Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
9
We dove into the effectiveness of saccharomyces boulardii in preventing antibiotic-associated diarrhoea through a meta-analysis of 21 randomized controlled trials involving nearly 4,800 participants.
Our findings showed that this probiotic significantly reduced the incidence of diarrhoea from 18.7% to 8.5%. Notably, in children, the risk dropped from 20.9% to 8.8%, while in adults, it decreased from 17.4% to 8.2%.
While S. boulardii also showed some benefit against Clostridium difficile-associated diarrhoea, this effect was primarily noted in children. Overall, we confirmed that saccharomyces boulardii offers a viable preventive measure against diarrhoea linked to antibiotic treatments.
Our findings showed that this probiotic significantly reduced the incidence of diarrhoea from 18.7% to 8.5%. Notably, in children, the risk dropped from 20.9% to 8.8%, while in adults, it decreased from 17.4% to 8.2%.
While S. boulardii also showed some benefit against Clostridium difficile-associated diarrhoea, this effect was primarily noted in children. Overall, we confirmed that saccharomyces boulardii offers a viable preventive measure against diarrhoea linked to antibiotic treatments.
Read More
7
We searched various databases and analyzed 29 randomized controlled trials to probe the effectiveness of Saccharomyces boulardii in treating acute gastroenteritis in children.
Our findings show that while S boulardii may help shorten the duration of diarrhea and reduce hospital stays, the evidence supporting these benefits remains low to very low in quality.
Overall, it appears that S boulardii could have some positive effects on diarrhea outcomes, but more robust studies are needed to confirm its true efficacy.
Our findings show that while S boulardii may help shorten the duration of diarrhea and reduce hospital stays, the evidence supporting these benefits remains low to very low in quality.
Overall, it appears that S boulardii could have some positive effects on diarrhea outcomes, but more robust studies are needed to confirm its true efficacy.
Read More
9.5
Saccharomyces boulardii effectively controls diarrhoea
We assessed how effective saccharomyces boulardii CNCM I-745 is in helping adults with diarrhoea based on real-world data from Indian patients. In our study, we looked at records from over 30,000 patients and found that 77.8% of those treated with the probiotic reported no further diarrhoea. In contrast, only 15.8% of those receiving other treatments experienced similar outcomes. This suggests that saccharomyces boulardii was notably more effective than traditional anti-diarrhoeal therapies, even when antibiotics were used alongside it.
Read More
Most Useful Reviews
9
Gut healing success
3 people found this helpful
Great for restoring gut health after taking powerful hospital IV antibiotics, which resulted in persistent diarrhoea and poor digestion. My doctor advised a 6 to 12-month course to repopulate my gut with beneficial bacteria. It began to work within days, normalising my bathroom visits. It took about a year before I could stop taking the pills entirely, and now I don’t need them any longer. I keep a bottle ready for anyone in my household who might require antibiotics.
Read More
9
Gut settling aid
2 people found this helpful
These probiotics are excellent for settling my gut. I have no diarrhoea or gut issues, and they also benefit women's health.
Read More
9
Effective gentle solution
This helps significantly with diarrhoea. Simply take two capsules; it’s gentle and pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
- All Researches
9.5
Saccharomyces boulardii effectively controls diarrhoea
We assessed how effective saccharomyces boulardii CNCM I-745 is in helping adults with diarrhoea based on real-world data from Indian patients. In our study, we looked at records from over 30,000 patients and found that 77.8% of those treated with the probiotic reported no further diarrhoea. In contrast, only 15.8% of those receiving other treatments experienced similar outcomes. This suggests that saccharomyces boulardii was notably more effective than traditional anti-diarrhoeal therapies, even when antibiotics were used alongside it.
Read More
9
Saccharomyces boulardii helps diarrhoea
We explored how the probiotic Saccharomyces boulardii can impact antibiotic-associated diarrhoea caused by gut dysbiosis. The findings highlight that this strain is uniquely resistant to antibiotics, making it a useful ally in restoring gut balance. Research shows that timely intake of S. boulardii can effectively prevent or alleviate the diarrhoea linked with antibiotic use. Overall, this suggests that incorporating this probiotic may help in returning the gut microbiota to a healthier state after antibiotic treatment.
Read More
9
We explored the benefits of Saccharomyces boulardii CNCM I-745, a yeast probiotic, in preventing antibiotic-associated diarrhea and pediatric gastroenteritis. The review highlights its impressive qualities, including resistance to antibiotic genes and stability across various pH levels. We observed that when used preventively, this probiotic significantly lowered the risk of diarrhea and helped restore gut health. It was also found to reduce diarrhea duration and hospital stays in children. Overall, Saccharomyces boulardii CNCM I-745 is safe and effective, making it a reliable option for managing acute diarrhea.
Read More
9
Saccharomyces boulardii aids diarrhoea recovery
We investigated how Saccharomyces boulardii, a type of yeast probiotic, helps children with acute diarrhoea in outpatient settings.
Our study looked at medical records from 160 children treated with conventional treatments and compared those who received the probiotic.
We found that those who took Saccharomyces boulardii had diarrhoea for a shorter time—3 days versus 4 days—and experienced fewer stools after treatment. Their overall health improved significantly, showing weight gain compared to those without the probiotic.
This supports the positive impact of Saccharomyces boulardii in managing acute diarrhoea in children, especially those who are dehydrated.
Our study looked at medical records from 160 children treated with conventional treatments and compared those who received the probiotic.
We found that those who took Saccharomyces boulardii had diarrhoea for a shorter time—3 days versus 4 days—and experienced fewer stools after treatment. Their overall health improved significantly, showing weight gain compared to those without the probiotic.
This supports the positive impact of Saccharomyces boulardii in managing acute diarrhoea in children, especially those who are dehydrated.
Read More
9
Saccharomyces boulardii reduces inflammation
We investigated how Saccharomyces boulardii (Sb) could help treat diarrhoea caused by Blastocystis spp. In our study, rats infected with this parasite were treated with different methods, including Sb alone and alongside metronidazole.
We observed that live Sb significantly improved the colonic health of the rats by reducing inflammation markers. When combined with metronidazole, the results were even more promising, with complete elimination of the parasite from the rats’ systems. This suggests that Sb can be an effective treatment option for diarrhoea associated with Blastocystis infection.
We observed that live Sb significantly improved the colonic health of the rats by reducing inflammation markers. When combined with metronidazole, the results were even more promising, with complete elimination of the parasite from the rats’ systems. This suggests that Sb can be an effective treatment option for diarrhoea associated with Blastocystis infection.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Gut healing success
3 people found this helpful
Great for restoring gut health after taking powerful hospital IV antibiotics, which resulted in persistent diarrhoea and poor digestion. My doctor advised a 6 to 12-month course to repopulate my gut with beneficial bacteria. It began to work within days, normalising my bathroom visits. It took about a year before I could stop taking the pills entirely, and now I don’t need them any longer. I keep a bottle ready for anyone in my household who might require antibiotics.
Read More
9
Gut settling aid
2 people found this helpful
These probiotics are excellent for settling my gut. I have no diarrhoea or gut issues, and they also benefit women's health.
Read More
9
Effective gentle solution
This helps significantly with diarrhoea. Simply take two capsules; it’s gentle and pleasant.
Read More
9
Diarrhoea control
Excellent for gut health, offering a good quantity of Saccharomyces at an affordable price. It has greatly helped in managing my diarrhoea.
Read More
9
Pathogen effective
This well-researched probiotic aids with diarrhoea regardless of the cause and is effective against harmful pathogens.
Read More
Frequently Asked Questions
9
Gut healing success
3 people found this helpful
Great for restoring gut health after taking powerful hospital IV antibiotics, which resulted in persistent diarrhoea and poor digestion. My doctor advised a 6 to 12-month course to repopulate my gut with beneficial bacteria. It began to work within days, normalising my bathroom visits. It took about a year before I could stop taking the pills entirely, and now I don’t need them any longer. I keep a bottle ready for anyone in my household who might require antibiotics.
7.5
Travel friendly
We often travel to Thailand and Malaysia and usually struggle with stomach issues. This was recommended by my doctor, and after using it for about a month, I experienced good results without any stomach pains or diarrhoea.
7.5
IBS relief
It worked well in reducing diarrhoea caused by IBS. However, I found other brands to be more effective than this one.
9
Best for diarrhoea
I occasionally have a troublesome gut, and this product has proven to be the best solution for my diarrhoea, aside from avoiding gluten. Saccharomyces has been very beneficial for a variety of issues, and I always keep it on hand.
9
Effective gentle solution
This helps significantly with diarrhoea. Simply take two capsules; it’s gentle and pleasant.
9
Pathogen effective
This well-researched probiotic aids with diarrhoea regardless of the cause and is effective against harmful pathogens.
7.5
Essential for travellers
This product helps with travellers' diarrhoea and is great for gut health; it’s a must-have.
9
Diarrhoea control
Excellent for gut health, offering a good quantity of Saccharomyces at an affordable price. It has greatly helped in managing my diarrhoea.
9.5
Saccharomyces boulardii effectively controls diarrhoea
We assessed how effective saccharomyces boulardii CNCM I-745 is in helping adults with diarrhoea based on real-world data from Indian patients. In our study, we looked at records from over 30,000 patients and found that 77.8% of those treated with the probiotic reported no further diarrhoea. In contrast, only 15.8% of those receiving other treatments experienced similar outcomes. This suggests that saccharomyces boulardii was notably more effective than traditional anti-diarrhoeal therapies, even when antibiotics were used alongside it.
8
We conducted a thorough review of the best available research on probiotics for preventing antibiotic-associated diarrhoea (AAD). This included analyzing 37 clinical studies, of which 33 were randomized controlled trials.
Our findings revealed that Saccharomyces boulardii CNCM I-745 is the most studied probiotic and demonstrates strong evidence for preventing AAD in both adults and children. Meanwhile, some other probiotics showed limited effectiveness. Ultimately, effectiveness varies by strain, making it crucial to choose a well-supported probiotic to safeguard against AAD.
Our findings revealed that Saccharomyces boulardii CNCM I-745 is the most studied probiotic and demonstrates strong evidence for preventing AAD in both adults and children. Meanwhile, some other probiotics showed limited effectiveness. Ultimately, effectiveness varies by strain, making it crucial to choose a well-supported probiotic to safeguard against AAD.
9
Saccharomyces boulardii aids diarrhoea recovery
We investigated how Saccharomyces boulardii, a type of yeast probiotic, helps children with acute diarrhoea in outpatient settings.
Our study looked at medical records from 160 children treated with conventional treatments and compared those who received the probiotic.
We found that those who took Saccharomyces boulardii had diarrhoea for a shorter time—3 days versus 4 days—and experienced fewer stools after treatment. Their overall health improved significantly, showing weight gain compared to those without the probiotic.
This supports the positive impact of Saccharomyces boulardii in managing acute diarrhoea in children, especially those who are dehydrated.
Our study looked at medical records from 160 children treated with conventional treatments and compared those who received the probiotic.
We found that those who took Saccharomyces boulardii had diarrhoea for a shorter time—3 days versus 4 days—and experienced fewer stools after treatment. Their overall health improved significantly, showing weight gain compared to those without the probiotic.
This supports the positive impact of Saccharomyces boulardii in managing acute diarrhoea in children, especially those who are dehydrated.
7
We searched various databases and analyzed 29 randomized controlled trials to probe the effectiveness of Saccharomyces boulardii in treating acute gastroenteritis in children.
Our findings show that while S boulardii may help shorten the duration of diarrhea and reduce hospital stays, the evidence supporting these benefits remains low to very low in quality.
Overall, it appears that S boulardii could have some positive effects on diarrhea outcomes, but more robust studies are needed to confirm its true efficacy.
Our findings show that while S boulardii may help shorten the duration of diarrhea and reduce hospital stays, the evidence supporting these benefits remains low to very low in quality.
Overall, it appears that S boulardii could have some positive effects on diarrhea outcomes, but more robust studies are needed to confirm its true efficacy.
References
- Pal BB, Bandagi RV, Pebbili KK, Rathod R, Kotak B, et al. Effectiveness of Saccharomyces boulardii CNCM I-745 in Adult Indian Patients with Diarrhoea: A Real-world, Multicentre, Retrospective, Comparative Study. Drugs Real World Outcomes. 2024;11:309. 10.1007/s40801-024-00424-3
- Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. 10.1007/s12325-024-02783-3
- Gopalan S, Ganapathy S, Mitra M, Kumar Joshi D, Veligandla KC, et al. Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review. Cureus. 2023;15:e46314. 10.7759/cureus.46314
- Salazar-Parra MA, Cruz-Neri RU, Trujillo-Trujillo XA, Dominguez-Mora JJ, Cruz-Neri HI, et al. Effectiveness of Saccharomyces Boulardii CNCM I-745 probiotic in acute inflammatory viral diarrhoea in adults: results from a single-centre randomized trial. BMC Gastroenterol. 2023;23:229. 10.1186/s12876-023-02863-8
- Storr M, Stengel A. [Systematic review: clinical evidence of probiotics in the prevention of antibiotic-associated diarrhoea]. MMW Fortschr Med. 2021;163:19. 10.1007/s15006-021-9762-5
- Collinson S, Deans A, Padua-Zamora A, Gregorio GV, Li C, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020;12:CD003048. 10.1002/14651858.CD003048.pub4
- Ragavan PSK, Kaur A, Kumar M, Singhal V, Patel AM, et al. Retrospective analysis of EMR database to assess the effectiveness of CNCM I-745 in children with acute diarrhoea during routine clinical practice. New Microbes New Infect. 2020;38:100766. 10.1016/j.nmni.2020.100766
- Szajewska H, Kołodziej M, Zalewski BM. Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update. Aliment Pharmacol Ther. 2020;51:678. 10.1111/apt.15659
- Méabed EMH, Abdelhafez DN, Abdelaliem YF. inhibits the expression of pro-inflammatory cytokines and inducible nitric oxide synthase genes in the colonic mucosa of rats experimentally-infected with subtype-3 cysts. Parasitology. 2019;146:1532. 10.1017/S0031182019000696
- Vermeersch SJ, Vandenplas Y, Tanghe A, Elseviers M, Annemans L. Economic evaluation of S. boulardii CNCM I-745 for prevention of antibioticassociated diarrhoea in hospitalized patients. Acta Gastroenterol Belg. 2018;81:269.
- Angelici MC, Nardis C, Scarpelli R, Ade P. Blastocystis hominis transmission by non-potable water: a case report in Italy. New Microbiol. 2018;41:173.
- Cottrell J, Koenig K, Perfekt R, Hofmann R. Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs R D. 2015;15:363. 10.1007/s40268-015-0111-y
- Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42:793. 10.1111/apt.13344
- Hancox LR, Le Bon M, Richards PJ, Guillou D, Dodd CE, et al. Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea. Animal. 2015;9:1756. 10.1017/S1751731114002687
- Szajewska H, Horvath A, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Aliment Pharmacol Ther. 2015;41:1237. 10.1111/apt.13214
- Xie C, Li J, Wang K, Li Q, Chen D. Probiotics for the prevention of antibiotic-associated diarrhoea in older patients: a systematic review. Travel Med Infect Dis. 2015;13:128. 10.1016/j.tmaid.2015.03.001
