Can NOW Supplements, Quercetin with Bromelain help with Gout?
' 
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.1
USERS' SCORE
Good
Based on 8 Reviews
8.8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
Quercetin alleviates gout symptoms
Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome.
Directly addresses quercetin's effectiveness
We explored the effects of quercetin, a natural compound, on gout arthritis induced by monosodium urate (MSU) crystals. Our research specifically looked at how quercetin alleviates pain and inflammation associated with gout while examining its interaction with naloxone, a substance known to block opioid receptors.
Mice were treated with quercetin, and we assessed their pain sensitivity from 1 to 24 hours post-MSU injection. Our observations included evaluating the recruitment of white blood cells, levels of inflammatory cytokines, oxidative stress, and activation of certain molecular pathways in the knee joints, all measured at 24 hours after the MSU was introduced.
The results were promising: quercetin effectively reduced MSU-induced pain, inflammation, and related oxidative stress. Notably, the presence of naloxone seemed to negate these benefits, indicating that quercetin's effects are linked to opioid pathways. These findings suggest that quercetin could be a valuable therapeutic option for managing gout symptoms, highlighting its dual role as both an analgesic and anti-inflammatory agent.
Mice were treated with quercetin, and we assessed their pain sensitivity from 1 to 24 hours post-MSU injection. Our observations included evaluating the recruitment of white blood cells, levels of inflammatory cytokines, oxidative stress, and activation of certain molecular pathways in the knee joints, all measured at 24 hours after the MSU was introduced.
The results were promising: quercetin effectively reduced MSU-induced pain, inflammation, and related oxidative stress. Notably, the presence of naloxone seemed to negate these benefits, indicating that quercetin's effects are linked to opioid pathways. These findings suggest that quercetin could be a valuable therapeutic option for managing gout symptoms, highlighting its dual role as both an analgesic and anti-inflammatory agent.
Read More
8
Quercetin shows promise for gout
Study on the effect and mechanism of quercetin in treating gout arthritis.
Highly relevant to gout treatment.
We conducted a study to understand how quercetin, a natural compound found in many plants, can help treat gout arthritis (GA). Using a mix of network pharmacology and laboratory experiments, we aimed to uncover its potential effects and the mechanisms behind them.
Through our research, we identified several common targets where quercetin interacts with the pathways involved in gout. These targets mainly include important cellular signaling pathways like interleukin-17 (IL-17), tumor necrosis factor (TNF), and others that play crucial roles in inflammation and joint damage.
In our experimental model, which involved rats with gout induced by monosodium urate, we observed that quercetin significantly reduced inflammation in the ankle joint. It also helped to protect against bone destruction and alleviate the damaging effects seen in histological analysis. Quercetin lowered the levels of several inflammatory markers linked to the IL-17 pathway and adjusted other immune responses beneficially.
Overall, our findings suggest that quercetin could be a promising alternative for managing gout arthritis through its anti-inflammatory effects and regulation of immune responses.
Through our research, we identified several common targets where quercetin interacts with the pathways involved in gout. These targets mainly include important cellular signaling pathways like interleukin-17 (IL-17), tumor necrosis factor (TNF), and others that play crucial roles in inflammation and joint damage.
In our experimental model, which involved rats with gout induced by monosodium urate, we observed that quercetin significantly reduced inflammation in the ankle joint. It also helped to protect against bone destruction and alleviate the damaging effects seen in histological analysis. Quercetin lowered the levels of several inflammatory markers linked to the IL-17 pathway and adjusted other immune responses beneficially.
Overall, our findings suggest that quercetin could be a promising alternative for managing gout arthritis through its anti-inflammatory effects and regulation of immune responses.
Read More
7
Quercetin inhibits xanthine oxidase
Mechanistic insights into the inhibition of quercetin on xanthine oxidase.
Highly relevant to gout treatment
We’ve examined how quercetin, a common flavonoid found in many foods, affects gout, particularly through its influence on xanthine oxidase (XOD)—the enzyme responsible for producing uric acid. The study showed that quercetin can effectively inhibit both uric acid and superoxide radicals generated by XOD.
The inhibition occurs in a mixed-type manner with a concentration that holds potential significance for treatment. Through a mechanism that resembles a ping-pong process, quercetin interacts with a specific binding site on XOD, significantly affecting its activity. This interaction is largely due to attractive forces like van der Waals and hydrogen bonds, which makes it an interesting candidate for gout management.
Furthermore, our exploration using molecular docking revealed that quercetin attaches to the isoalloxazine ring of the flavin adenine dinucleotide (FAD) in the XOD domain. By blocking the diffusion of reactive oxygen species, quercetin helps direct the production of hydrogen peroxide instead.
Overall, this study provides promising insights into the potential benefits of quercetin as a nutritional supplement for reducing gout symptoms and oxidative stress. Its ability to inhibit xanthine oxidase could help avoid high uric acid levels, potentially alleviating gout attacks.
The inhibition occurs in a mixed-type manner with a concentration that holds potential significance for treatment. Through a mechanism that resembles a ping-pong process, quercetin interacts with a specific binding site on XOD, significantly affecting its activity. This interaction is largely due to attractive forces like van der Waals and hydrogen bonds, which makes it an interesting candidate for gout management.
Furthermore, our exploration using molecular docking revealed that quercetin attaches to the isoalloxazine ring of the flavin adenine dinucleotide (FAD) in the XOD domain. By blocking the diffusion of reactive oxygen species, quercetin helps direct the production of hydrogen peroxide instead.
Overall, this study provides promising insights into the potential benefits of quercetin as a nutritional supplement for reducing gout symptoms and oxidative stress. Its ability to inhibit xanthine oxidase could help avoid high uric acid levels, potentially alleviating gout attacks.
Read More
Most Useful Reviews
9.5
Swelling reduced
I suffer from recurring gout. My latest episode affected my right hand, making it unusable. After learning about Quercetin, I ordered a bottle. Within three days, my swelling and pain significantly decreased, and I regained full use of my hand.
Read More
8.3
Stopped attacks
I’ve found that taking two capsules of this product alongside 250mg of naproxen three times daily can halt a gout attack as soon as symptoms begin.
Read More
9.5
Excellent for gout
An excellent product for those suffering from gout; I buy it regularly and take it daily.
Read More
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Medical Researches
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Moderately Effective
Based on 11 Researches
8.1
9
Quercetin reduces uric acid levels
Quercetin-enriched Lactobacillus aviarius alleviates hyperuricemia by hydrolase-mediated degradation of purine nucleosides.
Good correlation with quercetin's role
We examined the effects of quercetin on serum uric acid levels, which play a significant role in gout and hyperuricemia (HUA). In this study, quercetin was shown to lower uric acid in a chicken model known for elevated levels.
By exploring the impact of quercetin on the gut microbiota, we observed that it altered the chicken’s gut environment and increased the abundance of a specific strain of bacteria called Lactobacillus aviarius. This particular strain, known as CML180, was taken a step further by testing its effects on a mouse model of HUA.
Through direct testing, we found that giving the mice CML180 led to a significant reduction in serum uric acid levels. The key to this effect lies in CML180’s ability to degrade purine nucleosides, which are precursors to uric acid production. We also identified a specific gene in CML180 responsible for this degradation, enhancing our understanding of how gut bacteria can influence gout treatment.
Overall, these findings shed light on quercetin’s potential role in managing gout, particularly through its interaction with beneficial gut bacteria.
By exploring the impact of quercetin on the gut microbiota, we observed that it altered the chicken’s gut environment and increased the abundance of a specific strain of bacteria called Lactobacillus aviarius. This particular strain, known as CML180, was taken a step further by testing its effects on a mouse model of HUA.
Through direct testing, we found that giving the mice CML180 led to a significant reduction in serum uric acid levels. The key to this effect lies in CML180’s ability to degrade purine nucleosides, which are precursors to uric acid production. We also identified a specific gene in CML180 responsible for this degradation, enhancing our understanding of how gut bacteria can influence gout treatment.
Overall, these findings shed light on quercetin’s potential role in managing gout, particularly through its interaction with beneficial gut bacteria.
Read More
9
Quercetin's potential for gout relief
Identification of Inhibitory Activities of Dietary Flavonoids against URAT1, a Renal Urate Re-Absorber: In Vitro Screening and Fractional Approach Focused on Rooibos Leaves.
Relevant to gout treatment
We investigated the potential of quercetin, a flavonoid found in various plant sources, as a treatment for gout by focusing on its ability to inhibit a protein known as URAT1. This protein plays a key role in reabsorbing urate, which is linked to elevated urate levels and the onset of gout. By blocking URAT1, we could potentially help lower serum urate levels, making quercetin an interesting dietary option for those struggling with this condition.
Our study evaluated 162 plant extracts, and we utilized a cell-based assay to see how effective quercetin could be at inhibiting URAT1 activity. Among other dietary compounds, quercetin stood out, showing significant inhibitory effects with a measured IC value, meaning the concentration at which it was effective.
Although quercetin might offer a promising avenue for managing serum urate levels, more extensive human studies are necessary to fully understand its impact and confirm its effectiveness as a treatment. For now, the findings shed light on how incorporating quercetin-rich foods into our diets could contribute to better health and possibly alleviate some issues related to gout.
Our study evaluated 162 plant extracts, and we utilized a cell-based assay to see how effective quercetin could be at inhibiting URAT1 activity. Among other dietary compounds, quercetin stood out, showing significant inhibitory effects with a measured IC value, meaning the concentration at which it was effective.
Although quercetin might offer a promising avenue for managing serum urate levels, more extensive human studies are necessary to fully understand its impact and confirm its effectiveness as a treatment. For now, the findings shed light on how incorporating quercetin-rich foods into our diets could contribute to better health and possibly alleviate some issues related to gout.
Read More
9
Quercetin improves heart health
Effect of quercetin on the echocardiographic parameters of left ventricular diastolic function in patients with gout and essential hypertension.
Effectiveness in gout treatment noted
We explored the potential benefits of quercetin for patients dealing with both gout and essential hypertension (EH). The study included 84 male participants, split into two groups: one receiving quercetin alongside their regular treatment and the other following a treatment plan without it. This design allowed us to make meaningful comparisons regarding the effects of quercetin on heart function over a 12-month period.
Our findings revealed that quercetin seems to offer protective benefits for heart tissue, specifically enhancing the diastolic function of the left ventricle. We observed that patients taking quercetin experienced greater improvements in echocardiographic parameters compared to those who did not, particularly in measures like E/e' and left ventricular mass index.
Moreover, the addition of quercetin not only aided heart function but also helped achieve better control of uric acid levels and improved kidney function. Additionally, patients noted a cumulative reduction in blood pressure without needing higher doses of antihypertensive medications. Overall, these results suggest that incorporating quercetin into treatment regimens can significantly benefit those suffering from gout and hypertension, not just in heart health, but also in improving related metabolic indicators.
Our findings revealed that quercetin seems to offer protective benefits for heart tissue, specifically enhancing the diastolic function of the left ventricle. We observed that patients taking quercetin experienced greater improvements in echocardiographic parameters compared to those who did not, particularly in measures like E/e' and left ventricular mass index.
Moreover, the addition of quercetin not only aided heart function but also helped achieve better control of uric acid levels and improved kidney function. Additionally, patients noted a cumulative reduction in blood pressure without needing higher doses of antihypertensive medications. Overall, these results suggest that incorporating quercetin into treatment regimens can significantly benefit those suffering from gout and hypertension, not just in heart health, but also in improving related metabolic indicators.
Read More
9
Isorhamnetin reduces uric acid levels
Anti-hyperuricemic effect of isorhamnetin in cultured hepatocytes and model mice: structure-activity relationships of methylquercetins as inhibitors of uric acid production.
Study suggests potential gout treatment
We explored the effects of isorhamnetin, a natural compound derived from quercetin, on regulating uric acid levels, which is crucial for managing gout. In our study, we utilized both cultured liver cells and mice that suffered from increased uric acid due to purine intake to deeply analyze isorhamnetin's anti-hyperuricemic properties.
Our findings showed that isorhamnetin significantly reduces uric acid production in liver cells. It achieved this through a dose-dependent manner, indicating that higher concentrations led to better results. Moreover, when tested in mice, isorhamnetin not only lowered uric acid levels in the blood and liver but also inhibited an enzyme called xanthine oxidase, which contributes to uric acid production, without altering the amount of the protein itself.
These results indicate that isorhamnetin could serve as a promising option for tackling hyperuricemia, hopefully offering a new avenue for those at risk of gout. It’s thrilling to consider how compounds like isorhamnetin from everyday foods could help in managing such a common condition.
Our findings showed that isorhamnetin significantly reduces uric acid production in liver cells. It achieved this through a dose-dependent manner, indicating that higher concentrations led to better results. Moreover, when tested in mice, isorhamnetin not only lowered uric acid levels in the blood and liver but also inhibited an enzyme called xanthine oxidase, which contributes to uric acid production, without altering the amount of the protein itself.
These results indicate that isorhamnetin could serve as a promising option for tackling hyperuricemia, hopefully offering a new avenue for those at risk of gout. It’s thrilling to consider how compounds like isorhamnetin from everyday foods could help in managing such a common condition.
Read More
9
Quercetin alleviates gout symptoms
Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome.
Directly addresses quercetin's effectiveness
We explored the effects of quercetin, a natural compound, on gout arthritis induced by monosodium urate (MSU) crystals. Our research specifically looked at how quercetin alleviates pain and inflammation associated with gout while examining its interaction with naloxone, a substance known to block opioid receptors.
Mice were treated with quercetin, and we assessed their pain sensitivity from 1 to 24 hours post-MSU injection. Our observations included evaluating the recruitment of white blood cells, levels of inflammatory cytokines, oxidative stress, and activation of certain molecular pathways in the knee joints, all measured at 24 hours after the MSU was introduced.
The results were promising: quercetin effectively reduced MSU-induced pain, inflammation, and related oxidative stress. Notably, the presence of naloxone seemed to negate these benefits, indicating that quercetin's effects are linked to opioid pathways. These findings suggest that quercetin could be a valuable therapeutic option for managing gout symptoms, highlighting its dual role as both an analgesic and anti-inflammatory agent.
Mice were treated with quercetin, and we assessed their pain sensitivity from 1 to 24 hours post-MSU injection. Our observations included evaluating the recruitment of white blood cells, levels of inflammatory cytokines, oxidative stress, and activation of certain molecular pathways in the knee joints, all measured at 24 hours after the MSU was introduced.
The results were promising: quercetin effectively reduced MSU-induced pain, inflammation, and related oxidative stress. Notably, the presence of naloxone seemed to negate these benefits, indicating that quercetin's effects are linked to opioid pathways. These findings suggest that quercetin could be a valuable therapeutic option for managing gout symptoms, highlighting its dual role as both an analgesic and anti-inflammatory agent.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.8
9.5
Swelling reduced
I suffer from recurring gout. My latest episode affected my right hand, making it unusable. After learning about Quercetin, I ordered a bottle. Within three days, my swelling and pain significantly decreased, and I regained full use of my hand.
9.5
Excellent for gout
An excellent product for those suffering from gout; I buy it regularly and take it daily.
8.8
Strong anti-inflammatory
Cospa is highly effective! It appears to lower uric acid levels without affecting purine metabolism. This product also contains bromelain, which alleviates gout inflammation, while kerasetin aids in bromelain absorption. Overall, it seems to offer anti-inflammatory and antioxidant benefits, as well as reduce fat absorption, so I purchased it.
Read More
8.8
Prevented episodes
Since taking this product, I have not experienced any severe gout episodes hindering my daily activities. I've used it for about three months. Quercetin reportedly reduces uric acid production, while bromelain enhances its absorption.
8.8
Pain and swelling lessened
I acquired this on Dr. Petrik's recommendation. I have some hopes for relief from hay fever and long-term inflammation in my big toe joint. After two weeks of use, I’ve noticed less pain and swelling.
