' 
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
7
Magnesium supplements lower heart failure risk
Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation.
Findings support further investigation
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
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9
Magnesium reduces mortality in HFpEF
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
High relevance to heart health
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
Magnesium levels and heart disease mortality
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
High relevance for cardiovascular research
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Read More
Most Useful Reviews
9.5
Heart symptoms vanish
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
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8.3
Better overall health
I recently bought these vitamins as they were frequently out of stock. Since starting them, my bone and muscle health have improved. Calcium and magnesium are vital for heart and nervous system health, and I feel more energetic. The capsules are easy to swallow and convenient. I recommend these vitamins for anyone aiming to maintain their health.
Read More
7
Muscle pain relief
This product is fantastic for elderly muscle pain, heart health, and those with insomnia. It helps me sleep better at night.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
- All Researches
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
Magnesium reduces mortality in HFpEF
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
High relevance to heart health
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
Calcium scoring aids heart disease prevention
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
Moderate relevance to calcium treatment
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
8
Magnesium levels and heart disease mortality
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
High relevance for cardiovascular research
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Read More
8
Magnesium intake impacts heart disease risk
Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study.
Moderate relevance for heart health.
We explored the link between magnesium intake and heart disease risk in young adults, using a comprehensive study of U.S. adults aged 20 to 34. This cross-sectional research analyzed data from the National Health and Nutrition Examination Survey, examining dietary habits and various cardiovascular factors.
Our findings suggest that higher magnesium intake is associated with a lower risk of future cardiovascular issues and non-HDL cholesterol problems. This suggests that including magnesium-rich foods in our diets could promote heart health early in life.
Our findings suggest that higher magnesium intake is associated with a lower risk of future cardiovascular issues and non-HDL cholesterol problems. This suggests that including magnesium-rich foods in our diets could promote heart health early in life.
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User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Heart symptoms vanish
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
Read More
8.3
Better overall health
I recently bought these vitamins as they were frequently out of stock. Since starting them, my bone and muscle health have improved. Calcium and magnesium are vital for heart and nervous system health, and I feel more energetic. The capsules are easy to swallow and convenient. I recommend these vitamins for anyone aiming to maintain their health.
Read More
7
Muscle pain relief
This product is fantastic for elderly muscle pain, heart health, and those with insomnia. It helps me sleep better at night.
9.5
Reduced heart symptoms
I take magnesium and calcium together, which effectively calmed my nervous system and improved my heart health. I suffer from epilepsy and surgical menopause, leading to mood swings and depression, but since taking these vitamins, my symptoms have alleviated. My hair and nails have improved as well. The dosage is good, and it's natural, which is hard to find for such a price.
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9.5
Support for menopause
This calcium supplement is excellent and particularly beneficial for my mother during menopause as it strengthens her bones and mitigates heart disease risks. She feels much better taking it alongside vitamin D, as advised by our endocrinologist. The convenient packaging makes it easy to recommend.
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