Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Polyunsaturated Fat
1 g
†
Protein
<1 g
Fish Oil Concentrate
2 g (2,000 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
720 mg
†
Docosahexaenoic Acid (DHA)
480 mg
†
Top Medical Research Studies
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
Most Useful Reviews
7.5
Beautifully effective replacement
5 people found this helpful
Super EPA. I began using this product years ago when Vioxx was withdrawn. After taking NSAIDs for eight years, I developed a hiatal hernia due to the medication. I have chronic osteoarthritis and have been treated by a chiropractor for 8-10 years. They recommended this as a replacement for Aleve, and it works beautifully. Typically, I take five in the morning, and on really painful days, I take another five at bedtime. I will never resort to pain prescriptions or NSAIDs again, as I trust NOW FOODS for quality products.
Read More
7.5
Positive for arthritis
2 people found this helpful
Works well for human and canine family members. We used to buy the cheapest fish oil available, but our dog developed an autoimmune disorder affecting his toenails (SLO). Our vet recommended a high EPA to DHA ratio, so we switched to this product, which helped the dog towards remission. A family member with borderline rheumatoid arthritis also switched to this and felt clear improvement in symptoms. Just our experience, but very positive! Delivery was also quick.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
8
We investigated the effectiveness of a smart cage system for measuring locomotor activity in mice with inflammatory arthritis. The study induced arthritis and tracked changes over time, focusing on mice fed diets with or without fish oil.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Beautifully effective replacement
5 people found this helpful
Super EPA. I began using this product years ago when Vioxx was withdrawn. After taking NSAIDs for eight years, I developed a hiatal hernia due to the medication. I have chronic osteoarthritis and have been treated by a chiropractor for 8-10 years. They recommended this as a replacement for Aleve, and it works beautifully. Typically, I take five in the morning, and on really painful days, I take another five at bedtime. I will never resort to pain prescriptions or NSAIDs again, as I trust NOW FOODS for quality products.
Read More
7.5
Positive for arthritis
2 people found this helpful
Works well for human and canine family members. We used to buy the cheapest fish oil available, but our dog developed an autoimmune disorder affecting his toenails (SLO). Our vet recommended a high EPA to DHA ratio, so we switched to this product, which helped the dog towards remission. A family member with borderline rheumatoid arthritis also switched to this and felt clear improvement in symptoms. Just our experience, but very positive! Delivery was also quick.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Marushack GK, Savadipour A, Tang R, Garcia-Castorena JM, Rashidi N, et al. Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes. FASEB J. 2025;39:e70290. doi:10.1096/fj.202400544RR
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. doi:10.1017/S0007114524002721
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0
- Scherer D, Leite BF, Morimoto MA, Oliveira TL, Klemz BNC, et al. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. Adv Rheumatol. 2024;64:47. doi:10.1186/s42358-024-00389-5
- Liu Y, Song F, Liu M, Huang X, Xue S, et al. Association between omega-3 polyunsaturated fatty acids and osteoarthritis: results from the NHANES 2003-2016 and Mendelian randomization study. Lipids Health Dis. 2024;23:147. doi:10.1186/s12944-024-02139-4
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. doi:10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. doi:10.1007/s00394-024-03397-9
- Doucet MR, Laevski AM, Doiron JA, Boudreau LH, Surette ME. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLoS One. 2024;19:e0291399. doi:10.1371/journal.pone.0291399
- Xiong T, Huang S, Wang X, Shi Y, He J, et al. n-3 polyunsaturated fatty acids alleviate the progression of obesity-related osteoarthritis and protect cartilage through inhibiting the HMGB1-RAGE/TLR4 signaling pathway. Int Immunopharmacol. 2024;128:111498. doi:10.1016/j.intimp.2024.111498
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. doi:10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. doi:10.1016/j.biopha.2022.113608
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. doi:10.3390/nu14142947
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
