5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
7
We investigated whether Saccharomyces boulardii could alleviate nausea and other discomforts during a 14-day treatment for Helicobacter pylori. In our study with 124 patients, half received S. boulardii while the other half received a placebo.
Participants reported improvements in gastrointestinal symptoms, such as diarrhea and epigastric discomfort. However, while S. boulardii helped with treatment tolerability and post-treatment nausea, it did not significantly enhance the overall success rate of eradicating H. pylori.
Participants reported improvements in gastrointestinal symptoms, such as diarrhea and epigastric discomfort. However, while S. boulardii helped with treatment tolerability and post-treatment nausea, it did not significantly enhance the overall success rate of eradicating H. pylori.
Read More
8
Saccharomyces boulardii reduces nausea effectively
We explored how Saccharomyces boulardii supplementation, when added to standard triple therapy (STT), can impact children’s nausea during H. pylori treatment. Analyzing data from 15 randomized controlled trials with over 2,000 participants, we found that S. boulardii significantly reduced nausea rates compared to STT alone—down to 12.7% from 21.3%.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
Read More
We conducted a double-blind, placebo-controlled study to see how Saccharomyces boulardii might help in reducing nausea during Helicobacter pylori eradication therapy.
Our findings suggest that those taking S. boulardii experienced significantly fewer gastrointestinal symptoms, including nausea, when compared to the control group.
While S. boulardii showed promise in alleviating some treatment-related side effects, Lactobacillus reuteri did not have notable effects. Further research with larger sample sizes is recommended to deepen our understanding.
Our findings suggest that those taking S. boulardii experienced significantly fewer gastrointestinal symptoms, including nausea, when compared to the control group.
While S. boulardii showed promise in alleviating some treatment-related side effects, Lactobacillus reuteri did not have notable effects. Further research with larger sample sizes is recommended to deepen our understanding.
Read More
Most Useful Reviews
9
Best for nausea
1 people found this helpful
Must have—this is the best probiotic for me. It alleviated my diarrhoea, nausea, and issues with Candida overgrowth.
Read More
9
First aid for nausea
This product should be available in every pharmacy, especially for nausea and diarrhoea—it’s essential first aid. I took it alongside antibiotics and experienced no issues. This is incredibly good.
Read More
7.5
Helps morning nausea
It tastes good, is easy to swallow, and is particularly helpful for morning nausea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
- All Researches
8
We examined how adding Saccharomyces boulardii to conventional treatments could aid in eradicating certain gastric infections. Through a thorough search of databases over the past two decades, we focused on outcomes, including nausea and other side effects.
Our findings suggest that incorporating Saccharomyces boulardii significantly enhances eradication rates while also decreasing nausea and other gastrointestinal issues. This gives us hope for better treatment options in battling these prevalent gastric conditions.
Our findings suggest that incorporating Saccharomyces boulardii significantly enhances eradication rates while also decreasing nausea and other gastrointestinal issues. This gives us hope for better treatment options in battling these prevalent gastric conditions.
Read More
8
Saccharomyces boulardii reduces nausea effectively
We explored how Saccharomyces boulardii supplementation, when added to standard triple therapy (STT), can impact children’s nausea during H. pylori treatment. Analyzing data from 15 randomized controlled trials with over 2,000 participants, we found that S. boulardii significantly reduced nausea rates compared to STT alone—down to 12.7% from 21.3%.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
Read More
We conducted a double-blind, placebo-controlled study to see how Saccharomyces boulardii might help in reducing nausea during Helicobacter pylori eradication therapy.
Our findings suggest that those taking S. boulardii experienced significantly fewer gastrointestinal symptoms, including nausea, when compared to the control group.
While S. boulardii showed promise in alleviating some treatment-related side effects, Lactobacillus reuteri did not have notable effects. Further research with larger sample sizes is recommended to deepen our understanding.
Our findings suggest that those taking S. boulardii experienced significantly fewer gastrointestinal symptoms, including nausea, when compared to the control group.
While S. boulardii showed promise in alleviating some treatment-related side effects, Lactobacillus reuteri did not have notable effects. Further research with larger sample sizes is recommended to deepen our understanding.
Read More
8
Probiotics prevent diarrhea in children
We examined the use of probiotics—specifically Saccharomyces boulardii—as a remedy for preventing antibiotic-associated diarrhea (AAD) in children. Our analysis included 23 studies with nearly 4,000 participants, and we found that probiotics significantly reduced AAD incidence from 19% in control groups to 8% in those receiving probiotics.
While this suggests that probiotics can be beneficial, the overall evidence quality was moderate. Importantly, no serious side effects were reported, making probiotics a safe option for many children, though caution is advised in those with pre-existing health conditions.
While this suggests that probiotics can be beneficial, the overall evidence quality was moderate. Importantly, no serious side effects were reported, making probiotics a safe option for many children, though caution is advised in those with pre-existing health conditions.
Read More
8
We aimed to find out if probiotics could help prevent antibiotic-associated diarrhea (AAD) in children. In our evaluation of 23 studies involving nearly 4,000 kids, we discovered that probiotics, especially Lactobacillus rhamnosus and Saccharomyces boulardii, significantly reduced the incidence of AAD compared to placebo or no treatment.
The results showed that only 8% of children taking probiotics experienced AAD, versus 19% in the control group. Importantly, no serious adverse events were linked to probiotic use, making it a safe option. However, we also emphasized the need for further research to explore other probiotic strains and ensure consistent results.
The results showed that only 8% of children taking probiotics experienced AAD, versus 19% in the control group. Importantly, no serious adverse events were linked to probiotic use, making it a safe option. However, we also emphasized the need for further research to explore other probiotic strains and ensure consistent results.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Best for nausea
1 people found this helpful
Must have—this is the best probiotic for me. It alleviated my diarrhoea, nausea, and issues with Candida overgrowth.
Read More
9
First aid for nausea
This product should be available in every pharmacy, especially for nausea and diarrhoea—it’s essential first aid. I took it alongside antibiotics and experienced no issues. This is incredibly good.
Read More
7.5
Helps morning nausea
It tastes good, is easy to swallow, and is particularly helpful for morning nausea.
Read More
Frequently Asked Questions
7.5
Helps morning nausea
It tastes good, is easy to swallow, and is particularly helpful for morning nausea.
9
First aid for nausea
This product should be available in every pharmacy, especially for nausea and diarrhoea—it’s essential first aid. I took it alongside antibiotics and experienced no issues. This is incredibly good.
9
Best for nausea
1 people found this helpful
Must have—this is the best probiotic for me. It alleviated my diarrhoea, nausea, and issues with Candida overgrowth.
8
Saccharomyces boulardii reduces nausea effectively
We explored how Saccharomyces boulardii supplementation, when added to standard triple therapy (STT), can impact children’s nausea during H. pylori treatment. Analyzing data from 15 randomized controlled trials with over 2,000 participants, we found that S. boulardii significantly reduced nausea rates compared to STT alone—down to 12.7% from 21.3%.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
Besides nausea, there were also lower occurrences of other gastrointestinal side effects. This suggests that S. boulardii not only aids in treating the infection but also makes the treatment process easier for kids.
7
Saccharomyces boulardii reduces nausea
To explore the impact of saccharomyces boulardii on nausea during H. pylori treatment, we conducted a double-blind, randomized trial involving 108 patients. Those receiving a 7- or 14-day regimen of moxifloxacin and dexlansoprazole experienced fewer side effects, including nausea, when taking the probiotic compared to the placebo group. Specifically, nausea rates were 7.4% in the probiotic group versus 22.2% in the placebo. This suggests that adding saccharomyces boulardii can effectively reduce therapy-related nausea.
7
Probiotic eases nausea without improving eradication
We explored the effect of adding the probiotic Saccharomyces boulardii to standard therapy for H. pylori infection in a randomized controlled trial involving 160 adults.
While the probiotic didn’t significantly improve H. pylori eradication rates, we observed that patients who received it reported fewer side effects like nausea and abdominal discomfort during treatment.
This suggests that Saccharomyces boulardii could help manage adverse effects associated with antibiotic therapy.
While the probiotic didn’t significantly improve H. pylori eradication rates, we observed that patients who received it reported fewer side effects like nausea and abdominal discomfort during treatment.
This suggests that Saccharomyces boulardii could help manage adverse effects associated with antibiotic therapy.
References
- Li M, Xie Y. Efficacy and safety of as an adjuvant therapy for the eradication of : a meta-analysis. Front Cell Infect Microbiol. 2025;15:1441185. 10.3389/fcimb.2025.1441185
- Liu LH, Han B, Tao J, Zhang K, Wang XK, et al. The effect of Saccharomyces boulardii supplementation on Helicobacter pylori eradication in children: a systematic review and meta-analysis of Randomized controlled trials. BMC Infect Dis. 2023;23:878. 10.1186/s12879-023-08896-4
- Naghibzadeh N, Salmani F, Nomiri S, Tavakoli T. Investigating the effect of quadruple therapy with Saccharomyces boulardii or Lactobacillus reuteri strain (DSMZ 17648) supplements on eradication of Helicobacter pylori and treatments adverse effects: a double-blind placebo-controlled randomized clinical trial. BMC Gastroenterol. 2022;22:107. 10.1186/s12876-022-02187-z
- Sirchak YS, Patskun SV, Bedey NV. DYNAMICS OF GASTRIN LEVEL IN PATIENTS WITH DIABETES MELLITUS 2 TYPE AND CHRONIC GASTRITIS AFTER HELICOBACTER PYLORI ERADICATION THERAPY. Wiad Lek. 2020;73:2512.
- He CX, Kong FT, Liang F, Wang KX, Li H, et al. [Influence of different timing of combined with bismuth quadruple therapy for eradication]. Zhonghua Yi Xue Za Zhi. 2019;99:1731. 10.3760/cma.j.issn.0376-2491.2019.22.010
- Chotivitayatarakorn P, Mahachai V, Vilaichone RK. Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2017;18:2839.
- Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73:1199. 10.1007/s00228-017-2291-6
- Hayes SR, Vargas AJ. Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea. Explore (NY). 2016;12:463. 10.1016/j.explore.2016.08.015
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD004827.pub4
- Szajewska H, Horvath A, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Aliment Pharmacol Ther. 2015;41:1237. 10.1111/apt.13214
- Zojaji H, Ghobakhlou M, Rajabalinia H, Ataei E, Jahani Sherafat S, et al. The efficacy and safety of adding the probiotic Saccharomyces boulardiito standard triple therapy for eradication of H.pylori: a randomized controlled trial. Gastroenterol Hepatol Bed Bench. 2013;6:S99.
- Dinleyici EC, Eren M, Dogan N, Reyhanioglu S, Yargic ZA, et al. Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection. Parasitol Res. 2011;108:541. 10.1007/s00436-010-2095-4
- Cindoruk M, Erkan G, Karakan T, Dursun A, Unal S. Efficacy and safety of Saccharomyces boulardii in the 14-day triple anti-Helicobacter pylori therapy: a prospective randomized placebo-controlled double-blind study. Helicobacter. 2007;12:309.
- Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 2002;97:2744.
- Polese B, Nicolai E, Genovese D, Verlezza V, La Sala CN, et al. Postprandial Gastrointestinal Function Differs after Acute Administration of Sourdough Compared with Brewer's Yeast Bakery Products in Healthy Adults. J Nutr. 2018;148:202. 10.1093/jn/nxx049
