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Over a span of ten weeks, we administered different doses of vitamin K2 to rabbits fed a cholesterol-rich diet.
The findings were encouraging; the vitamin K2-treated rabbits had significantly lower cholesterol levels compared to a control group.
Additionally, it seems that vitamin K2 at moderate doses helped slow down the development of atherosclerosis without any adverse effects on blood coagulation.
After 6 and 12 weeks, we found that this combination didn't significantly lower total cholesterol, LDL cholesterol, or triglycerides. It also had no impact on various inflammatory biomarkers.
Our findings indicate that, at the doses used, the nutraceutical combination did not effectively change cholesterol or inflammatory markers.
However, we found that the relationship between the changes in PCSK9 and LDL cholesterol normalized in participants taking the supplement. This suggests that while cholesterol levels remained steady, the supplement might help improve how these two important factors relate to each other in the context of statin therapy.
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Over a span of ten weeks, we administered different doses of vitamin K2 to rabbits fed a cholesterol-rich diet.
The findings were encouraging; the vitamin K2-treated rabbits had significantly lower cholesterol levels compared to a control group.
Additionally, it seems that vitamin K2 at moderate doses helped slow down the development of atherosclerosis without any adverse effects on blood coagulation.
However, we found that the relationship between the changes in PCSK9 and LDL cholesterol normalized in participants taking the supplement. This suggests that while cholesterol levels remained steady, the supplement might help improve how these two important factors relate to each other in the context of statin therapy.
After 6 and 12 weeks, we found that this combination didn't significantly lower total cholesterol, LDL cholesterol, or triglycerides. It also had no impact on various inflammatory biomarkers.
Our findings indicate that, at the doses used, the nutraceutical combination did not effectively change cholesterol or inflammatory markers.
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Frequently Asked Questions
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Vitamin K is a fat-soluble vitamin crucial for various bodily functions, particularly in the clotting process of blood. It exists in two primary forms: K1 (phylloquinone), which is primarily found in leafy green vegetables like spinach and kale, and K2 (menaquinone), which is found in fermented foods and certain animal products. Vitamin K plays a significant role in the synthesis of proteins that regulate blood coagulation and is also essential for bone metabolism, assisting in the binding of calcium to bones and other tissues.
Deficiencies in vitamin K can lead to increased bleeding and bruising, and in severe cases, it may contribute to bone weakness. While most people can obtain adequate amounts of vitamin K through a balanced diet rich in vegetables and fermented foods, those with certain medical conditions or who are on specific medications may require monitoring and supplementation. Incorporating a variety of nutrient-dense foods into your diet is the best way to ensure you get enough vitamin K for optimal health.
Based on user reviews, individuals taking vitamin K2, particularly the MK7 form, often report noticeable health benefits within a relatively short timeframe. Many users noted improvements in cholesterol levels and overall cardiovascular health after a few weeks to a couple of months of consistent supplementation. For instance, one user experienced a significant drop in blood pressure after just two weeks of use (Read Review). Others emphasized the importance of taking K2 alongside vitamin D3 for optimal effects, suggesting that users may start to see benefits sooner when both are combined.
While specific timelines for cholesterol improvement can vary, a review indicated that the benefits are often realized between one to four months of regular intake (Read Review). Users have mentioned feeling rejuvenated and experiencing lower cholesterol levels, underscoring that patience and consistency are key factors in reaping the full benefits of this supplement (Read Review). Regular intake along with dietary considerations appears vital for the best outcomes.
When it comes to managing high cholesterol, the scientific support for vitamin K supplementation appears to be mixed. A double-blind, placebo-controlled trial involving 118 participants found that a nutraceutical combination including vitamin K did not significantly lower total cholesterol, LDL cholesterol, or triglycerides after six and twelve weeks [1]. Similarly, another study focusing on a dietary supplement containing octacosanol and vitamin K2 found no major changes in overall cholesterol levels among participants over 13 weeks, although there was some evidence that supplementation improved the relationship between PCSK9 and LDL cholesterol in those on atorvastatin therapy [2].
In contrast, animal studies have shown more promising results. A study conducted on rabbits indicated that vitamin K2 reduced cholesterol levels and slowed down atherosclerosis, which suggests potential benefits in cholesterol management, though these results may not directly translate to human health [3]. Overall, while certain studies indicate that vitamin K has interactions worth exploring, the direct support for vitamin K supplementation in effectively lowering high cholesterol in humans remains inconclusive at this time.
Based on user reviews, many individuals report significant improvements in their health after incorporating vitamin K2 MK7 into their daily regimen, especially when taken alongside vitamin D3. Users frequently highlight lower cholesterol levels and improved blood pressure as notable benefits. For instance, one user mentioned a substantial reduction in blood pressure within just two weeks of starting the supplement, suggesting that consistent use can yield positive cardiovascular outcomes (Read Review). Another user emphasized the supplement's role in reducing vascular calcification and promoting better calcium distribution in the body, underscoring its impact on heart health and artery function (Read Review).
Anecdotal accounts also reveal that users have experienced a sense of rejuvenation and improvement in their overall vitality, attributing these benefits to the supplement’s ability to support both bone health and cardiovascular wellness (Read Review). However, it's worth noting that individual results can vary significantly; while some users see rapid improvements, others may need to maintain consistent supplementation over longer periods for optimal effects (Read Review). This collective insight highlights the importance of patience and the potential need for a tailored approach, especially regarding dosage and dietary considerations.
Based on user reviews, there is widespread agreement that combining vitamin K2 MK7 with vitamin D3 significantly enhances the effectiveness of managing high cholesterol. Many users report that this combination assists in calcium distribution, thereby preventing arterial calcification and contributing to lower cholesterol levels. For example, one user mentioned that when taken together, these supplements help "flush" calcium from blood vessels into bones, which is beneficial for cardiovascular health and cholesterol management (Read Review). Another noted experiencing remarkable health benefits, including rejuvenated blood vessels, from this synergistic effect (Read Review).
Additionally, users have emphasized the need for proper dosages, suggesting that 100 mcg of K2 for every 5000 IU of D3 is optimal for achieving the best outcomes (Read Review). It is also recommended to take these supplements with dietary fats during breakfast for improved absorption (Read Review). This consensus indicates that those looking to manage high cholesterol levels should consider incorporating both vitamin K2 and D3 into their supplement regimen for enhanced cardiovascular benefits.
Based on user reviews, the appropriate dose of Vitamin K2, specifically MK7, for treating high cholesterol seems to be around 100 mcg. Users report that this dosage is optimal for promoting cardiovascular health and aiding in the distribution of calcium, which can help reduce cholesterol levels. One user noted that high doses of MK7 are effective in lowering circulating cholesterol levels and inhibiting atherosclerosis progression (Read Review). Another review emphasized that alongside vitamin D3, the 100 mcg dosage is ideal for supporting overall health and preventing blood clotting without thickening the blood (Read Review).
Additionally, users highlighted the importance of pairing Vitamin K2 with vitamin D3 for optimal absorption and effectiveness. One reviewer mentioned needing 100 mcg of K2 for every 5000 IU of D3, underscoring the relationship between these supplements in promoting calcium distribution and supporting cardiovascular health (Read Review). Overall, users consistently recommend a dose of 100 mcg of Vitamin K2, especially in conjunction with vitamin D3, to maximize health benefits and manage high cholesterol levels effectively.
After 6 and 12 weeks, we found that this combination didn't significantly lower total cholesterol, LDL cholesterol, or triglycerides. It also had no impact on various inflammatory biomarkers.
Our findings indicate that, at the doses used, the nutraceutical combination did not effectively change cholesterol or inflammatory markers.
However, we found that the relationship between the changes in PCSK9 and LDL cholesterol normalized in participants taking the supplement. This suggests that while cholesterol levels remained steady, the supplement might help improve how these two important factors relate to each other in the context of statin therapy.
Over a span of ten weeks, we administered different doses of vitamin K2 to rabbits fed a cholesterol-rich diet.
The findings were encouraging; the vitamin K2-treated rabbits had significantly lower cholesterol levels compared to a control group.
Additionally, it seems that vitamin K2 at moderate doses helped slow down the development of atherosclerosis without any adverse effects on blood coagulation.
References
- Protic O, Di Pillo R, Montesanto A, Galeazzi R, Matacchione G, et al. Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia. Nutrients. 2022;14. doi:10.3390/nu14142812
- Ciric MZ, Ostojic M, Baralic I, Kotur-Stevuljevic J, Djordjevic BI, et al. Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy. Nutrients. 2021;13. doi:10.3390/nu13030903
- Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, et al. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997;75:135.
