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NOW Supplements P-5-P
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%

Top Medical Research Studies

4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Focus on vitamin B6 effects
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.

Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.

A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.

Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Read More
8
Pyridoxine reduces postoperative nausea
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial.
Combined medication limits assessment
We examined the effects of pyridoxine, or vitamin B6, in reducing postoperative nausea and vomiting (PONV) for patients undergoing elective gynecological laparoscopic surgery. In this study, patients aged 18 to 65 were randomly assigned to receive either pyridoxine or a placebo (normal saline) before anesthesia.

All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.

While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
Read More

Most Useful Reviews

10
Helpful for nausea
Helpful for nausea I did some research and found that pregnant women use P5P for nausea, so I tried it, because even though I’m not pregnant, I struggle with nausea, and it really works!
Read More
9.5
Excellent for nausea
Excellent product for those unable to take vitamin B6 due to nausea.
Read More
10
Helps with nausea
I was feeling really nauseous, and my doctor mentioned this product. It genuinely helped me feel better.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
  • All Researches
8
Pyridoxine reduces postoperative nausea
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial.
Combined medication limits assessment
We examined the effects of pyridoxine, or vitamin B6, in reducing postoperative nausea and vomiting (PONV) for patients undergoing elective gynecological laparoscopic surgery. In this study, patients aged 18 to 65 were randomly assigned to receive either pyridoxine or a placebo (normal saline) before anesthesia.

All patients also received a regimen that included dexamethasone and ondansetron, two well-known anti-nausea medications. Reports from the patients indicated that those who received pyridoxine experienced a reduced incidence of nausea and vomiting following their surgery compared to those who received the placebo.

While our findings are promising, it is important to note that pyridoxine was used in conjunction with other medications, making it difficult to ascertain its effect in isolation. Future multicenter studies will help us confirm the effectiveness of pyridoxine in more diverse settings and populations.
Read More
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Focus on vitamin B6 effects
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.

Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.

A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.

Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Read More

User Reviews

USERS' SCORE
Good
Based on 10 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Helpful for nausea
Helpful for nausea I did some research and found that pregnant women use P5P for nausea, so I tried it, because even though I’m not pregnant, I struggle with nausea, and it really works!
9.5
Excellent for nausea
Excellent product for those unable to take vitamin B6 due to nausea.
10
Helps with nausea
I was feeling really nauseous, and my doctor mentioned this product. It genuinely helped me feel better.
9.5
Nausea reduced
Excellent! My nausea was reduced, and I felt various other health benefits.
8.8
Improves nausea
Good composition, fast delivery, and convenient packaging. After 10 days of taking it, I noticed benefits in energy and reduction of fatigue and nausea.
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