Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Calcium (elemental)(from 2,273 mg MCHA)**
500 mg
38%
Phosphorus (elemental)(from 2,273 mg MCHA)**
200 mg
16%
The product is found useful for the following medical conditions
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 88 Reviews
8.8
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
Most Relevant Research
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
9.5
Reduced sensitivity
Most Useful Review
I’ve taken calcium supplements regularly as I avoid dairy. Though I consume green veggies and nuts, I still notice enamel sensitivity. Hydroxyapatite works just as well to strengthen my teeth and reduce sensitivity, which has improved as I’ve noted new enamel growth on defects. It’s crucial to monitor vitamin D levels for calcium absorption. Avoid breathing through your mouth, particularly at night, for better dental health.
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 17 Reviews
8.8
5
Calcium's role in kidney stones
Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
Most Relevant Research
We explored the connections between calcium levels and kidney stones using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2013 to 2018, along with more advanced genetic analyses. Our aim was to understand how the levels of 25-hydroxyvitamin D, calcium, and alkaline phosphatase (ALP) might influence the risk of developing kidney stones.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
9.5
No new stones formed
Most Useful Review
This is the best calcium form! As I have urolithiasis, my urologist advised that calcium should only be taken in this form. It’s the mildest and is absorbed quickly without leading to new stones. This calcium has been a lifesaver. I just wish it wasn’t so often out of stock.
Cancer details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.7
7
Calcium treatment impacts cancer viability
Investigation of the Bystander Effect on Cell Viability After Application of Combined Electroporation-Based Methods.
Most Relevant Research
We investigated how calcium treatment, in conjunction with various electroporation methods, affects cancer cell viability. In our study, we used 4T1 breast cancer cells and applied different forms of electroporation, such as reversible and irreversible treatments along with calcium electroporation. We were particularly interested in the bystander effect, where treated cells might affect untreated nearby cells.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
9.5
Significant improvement
Most Useful Review
I ordered this calcium for my sister when she had cancer, based on a doctor's recommendation. To be honest, it helped her immensely, and it works best when taken alongside omega 3.
Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.7
9.5
Quick results for cold
Most Useful Review
This calcium has been a game-changer for my sensitive tooth enamel. For years, I found that various toothpastes had no effect. Following local reviews, I chose this specific product, and I'm delighted with the outcome; it lessened my reaction to cold, hot, and sour foods by the third day! I've stocked up on it and feel incredibly satisfied. I've also noticed improvements in my restless legs syndrome after taking two capsules daily.
Food Poisoning details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Calcium's importance in spore germination
Divalent Cation Signaling in Spore Germination.
Most Relevant Research
We explored how calcium affects spore germination, which is crucial in the context of food poisoning. The research aimed to understand if calcium, particularly in a complex with dipicolinic acid (Ca-DPA), could initiate spore germination, as previous studies suggested it played a vital role.
Through our experiments, we observed that while Ca-DPA effectively stimulated spore germination, dipicolinic acid alone did not produce the same effect. This indicates that calcium is essential for promoting germination. Moreover, we found that not only calcium salts but also other divalent cations like manganese and magnesium contributed to this process, while zinc did not.
Interestingly, the study revealed that endogenous calcium and magnesium stored within spores were not critical for germination induction. Instead, it was the external calcium and manganese that proved necessary. Overall, our findings suggest that exogenous sources of divalent cations are more significant in triggering spore germination than the spores' internal reserves.
Through our experiments, we observed that while Ca-DPA effectively stimulated spore germination, dipicolinic acid alone did not produce the same effect. This indicates that calcium is essential for promoting germination. Moreover, we found that not only calcium salts but also other divalent cations like manganese and magnesium contributed to this process, while zinc did not.
Interestingly, the study revealed that endogenous calcium and magnesium stored within spores were not critical for germination induction. Instead, it was the external calcium and manganese that proved necessary. Overall, our findings suggest that exogenous sources of divalent cations are more significant in triggering spore germination than the spores' internal reserves.
9.5
Halting tooth decay
Most Useful Review
I often drink this calcium as it has a significant impact when my teeth crumbled. Its absorption is enhanced when combined with trace elements. The results were visible quickly; since I started, crumbling has ceased and caries no longer developed. Overall health plays a vital role—healthy nutrition maximises the benefits and prevents issues.
Allergies details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
8.8
Health improvement
Most Useful Review
I'm ordering for my mother, who is 65 and undergoing treatment for osteoporosis. She takes it with vitamins D and B group. After starting this calcium, her joints no longer hurt, and she experienced no allergies or stomach discomfort. She's feeling better, and even her nails are growing faster and stronger.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
Calcium's limited impact on hypertension
Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.
Most Relevant Research
We sought to understand how calcium affects hypertension and cardiovascular disease risk. Through a thorough review of existing literature, we evaluated data from a significant number of studies, focusing on the effects of calcium, magnesium, and vitamin D supplements on blood pressure levels and pulse rates.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
Our analysis revealed that while calcium supplementation was linked to a noteworthy drop in diastolic blood pressure (the bottom number in blood pressure readings), it did not show a significant impact on systolic blood pressure (the top number) or pulse rate. This indicates that calcium could play a role in managing the lower blood pressure readings but may not be entirely effective on its own regarding overall blood pressure control.
Additionally, we identified that magnesium also contributed positively by reducing diastolic blood pressure, whereas vitamin D exhibited a broader beneficial effect by lowering both systolic and diastolic blood pressure. Despite these encouraging results for magnesium and vitamin D, calcium’s isolated effectiveness in addressing hypertension remains limited.
Overall, while calcium may help with certain aspects of blood pressure management, its role in controlling hypertension is not as clear-cut as we might hope.
9
Bone health improved
Most Useful Review
Calcium hydroxyapatite is an exceptional tool for maintaining healthy bones and teeth. It's easy to take and a crucial part of my health regimen. I've noticed a marked improvement in my bone health and strength, allowing me to lead an active lifestyle free from the worry of injury. I appreciate its benefits and recommend it for anyone aiming to maintain excellent bone health.
Chest Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 4 Researches
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Calcium treatment effective for angina
Case Report: Vasospastic angina presenting as phantom odor perception.
Most Relevant Research
We looked at the case of a 69-year-old woman experiencing intermittent shortness of breath and chest pain. Interestingly, she also described a peculiar symptom—a phantom odor sensation that preceded her episodes. During an exercise stress echocardiography, she demonstrated abnormal smell perception alongside transient changes in her heart's electrical activity, which indicated possible cardiac issues.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
8.8
Knee pain improvement
Most Useful Review
The best form of calcium! It greatly helps with my knee pain; I take it myself and highly recommend it to others.
Cold Sores details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
Calcium spirulan may help cold sores
Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis.
Most Relevant Research
We investigated the potential of calcium spirulan, a compound derived from the microalga Spirulina platensis, to help prevent cold sores caused by the herpes simplex virus type 1 (HSV-1). In a thorough study, we assessed the effectiveness of this sulfated polysaccharide both in laboratory tests and through a practical trial involving people with recurring herpes labialis, also known as cold sores.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
Our approach included examining how calcium spirulan affected the virus’s ability to attach to human skin cells. Using various experiments such as plaque reduction assays and analyzing viral proteins, we confirmed that calcium spirulan had significant inhibitory effects on HSV-1. In the practical trial, we compared the effects of topical calcium spirulan treatment against other commonly used antiviral medications among 198 participants, all of whom dealt with repeat cold sore outbreaks.
The results suggest that calcium spirulan could be a valuable option for topical treatment, offering new hope for those who suffer from cold sores. Additionally, our findings indicate that calcium spirulan may also show effectiveness against other herpesviruses. This points to the broader clinical implications of using natural compounds like calcium spirulan in managing viral infections.
9.5
Sensitive enamel restored
Most Useful Review
Proven effective! I took this product to reduce the sensitivity of my enamel, and within a month everything returned to normal; I can now safely eat hot or cold food. There was no need for fluoridation of my teeth. Overall, I highly recommend it.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 8 Reviews
8.6
9
Calcium dobesilate reduces leg cramps
Calcium dobesilate for chronic venous insufficiency: a systematic review.
Most Relevant Research
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
9.5
Cramps eliminated
Most Useful Review
I really liked this calcium. I brought it for my nephew, who often suffers from leg cramps. After he started taking it, all the unpleasant sensations disappeared.
Liver Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Bone health enhanced
Most Useful Review
This product is effective in preventing osteoporosis, especially for those over 50, as bones become more fragile due to insufficient calcium. Its formula not only includes calcium but also phosphorus, which aids in calcium absorption—a highly effective combination. Taken prophylactically, this essential mineral can help avert this dreadful disease. Its easily absorbed form is a great advantage.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved skin condition
Most Useful Review
Positive result, but not where I expected! I have very sensitive tooth enamel, which necessitates the use of sensitive toothpaste. I’d heard about hydroxyapatite calcium and even took it during pregnancy; the pharmacy option is rather expensive. Eventually, I decided to trial this dietary supplement. The parcel arrived promptly and in good condition, which was pleasing. My husband and I took one capsule a day until the jar was empty. There were no side effects, and unfortunately, my tooth sensitivity remained unchanged. However, I noticed that the rashes on my face disappeared completely! My skin improved remarkably! This result was unexpected, as I had taken it primarily to strengthen my enamel.
Toothache details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Calcium treatment shows comparable results
Eighteen-month clinical and radiographic evaluation of two root canal-filling materials in primary teeth with pulp necrosis secondary to trauma.
Most Relevant Research
We compared two root canal-filling materials used in treating primary teeth with pulp necrosis caused by trauma. Our main focus was on the effectiveness of a calcium hydroxide-based paste versus traditional zinc oxide and eugenol cement, specifically looking at clinical and radiographic outcomes after 18 months.
In our study involving 26 children, we found that both materials demonstrated similar success rates. Clinical success included factors like the absence of pain and tooth mobility, while radiographic success was determined by the healing of tooth roots. Our results indicated that both calcium treatment and zinc oxide function well for the root canal filling in children suffering from pulp necrosis, making them suitable options.
Overall, our findings suggest that whether we use calcium hydroxide or zinc oxide, parents and dentists can expect effective outcomes when treating dental trauma in young children. Thus, both materials are viable choices for addressing toothache related to pulp issues in primary teeth.
In our study involving 26 children, we found that both materials demonstrated similar success rates. Clinical success included factors like the absence of pain and tooth mobility, while radiographic success was determined by the healing of tooth roots. Our results indicated that both calcium treatment and zinc oxide function well for the root canal filling in children suffering from pulp necrosis, making them suitable options.
Overall, our findings suggest that whether we use calcium hydroxide or zinc oxide, parents and dentists can expect effective outcomes when treating dental trauma in young children. Thus, both materials are viable choices for addressing toothache related to pulp issues in primary teeth.
8.8
Eased discomfort
Most Useful Review
I selected this calcium based on advice that it was more beneficial for teeth. I’ve ordered it twice now and have noticed improvement. The toothache has lessened significantly; I do still need to visit the dentist, but the spasms are gone. I'll have my calcium levels tested later.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Calcium type affects clot risk
Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?
Most Relevant Research
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
9.5
Stable blood counts
Most Useful Review
It works perfectly! I've trusted this brand for three years. I received it as guided by a reproductive specialist. For three years, I have been consistently using it. It absorbs well and maintains stable blood counts.
Autoimmune Disorder details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 11 Reviews
8.4
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Most Relevant Research
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
9.5
Nails strengthened
Most Useful Review
I recommend this supplement. My nails have grown stronger, but the improvement came gradually. After finishing the course in December, my nails were still peeling, but by March, they improved significantly. This supplement raises calcium levels, and my test results pleased my doctor. I intend to continue using it.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Calcium injection aids knee function
Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee.
Most Relevant Research
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
9.5
Positive family effects
Most Useful Review
High-quality calcium! I have tried various brands, but this one is my favourite! My joints crunch and ache much less now. I purchased this calcium for my mother, who had a knee injury, and her knee pain has diminished significantly, as well as the crunching. She also noted improvements in her tooth enamel! I'm pleased that this calcium is economical, and I will definitely buy more!
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
Calcium maltobionate supports bone health
Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Most Relevant Research
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
8
Reduced tooth sensitivity
Most Useful Review
Following menopause, I had a DEXA scan which revealed low bone density, prompting me to take calcium. Initially, I used calcium citrate but observed no significant changes. Upon switching to this calcium, my tooth sensitivity disappeared in days, which was surprising as it had worsened over the previous year. Moreover, I have not experienced palpitations recently, likely thanks to the calcium. I take a magnesium tablet daily and hope for positive effects on my bones, alongside my exercises.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
Calcium aids heartburn relief
Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus.
Most Relevant Research
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
9.5
No heartburn reported
Most Useful Review
Being a pregnant woman over 35, I must be cautious. My obstetrician-gynecologist advised supplements to maintain my health and that of my baby. This calcium form is well absorbed, benefiting my bones, teeth, and nails. I was advised to monitor for heartburn while taking calcium, but thankfully, I’ve experienced none.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8.3
9.5
Supports healthy sleep
Most Useful Review
This supplement has helped maintain healthy sleep patterns and lowered the risk of sleep-related health issues like insomnia and sleep apnea. It's especially beneficial for individuals who experience sleep difficulties or wish to keep their sleep patterns healthy through dietary supplements.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
7
Calcium reduces constipation risk
Association between dietary calcium intake and constipation in a metabolic syndrome population: evidence from NHANES 2005-2010.
Most Relevant Research
We explored how calcium intake relates to constipation, particularly focusing on individuals with metabolic syndrome, a condition that significantly impacts health. Using data from the National Health and Nutrition Examination Survey conducted between 2005 and 2010, we assessed the dietary habits of participants and looked at how often they experienced constipation.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
7
Calcium carbonate warning
Most Useful Review
This type of calcium boasts the best absorption rate. I wouldn't recommend calcium carbonate as a necessity for my family, as prolonged use may lead to constipation.
Nausea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
9.5
No nausea
Most Useful Review
I purchased this for my mother-in-law after hearing about a friend who found this medication very beneficial! It’s easy to consume and does not cause nausea.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Most Relevant Research
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
8.8
Effective prevention
Most Useful Review
The doctor prescribed this to prevent osteoporosis. It’s a good product that helps me. I recommend it.
