassium dichromate to induce oxidative stress, while vitamin B6 was given either before or simultaneously with the chromium treatment.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Read More
8
We explored the effects of vitamin B6 on liver diseases, particularly looking at its potential benefits in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The study involved analyzing tissue and plasma samples from 44 HCC patients and 28 patients with advanced liver cirrhosis. To gain deeper insights, researchers conducted microbiome, metabolome, and proteome analyses.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
Read More
4
We examined how vitamin B6, specifically pyridoxine, affects patients with liver cirrhosis compared to healthy individuals. By measuring blood and urine samples from 31 cirrhotic patients and 15 healthy controls, we found that the active form of B6 was significantly lower in those with cirrhosis.
After administering pyridoxine, the response differed between groups; although levels of pyridoxal-5'-phosphate rose in cirrhotics, their overall response was weaker compared to those without liver disease. This highlights potential issues with B6 metabolism in affected individuals, but the treatment did not show significant benefits in reversing liver effects.
After administering pyridoxine, the response differed between groups; although levels of pyridoxal-5'-phosphate rose in cirrhotics, their overall response was weaker compared to those without liver disease. This highlights potential issues with B6 metabolism in affected individuals, but the treatment did not show significant benefits in reversing liver effects.
Read More
Most Useful Reviews
9
Gallstone relief
69 people found this helpful
Helps dissolve gallstones. I found this B6 form effective in dissolving cholesterol stones in gallstones, including those with calcifications. Vitamin B6 enhances bile's capability to hold cholesterol. After the first treatment, solid crusts detached, accompanied by sand. A second session led to a small stone (0.5 cm) disappearing, while a 1 cm stone became soft. After the third course, no gallstones remained. Other vitamins and supplements supported my liver and digestion.
Read More
9
Inflammation relief
4 people found this helpful
With a problematic liver, I often experience heightened histamine reactions. Following an indulgence in chocolate, I faced itching and body aches. I decided to take a B6 capsule, which relieved symptoms within 30 minutes. I’m truly grateful – it’s been a lifesaver!
Read More
7.5
Effective emotional regulation
1 people found this helpful
A good preparation for emotional regulation. The active form of vitamin B6 absorbs much faster, I can confidently confirm. Following liver problems after hepatitis B, I experienced significant food intolerance. This vitamin bypasses my damaged liver and works directly as an active metabolite. It's also beneficial for cardioneurosis and emotional lability, hence I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
- All Researches
9
Vitamin B6 shows antioxidant effects
We explored the effects of vitamin B6 on liver damage caused by chromium-related oxidative stress in a study involving adult male Wistar rats. The rats received potassium dichromate to induce oxidative stress, while vitamin B6 was given either before or simultaneously with the chromium treatment.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Read More
8
We explored the effects of vitamin B6 in combating nonalcoholic fatty liver disease (NAFLD) through a study that utilized a mouse model. The mice were fed a diet designed to induce NAFLD, and then we treated them with green pea hull polyphenol extract, which is rich in beneficial compounds, including vitamin B6.
Our findings revealed that vitamin B6 plays a crucial role in alleviating the symptoms of NAFLD. We observed that after the intervention with the green pea extract, the vitamin B6 levels significantly increased in the mice's livers. This surge in vitamin B6 appears to activate important signaling pathways that aid in reducing fat accumulation in the liver, enhancing antioxidant activity, and improving overall lipid metabolism.
Moreover, we noted that increased intestinal permeability was linked to a worsening of NAFLD symptoms. With the help of cutting-edge metabolomics and transcriptomic analysis, we pinpointed the significance of vitamin B6, which may act as a metabolite produced by gut bacteria. This insight suggests a promising direction for NAFLD treatments that incorporate dietary sources of vitamin B6.
Our findings revealed that vitamin B6 plays a crucial role in alleviating the symptoms of NAFLD. We observed that after the intervention with the green pea extract, the vitamin B6 levels significantly increased in the mice's livers. This surge in vitamin B6 appears to activate important signaling pathways that aid in reducing fat accumulation in the liver, enhancing antioxidant activity, and improving overall lipid metabolism.
Moreover, we noted that increased intestinal permeability was linked to a worsening of NAFLD symptoms. With the help of cutting-edge metabolomics and transcriptomic analysis, we pinpointed the significance of vitamin B6, which may act as a metabolite produced by gut bacteria. This insight suggests a promising direction for NAFLD treatments that incorporate dietary sources of vitamin B6.
Read More
8
We recently delved into the intriguing connections between genetic variants and clinical responses in patients suffering from primary hyperoxaluria (PH), a rare metabolic disorder. Our study identified 21 Chinese patients with PH, uncovering four novel genetic variants, including those that may influence the effectiveness of vitamin B6 treatment.
Among these patients, we noted a diverse range of symptoms and disease severity, which seemed closely linked to their specific genetic make-up. Interestingly, we found that four patients responded favorably to vitamin B6, leading us to believe that certain genetic traits, specifically variants c.823_824dup and c.145A > C, may indicate a heightened sensitivity to this treatment. This discovery opens up new avenues for improving management strategies in PH, especially for those individuals affected by the disorder.
While vitamin B6 could provide benefits for some patients, we are cautious about generalizing its effectiveness to all individuals with primary hyperoxaluria. Our findings emphasize the importance of tailored treatment approaches based on genetic profiles and early diagnosis to enhance outcomes for affected patients.
Among these patients, we noted a diverse range of symptoms and disease severity, which seemed closely linked to their specific genetic make-up. Interestingly, we found that four patients responded favorably to vitamin B6, leading us to believe that certain genetic traits, specifically variants c.823_824dup and c.145A > C, may indicate a heightened sensitivity to this treatment. This discovery opens up new avenues for improving management strategies in PH, especially for those individuals affected by the disorder.
While vitamin B6 could provide benefits for some patients, we are cautious about generalizing its effectiveness to all individuals with primary hyperoxaluria. Our findings emphasize the importance of tailored treatment approaches based on genetic profiles and early diagnosis to enhance outcomes for affected patients.
Read More
8
We explored the effects of vitamin B6 on liver diseases, particularly looking at its potential benefits in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The study involved analyzing tissue and plasma samples from 44 HCC patients and 28 patients with advanced liver cirrhosis. To gain deeper insights, researchers conducted microbiome, metabolome, and proteome analyses.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
Read More
7
Metadoxine improves alcohol-related liver function
We conducted a thorough review of clinical trials examining metadoxine, a combination of pyroglutamic acid and vitamin B6. Our focus was on its role in treating acute alcohol intoxication and chronic alcoholism, including impacts on liver function.
The analysis revealed that metadoxine is generally safe and effective in improving liver function related to alcohol-related diseases. While its effects on brain disorders are promising, further studies are needed to confirm this potential.
The analysis revealed that metadoxine is generally safe and effective in improving liver function related to alcohol-related diseases. While its effects on brain disorders are promising, further studies are needed to confirm this potential.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Gallstone relief
69 people found this helpful
Helps dissolve gallstones. I found this B6 form effective in dissolving cholesterol stones in gallstones, including those with calcifications. Vitamin B6 enhances bile's capability to hold cholesterol. After the first treatment, solid crusts detached, accompanied by sand. A second session led to a small stone (0.5 cm) disappearing, while a 1 cm stone became soft. After the third course, no gallstones remained. Other vitamins and supplements supported my liver and digestion.
Read More
9
Inflammation relief
4 people found this helpful
With a problematic liver, I often experience heightened histamine reactions. Following an indulgence in chocolate, I faced itching and body aches. I decided to take a B6 capsule, which relieved symptoms within 30 minutes. I’m truly grateful – it’s been a lifesaver!
Read More
7.5
Effective emotional regulation
1 people found this helpful
A good preparation for emotional regulation. The active form of vitamin B6 absorbs much faster, I can confidently confirm. Following liver problems after hepatitis B, I experienced significant food intolerance. This vitamin bypasses my damaged liver and works directly as an active metabolite. It's also beneficial for cardioneurosis and emotional lability, hence I highly recommend it!
Read More
9
Improves liver function
Excellent set of B vitamins that aid in the absorption of iron and enhance liver function, mood, and energy the very next day. I noticed an excellent effect almost immediately, and the price-to-quality ratio is outstanding. The ingredients are optimally selected, and I recommend a course intake.
Read More
7.5
Improved sleep
25 people found this helpful
P-5-P has significantly enhanced my sleep quality after poor experiences with inactive B6 damaged my liver. The remarkable suppression of nightmares wasn't achieved with regular B6. Despite the higher cost, it's worth the investment. P-5-P, alongside Holy Basil and B3 Niacin, has proven beneficial for those prone to nightmares.
Read More
Frequently Asked Questions
9
Inflammation relief
4 people found this helpful
With a problematic liver, I often experience heightened histamine reactions. Following an indulgence in chocolate, I faced itching and body aches. I decided to take a B6 capsule, which relieved symptoms within 30 minutes. I’m truly grateful – it’s been a lifesaver!
9
Improves liver function
Excellent set of B vitamins that aid in the absorption of iron and enhance liver function, mood, and energy the very next day. I noticed an excellent effect almost immediately, and the price-to-quality ratio is outstanding. The ingredients are optimally selected, and I recommend a course intake.
9
Gallstone relief
69 people found this helpful
Helps dissolve gallstones. I found this B6 form effective in dissolving cholesterol stones in gallstones, including those with calcifications. Vitamin B6 enhances bile's capability to hold cholesterol. After the first treatment, solid crusts detached, accompanied by sand. A second session led to a small stone (0.5 cm) disappearing, while a 1 cm stone became soft. After the third course, no gallstones remained. Other vitamins and supplements supported my liver and digestion.
7.5
Improved sleep
25 people found this helpful
P-5-P has significantly enhanced my sleep quality after poor experiences with inactive B6 damaged my liver. The remarkable suppression of nightmares wasn't achieved with regular B6. Despite the higher cost, it's worth the investment. P-5-P, alongside Holy Basil and B3 Niacin, has proven beneficial for those prone to nightmares.
6
Aids liver absorption
I began using it as advised by Nutri, alongside magnesium, as they work in synergy for optimal absorption. This dosage is ideal since, in the form of p5p, it does not need to pass through the liver for absorption. I take it at night because, with magnesium, it assists in relaxation.
7.5
Effective emotional regulation
1 people found this helpful
A good preparation for emotional regulation. The active form of vitamin B6 absorbs much faster, I can confidently confirm. Following liver problems after hepatitis B, I experienced significant food intolerance. This vitamin bypasses my damaged liver and works directly as an active metabolite. It's also beneficial for cardioneurosis and emotional lability, hence I highly recommend it!
7
Metadoxine improves alcohol-related liver function
We conducted a thorough review of clinical trials examining metadoxine, a combination of pyroglutamic acid and vitamin B6. Our focus was on its role in treating acute alcohol intoxication and chronic alcoholism, including impacts on liver function.
The analysis revealed that metadoxine is generally safe and effective in improving liver function related to alcohol-related diseases. While its effects on brain disorders are promising, further studies are needed to confirm this potential.
The analysis revealed that metadoxine is generally safe and effective in improving liver function related to alcohol-related diseases. While its effects on brain disorders are promising, further studies are needed to confirm this potential.
2
We explored the impact of vitamin B-6 and glutathione on patients with liver cirrhosis through a double-blind randomized controlled trial. Sixty-one participants received either a placebo, vitamin B-6, glutathione, or a combination for 12 weeks.
Unfortunately, neither vitamin B-6 nor glutathione showed significant benefits in reducing oxidative stress or improving antioxidant capacity. Although we observed that baseline levels of glutathione were linked to better disease indicators, the supplementation did not have the desired therapeutic effects.
Unfortunately, neither vitamin B-6 nor glutathione showed significant benefits in reducing oxidative stress or improving antioxidant capacity. Although we observed that baseline levels of glutathione were linked to better disease indicators, the supplementation did not have the desired therapeutic effects.
7
We examined the impact of vitamin B6 on individuals suffering from primary sclerosing cholangitis (PSC), a serious liver condition. Our research involved a thorough analysis of blood samples from several distinct groups, totaling 373 PSC patients and 100 healthy individuals, using advanced testing methods to measure B6 levels.
It became clear that a significant number of people with PSC, many of whom were already diagnosed with liver disease, experience low vitamin B6 levels. Even after undergoing liver transplantation, these patients often continued to show signs of vitamin B6 deficiency. Importantly, we found that low levels of vitamin B6 were closely linked to poorer outcomes, including a decreased chance of survival without the need for liver transplantation.
Despite the connection between vitamin B6 status and disease outcomes, the study did not directly address whether vitamin B6 supplementation could yield significant benefits in treating liver disease. Nevertheless, our findings suggest that monitoring and potentially enhancing vitamin B6 levels could be an important aspect of managing PSC and improving patient outcomes. Therefore, exploring vitamin B6 supplementation or adjusting the gut microbiome might be worthwhile areas for future research to see if they can help PSC patients.
It became clear that a significant number of people with PSC, many of whom were already diagnosed with liver disease, experience low vitamin B6 levels. Even after undergoing liver transplantation, these patients often continued to show signs of vitamin B6 deficiency. Importantly, we found that low levels of vitamin B6 were closely linked to poorer outcomes, including a decreased chance of survival without the need for liver transplantation.
Despite the connection between vitamin B6 status and disease outcomes, the study did not directly address whether vitamin B6 supplementation could yield significant benefits in treating liver disease. Nevertheless, our findings suggest that monitoring and potentially enhancing vitamin B6 levels could be an important aspect of managing PSC and improving patient outcomes. Therefore, exploring vitamin B6 supplementation or adjusting the gut microbiome might be worthwhile areas for future research to see if they can help PSC patients.
8
We explored the effects of vitamin B6 in combating nonalcoholic fatty liver disease (NAFLD) through a study that utilized a mouse model. The mice were fed a diet designed to induce NAFLD, and then we treated them with green pea hull polyphenol extract, which is rich in beneficial compounds, including vitamin B6.
Our findings revealed that vitamin B6 plays a crucial role in alleviating the symptoms of NAFLD. We observed that after the intervention with the green pea extract, the vitamin B6 levels significantly increased in the mice's livers. This surge in vitamin B6 appears to activate important signaling pathways that aid in reducing fat accumulation in the liver, enhancing antioxidant activity, and improving overall lipid metabolism.
Moreover, we noted that increased intestinal permeability was linked to a worsening of NAFLD symptoms. With the help of cutting-edge metabolomics and transcriptomic analysis, we pinpointed the significance of vitamin B6, which may act as a metabolite produced by gut bacteria. This insight suggests a promising direction for NAFLD treatments that incorporate dietary sources of vitamin B6.
Our findings revealed that vitamin B6 plays a crucial role in alleviating the symptoms of NAFLD. We observed that after the intervention with the green pea extract, the vitamin B6 levels significantly increased in the mice's livers. This surge in vitamin B6 appears to activate important signaling pathways that aid in reducing fat accumulation in the liver, enhancing antioxidant activity, and improving overall lipid metabolism.
Moreover, we noted that increased intestinal permeability was linked to a worsening of NAFLD symptoms. With the help of cutting-edge metabolomics and transcriptomic analysis, we pinpointed the significance of vitamin B6, which may act as a metabolite produced by gut bacteria. This insight suggests a promising direction for NAFLD treatments that incorporate dietary sources of vitamin B6.
9
Vitamin B6 shows antioxidant effects
We explored the effects of vitamin B6 on liver damage caused by chromium-related oxidative stress in a study involving adult male Wistar rats. The rats received potassium dichromate to induce oxidative stress, while vitamin B6 was given either before or simultaneously with the chromium treatment.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
References
- Lai CY, Cheng SB, Lee TY, Hsiao YF, Liu HT, et al. Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study. Nutrients. 2020;12. doi:10.3390/nu12071978
- Di Miceli M, Gronier B. Pharmacology, Systematic Review and Recent Clinical Trials of Metadoxine. Rev Recent Clin Trials. 2018;13:114. doi:10.2174/1574887113666180227100217
- Anand SS. Protective effect of vitamin B6 in chromium-induced oxidative stress in liver. J Appl Toxicol. 2005;25:440.
- Komar VI, Vasil'ev VS. [The use of water-soluble vitamins in viral hepatitis A]. Klin Med (Mosk). 1992;70:73.
- Henderson JM, Codner MA, Hollins B, Kutner MH, Merrill AH. The fasting B6 vitamer profile and response to a pyridoxine load in normal and cirrhotic subjects. Hepatology. 1986;6:464.
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. doi:10.1097/HC9.0000000000000599
- Guo F, Xiong H, Tsao R, Shahidi F, Wen X, et al. Green Pea ( L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways. J Agric Food Chem. 2023;71:16067. doi:10.1021/acs.jafc.3c02337
- Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, et al. Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. J Hepatol. 2023;79:955. doi:10.1016/j.jhep.2023.05.038
- Xin Q, Dong Y, Guo W, Zhao X, Liu Z, et al. Four novel variants identified in primary hyperoxaluria and genotypic and phenotypic analysis in 21 Chinese patients. Front Genet. 2023;14:1124745. doi:10.3389/fgene.2023.1124745
- Lin S, Huang L, Wu Y, Huang L, Wu P, et al. Uncovering the protective mechanism of Pien-Tze-Huang in rat with alcoholic liver injury based on cytokines analysis and untargeted metabonomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2023;1217:123626. doi:10.1016/j.jchromb.2023.123626
- Mei M, Liu D, Tang X, You Y, Peng B, et al. Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis. J Hepatocell Carcinoma. 2022;9:729. doi:10.2147/JHC.S370255
