Last update
3/29/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 12 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Potassium (from 310 mg Potassium Citrate)
99 mg
2%
Top Medical Research Studies
9.5
Niferidil effective for atrial flutter
We evaluated the effectiveness of niferidil, a novel antiarrhythmic agent, in restoring normal heart rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFL). Administered through three intravenous boluses, 134 patients were monitored for their response over 24 hours. We found that 84.6% of patients regained a normal sinus rhythm (SR) after the final dose, with complete success in those with AFL. While a small number of patients experienced minor heart rhythm disturbances, overall, the findings suggest that niferidil is a promising alternative to traditional electrical cardioversion.
Read More
8
We explored the effects of nifekalant, a specialized I(Kr) blocker, on typical atrial flutter in 17 patients. After administering nifekalant, we noted a significant increase in the atrial effective refractory period and variability in the AFL-cycle length. This led to the termination of atrial flutter in about 65% of patients, either spontaneously or through stimulated intervention. However, there was no change in AFL-cycle length itself. Overall, nifekalant appears to effectively aid in stopping atrial flutter by modifying electrical conduction patterns in the heart.
Read More
8
We examined a unique case involving a middle-aged woman who arrived at the Emergency Department with sudden leg weakness linked to low potassium levels caused by hyperthyroidism. Upon further evaluation, she was found to have atrial flutter.
After administering potassium replacement, we saw a remarkable change—her heart rhythm returned to normal and her muscle strength improved significantly. This highlights the importance of understanding how electrolyte imbalances, like hypokalemia, can lead to serious heart issues and paralysis.
After administering potassium replacement, we saw a remarkable change—her heart rhythm returned to normal and her muscle strength improved significantly. This highlights the importance of understanding how electrolyte imbalances, like hypokalemia, can lead to serious heart issues and paralysis.
Read More
Most Useful Reviews
9
Cardiovascular support
3 people found this helpful
I'm very satisfied. I've had vegetative-vascular dystonia and arrhythmia during the off-season. This year, apple cider vinegar didn't help, but potassium citrate did. It's beneficial for various cardiovascular issues. Potassium citrate is better absorbed and effective; my heart rate normalised quickly after taking it for a short time.
Read More
9
Arrhythmia relief
1 people found this helpful
Taking potassium with magnesium helped me after I experienced frequent arrhythmias following severe stress. This potassium, paired with magnesium taurate, is more effective than an over-the-counter analogue. After six months, I nearly forgot about my arrhythmia! It's essential for my cardiovascular wellbeing and offers numerous health benefits as well.
Read More
9
Breathless feeling gone
1 people found this helpful
I rarely experienced feelings of arrhythmia and breathlessness while climbing stairs. After taking potassium citrate, all those symptoms vanished unexpectedly. I noticed no negative effects, and it's convenient to take just one small capsule daily. I will definitely continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
- All Researches
9.5
Niferidil effective for atrial flutter
We evaluated the effectiveness of niferidil, a novel antiarrhythmic agent, in restoring normal heart rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFL). Administered through three intravenous boluses, 134 patients were monitored for their response over 24 hours. We found that 84.6% of patients regained a normal sinus rhythm (SR) after the final dose, with complete success in those with AFL. While a small number of patients experienced minor heart rhythm disturbances, overall, the findings suggest that niferidil is a promising alternative to traditional electrical cardioversion.
Read More
9.5
We examined the potential of niferidile, a new class III antiarrhythmic drug, in treating atrial flutter and fibrillation. This medication works by blocking potassium currents, which helps prolong the heart's recovery time after each beat.
In our analysis, we found that intravenous niferidile successfully converted up to 100% of patients experiencing persistent atrial flutter. While it showed a high effectiveness, there were some risks involved, including a low incidence of serious heart rhythm issues.
Overall, niferidile could serve as a valuable alternative for treating these arrhythmias, particularly when electrical cardioversion isn't suitable.
In our analysis, we found that intravenous niferidile successfully converted up to 100% of patients experiencing persistent atrial flutter. While it showed a high effectiveness, there were some risks involved, including a low incidence of serious heart rhythm issues.
Overall, niferidile could serve as a valuable alternative for treating these arrhythmias, particularly when electrical cardioversion isn't suitable.
Read More
9
We investigated how NIP-142, a new drug that blocks potassium and other channels, affects atrial flutter and atrial fibrillation (AF). This medication specifically targets potassium currents that are more prevalent in the atria, potentially leading to safer treatment options.
In our studies with canine models, NIP-142 effectively terminated specific types of AF and prolonged the atrial refractory period without impacting conduction times. Despite promising results, more clinical trials are needed to confirm NIP-142's efficacy and safety in humans.
In our studies with canine models, NIP-142 effectively terminated specific types of AF and prolonged the atrial refractory period without impacting conduction times. Despite promising results, more clinical trials are needed to confirm NIP-142's efficacy and safety in humans.
Read More
8
We examined a unique case involving a middle-aged woman who arrived at the Emergency Department with sudden leg weakness linked to low potassium levels caused by hyperthyroidism. Upon further evaluation, she was found to have atrial flutter.
After administering potassium replacement, we saw a remarkable change—her heart rhythm returned to normal and her muscle strength improved significantly. This highlights the importance of understanding how electrolyte imbalances, like hypokalemia, can lead to serious heart issues and paralysis.
After administering potassium replacement, we saw a remarkable change—her heart rhythm returned to normal and her muscle strength improved significantly. This highlights the importance of understanding how electrolyte imbalances, like hypokalemia, can lead to serious heart issues and paralysis.
Read More
8
We explored the effects of nifekalant, a specialized I(Kr) blocker, on typical atrial flutter in 17 patients. After administering nifekalant, we noted a significant increase in the atrial effective refractory period and variability in the AFL-cycle length. This led to the termination of atrial flutter in about 65% of patients, either spontaneously or through stimulated intervention. However, there was no change in AFL-cycle length itself. Overall, nifekalant appears to effectively aid in stopping atrial flutter by modifying electrical conduction patterns in the heart.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cardiovascular support
3 people found this helpful
I'm very satisfied. I've had vegetative-vascular dystonia and arrhythmia during the off-season. This year, apple cider vinegar didn't help, but potassium citrate did. It's beneficial for various cardiovascular issues. Potassium citrate is better absorbed and effective; my heart rate normalised quickly after taking it for a short time.
Read More
9
Arrhythmia relief
1 people found this helpful
Taking potassium with magnesium helped me after I experienced frequent arrhythmias following severe stress. This potassium, paired with magnesium taurate, is more effective than an over-the-counter analogue. After six months, I nearly forgot about my arrhythmia! It's essential for my cardiovascular wellbeing and offers numerous health benefits as well.
Read More
9
Breathless feeling gone
1 people found this helpful
I rarely experienced feelings of arrhythmia and breathlessness while climbing stairs. After taking potassium citrate, all those symptoms vanished unexpectedly. I noticed no negative effects, and it's convenient to take just one small capsule daily. I will definitely continue using it.
Read More
9
Arrhythmia improvement
The cardiologist prescribed potassium for my arrhythmia. I ordered it here and took 1-2 capsules a day for several months, alongside magnesium. Gradually, my arrhythmia dissipated. I plan to buy more!
Read More
9
Atrial flutter relief
Excellent! It helps prevent my arrhythmia!
Read More
Frequently Asked Questions
7.5
Energy boost
I found this product effective; after three days of taking two capsules each morning and evening, the swelling disappeared, and I felt more energised. I now wake up feeling more vigorous. I recommend it for anyone suffering from arrhythmia.
9
Arrhythmia improvement
The cardiologist prescribed potassium for my arrhythmia. I ordered it here and took 1-2 capsules a day for several months, alongside magnesium. Gradually, my arrhythmia dissipated. I plan to buy more!
9
Arrhythmia relief
1 people found this helpful
Taking potassium with magnesium helped me after I experienced frequent arrhythmias following severe stress. This potassium, paired with magnesium taurate, is more effective than an over-the-counter analogue. After six months, I nearly forgot about my arrhythmia! It's essential for my cardiovascular wellbeing and offers numerous health benefits as well.
9
Cardiovascular support
3 people found this helpful
I'm very satisfied. I've had vegetative-vascular dystonia and arrhythmia during the off-season. This year, apple cider vinegar didn't help, but potassium citrate did. It's beneficial for various cardiovascular issues. Potassium citrate is better absorbed and effective; my heart rate normalised quickly after taking it for a short time.
9
Breathless feeling gone
1 people found this helpful
I rarely experienced feelings of arrhythmia and breathlessness while climbing stairs. After taking potassium citrate, all those symptoms vanished unexpectedly. I noticed no negative effects, and it's convenient to take just one small capsule daily. I will definitely continue using it.
9
Adjusted dosage
This product is of excellent quality, and the dosage can be adjusted. My mum takes two capsules in the morning; it effectively lowers her blood pressure and reduces her arrhythmia.
9
Atrial flutter relief
Excellent! It helps prevent my arrhythmia!
6
Better absorption
1 people found this helpful
A doctor recommended potassium for my arrhythmia. I switched from potassium orotate to citrate, which is better absorbed and more cost-effective. It helps combat edema, and I take 2-3 capsules daily.
6
Lowered blood pressure
I purchased these minerals for my father, who has arrhythmia and leg cramps. After two months, his blood pressure decreased and leg cramps became less frequent. However, it's crucial to monitor kidney health. The quality was good, and the powder diluted well in warm water.
References
- Li S, Zhang Z, Ding Y, Yu T, Qin Z, et al. Dissecting the associations of KCNH2 genetic polymorphisms with various types of cardiac arrhythmias. Gene. 2024;899:148132. 10.1016/j.gene.2024.148132
- Yahya AMB, Ahmed N, Qayyum H. An Interesting Case of Weakness and Atrial Tachycardia in the Emergency Department: Thinking Beyond Hearts and Minds. Cureus. 2023;15:e38002. 10.7759/cureus.38002
- Cacioppo F, Reisenbauer D, Herkner H, Oppenauer J, Schuetz N, et al. Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department. JAMA Netw Open. 2022;5:e2237234. 10.1001/jamanetworkopen.2022.37234
- Harkness W, Watts P, Kopstein M, Dziadkowiec O, Hicks G, et al. Correcting Hypokalemia in Hospitalized Patients Does Not Decrease Risk of Cardiac Arrhythmias. Adv Med. 2019;2019:4919707. 10.1155/2019/4919707
- Maykov EB, Yuricheva YA, Mironov NY, Sokolov SF, Golitsyn SP, et al. [Refralon (niferidil) is a new class III antiarrhythmic agent for pharmacological cardioversion for persistent atrial fibrillation and atrial flutter]. Ter Arkh. 2015;87:38. 10.17116/terarkh201587138-48
- Maĭkov EB, Iuricheva IuA, Mironov NIu, Sokolov SF, Golitsyn SP, et al. [Novel class III antiarrhythmic agent niferidile: review of experimental and clinical studies]. Kardiologiia. 2014;54:4. PubMed
- Banchs JE, Baquero GA, Nickolaus MJ, Wolbrette DL, Kelleman JJ, et al. Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease. Congenit Heart Dis. 2014;9:221. 10.1111/chd.12129
- Yamabe H, Tanaka Y, Morihisa K, Uemura T, Koyama J, et al. Electrophysiologic mechanism of typical atrial flutter termination by nifekalant: effect of a pure IKr -selective blocking agent. Pacing Clin Electrophysiol. 2013;36:1123. 10.1111/pace.12147
- Serafimovski N, Burke P, Khawaja O, Sekulic M, Machado C. Usefulness of dofetilide for the prevention of atrial tachyarrhythmias (atrial fibrillation or flutter) after coronary artery bypass grafting. Am J Cardiol. 2008;101:1574. 10.1016/j.amjcard.2008.01.044
- Tanaka H, Hashimoto N. A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation. Cardiovasc Drug Rev. 2007;25:342. PubMed
- Vernakalant: RSD 1235, RSD-1235, RSD1235. Drugs R D. 2007;8:259. PubMed
