Last update
10/9/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Questionable
Based on 121 Reviews
5.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
Most Useful Reviews
9
Strengthened nails
94 people found this helpful
NowFoods provides excellent quality calcium and magnesium. This supplement noticeably improved my nails, making them stronger and shinier. I also experienced less tooth sensitivity thanks to magnesium's calming effects. Overall, I highly recommend this supplement for strengthening nails, teeth, and providing nervous system stability.
Read More
9
Improved teeth sensitivity
33 people found this helpful
Magnesium has significantly reduced my teeth sensitivity and improved my bone health. My nails grew stronger, and my skin looked fresher during the one-month course I completed regularly. I was pleased with the results, which lasted for months.
Read More
9
Pain relief achieved
14 people found this helpful
This calcium is remarkable! Previously, I had issues with my knee and hip joints for five years after surgery. After consuming half a jar of this calcium, I experienced significant relief. I had been limping but can now walk and even run. The pain that used to occur weekly has vanished. I'm thrilled to have forgotten about my arthritis!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Questionable
Based on 121 Reviews
5.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strengthened nails
94 people found this helpful
NowFoods provides excellent quality calcium and magnesium. This supplement noticeably improved my nails, making them stronger and shinier. I also experienced less tooth sensitivity thanks to magnesium's calming effects. Overall, I highly recommend this supplement for strengthening nails, teeth, and providing nervous system stability.
Read More
9
Improved teeth sensitivity
33 people found this helpful
Magnesium has significantly reduced my teeth sensitivity and improved my bone health. My nails grew stronger, and my skin looked fresher during the one-month course I completed regularly. I was pleased with the results, which lasted for months.
Read More
9
Pain relief achieved
14 people found this helpful
This calcium is remarkable! Previously, I had issues with my knee and hip joints for five years after surgery. After consuming half a jar of this calcium, I experienced significant relief. I had been limping but can now walk and even run. The pain that used to occur weekly has vanished. I'm thrilled to have forgotten about my arthritis!
Read More
9
Eliminated leg pain
12 people found this helpful
I started taking this during pregnancy after waking up at night with leg pain. Since then, I haven’t experienced any pain, and my muscles aren’t cramping. The capsules are large but easy to swallow. I noticed a positive effect on my teeth as well.
Read More
10
Stopped leg cramps
10 people found this helpful
This product is miraculous! I had sharp pains in my legs and cramps, but after starting it, everything disappeared within five days. Even my 70-year-old neighbour experienced similar relief after taking it.
Read More
Frequently Asked Questions
10
Stopped leg cramps
10 people found this helpful
This product is miraculous! I had sharp pains in my legs and cramps, but after starting it, everything disappeared within five days. Even my 70-year-old neighbour experienced similar relief after taking it.
9
Relieved knee stiffness
1 people found this helpful
My knees hurt suddenly. After discovering my calcium deficiency and starting these tablets nightly for two weeks, my bone pain has completely subsided.
9
Pain relief
4 people found this helpful
After initially struggling with bone pain, after two months of taking this supplement, I noticed significant improvements. It helped with back and muscle pain, and my nails also became stronger.
9
Strong body
5 people found this helpful
After three months of use, my blood test showed remarkable improvement in calcium levels. I now have stronger nails and hair, deeper sleep, and I can exercise without any bone pain.
9
Pain relief achieved
14 people found this helpful
This calcium is remarkable! Previously, I had issues with my knee and hip joints for five years after surgery. After consuming half a jar of this calcium, I experienced significant relief. I had been limping but can now walk and even run. The pain that used to occur weekly has vanished. I'm thrilled to have forgotten about my arthritis!
9
Eliminated leg pain
12 people found this helpful
I started taking this during pregnancy after waking up at night with leg pain. Since then, I haven’t experienced any pain, and my muscles aren’t cramping. The capsules are large but easy to swallow. I noticed a positive effect on my teeth as well.
9
Relieved menstrual discomfort
6 people found this helpful
I've used this magnesium three times, and it significantly reduces menstrual pain and helps me sleep well. Following advice, taking three tablets on the first day of menstruation works quickly, easing my discomfort in about 20 minutes; highly effective.
9
Reduced bone pain
2 people found this helpful
After a month of regularly taking calcium and magnesium, I've noticed significant improvements. My bone pain and joint discomfort during physical activities have lessened, particularly when lifting heavy items. Muscle spasms in my legs at night have also vanished, leading to more restful sleep. My mood has improved, and managing stress is easier. The pills are quite large, which makes swallowing them difficult.
9
Alleviates joint pain
1 people found this helpful
My husband and I have taken this supplement with collagen for a month. It has significantly relieved his bone pain from arthrosis and helped me post-childbirth.
9
Eases muscle tension
1 people found this helpful
I take magnesium with calcium for muscle tension relief. It unexpectedly alleviated my menstrual pain and has also benefited my bone pain.
9
No bone pain
1 people found this helpful
This supplement keeps my nervous system in order and supports my bones during breastfeeding. I've taken it for four months and noticed that cramps no longer trouble me, which I attribute to the calcium-magnesium content. Despite being at home with my child for nine months, I remain calm and content. I also believe it has helped me maintain my teeth and nails without any issues.
9
Pain relief for hands
6 people found this helpful
I purchased this for my mother, who experienced pain in her hands and feet. She reports it works very well; after one tablet a day, her bone pain is gone and she sleeps soundly. It's large but reasonably priced, making it a good buy.
9
Reduced joint pain
4 people found this helpful
I ordered this calcium and magnesium for a friend. I previously took it myself and noticed my bone pain was alleviated. I drink it in courses of 3-4 months in spring and autumn. By the end of the course, my joints no longer hurt, and my husband also stopped complaining about knee pain.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
References
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
