We explored the potential of a new ascorbic acid derivative, 6-Deoxy-2-methyl-6-(-hexadecanoyl)amino-l-ascorbic acid, as a treatment for allergies. This study involved synthesizing various palmitoyl derivatives and assessing their ability to inhibit allergic responses in a lab setting. The findings indicated that 2-Me-6-Palm-AA showed significantly more promise in reducing allergic reactions compared to earlier derivatives. However, while these results are exciting, further research is needed to fully understand its effectiveness and potential as a therapeutic solution.
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9
Vitamin C reduces hair dye allergies
Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine.
We investigated whether applying the antioxidant vitamin C to the skin could lessen allergic reactions to p-phenylenediamine (PPD), a common ingredient in hair dyes. In a study involving 28 volunteers with known PPD allergies, we treated skin with a vitamin C formulation for 10 minutes before exposing it to PPD.
The results were promising, showing that about 75% of the participants experienced reduced allergic reactions compared to untreated skin. This suggests that adding vitamin C to the skin before hair dyeing could effectively help manage allergic contact dermatitis.
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8
Sodium ascorbate shows allergy promise
Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides.
We investigated the effects of sodium ascorbate, a derivative of vitamin C, on allergies. Our findings from a study using various synthesized forms of this compound indicated that certain derivatives effectively reduced allergy-related reactions in mice. The results demonstrated a clear inhibition of harmful enzymes and degranulation, particularly with one potent derivative. This suggests sodium ascorbate could become a valuable option for allergy treatment, showcasing its potential benefits in managing allergic responses.
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Most Useful Reviews
9
Helps prevent illnesses
115 people found this helpful
Good vitamin C! The jar lasts a long time and does not irritate my stomach. It is well absorbed and does not cause allergies. We take a loading dose at the first signs of ARVI, which helps the whole family avoid getting ill.
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10
No allergic reactions
2 people found this helpful
I'm allergic, and this vitamin C is the only form that hasn’t caused allergies. Other forms led to immediate skin rashes, but this one suits me perfectly.
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7.5
Gentle on stomach
2 people found this helpful
Excellent vitamin C for the entire family. It lasts for ages, has no taste, and does not irritate the stomach. I haven't experienced any allergies. Highly recommend.
Reduced allergenicity of hydrolysed whey protein concentrate complexed with iron: the effect of different enzymes, degree of hydrolysis and ascorbic acid.
We investigated how adding ascorbic acid affects whey protein's allergenicity in the context of cow's milk allergy. Our study tested various treatments, including iron-complexed protein hydrolysates. We found that the allergenic potential was significantly lowered—up to 60%—when ascorbic acid was involved. The results demonstrate a promising approach to creating hypoallergenic supplements, making it kinder for those with milk sensitivities.
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9
Promising allergy treatment candidate
Antiallergic Activity of 6-Deoxy-2--methyl-6-(-hexadecanoyl)amino-l-ascorbic Acid.
We explored the potential of a new ascorbic acid derivative, 6-Deoxy-2-methyl-6-(-hexadecanoyl)amino-l-ascorbic acid, as a treatment for allergies. This study involved synthesizing various palmitoyl derivatives and assessing their ability to inhibit allergic responses in a lab setting. The findings indicated that 2-Me-6-Palm-AA showed significantly more promise in reducing allergic reactions compared to earlier derivatives. However, while these results are exciting, further research is needed to fully understand its effectiveness and potential as a therapeutic solution.
Read More
9
Scurvy linked to vitamin C deficiency
A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis.
We observed a case of scurvy in a patient who presented with sudden joint pain and purple spots on the skin due to a vitamin C deficiency. After testing low vitamin C levels, we treated the patient with vitamin C supplements, leading to significant improvement.
This condition, often seen in people with limited access to fruits and vegetables, can sometimes manifest in unusual ways, such as unexplained skin bleeding. Identifying scurvy early can have a major impact on treatment and recovery.
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9
Vitamin C reduces hair dye allergies
Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine.
We investigated whether applying the antioxidant vitamin C to the skin could lessen allergic reactions to p-phenylenediamine (PPD), a common ingredient in hair dyes. In a study involving 28 volunteers with known PPD allergies, we treated skin with a vitamin C formulation for 10 minutes before exposing it to PPD.
The results were promising, showing that about 75% of the participants experienced reduced allergic reactions compared to untreated skin. This suggests that adding vitamin C to the skin before hair dyeing could effectively help manage allergic contact dermatitis.
Read More
8
Sodium ascorbate shows allergy promise
Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides.
We investigated the effects of sodium ascorbate, a derivative of vitamin C, on allergies. Our findings from a study using various synthesized forms of this compound indicated that certain derivatives effectively reduced allergy-related reactions in mice. The results demonstrated a clear inhibition of harmful enzymes and degranulation, particularly with one potent derivative. This suggests sodium ascorbate could become a valuable option for allergy treatment, showcasing its potential benefits in managing allergic responses.
Good vitamin C! The jar lasts a long time and does not irritate my stomach. It is well absorbed and does not cause allergies. We take a loading dose at the first signs of ARVI, which helps the whole family avoid getting ill.
Read More
10
No allergic reactions
2 people found this helpful
I'm allergic, and this vitamin C is the only form that hasn’t caused allergies. Other forms led to immediate skin rashes, but this one suits me perfectly.
Read More
7.5
Gentle on stomach
2 people found this helpful
Excellent vitamin C for the entire family. It lasts for ages, has no taste, and does not irritate the stomach. I haven't experienced any allergies. Highly recommend.
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10
Safe for children
An excellent product suitable for all ages and allergy sufferers. I recommend using it at the first sign of a cold. It barely has a taste, so my child willingly drinks it. There were no allergic reactions, and my child stayed well for kindergarten.
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10
Better absorption
Sodium ascorbate is a buffered form of vitamin C that’s better absorbed and does not irritate my stomach. It does not cause allergies and preserves tooth enamel, even with high doses.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Sodium ascorbate is the sodium salt of ascorbic acid, commonly known as vitamin C. It is often used as a dietary supplement and food preservative due to its antioxidant properties. Unlike ascorbic acid, sodium ascorbate is better tolerated by individuals experiencing gastrointestinal discomfort from acidic forms of vitamin C, making it a popular choice for those looking to increase their vitamin C intake without the potential for stomach upset.
Sodium ascorbate serves a variety of functions beyond supplementation. It can act as a food preservative by inhibiting oxidation, thereby prolonging shelf life and maintaining the quality of packaged foods. Additionally, it is often used in cosmetic formulations for its skin-beneficial properties, including reducing oxidative stress and promoting collagen synthesis. When considering sodium ascorbate, it’s essential to consult with a healthcare provider, particularly if you have specific dietary needs or medical conditions that could be affected by sodium intake.
Sodium ascorbate, a salt form of vitamin C, is often touted for its antioxidant properties and potential health benefits. While vitamin C itself is known for its role in supporting the immune system and reducing inflammation, the effectiveness of sodium ascorbate specifically for allergies is not conclusively established. Some studies suggest that vitamin C can help alleviate certain allergic reactions by stabilizing mast cells and reducing histamine release, which may lead to fewer allergy symptoms. However, research directly linking sodium ascorbate with significant improvements in allergy symptoms is limited.
It's important to note that while increasing your vitamin C intake might provide some benefits for those suffering from allergies, it should not replace conventional allergy treatments or medications prescribed by a healthcare professional. Those interested in using sodium ascorbate or other forms of vitamin C for allergy relief should consult with a doctor to discuss potential benefits and appropriate dosages. As always, personal experiences may vary, and what works for one individual may not work for another.
Based on user reviews, the time it typically takes to see results from this vitamin C supplement when used for allergies can vary. Many users report experiencing noticeable benefits relatively quickly, often within a few days. For instance, one user mentioned that their child’s symptoms improved within two days after administering a loading dose during a cold Read Review. This aligns with other users who also indicated that they felt better by taking the supplement at the first signs of illness, suggesting a proactive approach can yield quicker results Read Review.
However, not all experiences were positive. One reviewer noted that they experienced stomach pain and worsening allergies after two weeks of use Read Review, highlighting that individual reactions can vary widely. Therefore, while some may see improvement rapidly, others might encounter side effects that delay any benefits. Overall, if you're considering this vitamin C supplement for allergies, it's recommended to monitor your response during the initial weeks of use.
This supplement, particularly ascorbic acid and its derivatives, shows potential in managing allergies based on various scientific studies. One investigation revealed that intravenous sodium ascorbate significantly reduced allergy symptoms in patients, with over half relying on this treatment alone for relief [3]. Additionally, another study found that certain forms of sodium ascorbate effectively inhibited allergic reactions in animal models, indicating its potential as an allergy treatment option [4].
Moreover, there are promising findings around the combination of ascorbic acid and other substances, such as pleuran, which demonstrated improvements in asthma control for children [7]. On another front, the use of vitamin C applied topically showed effectiveness in lessening allergic reactions to hair dye in participants [6]. Collectively, while these studies indicate the potential of vitamin C and its derivatives in alleviating allergy symptoms, further large-scale research is necessary to establish their efficacy and optimal use.
Users have reported various improvements in symptoms after taking this vitamin C supplement, particularly in relation to allergies and cold symptoms. Many indicated that the product is gentle on the stomach and does not cause allergic reactions, which is often a concern with vitamin C. For example, one reviewer noted that after using this form, they saw no allergic reactions and that their family experienced milder colds that passed quickly without complications Read Review. Another user highlighted the benefits of taking a loading dose at the first signs of a cold, stating that it was effective in improving their child's symptoms within just two days Read Review.
Additionally, several users specifically praised this vitamin C for being well-absorbed, with one reviewer emphasizing that it successfully alleviated their symptoms without any adverse reactions Read Review. Overall, while individual results can vary—some have experienced discomfort or worsened allergies after use Read Review—the prevailing sentiment is that the supplement offers a timely and effective option for those seeking to manage cold symptoms and minimize allergic responses.
Based on user reviews, many have successfully combined this vitamin C supplement with other remedies to manage their allergies effectively. Users have reported that this particular form of vitamin C, which is buffered and easily absorbed, does not cause allergic reactions, making it suitable for allergy sufferers. For instance, one user noted that this supplement did not lead to skin rashes, unlike other forms they had tried, and they recommended it for their entire family Read Review. In addition, another reviewer specifically mentioned using it in conjunction with juices during colds, highlighting its versatility and good absorption without adverse allergic effects Read Review.
However, it's important to note that not all experiences were positive. One reviewer expressed disappointment as they experienced worsened allergies and discomfort after combining this supplement with their usual regimen Read Review. Additionally, there was a cautionary tale from a user whose child developed swelling after a high loading dose, suggesting that while this vitamin C can be beneficial, careful dosage management is essential to avoid potential allergic responses Read Review. Overall, users generally appreciated the supplement's gentleness on the stomach and its compatibility with their allergy management routines.
Based on user reviews, recommendations for the right dose of Sodium Ascorbate for treating allergies vary, with many users advocating a cautious approach to dosages. One user highlighted that they took a double dose at the first sign of a cold, noting it helped them recover quickly without any allergy issues Read Review. However, caution is warranted, as another review mentioned an instance where a high dose led to allergic reactions, prompting a reduction in intake to avoid further issues Read Review.
Overall, while many users report no allergic reactions and good absorption with Sodium Ascorbate, there are accounts of stomach discomfort and allergic responses when dosages were increased. As such, starting with a lower dose and monitoring individual reactions seems advisable for anyone considering this vitamin C form for allergy treatment.
7.5
Temporary swelling
I tried this vitamin C on a blogger's recommendation. After giving my daughter a loading dose during a cold, her symptoms improved within two days. However, she later developed a pink swelling on her forehead, which I believe was an allergy due to the high dose. I reduced her intake, and she didn't experience further allergies. Be cautious with dosages!
10
Safe for children
An excellent product suitable for all ages and allergy sufferers. I recommend using it at the first sign of a cold. It barely has a taste, so my child willingly drinks it. There were no allergic reactions, and my child stayed well for kindergarten.
0
Worsened allergies
3 people found this helpful
I had hoped this would help with my allergies and fatigue, but it caused stomach pain and headaches instead. After two weeks, I still felt discomfort and an odd pressure in my head. Oddly, I craved lemons after taking it. Overall, it wasn’t for me—and it surprisingly worsened my allergies.
7.5
No allergies noted
16 people found this helpful
Good vitamin C! The extra large packaging lasts a long time. I find this buffered ascorbate form gentle on the kidneys. My family, including my 5-year-old, has benefitted from it—coughs and colds have been milder and pass quickly without complications. There were no allergies or rashes, even with my child's atopic dermatitis. I personally increased my dosage without issues, but found a cheaper alternative by another brand.
10
No allergic reactions
2 people found this helpful
I'm allergic, and this vitamin C is the only form that hasn’t caused allergies. Other forms led to immediate skin rashes, but this one suits me perfectly.
10
Child-friendly option
I always have this at home! I add it to juices during colds, and it's well absorbed without causing allergies. My child has no problems with it.
7.5
Quick recovery
This vitamin C is easily absorbed, and I’ve seen no allergies. I take a double dose at the first sign of a cold and recover quickly.
7
Intravenous vitamin C shows promise
Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study.
We investigated how intravenous vitamin C, particularly sodium ascorbate, could impact allergy symptoms in a group of 71 patients. In this observational study, we noted significant reductions in both allergy-specific and general symptoms, such as fatigue and mental concentration issues, indicating potential benefits from sodium ascorbate treatment. Notably, over half of the patients relied solely on vitamin C without other allergy medications. While our findings are promising, we stress the need for a larger randomized controlled trial to confirm these initial results.
8
Sodium ascorbate shows allergy promise
Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides.
We investigated the effects of sodium ascorbate, a derivative of vitamin C, on allergies. Our findings from a study using various synthesized forms of this compound indicated that certain derivatives effectively reduced allergy-related reactions in mice. The results demonstrated a clear inhibition of harmful enzymes and degranulation, particularly with one potent derivative. This suggests sodium ascorbate could become a valuable option for allergy treatment, showcasing its potential benefits in managing allergic responses.
8
Pleuran and Vitamin C aid asthma
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
9
Vitamin C reduces hair dye allergies
Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine.
We investigated whether applying the antioxidant vitamin C to the skin could lessen allergic reactions to p-phenylenediamine (PPD), a common ingredient in hair dyes. In a study involving 28 volunteers with known PPD allergies, we treated skin with a vitamin C formulation for 10 minutes before exposing it to PPD.
The results were promising, showing that about 75% of the participants experienced reduced allergic reactions compared to untreated skin. This suggests that adding vitamin C to the skin before hair dyeing could effectively help manage allergic contact dermatitis.
References
Lukose SJ, Divya MP, Beena AK, Rajakumar SN, Babu PS. Reduced allergenicity of hydrolysed whey protein concentrate complexed with iron: the effect of different enzymes, degree of hydrolysis and ascorbic acid. J Food Sci Technol. 2025;62:940. doi:10.1007/s13197-024-06085-y
Miura K, Matsuno H, Iwaoka Y, Ito H, Tai A. Antiallergic Activity of 6-Deoxy-2--methyl-6-(-hexadecanoyl)amino-l-ascorbic Acid. Molecules. 2021;26. doi:10.3390/molecules26154684
Vollbracht C, Raithel M, Krick B, Kraft K, Hagel AF. Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study. J Int Med Res. 2018;46:3640. doi:10.1177/0300060518777044
Miura K, Morishita Y, Matsuno H, Aota Y, Ito H, et al. Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides. Molecules. 2017;22. doi:10.3390/molecules22122202
Mintsoulis D, Milman N, Fahim S. A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis. J Cutan Med Surg. 2016;20:592.
Basketter DA, White IR, Kullavanijaya P, Tresukosol P, Wichaidit M, et al. Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine. Contact Dermatitis. 2016;74:368. doi:10.1111/cod.12576
Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. doi:10.1038/s41598-025-91830-2