Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
USERS' SCORE
Good
Based on 21 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
We explored the effects of quercetin, a natural compound with potential benefits for treating osteoarthritis (OA), specifically focusing on its ability to target damaged chondrocytes, the cartilage cells that play a crucial role in joint health. In our study, we utilized specialized nanoparticles to increase the effectiveness of quercetin, overcoming its usual limitations related to absorption and bioavailability.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Read More
9
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
9
Significant relief
119 people found this helpful
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
Read More
10
Remarkable transformation
101 people found this helpful
Quercetin review: I hated writing reviews, but I empathise with those with my condition. I had chronic arthritis in my left foot from an injury. The pain was unbearable and affected my sleep and focus. After various treatments, including tart cherry extract and meloxicam, I discovered quercetin, which significantly improved my condition. Eventually, I switched to NOW quercetin, which fully alleviated my arthritis discomfort.
Read More
9
Strong antioxidant
3 people found this helpful
Quercetin, a top flavonoid antioxidant, protects cell membranes from free radicals and is beneficial for arthritis and asthma. In addition, it strengthens immune function and is effective against viral infections.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.9
- All Researches
9
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
9
We explored how quercetin, when combined with teriflunomide, could potentially enhance treatment for rheumatoid arthritis (RA). This study involved developing a special topical gel that allowed for these compounds to be delivered directly to joint tissues. Using a method known as Box-Behnken design, we created transferosomes loaded with teriflunomide and quercetin, which showed promising results in terms of sustained drug release and improved skin permeability.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Read More
9
Quercetin's unclear solo impact
Our exploration into the effects of quercetin on arthritis took a holistic approach, using a combination treatment of Dasatinib and Quercetin on human articular chondrocytes, which are cells in the cartilage. This innovative therapy aimed to tackle the challenges posed by cellular senescence, a condition linked to the worsening of osteoarthritis (OA).
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
Read More
9
Quercetin reduces arthritis inflammation
We examined the potential of quercetin, a well-known flavonoid, in managing rheumatoid arthritis. Using a collagen-induced arthritis model in Wistar rats, we administered quercetin at doses of 50 or 100 mg/kg for four weeks. Throughout this period, we carefully monitored changes in arthritis severity, joint health, and various biochemical markers.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant relief
119 people found this helpful
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
Read More
10
Remarkable transformation
101 people found this helpful
Quercetin review: I hated writing reviews, but I empathise with those with my condition. I had chronic arthritis in my left foot from an injury. The pain was unbearable and affected my sleep and focus. After various treatments, including tart cherry extract and meloxicam, I discovered quercetin, which significantly improved my condition. Eventually, I switched to NOW quercetin, which fully alleviated my arthritis discomfort.
Read More
9
Strong antioxidant
3 people found this helpful
Quercetin, a top flavonoid antioxidant, protects cell membranes from free radicals and is beneficial for arthritis and asthma. In addition, it strengthens immune function and is effective against viral infections.
Read More
10
Pain reduction
2 people found this helpful
I added Quercetin for its anti-inflammatory properties due to Covid. It significantly reduced my arthritis pain, allowing me to be free of discomfort in my hands.
Read More
9
Skin and joint aid
2 people found this helpful
I’m truly grateful for this product. Initially, I bought it to prepare for illness, but it has greatly helped my arthritis and skin. I will be reordering and recommending it to others!
Read More
Frequently Asked Questions
7.5
Reduced inflammation
1 people found this helpful
Quercetin is an excellent supplement for tackling inflammatory diseases, including arthritis. I took two capsules daily for three months, alongside selenium and curcumin as advised by my doctor, to lower antibodies and alleviate inflammation in my thyroid.
7.5
Swelling reduction
I took this for arthritis and bladder infections, and it made a significant difference; my well-being improved, and swelling subsided considerably.
6
Long-term benefits
1 people found this helpful
While I haven’t noticed significant changes, I continue with this for anti-aging alongside arthritis management. A family member benefits greatly from it for allergies, and my pollen-related reactions have significantly diminished.
9
Skin and joint aid
2 people found this helpful
I’m truly grateful for this product. Initially, I bought it to prepare for illness, but it has greatly helped my arthritis and skin. I will be reordering and recommending it to others!
10
Pain reduction
2 people found this helpful
I added Quercetin for its anti-inflammatory properties due to Covid. It significantly reduced my arthritis pain, allowing me to be free of discomfort in my hands.
8
Improves congestion
3 people found this helpful
This product works well. My son notices a difference when using this with bromelain; it eases his allergy-related congestion and discomfort from arthritis.
7.5
Effective dosage
This reputable brand provides 800 mg of quercetin per serving, which is effective for managing my arthritis symptoms alongside probiotics.
7.5
Improved circulation
1 people found this helpful
Quercetin is a flavonoid found in many fruits. We typically consume 25-50 mg daily, while higher doses are beneficial. I've found it assists with arthritis and respiratory issues, improving exercise tolerance and blood circulation.
8
We conducted a systematic review and network meta-analysis to assess the effectiveness of quercetin and other plant active substances for treating rheumatoid arthritis (RA). Our findings revealed that quercetin particularly stands out for its ability to reduce pain and inflammation, as measured by the Visual Analogue Scale (VAS).
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
8
Quercetin's role in RA treatment
We examined the effects of quercetin, alongside other key ingredients, on managing rheumatoid arthritis (RA). Our study utilized network pharmacology and molecular dynamics simulations to understand how quercetin interacts with various biological targets related to inflammation.
Through our research, we found that quercetin, along with kaempferol and luteolin, plays a substantial role in reducing inflammation by affecting specific pathways in the body, namely the PI3K-AKT, TNF, and IL-17 signaling pathways. These pathways are particularly important in the context of RA, where inflammation can lead to joint damage.
By experimenting on lipopolysaccharide-stimulated macrophages, we confirmed that quercetin helps lower the production of pro-inflammatory factors. It achieves this by inhibiting key proteins associated with glycolysis, thereby reducing inflammation within the body.
Our findings not only highlight the potential of quercetin in treating RA but also underline the collaborative effect of these ingredients in traditional Chinese medicine. Together, they may offer a meaningful approach for those suffering from this chronic condition.
Through our research, we found that quercetin, along with kaempferol and luteolin, plays a substantial role in reducing inflammation by affecting specific pathways in the body, namely the PI3K-AKT, TNF, and IL-17 signaling pathways. These pathways are particularly important in the context of RA, where inflammation can lead to joint damage.
By experimenting on lipopolysaccharide-stimulated macrophages, we confirmed that quercetin helps lower the production of pro-inflammatory factors. It achieves this by inhibiting key proteins associated with glycolysis, thereby reducing inflammation within the body.
Our findings not only highlight the potential of quercetin in treating RA but also underline the collaborative effect of these ingredients in traditional Chinese medicine. Together, they may offer a meaningful approach for those suffering from this chronic condition.
9
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
References
- Peng Q, Wang J, Li K, Xia C, Yao C, et al. Effects of plant active substances in rheumatoid arthritis-a systematic review and network meta-analysis. Front Pharmacol. 2025;16:1536023. doi:10.3389/fphar.2025.1536023
- Ren J, Liu Z, Qi X, Meng X, Guo L, et al. Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification. Drug Des Devel Ther. 2025;19:405. doi:10.2147/DDDT.S489323
- Dong S, Li X, Xu G, Chen L, Zhao J. Quercetin attenuates the symptoms of osteoarthritis and by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling. Mol Med Rep. 2025;31. doi:10.3892/mmr.2024.13425
- Zhendong Y, Changjun C, Haocheng H, Qibin L, Dailing C, et al. Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways. Int Immunopharmacol. 2025;146:113855. doi:10.1016/j.intimp.2024.113855
- Sun H, Zhan M, Zou Y, Ma J, Liang J, et al. Bioactive phosphorus dendrimers deliver protein/drug to tackle osteoarthritis via cooperative macrophage reprogramming. Biomaterials. 2025;316:122999. doi:10.1016/j.biomaterials.2024.122999
- Zhang H, Yuan S, Zheng B, Wu P, He X, et al. Lubricating and Dual-Responsive Injectable Hydrogels Formulated From ZIF-8 Facilitate Osteoarthritis Treatment by Remodeling the Microenvironment. Small. 2025;21:e2407885. doi:10.1002/smll.202407885
- Kamboj A, Malhotra H, Mukhija H, Babu A. Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of leaves in rat model. J Asian Nat Prod Res. 2024. doi:10.1080/10286020.2024.2422974
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. doi:10.1016/j.micpath.2024.107086
- Ilyas S, Baek CY, Manan A, Choi Y, Jo HG, et al. Mechanistic Exploration of Roxb. in Osteoarthritis: Insights from Network Pharmacology, Molecular Docking, and In Vitro Validation. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17101285
- Dos Santos JM, Marangoni Faoro JA, Fava de Souza M, de Matos Balsalobre N, Leite Kassuya CA, et al. Anti-arthritic potential and antioxidant properties of infusion, fractions and flavonoid glycosides from Dipteryx alata (baru) leaves. J Ethnopharmacol. 2025;338:118973. doi:10.1016/j.jep.2024.118973
- Karnam S, Jindal AB, Paul AT. Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis. Int J Pharm. 2024;666:124829. doi:10.1016/j.ijpharm.2024.124829
- Maurer S, Kirsch V, Ruths L, Brenner RE, Riegger J. Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators. Aging Cell. 2025;24:e14361. doi:10.1111/acel.14361
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. doi:10.1186/s10020-024-00929-1
- Zhao J, Zheng L, Dai G, Sun Y, He R, et al. Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice. Spine J. 2025;25:184. doi:10.1016/j.spinee.2024.09.017
- Yu H, Lou J, Ni L, Yan M, Zhu K, et al. Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study. Chem Biol Drug Des. 2024;104:e14620. doi:10.1111/cbdd.14620
- Karim A, Qaisar R, Suresh S, Jagal J, Rawas-Qalaji M. Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes. Nanomedicine (Lond). 2024;19:2159. doi:10.1080/17435889.2024.2393074
- Chen J, Wu G, Wu J, Jiao Z. Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy. J Orthop Surg Res. 2025;20:300. doi:10.1186/s13018-025-05698-z
- Kan T, Tian Z, Sun L, Kong W, Yan R, et al. Quercetin-Loaded Zeolitic Imidazolate Framework-8 (ZIF-8) Nanoparticles Attenuate Osteoarthritis by Activating Autophagy via the Pi3k/Akt Signaling. ACS Appl Mater Interfaces. 2024;16:40444. doi:10.1021/acsami.4c04649
- Brochard S, Pontin J, Bernay B, Boumediene K, Conrozier T, et al. The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells. BMC Complement Med Ther. 2021;21:261. doi:10.1186/s12906-021-03435-7
- Sharma M, Chaudhary D. Exploration of bromelain laden nanostructured lipid carriers: An oral platform for bromelain delivery in rheumatoid arthritis management. Int J Pharm. 2021;594:120176. doi:10.1016/j.ijpharm.2020.120176
- Italiano G, Raimondo M, Giannetti G, Gargiulo A. Benefits of a Food Supplement Containing and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study. J Altern Complement Med. 2020;26:123. doi:10.1089/acm.2019.0258
- Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016;35:2531. doi:10.1007/s10067-016-3363-1
- Ucuncu Y, Celik N, Ozturk C, Turkoglu M, Cetin N, et al. Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation. Life Sci. 2015;130:31. doi:10.1016/j.lfs.2015.03.012
- Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, et al. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20 Suppl 1:32.
- Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004;23:410.
- Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002;9:681.
- Desser L, Holomanova D, Zavadova E, Pavelka K, Mohr T, et al. Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood. Cancer Chemother Pharmacol. 2001;47 Suppl:S10.
