Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
†
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
†
Top Medical Research Studies
8
We delved into the benefits of docosahexaenoic acid (DHA) in relation to blood clotting, especially in the context of cardiovascular health and COVID-19. DHA, a form of omega-3 fatty acid, shows promise in influencing how our body's clotting mechanism works. By integrating into cell membranes, DHA helps reduce inflammation and support overall epithelial function.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Read More
8
We sought to understand how docosahexaenoic acid (DHA), an omega-3 fatty acid, influences blood clotting and platelet activity. To do this, we examined DHA and its oxidized forms, known as oxylipins (11-HDHA and 14-HDHA), to see how they affected platelet function and the formation of blood clots.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
Read More
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences the risk of blood clots associated with different types of ischemic strokes. The study analyzed data from three large US cohorts, allowing us to assess the relationship between DHA levels and the occurrence of total ischemic strokes, as well as their subtypes—atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Read More
Most Useful Reviews
6
Improved concentration
1 people found this helpful
I feel as though my brain is receiving better blood flow. There's a sense that my concentration lasts longer, but taking it in the afternoon can make it challenging to fall asleep. Occasionally, I experience burps with a fishy smell.
Read More
7.5
Anti-inflammatory properties
I generally take this alongside the ultra to cover my preferred amounts of DHA and EPA. It is effective for medical issues like thinning blood, serves as an anti-inflammatory agent, and also nourishes the brain. I recommend it.
Read More
7.5
Mood enhancement
These Omega-3 vitamins are excellent—reducing the negative effects of stress on the nervous system, improving mood, acting as an antidepressant, and enhancing concentration and memory. They help normalise blood pressure and decrease the chances of developing cardiovascular diseases. The quality from this manufacturer is top-notch!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
8
We delved into the benefits of docosahexaenoic acid (DHA) in relation to blood clotting, especially in the context of cardiovascular health and COVID-19. DHA, a form of omega-3 fatty acid, shows promise in influencing how our body's clotting mechanism works. By integrating into cell membranes, DHA helps reduce inflammation and support overall epithelial function.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Read More
8
We sought to understand how docosahexaenoic acid (DHA), an omega-3 fatty acid, influences blood clotting and platelet activity. To do this, we examined DHA and its oxidized forms, known as oxylipins (11-HDHA and 14-HDHA), to see how they affected platelet function and the formation of blood clots.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
Read More
8
In our evaluation of fish oil supplementation, which includes docosahexaenoic acid (DHA), we sought to understand its impact on blood clotting and perioperative bleeding in patients undergoing surgery. The study involved 1,516 patients who were randomly assigned to receive either fish oil or a placebo before and after their operations.
The main finding revealed that fish oil did not significantly increase the risk of major bleeding compared to the placebo group. In fact, the risk of bleeding, as defined by the Bleeding Academic Research Consortium, was not worse among those taking fish oil. Interestingly, we also observed that participants who had higher levels of DHA showed a substantially lower risk of bleeding.
Additionally, the total amount of blood transfusions needed was lower for the fish oil group. These results suggest that DHA, an essential component of fish oil, may be beneficial in managing bleeding risks during surgery. However, the exact isolated effects of DHA alone on blood clotting require further research since this study evaluated it as part of a mix with eicosapentaenoic acid.
Overall, the findings question the common practice of halting fish oil supplements prior to surgery, showing that they might actually support better outcomes in surgical settings.
The main finding revealed that fish oil did not significantly increase the risk of major bleeding compared to the placebo group. In fact, the risk of bleeding, as defined by the Bleeding Academic Research Consortium, was not worse among those taking fish oil. Interestingly, we also observed that participants who had higher levels of DHA showed a substantially lower risk of bleeding.
Additionally, the total amount of blood transfusions needed was lower for the fish oil group. These results suggest that DHA, an essential component of fish oil, may be beneficial in managing bleeding risks during surgery. However, the exact isolated effects of DHA alone on blood clotting require further research since this study evaluated it as part of a mix with eicosapentaenoic acid.
Overall, the findings question the common practice of halting fish oil supplements prior to surgery, showing that they might actually support better outcomes in surgical settings.
Read More
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences the risk of blood clots associated with different types of ischemic strokes. The study analyzed data from three large US cohorts, allowing us to assess the relationship between DHA levels and the occurrence of total ischemic strokes, as well as their subtypes—atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Read More
8
We explored how docosahexaenoic acid (DHA), specifically in the form of Lovaza, affects blood clot remodeling in patients with coronary artery disease (CAD). In this study, six individuals with stable CAD were split into two groups: one received daily doses of Lovaza for a year, while the other did not.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
6
Improved concentration
1 people found this helpful
I feel as though my brain is receiving better blood flow. There's a sense that my concentration lasts longer, but taking it in the afternoon can make it challenging to fall asleep. Occasionally, I experience burps with a fishy smell.
Read More
7.5
Anti-inflammatory properties
I generally take this alongside the ultra to cover my preferred amounts of DHA and EPA. It is effective for medical issues like thinning blood, serves as an anti-inflammatory agent, and also nourishes the brain. I recommend it.
Read More
7.5
Mood enhancement
These Omega-3 vitamins are excellent—reducing the negative effects of stress on the nervous system, improving mood, acting as an antidepressant, and enhancing concentration and memory. They help normalise blood pressure and decrease the chances of developing cardiovascular diseases. The quality from this manufacturer is top-notch!
Read More
Frequently Asked Questions
6
Improved concentration
1 people found this helpful
I feel as though my brain is receiving better blood flow. There's a sense that my concentration lasts longer, but taking it in the afternoon can make it challenging to fall asleep. Occasionally, I experience burps with a fishy smell.
7.5
Mood enhancement
These Omega-3 vitamins are excellent—reducing the negative effects of stress on the nervous system, improving mood, acting as an antidepressant, and enhancing concentration and memory. They help normalise blood pressure and decrease the chances of developing cardiovascular diseases. The quality from this manufacturer is top-notch!
7.5
Anti-inflammatory properties
I generally take this alongside the ultra to cover my preferred amounts of DHA and EPA. It is effective for medical issues like thinning blood, serves as an anti-inflammatory agent, and also nourishes the brain. I recommend it.
7
We set out to explore how docosahexaenoic acid, commonly known as DHA, influences blood clotting in patients with atrial fibrillation. In a detailed analysis of 2,373 individuals, we examined the relationship between total omega-3 fatty acids and specific clotting markers, D-dimer, and beta-thromboglobulin (BTG).
Our findings revealed that higher overall levels of omega-3 fatty acids were associated with lower levels of D-dimer and BTG, indicating a potential antithrombotic effect. Notably, individual omega-3s, including DHA, showed an inverse relationship with D-dimer levels, suggesting that as DHA increases, the likelihood of clot formation may decrease.
However, when it came to BTG, while DHA was linked to lower levels, the results also showed that EPA, another omega-3, had a positive correlation with BTG. This finding indicates that while DHA might play a beneficial role, the overall effects of omega-3 fatty acids on platelet activation could be complex.
In summary, the study suggests that higher levels of DHA could contribute to lower blood clotting markers, which is promising news for managing atrial fibrillation, but it also highlights the need for further investigation into the nuanced roles of different omega-3 fatty acids in blood clotting dynamics.
Our findings revealed that higher overall levels of omega-3 fatty acids were associated with lower levels of D-dimer and BTG, indicating a potential antithrombotic effect. Notably, individual omega-3s, including DHA, showed an inverse relationship with D-dimer levels, suggesting that as DHA increases, the likelihood of clot formation may decrease.
However, when it came to BTG, while DHA was linked to lower levels, the results also showed that EPA, another omega-3, had a positive correlation with BTG. This finding indicates that while DHA might play a beneficial role, the overall effects of omega-3 fatty acids on platelet activation could be complex.
In summary, the study suggests that higher levels of DHA could contribute to lower blood clotting markers, which is promising news for managing atrial fibrillation, but it also highlights the need for further investigation into the nuanced roles of different omega-3 fatty acids in blood clotting dynamics.
8
We delved into the benefits of docosahexaenoic acid (DHA) in relation to blood clotting, especially in the context of cardiovascular health and COVID-19. DHA, a form of omega-3 fatty acid, shows promise in influencing how our body's clotting mechanism works. By integrating into cell membranes, DHA helps reduce inflammation and support overall epithelial function.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
7
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on blood clotting and thrombus formation in our study. Instead of relying merely on simple lab tests, we aimed for a more realistic approach using human platelets exposed to DHA and stimulated with various agents that mimic the conditions found in growing blood clots.
Our results showed that while DHA did not significantly change many basic functions of platelets in conventional tests, it did have a notable impact on thrombin generation—a key factor in blood clotting. Specifically, DHA delayed the production of thrombin in both human samples and mouse models, which are critical for forming stable blood clots.
Furthermore, in mice fed a DHA-enriched diet, we observed reduced platelet accumulation in thrombi formed in both small arterioles and larger arteries. This contrasted with unchanged levels of P-selectin, which indicates platelet activation. These findings suggest that although DHA may not dramatically alter standard platelet activities, it has the potential to enhance heart health by reducing thrombin generation and diminishing the formation of blood clots in the body.
Overall, the study reinforces the idea that incorporating omega-3 fatty acids like DHA into our diet could offer cardioprotective benefits, particularly in managing blood clotting processes.
Our results showed that while DHA did not significantly change many basic functions of platelets in conventional tests, it did have a notable impact on thrombin generation—a key factor in blood clotting. Specifically, DHA delayed the production of thrombin in both human samples and mouse models, which are critical for forming stable blood clots.
Furthermore, in mice fed a DHA-enriched diet, we observed reduced platelet accumulation in thrombi formed in both small arterioles and larger arteries. This contrasted with unchanged levels of P-selectin, which indicates platelet activation. These findings suggest that although DHA may not dramatically alter standard platelet activities, it has the potential to enhance heart health by reducing thrombin generation and diminishing the formation of blood clots in the body.
Overall, the study reinforces the idea that incorporating omega-3 fatty acids like DHA into our diet could offer cardioprotective benefits, particularly in managing blood clotting processes.
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences the risk of blood clots associated with different types of ischemic strokes. The study analyzed data from three large US cohorts, allowing us to assess the relationship between DHA levels and the occurrence of total ischemic strokes, as well as their subtypes—atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
7
We delved into how docosahexaenoic acid (DHA), a popular omega-3 fatty acid, influences blood clotting. The study focused on specific compounds known as oxylipins—7S,14S-diHDHA and resolvin D5 (RvD5)—that originate from DHA and are believed to aid in resolving inflammation and regulating blood clots.
Through our experiments, we discovered that both 7S,14S-diHDHA and RvD5 possess notable properties that can help prevent platelet aggregation, which is essential in the context of blood clotting. Interestingly, we learned that these compounds are produced through intricate processes involving lipoxygenase enzymes. Notably, one of these enzymes, 15-LOX-2, was found to convert DHA into RvD5 more efficiently than its counterpart, 15-LOX-1.
While our findings highlight the potential of 7S,14S-diHDHA and RvD5 in managing clot-related issues, they also indicate that the basal effects of DHA were not directly isolated in this study. Instead, the focus was primarily on the roles of these oxylipins, which may provide insight into how DHA could contribute to clot resolution in broader terms. Overall, our research suggests a fascinating relationship between DHA and blood clot regulation via these specialized mediators.
Through our experiments, we discovered that both 7S,14S-diHDHA and RvD5 possess notable properties that can help prevent platelet aggregation, which is essential in the context of blood clotting. Interestingly, we learned that these compounds are produced through intricate processes involving lipoxygenase enzymes. Notably, one of these enzymes, 15-LOX-2, was found to convert DHA into RvD5 more efficiently than its counterpart, 15-LOX-1.
While our findings highlight the potential of 7S,14S-diHDHA and RvD5 in managing clot-related issues, they also indicate that the basal effects of DHA were not directly isolated in this study. Instead, the focus was primarily on the roles of these oxylipins, which may provide insight into how DHA could contribute to clot resolution in broader terms. Overall, our research suggests a fascinating relationship between DHA and blood clot regulation via these specialized mediators.
8
We explored how docosahexaenoic acid (DHA), specifically in the form of Lovaza, affects blood clot remodeling in patients with coronary artery disease (CAD). In this study, six individuals with stable CAD were split into two groups: one received daily doses of Lovaza for a year, while the other did not.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
References
- Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. 10.3390/nu16020178
- Lu LW, Quek SY, Lu SP, Chen JH. Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023. Metabolites. 2023;13. 10.3390/metabo13050630
- Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, et al. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. J Thromb Haemost. 2021;19:839. 10.1111/jth.15184
- Takagaki S, Suzuki M, Suzuki E, Hasumi K. Unsaturated fatty acids enhance the fibrinolytic activity of subtilisin NAT (nattokinase). J Food Biochem. 2020;44:e13326. 10.1111/jfbc.13326
- Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, et al. 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. J Lipid Res. 2020;61:1087. 10.1194/jlr.RA120000777
- Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, et al. Fish Oil and Perioperative Bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584. 10.1161/CIRCOUTCOMES.118.004584
- Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, et al. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2019;30:271. 10.1080/09537104.2017.1420154
- Saber H, Yakoob MY, Shi P, Longstreth WT, Lemaitre RN, et al. Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts. Stroke. 2017;48:2678. 10.1161/STROKEAHA.117.018235
- Unsworth AJ, Flora GD, Sasikumar P, Bye AP, Sage T, et al. RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arterioscler Thromb Vasc Biol. 2017;37:812. 10.1161/ATVBAHA.117.309207
- Elajami TK, Colas RA, Dalli J, Chiang N, Serhan CN, et al. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 2016;30:2792. 10.1096/fj.201500155R
