5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
9
Saccharomyces boulardii reduces ulcer risk
We explored the effects of Saccharomyces boulardii on ulcerative colitis-related cancer in a mouse model.
Mice treated with a combination of azoxymethane and dextran sulfate sodium were given S. boulardii for 12 weeks.
Results showed that S. boulardii significantly lowered tumor load and reduced harmful substances TNF-α and IL-6 in the colon.
Additionally, it positively shifted the gut microbiota composition, suggesting a connection between the treatment and these beneficial outcomes.
Mice treated with a combination of azoxymethane and dextran sulfate sodium were given S. boulardii for 12 weeks.
Results showed that S. boulardii significantly lowered tumor load and reduced harmful substances TNF-α and IL-6 in the colon.
Additionally, it positively shifted the gut microbiota composition, suggesting a connection between the treatment and these beneficial outcomes.
9
We explored how the yeast strain QHNLD8L1 may help with ulcerative colitis. In our study, we looked at four different yeast strains and their effects on mice with induced colitis. Notably, QHNLD8L1 showed protective effects, improving body weight and colon length, while reducing inflammation. We also found that it decreased harmful bacteria and boosted beneficial ones, enhancing gut health overall. This indicates that QHNLD8L1 could be a promising approach to manage ulcerative colitis symptoms.
Most Useful Reviews
10
Powerful ulcer relief.
343 people found this helpful
The most effective remedy I've discovered over the last ten years for tackling ulcers and stomach problems. This product surpasses everything I've tried, including antibiotics for various stomach issues. It offers an environment conducive to healing from ulcers. I typically take one three times a day; if symptoms are severe, I increase the dosage. I can heal ulcers within 24 to 48 hours and struggle without it.
7.5
Significant improvement noted.
156 people found this helpful
After enduring flare-ups for 25 years, I've often relied on steroids for relief. Recently, despite avoiding gluten and dairy, flare-ups became more frequent. However, since starting this once daily, I’ve seen remarkable improvement—no flare-ups for two months now. I can eat more freely without concerns about soft stools and have reduced my colitis medication. I feel liberated; this truly works!
7.5
Beneficial for ulcers
4 people found this helpful
S. boulardii has been prescribed for the prevention and treatment of diarrheal diseases for 30 years. Evidence suggests this probiotic may help patients with inflammatory bowel disease and irritable bowel syndrome. Boulardii has notably reduced stomach ulcers and gastric mucosal surface issues.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
- All Researches
We looked into how the probiotic Saccharomyces boulardii affects the treatment of Helicobacter pylori in Thai patients. In a double-blind study, participants received either a probiotic or placebo with a moxifloxacin-dexlansoprazole therapy.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
While the treatment achieved high eradication rates of H. pylori, we found that the addition of the probiotic significantly reduced side effects like nausea and diarrhea compared to those on placebo. This suggests that Saccharomyces boulardii could enhance patient comfort during an effective antibiotic regimen.
9
Saccharomyces boulardii aids ulcer treatment
This study examined how Saccharomyces boulardii supernatant (SbS) impacts ulcerative colitis (UC) by activating the FXR-NLRP3 signaling pathway. We used a murine model to assess the effects of SbS compared to a control group.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
Our findings showed that SbS not only activated FXR but also suppressed the NLRP3 inflammasome in colonic tissues. It reduced macrophage pyroptosis, a process linked to inflammation. However, the benefits were reversed by an FXR inhibitor, indicating that FXR’s activation is crucial for SbS's effects.
9
Targeted Saccharomyces boulardii benefits ulcerative colitis
We investigated the impact of a targeted delivery system for Saccharomyces boulardii, a probiotic yeast, aimed at treating ulcerative colitis. In our preclinical studies on female mice, we found that this engineered strain significantly improved gut retention time, increasing it by an extra 24-48 hours.
This enhanced delivery led to a dramatic boost in the concentration of the probiotic in the colon, which resulted in notable improvements in colon health markers. Key indicators like colon length and inflammation scores returned to healthier levels, suggesting promising potential for this targeted treatment strategy in managing inflammatory bowel diseases.
This enhanced delivery led to a dramatic boost in the concentration of the probiotic in the colon, which resulted in notable improvements in colon health markers. Key indicators like colon length and inflammation scores returned to healthier levels, suggesting promising potential for this targeted treatment strategy in managing inflammatory bowel diseases.
9
We explored the effects of Saccharomyces boulardii (Sb) in mice with NSAID-induced enteropathy. Through various assessments, including clinical scores and intestinal analyses, we compared four groups: Control, Indomethacin, Sb, and Sb with Indomethacin.
Mice treated with Sb demonstrated significant improvements in their health compared to those only on indomethacin. Sb not only enhanced the intestinal barrier but also positively influenced gut bacteria, reducing inflammation and damage caused by NSAIDs.
Our findings suggest that Sb could serve as a protective agent against NSAID-related intestinal issues.
Mice treated with Sb demonstrated significant improvements in their health compared to those only on indomethacin. Sb not only enhanced the intestinal barrier but also positively influenced gut bacteria, reducing inflammation and damage caused by NSAIDs.
Our findings suggest that Sb could serve as a protective agent against NSAID-related intestinal issues.
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Powerful ulcer relief.
343 people found this helpful
The most effective remedy I've discovered over the last ten years for tackling ulcers and stomach problems. This product surpasses everything I've tried, including antibiotics for various stomach issues. It offers an environment conducive to healing from ulcers. I typically take one three times a day; if symptoms are severe, I increase the dosage. I can heal ulcers within 24 to 48 hours and struggle without it.
7.5
Significant improvement noted.
156 people found this helpful
After enduring flare-ups for 25 years, I've often relied on steroids for relief. Recently, despite avoiding gluten and dairy, flare-ups became more frequent. However, since starting this once daily, I’ve seen remarkable improvement—no flare-ups for two months now. I can eat more freely without concerns about soft stools and have reduced my colitis medication. I feel liberated; this truly works!
7.5
Beneficial for ulcers
4 people found this helpful
S. boulardii has been prescribed for the prevention and treatment of diarrheal diseases for 30 years. Evidence suggests this probiotic may help patients with inflammatory bowel disease and irritable bowel syndrome. Boulardii has notably reduced stomach ulcers and gastric mucosal surface issues.
6
Painful side effects.
10 people found this helpful
Cured my ulcer in three days but caused terrible colon pain and gas. Long-term, the ulcer is more manageable than the discomfort caused. It took several days for my body to adjust and return to its normal state.
7.5
Strong ingredients
3 people found this helpful
Excellent quality! The ingredients are robust, offering invaluable support for ulcers and irritable bowel issues. I wholeheartedly recommend purchasing it, especially given the substantial quantity.
Frequently Asked Questions
9
Helicobacter treatment
My husband was diagnosed with a stomach ulcer due to helicobacter. The doctor advised using boulardii alongside other medications. This good bacteria hinders Helicobacter pylori's activity, leading to an end to his stomach rumbling and a feeling of lightness.
7.5
Helpful for ulcers
As someone with constant ulcer and H. pylori issues, this product has proven to be beneficial. It contains no unnecessary additives, making it a great choice for anyone facing similar challenges.
7.5
Beneficial for ulcers
4 people found this helpful
S. boulardii has been prescribed for the prevention and treatment of diarrheal diseases for 30 years. Evidence suggests this probiotic may help patients with inflammatory bowel disease and irritable bowel syndrome. Boulardii has notably reduced stomach ulcers and gastric mucosal surface issues.
7.5
Strong ingredients
3 people found this helpful
Excellent quality! The ingredients are robust, offering invaluable support for ulcers and irritable bowel issues. I wholeheartedly recommend purchasing it, especially given the substantial quantity.
9
We explored how the probiotic yeast, Saccharomyces boulardii, impacts ulcerative colitis in mice. Through a careful setup, C57BL/6 mice received the treatment for three weeks and were later exposed to a harmful substance to induce the condition.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
The results were promising; we observed that Saccharomyces boulardii significantly improved various symptoms. It helped prevent weight loss, diarrhea, and inflammation while strengthening the intestinal barrier. Furthermore, it demonstrated an ability to counteract oxidative damage effectively.
However, we also noted that while these findings are positive, further research is needed to fully understand the comprehensive benefits of this treatment in humans.
8
Saccharomyces boulardii reduces inflammatory response
We explored the effects of Saccharomyces boulardii on immune cells from patients with ulcerative colitis and Crohn's disease. In our study, we looked at how well this probiotic influences dendritic cells, which are important for immune responses.
Our findings showed that S. boulardii significantly reduced certain inflammatory markers and T cell activity linked to these conditions. It also encouraged mucosal healing, suggesting a potential therapeutic role for this probiotic in managing inflammation related to IBD.
Our findings showed that S. boulardii significantly reduced certain inflammatory markers and T cell activity linked to these conditions. It also encouraged mucosal healing, suggesting a potential therapeutic role for this probiotic in managing inflammation related to IBD.
8
S. boulardii shows potential for ulcers
We investigated the potential of Saccharomyces boulardii, a non-pathogenic yeast, in aiding patients with ulcerative colitis. In a trial, 25 patients experiencing flare-ups took S. boulardii for four weeks alongside mesalazine, while unsuitable for steroids.
Impressively, 17 out of 24 participants achieved clinical remission, confirmed via endoscopy.
Our findings suggest that S. boulardii may be beneficial, pointing to the need for further controlled studies to thoroughly explore its effectiveness.
Impressively, 17 out of 24 participants achieved clinical remission, confirmed via endoscopy.
Our findings suggest that S. boulardii may be beneficial, pointing to the need for further controlled studies to thoroughly explore its effectiveness.
References
- Yang L, Li W, Zhao Q, Mo Q, Liu T, et al. Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis. J Inflamm Res. 2025;18:3161. 10.2147/JIR.S504957
- Zhang Y, Lu B, Dong Y, Zhang Y, Du Q, et al. Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection. Sci Rep. 2024;14:13152. 10.1038/s41598-024-63894-z
- Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. 10.1038/s41467-024-48128-0
- Simon O'Brien E, Robert A, Gauthier D, Le Cavorzin A, Planchais J, et al. Protective effects of Saccharomyces boulardii CNCM I-745 in an experimental model of NSAID-induced enteropathy. Benef Microbes. 2023;14:239. 10.3920/BM2023.0003
- Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. 10.1155/2021/1622375
- Wang C, Li W, Wang H, Ma Y, Zhao X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol. 2019;19:246. 10.1186/s12866-019-1610-8
- Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50:1159. 10.1111/apt.15523
- Chotivitayatarakorn P, Mahachai V, Vilaichone RK. Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2017;18:2839.
- Ganji-Arjenaki M, Rafieian-Kopaei M. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. J Cell Physiol. 2018;233:2091. 10.1002/jcp.25911
- Thomas S, Metzke D, Schmitz J, Dörffel Y, Baumgart DC. Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1083. 10.1152/ajpgi.00217.2011
- Girard P, Coppé MC, Pansart Y, Gillardin JM. Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer. Pharmacology. 2010;85:188. 10.1159/000275146
- Duman DG, Bor S, Ozütemiz O, Sahin T, Oğuz D, et al. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradication. Eur J Gastroenterol Hepatol. 2005;17:1357.
- Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol. 2003;15:697.
- Han X, Luo R, Qi S, Wang Y, Dai L, et al. "Dual sensitive supramolecular curcumin nanoparticles" in "advanced yeast particles" mediate macrophage reprogramming, ROS scavenging and inflammation resolution for ulcerative colitis treatment. J Nanobiotechnology. 2023;21:321. 10.1186/s12951-023-01976-2
- Hu Q, Yu L, Zhai Q, Zhao J, Tian F. Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice. Int J Mol Sci. 2023;24. 10.3390/ijms24076721
- Valibouze C, Speca S, Dubuquoy C, Mourey F, M'Ba L, et al. prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats. World J Gastroenterol. 2023;29:851. 10.3748/wjg.v29.i5.851
- Magnoli AP, Parada J, de la Torre FC, Watson S, Poloni V, et al. Respiratory tract clinometry, fat thickness, haematology and productive parameters associated with direct-fed microbials used as growth promoter antibiotic alternative in weaned piglets. Vet Anim Sci. 2022;16:100246. 10.1016/j.vas.2022.100246
