Quercetin as potential Alzheimer's treatmentExploring therapeutic potential of bioactive compounds against Alzheimer's and Parkinson's diseases.
We looked into how quercetin, a bioactive component of an ayurvedic herb, could help in treating Alzheimer's disease. The study proposed a deep dive into various therapeutic targets associated with Alzheimer's, including toxic proteins like amyloid beta and tau.
Our findings from the docking analysis indicated that quercetin shows a strong binding affinity to these targets. This suggests that it could potentially intervene in the processes that contribute to the disease. Further experiments demonstrated that quercetin effectively inhibits the production of alpha-synuclein, a protein that plays a role in neurodegeneration.
While quercetin appeared promising, we also explored other compounds like Luteolin, which showed potential in preventing Alzheimer's disease by alleviating effects related to damaging treatments. The study highlights the need for more comprehensive testing, particularly in live models, to fully understand quercetin's effectiveness in treating Alzheimer’s and its potential role in prevention.
Overall, the evidence points to quercetin being a valuable candidate in our quest for effective Alzheimer's treatments, although further validation is essential.
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Quercetin shows potential cognitive benefitsA pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease.
We set out to investigate the feasibility, safety, and potential effects of quercetin, along with Dasatinib, on cognitive function in older adults at risk of Alzheimer's disease. In this pilot study, twelve participants received a regimen of 100 mg of Dasatinib and 1250 mg of quercetin for two days every two weeks over a 12-week period.
While we observed a slight increase in cognitive scores, specifically a 1.0-point rise on the Montreal Cognitive Assessment (MoCA), this was not statistically significant for all participants. However, those who initially scored lower saw a more notable increase of 2.0 points, indicating a possible benefit for a particular group.
Furthermore, we noted a slight decrease in a specific biomarker, tumor necrosis factor-alpha (TNF-α), associated with aging and cognitive decline, although this change was also not statistically significant. More importantly, we discovered a correlation where decreases in TNF-α were associated with increases in MoCA scores, suggesting that quercetin may help improve cognition by influencing this biomarker.
Nonetheless, given that our study did not include a control group, the findings should be interpreted with caution. Overall, quercetin treatment appears feasible and safe but requires further investigation to confirm its effectiveness in improving cognitive function for those at risk of Alzheimer's disease.
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