' 
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.1
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium protects against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
High relevance to gout management
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
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9
Magnesium alters arthritis-related gene expression
Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Focus on magnesium's effect
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
High relevance to arthritis treatment
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
Most Useful Reviews
9.5
Significant pain relief
Very effective calcium! I've previously tried pharmaceutical calcium products, but this one truly surprised me. I took it with vitamin D3 for my knee and hip joint issues stemming from a meniscus operation. After consuming half a jar, I experienced incredible relief. I used to hobble, but now I can run slowly every day. The frequent pain has vanished, and I’m delighted. Despite scepticism towards reviews like this, I’m now sharing my own. I’ve forgotten about my arthritis and took this for myself as well.
Read More
9.5
Improved well-being
I would recommend this to anyone with any arthritis issue. As a woman, we know calcium is beneficial, but if you have other bone issues, this made me feel significantly better after taking it every day for two weeks.
Read More
8.8
Improved sleep quality
Wonderful calcium! I started taking it regularly six months ago on my physician's and homeopath's advice, mainly for my rheumatoid arthritis. I've tried various calcium forms, but this is the only one without side effects that my body absorbs well. My nails no longer separate, a problem I struggled with for a decade, and I have no stomach issues. I've noticed I'm calmer and sleep better, which is remarkable given my long-term insomnia. My husband and son have also ordered it. I believe this calcium should be taken daily, and now it's a staple in my shopping.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.1
9
Calcium enhances arthritis therapy
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Importance of calcium in treatment.
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
Read More
9
Magnesium alters arthritis-related gene expression
Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Focus on magnesium's effect
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Read More
9
Magnesium potentially alleviates OA
Engineered MgO nanoparticles for cartilage-bone synergistic therapy.
Moderate relevance to magnesium therapy.
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
Magnesium chloride alleviates arthritis
Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
High relevance to arthritis treatment
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
Read More
9
Magnesium reduces arthritis severity
Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome.
Highly relevant arthritis treatment insights
We investigated how a high magnesium diet affects arthritis, focusing on its impact on inflammation and T cell development in two mouse models of rheumatoid arthritis. Our findings revealed that the mice receiving a diet rich in magnesium experienced less severe arthritis and reduced joint damage.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
9.5
Significant pain relief
Very effective calcium! I've previously tried pharmaceutical calcium products, but this one truly surprised me. I took it with vitamin D3 for my knee and hip joint issues stemming from a meniscus operation. After consuming half a jar, I experienced incredible relief. I used to hobble, but now I can run slowly every day. The frequent pain has vanished, and I’m delighted. Despite scepticism towards reviews like this, I’m now sharing my own. I’ve forgotten about my arthritis and took this for myself as well.
Read More
9.5
Joint pain alleviation
This miracle product has saved me from joint pain. I take it in the evening, two tablets after dinner. It has assisted with my arthritis and also improved my sleep; I definitely recommend it.
9.5
Less stiffness
I bought these exact pills and ran out for about a month. There is a noticeable difference between when I take them and when I don't. I get super stiff and achy, particularly in my feet, possibly due to early onset arthritis. When I resumed taking these, the aches vanished. If you are an adult who can take pills easily and often experience stiffness, these might be the miracle cure you need!
Read More
9.5
Improved well-being
I would recommend this to anyone with any arthritis issue. As a woman, we know calcium is beneficial, but if you have other bone issues, this made me feel significantly better after taking it every day for two weeks.
8.8
Improved sleep quality
Wonderful calcium! I started taking it regularly six months ago on my physician's and homeopath's advice, mainly for my rheumatoid arthritis. I've tried various calcium forms, but this is the only one without side effects that my body absorbs well. My nails no longer separate, a problem I struggled with for a decade, and I have no stomach issues. I've noticed I'm calmer and sleep better, which is remarkable given my long-term insomnia. My husband and son have also ordered it. I believe this calcium should be taken daily, and now it's a staple in my shopping.
Read More
