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SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Excellent
Based on 21 Reviews
9
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
Quercetin nanoparticles reduce senescence
Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes.
High relevance to arthritis treatment
We explored the effects of quercetin, a natural compound with potential benefits for treating osteoarthritis (OA), specifically focusing on its ability to target damaged chondrocytes, the cartilage cells that play a crucial role in joint health. In our study, we utilized specialized nanoparticles to increase the effectiveness of quercetin, overcoming its usual limitations related to absorption and bioavailability.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Read More
9
Quercetin alleviates osteoarthritis symptoms
Quercetin attenuates the symptoms of osteoarthritis and by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling.
Strong evidence of quercetin benefits
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
Quercetin shows promise for arthritis
Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of leaves in rat model.
Highly relevant anti-arthritic effects
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
9.5
Significant relief
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
Read More
10
Remarkable transformation
Quercetin review: I hated writing reviews, but I empathise with those with my condition. I had chronic arthritis in my left foot from an injury. The pain was unbearable and affected my sleep and focus. After various treatments, including tart cherry extract and meloxicam, I discovered quercetin, which significantly improved my condition. Eventually, I switched to NOW quercetin, which fully alleviated my arthritis discomfort.
Read More
9.5
Strong antioxidant
Quercetin, a top flavonoid antioxidant, protects cell membranes from free radicals and is beneficial for arthritis and asthma. In addition, it strengthens immune function and is effective against viral infections.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
9
Quercetin alleviates osteoarthritis symptoms
Quercetin attenuates the symptoms of osteoarthritis and by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling.
Strong evidence of quercetin benefits
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
Quercetin shows promise for arthritis
Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of leaves in rat model.
Highly relevant anti-arthritic effects
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
9
Combined gel shows anti-arthritic promise
Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis.
Quercetin’s isolated effect unclear
We explored how quercetin, when combined with teriflunomide, could potentially enhance treatment for rheumatoid arthritis (RA). This study involved developing a special topical gel that allowed for these compounds to be delivered directly to joint tissues. Using a method known as Box-Behnken design, we created transferosomes loaded with teriflunomide and quercetin, which showed promising results in terms of sustained drug release and improved skin permeability.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Read More
9
Quercetin's unclear solo impact
Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators.
Limited relevance due to context
Our exploration into the effects of quercetin on arthritis took a holistic approach, using a combination treatment of Dasatinib and Quercetin on human articular chondrocytes, which are cells in the cartilage. This innovative therapy aimed to tackle the challenges posed by cellular senescence, a condition linked to the worsening of osteoarthritis (OA).
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
Read More
9
Quercetin reduces arthritis inflammation
Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling.
Direct investigation of quercetin's effects
We examined the potential of quercetin, a well-known flavonoid, in managing rheumatoid arthritis. Using a collagen-induced arthritis model in Wistar rats, we administered quercetin at doses of 50 or 100 mg/kg for four weeks. Throughout this period, we carefully monitored changes in arthritis severity, joint health, and various biochemical markers.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 21 Reviews
9
10
Remarkable transformation
Quercetin review: I hated writing reviews, but I empathise with those with my condition. I had chronic arthritis in my left foot from an injury. The pain was unbearable and affected my sleep and focus. After various treatments, including tart cherry extract and meloxicam, I discovered quercetin, which significantly improved my condition. Eventually, I switched to NOW quercetin, which fully alleviated my arthritis discomfort.
Read More
9.5
Significant relief
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
Read More
9.5
Strong antioxidant
Quercetin, a top flavonoid antioxidant, protects cell membranes from free radicals and is beneficial for arthritis and asthma. In addition, it strengthens immune function and is effective against viral infections.
9.5
Skin and joint aid
I’m truly grateful for this product. Initially, I bought it to prepare for illness, but it has greatly helped my arthritis and skin. I will be reordering and recommending it to others!
9.5
Powerful treatment
Quercetin is regarded as the strongest antioxidant, useful for preventing cardiovascular issues and relieving arthritis. It possesses anti-allergic effects and combats various respiratory diseases. Its continual use benefits joint inflammation and aids in post-heart attack recovery.
