Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study.
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
8
Quercetin activates anti-allergic pathway
Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Read More
9.5
Quercetin reduces peanut allergy reactions
Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats.
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
Most Useful Reviews
7.5
Effective for allergies
526 people found this helpful
Excellent tool! Before ordering this drug, I read that Quercetin with Bromelain strengthens the immune system and helps with allergies. Since I started taking one capsule per day, my allergy symptoms have improved within a week. I'm looking forward to the ageing benefits too. Thank you for the excellent service!
Read More
10
Miracle for allergies
434 people found this helpful
I've tried many remedies for spring allergies over the past 10 years, but these capsules are the most effective! After a week of taking 2 capsules at night, I no longer experience tearing, dry cough, or breathing difficulties. They’ve transformed my experience.
Read More
9
Huge difference noted
281 people found this helpful
This is a miracle for my allergies! I suffer from chronic allergies year-round, yet this product has surpassed over 20 years of allergy shots and medications, all without side effects. While it’s not a complete cure, taking two capsules multiple times daily has made a significant positive impact. During peak allergy times, I can even take extra doses to alleviate symptoms throughout the day. I'd recommend it to anyone suffering from allergies, but do check with a doctor if you're on other medications.
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
9.5
Plant vaccines show no allergy risk
Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines.
The study looked into how plant-made influenza vaccines interact with the immune system, particularly concerning allergies. We followed 280 participants over six months, monitoring for allergic reactions and measuring specific antibodies.
While some subjects produced temporary IgG and occasionally IgE antibodies, no allergic symptoms were reported. Importantly, the study found these antibody responses were not tied to allergy worsening, indicating that these vaccines may be safe for those with known plant allergies.
Read More
9
Quercetin shows promise in allergies
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches.
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Read More
9
Quercetin leaf extract aids allergies
Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines.
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Read More
9
Quercetin may alleviate allergy symptoms
Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study.
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Excellent tool! Before ordering this drug, I read that Quercetin with Bromelain strengthens the immune system and helps with allergies. Since I started taking one capsule per day, my allergy symptoms have improved within a week. I'm looking forward to the ageing benefits too. Thank you for the excellent service!
Read More
10
Miracle for allergies
434 people found this helpful
I've tried many remedies for spring allergies over the past 10 years, but these capsules are the most effective! After a week of taking 2 capsules at night, I no longer experience tearing, dry cough, or breathing difficulties. They’ve transformed my experience.
Read More
9
Huge difference noted
281 people found this helpful
This is a miracle for my allergies! I suffer from chronic allergies year-round, yet this product has surpassed over 20 years of allergy shots and medications, all without side effects. While it’s not a complete cure, taking two capsules multiple times daily has made a significant positive impact. During peak allergy times, I can even take extra doses to alleviate symptoms throughout the day. I'd recommend it to anyone suffering from allergies, but do check with a doctor if you're on other medications.
Read More
9
Remarkable health boost
193 people found this helpful
It may just be my elixir for good health. Nothing has helped me as much as Quercetin+Bromelain. I've suffered from allergies and asthma for years, but after taking this for 3 or 4 years, I've noticed a complete change. I no longer fall sick like I used to. It’s not a magic solution, but for me, the benefits are undeniable. I don't even take allergy pills anymore as long as I'm consistently using my Quercetin+Bromelain.
Read More
9
Assists with allergies
179 people found this helpful
My family uses this for seasonal allergies, particularly for my son’s ragweed allergy. It has been very effective in alleviating his symptoms.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Quercetin is a naturally occurring flavonoid that is found in a variety of fruits, vegetables, and grains. Known for its antioxidant properties, quercetin is believed to help combat oxidative stress in the body, which can contribute to various health issues. You can commonly find it in foods such as apples, onions, berries, and citrus fruits, as well as in leafy greens. This makes it a popular dietary supplement among health enthusiasts looking to enhance their overall wellness.
Beyond its antioxidant capacity, quercetin is also being researched for its potential anti-inflammatory effects and benefits for immune support. Some studies suggest that it may help reduce allergy symptoms and improve exercise performance by decreasing muscle fatigue. With its wide range of potential health benefits, quercetin is often marketed as a natural remedy for various ailments, although it’s essential to consult a healthcare professional before starting any new supplement regimen to ensure its safety and effectiveness for your specific needs.
Quercetin is a natural flavonoid found in various fruits and vegetables, and it has garnered significant attention for its potential antihistamine properties. Some studies suggest that quercetin may help reduce allergy symptoms by stabilizing mast cells and preventing the release of histamines, the chemicals responsible for allergic reactions. Additionally, its anti-inflammatory effects might further alleviate the symptoms associated with allergies, such as nasal congestion, sneezing, and itchy eyes. However, while the preliminary research is promising, more robust clinical trials are needed to establish definitive conclusions regarding its effectiveness in allergy management.
It is essential for anyone considering quercetin as a supplement for allergies to consult with a healthcare professional first. Quercetin can interact with certain medications and may not be suitable for everyone. Furthermore, it's important to remember that individual responses to supplements can vary widely. Incorporating quercetin-rich foods, like onions, apples, and berries, into your diet might provide some benefits and is generally safe, but relying solely on supplementation without professional guidance can be risky. As of now, while quercetin may offer some help for allergy sufferers, it's best used as a potential complementary approach rather than a standalone treatment.
Based on user reviews, many people report experiencing noticeable improvements in their allergy symptoms within a week of starting Quercetin with Bromelain. For instance, one user indicated that their allergy symptoms improved significantly after just one week of taking a single capsule daily Read Review. Similarly, another reviewer found relief from severe allergy symptoms after a week of taking two capsules at night Read Review.
However, some users suggest a longer timeframe for optimal results. For example, others have noted significant improvements occurring after two weeks of consistent use Read Review. Overall, while individual responses may vary, those looking to tackle allergies with this supplement can generally expect to see some positive effects within the first couple of weeks.
Scientific research supports the use of quercetin as a potential treatment for allergies, particularly allergic rhinitis. Various studies have demonstrated that quercetin can reduce allergic symptoms through its anti-inflammatory properties and its ability to inhibit the release of histamine from immune cells. For instance, one study involving 66 adults showed that a quercetin-containing supplement led to significant improvements in allergy-related symptoms like eye itching and sneezing, enhancing participants' overall quality of life [5]. Additionally, quercetin has been shown to interact effectively with key cytokines involved in allergic reactions, thus reducing allergy symptoms [1].
Moreover, quercetin's effects are further amplified when combined with other compounds like fucoidan, suggesting that synergistic treatments may enhance allergy relief [4]. While these findings are promising, researchers emphasize the need for further experimental testing to better understand quercetin’s efficacy and the optimal ways to incorporate it into allergy management strategies [3]. In summary, while quercetin shows considerable potential for alleviating allergic symptoms, continued research is essential to substantiate its effectiveness for more widespread use.
Based on user reviews, many have reported significant improvements in their allergy symptoms after using Quercetin with Bromelain. For instance, one user noted a remarkable turnaround in their allergy symptoms after just one week of taking a daily capsule, stating it was an "excellent tool" for managing their allergies Read Review. Another reviewer, who had struggled with spring allergies for years, described experiencing their first symptom-free spring after starting the supplement Read Review. In particular, users have highlighted relief from common symptoms like tearing, dry cough, and breathing difficulties after taking the capsules for a week or two.
In addition to immediate symptom relief, some users have reported improved overall well-being and additional health benefits. For example, several individuals mentioned enhancements in their sleep quality or digestive issues, indicating broader supportive effects beyond just allergy management Read Review. It's important to note that while many users have found success with this supplement, individual results can vary, and factors like dosage and consistency play vital roles in effectiveness. Overall, those seeking a natural alternative for managing allergies may find Quercetin with Bromelain to be a valuable addition to their regimen.
Users report that combining Quercetin with other supplements can yield enhanced benefits for managing allergies. For instance, one user indicated that taking Quercetin alongside nettle root extract helped alleviate their severe allergies, allowing them to live medication-free for a month Read Review. Another user noted significant improvement in their asthma symptoms when taking Quercetin together with prescribed medications, highlighting the supplement's effectiveness in providing complementary support Read Review.
Moreover, several reviewers reported that combining Quercetin with Bromelain specifically resulted in better overall allergy relief, emphasizing the synergistic effects of this pair in combating symptoms like sinus congestion and respiratory issues Read Review. Others found that alongside antioxidants, Quercetin not only reduced their allergy symptoms but also improved digestion and overall well-being Read Review. Overall, many users advocate for the combined use of Quercetin with other natural supplements to maximize their allergy relief experience.
Based on user reviews, there appears to be a consensus on the effective dosage of Quercetin for treating allergies. Many users report positive results from taking two capsules daily. For instance, one user noted that after taking two capsules at night for a week, they no longer experienced tearing, dry cough, or breathing difficulties related to their spring allergies Read Review. Another user mentioned a two-week regimen of two capsules each night resulted in significant improvements in their allergy symptoms, with no eye or nose irritation Read Review.
On the other hand, some users report benefits from lower dosages, with one individual successfully managing allergies by taking just one capsule per day Read Review. This suggests that while a daily intake of two capsules may be effective for many, individual responses can vary, and starting at a lower dose might be a viable option for some. Overall, the combination of Quercetin with Bromelain appears to be a favored choice among users for enhancing effectiveness in allergy relief, highlighting its potential as a natural alternative to traditional antihistamines Read Review.
7.5
Effective for allergies
526 people found this helpful
Excellent tool! Before ordering this drug, I read that Quercetin with Bromelain strengthens the immune system and helps with allergies. Since I started taking one capsule per day, my allergy symptoms have improved within a week. I'm looking forward to the ageing benefits too. Thank you for the excellent service!
10
Miracle for allergies
434 people found this helpful
I've tried many remedies for spring allergies over the past 10 years, but these capsules are the most effective! After a week of taking 2 capsules at night, I no longer experience tearing, dry cough, or breathing difficulties. They’ve transformed my experience.
9
Reduced irritation
84 people found this helpful
This dietary supplement has been invaluable for my chronic allergies. After taking two capsules nightly for two weeks, my symptoms significantly improved, and I no longer experience eye or nose irritation. I highly recommend Quercetin for allergy relief.
9
Significant improvement
100 people found this helpful
I have suffered from spring allergies for many years and tried various remedies without success. Then I found this supplement and experienced my first symptom-free spring! I am thrilled and thankful for this product!
9
Less pain experienced
122 people found this helpful
We took quercetin to support our immune systems and noticed my mother's leg pain reduced. We decided to try it with bromelain for allergy relief. After two weeks, we experienced positive effects, including improved sleep and reduced sweating. I will continue to purchase this product.
8.5
Allergy management tool
35 people found this helpful
I bought this for my terrible allergies to wormwood and other herbs. I managed to live an entire month without any medications, though I combine it with nettle root extract. I took 2 capsules in the morning and 1 in the evening. This has been a life-changer for my allergies.
9
Aids asthma sufferers
36 people found this helpful
I find these capsules highly effective for my chest allergies (asthma). After a few days of taking them alongside my other medication, I noticed significant improvement without side effects, apart from a slight bright yellow tint to my urine. I strongly recommend using it if you suffer from asthma.
9
Effective for asthma
52 people found this helpful
Quercetin combined with Bromelain is the strongest remedy for allergies, including bronchial asthma in both adults and children. This powerful combination quickly cleanses and heals the sinuses, boosts the immune system, and normalises respiratory function. I’m delighted with the results I've experienced.
8
Eased allergy symptoms
142 people found this helpful
I decided to take quercetin for allergies, as well as an antioxidant. The capsules are pleasant-smelling and easy to swallow. After around a week, my allergies eased, digestion improved, and constipation vanished. Quercetin strengthens blood vessels and reduces blood clot risk; I'm feeling much better now.
9
Quercetin may alleviate allergy symptoms
Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study.
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
Quercetin shows promise in allergies
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches.
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
7
Quercetin enhances allergy relief
Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin.
We investigated how quercetin works alongside fucoidan to help manage allergies, particularly type I hypersensitivity like hay fever. Our findings showed that when quercetin was taken together with fucoidan, even lower amounts could still provide significant anti-allergic effects.
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
7
Quercetin shows potential for allergies
Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?
We explored the potential benefits of quercetin and other dietary components in managing allergic reactions. Research indicates that quercetin may play a role in reducing symptoms of allergic rhinitis by suppressing inflammatory mediators from mast cells, essential players in allergic responses.
Our analysis highlighted that while quercetin shows promise, it’s one of several dietary factors needing further investigation, especially due to concerns about how well our bodies can use these nutrients. Continued research on improving their bioavailability is crucial for maximizing their effects on allergies.
References
Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. doi:10.1016/j.compbiomed.2025.109754
Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. doi:10.3746/pnf.2025.30.1.68
Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. doi:10.3390/cells12222602
Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. doi:10.3390/ijms232012163
Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. doi:10.26355/eurrev_202206_29072
Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. doi:10.3389/fimmu.2021.611474
Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. doi:10.1016/j.intimp.2018.11.025
Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. doi:10.3390/ijms19092652
Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. doi:10.1007/s10616-017-0129-9
Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. doi:10.1021/jf405486c
Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. doi:10.1007/s00011-009-0039-1
Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. doi:10.1016/j.intimp.2008.07.006
Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
Abram DM, Fernandes LGR, Perez-Riverol A, Regina Brochetto-Braga M, Zollner RL. Cross-Reactive Carbohydrate Determinant in , and Venoms: Identification of Allergic Sensitization and Cross-Reactivity. Toxins (Basel). 2020;12. doi:10.3390/toxins12100649
Ward BJ, Landry N, Trépanier S, Mercier G, Dargis M, et al. Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines. Vaccine. 2014;32:6098. doi:10.1016/j.vaccine.2014.08.079
Secor ER, Carson WF, Cloutier MM, Guernsey LA, Schramm CM, et al. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol. 2005;237:68.
Braun JM, Schneider B, Beuth HJ. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. 2005;19:417.