5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.9
USERS' SCORE
Good
Based on 94 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
Most Useful Reviews
7.5
Effective for diarrhoea
231 people found this helpful
Replacing Enterola! Excellent preparation! It contains lactose, which was problematic for our baby's milk intolerance. We previously struggled with persistent diarrhoea until our gastroenterologist prescribed Enterol to stop it and eliminate harmful intestinal bacteria. Saccharomyces boulardii is excellent, but we couldn't find a lactose-free version. Nau Foods' preparation has been a lifesaver during critical times for our family, as it aids in cases of poisoning and diarrhoea, effectively binding harmful bacteria without impacting good flora. Additionally, it's four times cheaper than Enterol for a five-day course!
Read More
9
Herbal alternative works
134 people found this helpful
Initially sceptical, I’ve become a believer! After three weeks of watery diarrhoea, I consulted a GI specialist who prescribed the costly antibiotic Xifaxan. Instead, I researched herbal alternatives and tried NOW saccharomyces boulardii. To my surprise, I had my first normal stool in nearly five weeks. While I plan to supplement with additional products, I recommend this affordable alternative seriously.
Read More
9
Relieves diarrhoea
119 people found this helpful
This is a fantastic find that I bought for my sister. It significantly helps her manage diarrhoea; she used to have frequent stomach aches, but since taking saccharomyces, she doesn't recall experiencing them anymore.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.9
- All Researches
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
Read More
9
Probiotic reduces antibiotic-associated diarrhea
We examined how a high-dose, multistrain probiotic mix called Sinquanon helps prevent antibiotic-associated diarrhea (AAD) in adults taking broad-spectrum antibiotics. This well-structured clinical trial involved 564 participants, half receiving the probiotic and half a placebo.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Results showed that fewer people in the probiotic group experienced AAD—only 9.2% compared to 25.3% in the placebo group. This promising improvement suggests that Sinquanon may significantly enhance gastrointestinal health during antibiotic treatment without causing harmful side effects.
Read More
9
Probiotics mitigate antibiotic-related diarrhea
We looked into how probiotics, especially Saccharomyces boulardii CNCM I-745, can impact antibiotic-associated diarrhea. Through systematic reviews and clinical trials, we found that this yeast is effective in preventing and resolving diarrhea linked to antibiotic use. Since it isn't affected by antibiotics, S. boulardii can safely be administered at the start of treatment or within the first couple of days. This shows that using the right probiotics can help restore gut health after antibiotics, which is crucial for overall well-being.
Read More
9
We looked into how probiotics might help manage antibiotic-associated diarrhea (AAD) in children through a review of systematic reviews. Our review considered various databases and included 20 studies, evaluating their reporting quality and overall evidence strength. While we found that higher doses of probiotics show promise in preventing AAD, caution is needed as many studies had significant quality gaps. Overall, probiotics could benefit kids facing AAD, but more robust research is essential for clearer recommendations.
Read More
9
We explored the effects of Saccharomyces boulardii on diarrhea caused by the cancer drug abemaciclib in a study involving thirty rats. The rats were divided into three groups: a control group, a group receiving only abemaciclib, and a group receiving both abemaciclib and Saccharomyces boulardii.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Our results indicated that the group treated with Saccharomyces boulardii showed a significant reduction in diarrhea severity and weight loss compared to the group that only received abemaciclib. Furthermore, histopathological evaluations revealed less inflammation in the Saccharomyces boulardii group. Overall, this suggests that Saccharomyces boulardii might be a beneficial treatment option to alleviate chemotherapy-induced diarrhea.
Read More
User Reviews
USERS' SCORE
Good
Based on 94 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for diarrhoea
231 people found this helpful
Replacing Enterola! Excellent preparation! It contains lactose, which was problematic for our baby's milk intolerance. We previously struggled with persistent diarrhoea until our gastroenterologist prescribed Enterol to stop it and eliminate harmful intestinal bacteria. Saccharomyces boulardii is excellent, but we couldn't find a lactose-free version. Nau Foods' preparation has been a lifesaver during critical times for our family, as it aids in cases of poisoning and diarrhoea, effectively binding harmful bacteria without impacting good flora. Additionally, it's four times cheaper than Enterol for a five-day course!
Read More
9
Herbal alternative works
134 people found this helpful
Initially sceptical, I’ve become a believer! After three weeks of watery diarrhoea, I consulted a GI specialist who prescribed the costly antibiotic Xifaxan. Instead, I researched herbal alternatives and tried NOW saccharomyces boulardii. To my surprise, I had my first normal stool in nearly five weeks. While I plan to supplement with additional products, I recommend this affordable alternative seriously.
Read More
9
Relieves diarrhoea
119 people found this helpful
This is a fantastic find that I bought for my sister. It significantly helps her manage diarrhoea; she used to have frequent stomach aches, but since taking saccharomyces, she doesn't recall experiencing them anymore.
Read More
10
Infection relief
76 people found this helpful
I did extensive research before purchasing this product. After contracting an infection in the hospital, I experienced intense stomach pain and uncontrollable diarrhea. This product stopped it, and I was truly amazed at the results. I will avoid antibiotics in the future as the infection can remain dormant. Taking Saccharomyces Boulardii daily has made my digestive tract and colon feel wonderful.
Read More
9
Diarrhea resolved quickly
67 people found this helpful
I've recommended this for cats with diarrhea for years. Personally, I have experienced diarrhea since moving back to my farm due to the well water's high mineral content. I decided to try this for myself. After taking 2 capsules three times a day, the diarrhea was gone in just 3 days! After 3 weeks, I've reduced to 3 capsules daily with continued good results.
Read More
Frequently Asked Questions
8
Regulates intestines effectively
1 people found this helpful
I noticed immediate effects on my intestines after starting this. It helps regulate my digestive system when I have a bad diet and suffer from either constipation or diarrhea. I find it of excellent quality, though I alternate products monthly as my intestines seem to adjust to it.
9
Excellent for recovery
32 people found this helpful
Super remedy! Your stomach will thank you. An excellent aid for poisoning when digestion fails and for diarrhea. It helps from the first dose and also normalises intestinal microflora. I will buy more as it's indispensable for restoring my stomach. I take 1 capsule twice daily. Leave a like if my review was helpful.
10
IBS relief
9 people found this helpful
After a year of IBS with diarrhoea that seemed untreatable, I fortunately discovered this supplement. Taking 2 capsules in the morning and night, along with other natural supplements, has led to my recovery. I highly recommend it to anyone struggling with bowel issues and IBS associated with diarrhoea.
9
No more diarrhoea
11 people found this helpful
Since I must take long-term antibiotics, I find that taking three of these daily prevents any diarrhoea. It truly works! Other probiotic types have failed to do so for me. The capsules are small, odourless, and have no aftertaste.
9
Immediate improvement
4 people found this helpful
Saccharomyces Boulardii is my go-to for poisoning and diarrhoea. We take it at the first signs along with sorbents, and I notice immediate improvements. It’s suitable for children too, so I recommend it wholeheartedly!
9
Antibiotic relief
1 people found this helpful
BEST FOR UPSET GUT ISSUES! This probiotic is excellent for my stomach. While on high-dose antibiotics that often cause diarrhoea, Saccharomyces Boulardii is the best natural remedy to alleviate it. I take it everywhere.
9
Indispensable aid
1 people found this helpful
An excellent aid for food poisoning and diarrhoea. It begins to work from the first dose and helps to normalise the intestinal microflora. I will definitely repurchase, as it is essential for digestive recovery. I take one capsule twice daily.
7.5
Effective for digestion
3 people found this helpful
I use saccharomyces boulardii when I have diarrhea to aid my digestion. It seems to help my gut quickly and efficiently. For quicker results, you might consider taking two capsules. The quality is good, and it has no taste or smell.
9
Consistent relief
6 people found this helpful
After suffering for a year with IBS-diarrohea, this supplement has been a miracle for me. Taking 2 capsules morning and night along with other supplements has significantly improved my condition. I recommend it to anyone facing similar intestinal challenges.
9.5
Probiotic effectively reduces diarrhea
We investigated the effectiveness of the probiotic Saccharomyces boulardii CNCM I-745 in real-world settings for treating diarrhea. In a study involving over 30,000 patients, those treated with S. boulardii had a notable success rate of 77.8% in resolving their diarrhea, compared to just 15.8% in the control group.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
This study showed that S. boulardii worked well even when patients were on antibiotics, outperforming traditional anti-diarrheal treatments.
Overall, S. boulardii demonstrates significant promise in managing diarrhea effectively.
8
We evaluated the impact of a specific supplement as an added therapy in traditional treatments for gut issues. Our systematic review combined results from various studies and looked at everything from eradication rates to side effects like diarrhea and bloating.
We found that using this supplement significantly improved eradication rates while also lessening side effects, including diarrhea. This suggests that it could be a beneficial addition to conventional therapies, helping to ease some common adverse reactions.
We found that using this supplement significantly improved eradication rates while also lessening side effects, including diarrhea. This suggests that it could be a beneficial addition to conventional therapies, helping to ease some common adverse reactions.
8
By diving into existing studies, we found that probiotics, particularly strains like Saccharomyces boulardii, might help prevent Traveler's Diarrhea (TD). Our systematic review included ten well-structured trials, applying rigorous standards to assess the effectiveness of these probiotics. While some strains showed promise in reducing the risk of TD, others, like Lactobacillus acidophilus, did not perform well unless combined with others. Overall, the evidence suggests limited but potential value in using probiotics for TD prevention, meriting further exploration.
References
- Li M, Xie Y. Efficacy and safety of as an adjuvant therapy for the eradication of : a meta-analysis. Front Cell Infect Microbiol. 2025;15:1441185. 10.3389/fcimb.2025.1441185
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. 10.1007/s10620-024-08786-y
- Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. 10.1111/jgh.16809
- Hodzhev V, Dzhambazov K, Sapundziev N, Encheva M, Todorov S, et al. High-dose Probiotic Mix of spp., spp., , and to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA). Open Forum Infect Dis. 2024;11:ofae615. 10.1093/ofid/ofae615
- Chen Y, Teng T, Su Y, Chen WZ. The effect of supplementing with on bismuth quadruple therapy for eradicating : a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024;11:1344702. 10.3389/fmed.2024.1344702
- Pal BB, Bandagi RV, Pebbili KK, Rathod R, Kotak B, et al. Effectiveness of Saccharomyces boulardii CNCM I-745 in Adult Indian Patients with Diarrhoea: A Real-world, Multicentre, Retrospective, Comparative Study. Drugs Real World Outcomes. 2024;11:309. 10.1007/s40801-024-00424-3
- Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. 10.1016/j.tmaid.2024.102703
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. 10.1007/s12325-024-02783-3
- Liu LH, Han B, Tao J, Zhang K, Wang XK, et al. The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials. BMC Infect Dis. 2023;23:878. 10.1186/s12879-023-08896-4
- Sjomina O, Poļaka I, Suhorukova J, Vangravs R, Paršutins S, et al. Randomised clinical trial: efficacy and safety of H. pylori eradication treatment with and without Saccharomyces boulardii supplementation. Eur J Cancer Prev. 2024;33:217. 10.1097/CEJ.0000000000000858
- Gopalan S, Ganapathy S, Mitra M, Kumar Joshi D, Veligandla KC, et al. Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Cureus. 2023;15:e46314. 10.7759/cureus.46314
- Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. 10.3389/fphar.2023.1153070
- Salazar-Parra MA, Cruz-Neri RU, Trujillo-Trujillo XA, Dominguez-Mora JJ, Cruz-Neri HI, et al. Effectiveness of Saccharomyces Boulardii CNCM I-745 probiotic in acute inflammatory viral diarrhoea in adults: results from a single-centre randomized trial. BMC Gastroenterol. 2023;23:229. 10.1186/s12876-023-02863-8
- Cakcak İE, Aytın YE, Sayın S, Küçükarda A, Gökyer A, et al. An experimental study: the effect of S. boulardii on abemaciclibinduced diarrhea. Turk J Med Sci. 2023;53:51. 10.55730/1300-0144.5557
- He XJ, Wang XL, Sun DJ, Huang XY, Liu G, et al. The efficacy and safety of in addition to antofloxacin-based bismuth quadruple therapy for eradication: a single-center, prospective randomized-control study. Therap Adv Gastroenterol. 2023;16:17562848221147763. 10.1177/17562848221147763
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. 10.1159/000528954
- Dang X, Choi SY, Choi YJ, Lee JH, Castex M, et al. Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Ameliorating Post-weaning Diarrhea in Weaned Piglets. Probiotics Antimicrob Proteins. 2024;16:249. 10.1007/s12602-022-10008-8
- Duarte ME, Kim SW. Efficacy of Saccharomyces yeast postbiotics on cell turnover, immune responses, and oxidative stress in the jejunal mucosa of young pigs. Sci Rep. 2024;14:19235. 10.1038/s41598-024-70399-2
- Zhang H, Nuermaimaiti Y, Hao K, Qi Y, Xu Y, et al. Supplementation with Combined Additive Improved the Production of Dairy Cows and Their Offspring with Maintenance of Antioxidative Stability. Antioxidants (Basel). 2024;13. 10.3390/antiox13060650
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. 10.12669/pjms.40.3.8349
- Middelkoop A, Kettunen H, Guan X, Vuorenmaa J, Tichelaar R, et al. Effect of dietary tall oil fatty acids and hydrolysed yeast in SNP2-positive and SNP2-negative piglets challenged with F4 enterotoxigenic Escherichia coli. Sci Rep. 2024;14:2060. 10.1038/s41598-024-52586-3
- Miranda-Yuquilema J, Taboada J, Once V, Coyago M, Briñez W. Effect of Agroindustrial Waste Substrate Fermented with Lactic Acid Bacteria and Yeast on Changes in the Gut Microbiota of Guinea Pigs. Microorganisms. 2024;12. 10.3390/microorganisms12010133
- Salah N, Legendre H, Nenov V, Briche M, Serieys F, et al. Does micro-granulated yeast probiotic () supplementation in milk replacer affect health, growth, feed efficiency and economic gain of calves?. Vet Anim Sci. 2024;23:100329. 10.1016/j.vas.2023.100329
- Yan H, Xing Q, Xiao X, Yu B, He J, et al. Effect of Saccharomyces cerevisiae Postbiotics and Essential Oil on Growth Performance and Intestinal Health of Weanling Pigs During K88 ETEC Infection. J Anim Sci. 2024;102. 10.1093/jas/skae007
- Xu S, Jia X, Liu Y, Pan X, Chang J, et al. Effects of yeast-derived postbiotic supplementation in late gestation and lactation diets on performance, milk quality, and immune function in lactating sows. J Anim Sci. 2023;101. 10.1093/jas/skad201
- Santana DAD, Machado MO, de Azevedo BZ, Weber SH, Sotomaior CS, et al. Influence of probiotic supplementation on parasitological parameters in lambs. Vet Parasitol. 2023;318:109934. 10.1016/j.vetpar.2023.109934
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. 10.7717/peerj.14390
- Conway E, O'Doherty JV, Mukhopadhya A, Dowley A, Vigors S, et al. Maternal and/or direct supplementation with a combination of a casein hydrolysate and yeast β-glucan on post-weaning performance and intestinal health in the pig. PLoS One. 2022;17:e0265051. 10.1371/journal.pone.0265051
