Last update
5/17/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
8
Saccharomyces boulardii improves liver health
We explored the effects of Saccharomyces boulardii on liver fibrosis caused by carbon tetrachloride in 34 male Wistar rats. The rats were divided into different groups, including controls and those receiving treatment.
Our findings showed that S. boulardii reduced liver damage markers and levels of inflammatory substances in the treated group. This beneficial effect was linked to improved intestinal health and changes in gut bacteria. Overall, we observed that administering this probiotic can enhance liver function and slow down fibrosis progression.
Our findings showed that S. boulardii reduced liver damage markers and levels of inflammatory substances in the treated group. This beneficial effect was linked to improved intestinal health and changes in gut bacteria. Overall, we observed that administering this probiotic can enhance liver function and slow down fibrosis progression.
Read More
9
Saccharomyces boulardii reduces liver fat
We explored how Saccharomyces boulardii might alleviate non-alcoholic fatty liver disease (NAFLD) in rats suffering from fructose-induced liver damage. Thirty rats were divided into control, fatty liver, and treatment groups.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
Read More
9
We explored how Saccharomyces boulardii can protect the liver from damage caused by Salmonella Enteritidis. In a mouse study, we saw that pretreating with S. boulardii drastically reduced the movement of harmful bacteria to the liver by 96%, preventing significant hepatic injury. S. boulardii also minimized inflammatory responses that would typically harm liver tissue after infection. These findings suggest that S. boulardii could be a valuable tool for guarding against liver injury due to Salmonella infections in future treatments.
Read More
Most Useful Reviews
10
Rapid health recovery
634 people found this helpful
Healed my food allergies, IBS, autoimmune disease, arthritis, Candida infections, and liver disease. After suffering from glyphosate poisoning due to consuming GMO and non-organic foods, my health deteriorated. I experienced severe symptoms including skin issues, recurrent infections, and low energy, with my liver and pancreas failing. Doctors were unable to help, suggesting reducing sugar intake which proved ineffective. I began taking probiotic yeast alongside various supplements, and within two weeks, my health dramatically improved. My allergies subsided, liver pain vanished, and my gut began healing. I now recommend avoiding glyphosate-containing foods and supporting organic farmers.
Read More
6
Effective against diarrhoea
Much is already known about this unique biological probiotic, which has been shown to have beneficial properties for the gastrointestinal tract and is safe based on clinical studies. Saccharomycetes boulardii strengthen immunity and quickly relieve acute diarrhoea. These yeasts effectively combat antibiotic-associated diarrhoea and promote gentle restoration of intestinal microflora. They also improve liver steatosis, as their use is associated with beneficial effects in diabetes and obesity, reducing the risk of coronary heart disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
- All Researches
9
Saccharomyces boulardii reduces liver fat
We explored how Saccharomyces boulardii might alleviate non-alcoholic fatty liver disease (NAFLD) in rats suffering from fructose-induced liver damage. Thirty rats were divided into control, fatty liver, and treatment groups.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
Read More
9
We investigated whether probiotics could positively influence patients with cirrhosis. In our randomized placebo-controlled trial involving 40 participants, we found that those taking probiotics experienced improvements in circulation and symptoms associated with cirrhosis.
Specifically, patients showed reduced cardiac output, increased vascular resistance, and better liver function. Those receiving probiotics also had fewer complications, such as ascites and hepatic encephalopathy.
Overall, our findings suggest that probiotics may offer a beneficial effect on the management of cirrhosis.
Specifically, patients showed reduced cardiac output, increased vascular resistance, and better liver function. Those receiving probiotics also had fewer complications, such as ascites and hepatic encephalopathy.
Overall, our findings suggest that probiotics may offer a beneficial effect on the management of cirrhosis.
Read More
9
We explored how Saccharomyces boulardii can protect the liver from damage caused by Salmonella Enteritidis. In a mouse study, we saw that pretreating with S. boulardii drastically reduced the movement of harmful bacteria to the liver by 96%, preventing significant hepatic injury. S. boulardii also minimized inflammatory responses that would typically harm liver tissue after infection. These findings suggest that S. boulardii could be a valuable tool for guarding against liver injury due to Salmonella infections in future treatments.
Read More
9
We explored how Saccharomyces boulardii impacts rats treated with clarithromycin and methotrexate, both of which can cause liver and intestinal injury. In our study, rats receiving these drugs showed increased gut transit and marked oxidative damage.
However, those treated with S. boulardii experienced protection from these harmful effects. The probiotic not only improved antioxidant levels but also reduced inflammation in the liver and intestines.
These findings suggest that S. boulardii may serve as a useful addition to chemotherapy, helping to safeguard liver health during treatment.
However, those treated with S. boulardii experienced protection from these harmful effects. The probiotic not only improved antioxidant levels but also reduced inflammation in the liver and intestines.
These findings suggest that S. boulardii may serve as a useful addition to chemotherapy, helping to safeguard liver health during treatment.
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8
We systematically reviewed studies on the effects of Saccharomyces boulardii (SB) in treating liver diseases. Our analysis included sixteen studies, comprising ten animal experiments and six randomized controlled trials. We found that SB effectively lowered the severity of cirrhosis symptoms and improved liver health metrics.
Additionally, SB significantly reduced inflammatory markers and gene expressions associated with liver injury in various models. It also showed benefits in gut health by altering microbiota composition and enhancing barrier function. Overall, SB displays potential for supporting liver health, especially in cirrhosis and metabolic dysfunction.
Additionally, SB significantly reduced inflammatory markers and gene expressions associated with liver injury in various models. It also showed benefits in gut health by altering microbiota composition and enhancing barrier function. Overall, SB displays potential for supporting liver health, especially in cirrhosis and metabolic dysfunction.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Rapid health recovery
634 people found this helpful
Healed my food allergies, IBS, autoimmune disease, arthritis, Candida infections, and liver disease. After suffering from glyphosate poisoning due to consuming GMO and non-organic foods, my health deteriorated. I experienced severe symptoms including skin issues, recurrent infections, and low energy, with my liver and pancreas failing. Doctors were unable to help, suggesting reducing sugar intake which proved ineffective. I began taking probiotic yeast alongside various supplements, and within two weeks, my health dramatically improved. My allergies subsided, liver pain vanished, and my gut began healing. I now recommend avoiding glyphosate-containing foods and supporting organic farmers.
Read More
6
Effective against diarrhoea
Much is already known about this unique biological probiotic, which has been shown to have beneficial properties for the gastrointestinal tract and is safe based on clinical studies. Saccharomycetes boulardii strengthen immunity and quickly relieve acute diarrhoea. These yeasts effectively combat antibiotic-associated diarrhoea and promote gentle restoration of intestinal microflora. They also improve liver steatosis, as their use is associated with beneficial effects in diabetes and obesity, reducing the risk of coronary heart disease.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ulusan M, Erdogan MA, Simsek O, Gunes V, Erbas O. Mitigates Fructose-Induced Non-Alcoholic Fatty Liver in Rats. Medicina (Kaunas). 2024;60. 10.3390/medicina60101713
- Maslennikov R, Benuni N, Levshina A, Adzhieva F, Demina T, et al. Effect of on Liver Diseases: A Systematic Review. Microorganisms. 2024;12. 10.3390/microorganisms12081678
- Efremova I, Maslennikov R, Poluektova E, Medvedev O, Kudryavtseva A, et al. Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis. World J Hepatol. 2024;16:822. 10.4254/wjh.v16.i5.822
- Maslennikov R, Efremova I, Ivashkin V, Zharkova M, Poluektova E, et al. Effect of probiotics on hemodynamic changes and complications associated with cirrhosis: A pilot randomized controlled trial. World J Hepatol. 2022;14:1667. 10.4254/wjh.v14.i8.1667
- Barssotti L, Abreu ICME, Brandão ABP, Albuquerque RCMF, Ferreira FG, et al. Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice. Sci Rep. 2021;11:9189. 10.1038/s41598-021-88497-w
- Liu Y, Fan L, Cheng Z, Yu L, Cong S, et al. Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance. Sci Rep. 2021;11:1611. 10.1038/s41598-021-81263-y
- Yu L, Zhao XK, Cheng ML, Yang GZ, Wang B, et al. Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury. Sci Rep. 2017;7:1359. 10.1038/s41598-017-01271-9
- Liu YT, Li YQ, Wang YZ. [Protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2016;24:921. 10.3760/cma.j.issn.1007-3418.2016.12.009
- Wu D, Teng D, Wang X, Dai C, Wang J. Saccharomyces boulardii prevention of the hepatic injury induced by Salmonella Enteritidis infection. Can J Microbiol. 2014;60:681. 10.1139/cjm-2014-0259
- Li M, Zhu L, Xie A, Yuan J. Oral administration of Saccharomyces boulardii ameliorates carbon tetrachloride-induced liver fibrosis in rats via reducing intestinal permeability and modulating gut microbial composition. Inflammation. 2015;38:170. 10.1007/s10753-014-0019-7
- Everard A, Matamoros S, Geurts L, Delzenne NM, Cani PD. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. mBio. 2014;5:e01011. 10.1128/mBio.01011-14
- Duman DG, Kumral ZN, Ercan F, Deniz M, Can G, et al. Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats. Br J Nutr. 2013;110:493. 10.1017/S000711451200517X
- Geyik MF, Aldemir M, Hosoglu S, Ayaz C, Satilmis S, et al. The effects of Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice. Ann R Coll Surg Engl. 2006;88:176. PubMed
- Peret Filho LA, Penna FJ, Bambirra EA, Nicoli JR. Dose effect of oral Saccharomyces boulardii treatments on morbidity and mortality in immunosuppressed mice. J Med Microbiol. 1998;47:111. PubMed
- Huang H, Li Z, Qi Z, Ma L, Hu G, et al. Engineered S. cerevisiae-pYD1-ScFv-AFB1 mitigates aflatoxin B1 toxicity via bio-binding and intestinal microenvironment repair. Food Chem Toxicol. 2025;196:115232. 10.1016/j.fct.2024.115232
- Abdel-Latif GA, Al-Kashef AS, Nooman MU, Khattab AEA, Gebril SM, et al. The mechanistic interplay between Nrf-2, NF-κB/MAPK, caspase-dependent apoptosis, and autophagy in the hepatoprotective effects of Sophorolipids produced by microbial conversion of banana peels using Saccharomyces cerevisiae against doxorubicin-induced hepatotoxicity in rats. Food Chem Toxicol. 2023;182:114119. 10.1016/j.fct.2023.114119
- Abdel-Tawwab M, Khalil RH, Younis NA, Abo Selema TAM, Saad AH, et al. Saccharomyces cerevisiae supplemented diets mitigate the effects of waterborne cadmium toxicity on gilthead seabream (Sparus aurata L.): growth performance, haemato-biochemical, stress biomarkers, and histopathological investigations. Vet Res Commun. 2024;48:69. 10.1007/s11259-023-10176-0
- Cattaneo L, Lopreiato V, Piccioli-Cappelli F, Trevisi E, Minuti A. Effect of supplementing live Saccharomyces cerevisiae yeast on performance, rumen function, and metabolism during the transition period in Holstein dairy cows. J Dairy Sci. 2023;106:4353. 10.3168/jds.2022-23046
