' 
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g
†
Top Medical Research Studies
7
Inulin improves knee osteoarthritis
Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial.
High relevance to arthritis management
We examined the potential benefits of inulin, a type of prebiotic fiber, for improving the physical function and overall well-being of adults with knee osteoarthritis and obesity. Over six months, 54 participants, mostly women, were randomly assigned to take either inulin or a placebo while undergoing several performance tests, alongside monitoring their pain levels, body composition, gut health, and metabolic markers.
Our findings revealed several encouraging results. Those who received inulin showed greater improvements in certain physical performance tests compared to those taking the placebo. Notably, we observed a reduction in trunk fat among the inulin group, and there was a trend suggesting they experienced less knee pain as well. Interestingly, the gut microbiota analysis highlighted changes in beneficial bacteria, particularly an increase in Bifidobacterium, which was linked to better physical performance.
The changes in serum metabolites further underscored the positive effects of inulin, with enhancements in certain metabolic processes. While these results are promising and suggest that prebiotics could offer a new avenue for managing knee osteoarthritis in individuals with obesity, more extensive trials are necessary to confirm these findings. Overall, this study strengthens the case for considering dietary fibers, like inulin, in arthritis treatment strategies.
Our findings revealed several encouraging results. Those who received inulin showed greater improvements in certain physical performance tests compared to those taking the placebo. Notably, we observed a reduction in trunk fat among the inulin group, and there was a trend suggesting they experienced less knee pain as well. Interestingly, the gut microbiota analysis highlighted changes in beneficial bacteria, particularly an increase in Bifidobacterium, which was linked to better physical performance.
The changes in serum metabolites further underscored the positive effects of inulin, with enhancements in certain metabolic processes. While these results are promising and suggest that prebiotics could offer a new avenue for managing knee osteoarthritis in individuals with obesity, more extensive trials are necessary to confirm these findings. Overall, this study strengthens the case for considering dietary fibers, like inulin, in arthritis treatment strategies.
Read More
9
Inulin system enhances arthritis medication
Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography.
Focus on inulin's role in treatment
We explored an exciting new approach to delivering aceclofenac, a medication used for arthritis pain relief, utilizing an inulin-based system. This method involved developing a unique tablet-in-capsule design that allowed for two separate doses: one for immediate release and another for a slower, sustained release.
The formulation capitalized on both pH-sensitive and bacteria-responsive components to enhance drug delivery directly to the intestines and colon, which is crucial for maximizing the medication's efficacy. Through careful design and testing, we identified an optimized formulation that effectively released 98.64% of the drug in a controlled manner over time, achieving a significant impact on pain management.
The results showed promising colon-specific delivery and demonstrated that our approach could potentially reduce the frequency of medication intake, which is often a challenge for arthritis patients. However, while the system showed favorable drug release characteristics, the specific impact of inulin alone on arthritis symptoms wasn’t distinctly isolated in this study, marking an area for future research.
Overall, our findings highlight a potential advancement in how we can administer arthritis treatments more effectively, while also emphasizing the need for further exploration of inulin’s direct effects on arthritis conditions.
The formulation capitalized on both pH-sensitive and bacteria-responsive components to enhance drug delivery directly to the intestines and colon, which is crucial for maximizing the medication's efficacy. Through careful design and testing, we identified an optimized formulation that effectively released 98.64% of the drug in a controlled manner over time, achieving a significant impact on pain management.
The results showed promising colon-specific delivery and demonstrated that our approach could potentially reduce the frequency of medication intake, which is often a challenge for arthritis patients. However, while the system showed favorable drug release characteristics, the specific impact of inulin alone on arthritis symptoms wasn’t distinctly isolated in this study, marking an area for future research.
Overall, our findings highlight a potential advancement in how we can administer arthritis treatments more effectively, while also emphasizing the need for further exploration of inulin’s direct effects on arthritis conditions.
Read More
4
Inulin's effects on knee OA
Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial.
Direct investigation of inulin
We embarked on an investigation to see how inulin, a type of dietary fiber known for its prebiotic benefits, might affect knee osteoarthritis (OA) in adults who also struggle with obesity. This double-blind, placebo-controlled trial included 60 participants with a body mass index (BMI) over 30 and diagnosed with knee OA. They were divided into two groups—one receiving inulin supplementation and the other a calorie-matched placebo—for a duration of six months.
Throughout the study, we assessed participants on various fronts, including knee function, pain levels, quality of life, and changes in gut microbiota. By examining these factors over time, we aimed to uncover whether inulin could help improve not only joint function but also reduce inflammation linked to obesity.
Our findings, while still underway, hold promise. If successful, this research could introduce a simple yet effective intervention for managing knee OA, potentially delaying or even eliminating the need for joint replacement surgeries. This could lead to enhanced quality of life for many suffering from these intertwined health issues.
Throughout the study, we assessed participants on various fronts, including knee function, pain levels, quality of life, and changes in gut microbiota. By examining these factors over time, we aimed to uncover whether inulin could help improve not only joint function but also reduce inflammation linked to obesity.
Our findings, while still underway, hold promise. If successful, this research could introduce a simple yet effective intervention for managing knee OA, potentially delaying or even eliminating the need for joint replacement surgeries. This could lead to enhanced quality of life for many suffering from these intertwined health issues.
Read More
Most Useful Reviews
10
Knee relief
Excellent osteoarthritis treatment. This pretty much cured my knee osteoarthritis—evidence suggests FOS is very effective—so I can't recommend it highly enough. It also tastes pleasant and is affordable! For effectiveness, take at least 10g (4 tsp) daily; there may be some gas initially, so start slowly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
9
Inulin system enhances arthritis medication
Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography.
Focus on inulin's role in treatment
We explored an exciting new approach to delivering aceclofenac, a medication used for arthritis pain relief, utilizing an inulin-based system. This method involved developing a unique tablet-in-capsule design that allowed for two separate doses: one for immediate release and another for a slower, sustained release.
The formulation capitalized on both pH-sensitive and bacteria-responsive components to enhance drug delivery directly to the intestines and colon, which is crucial for maximizing the medication's efficacy. Through careful design and testing, we identified an optimized formulation that effectively released 98.64% of the drug in a controlled manner over time, achieving a significant impact on pain management.
The results showed promising colon-specific delivery and demonstrated that our approach could potentially reduce the frequency of medication intake, which is often a challenge for arthritis patients. However, while the system showed favorable drug release characteristics, the specific impact of inulin alone on arthritis symptoms wasn’t distinctly isolated in this study, marking an area for future research.
Overall, our findings highlight a potential advancement in how we can administer arthritis treatments more effectively, while also emphasizing the need for further exploration of inulin’s direct effects on arthritis conditions.
The formulation capitalized on both pH-sensitive and bacteria-responsive components to enhance drug delivery directly to the intestines and colon, which is crucial for maximizing the medication's efficacy. Through careful design and testing, we identified an optimized formulation that effectively released 98.64% of the drug in a controlled manner over time, achieving a significant impact on pain management.
The results showed promising colon-specific delivery and demonstrated that our approach could potentially reduce the frequency of medication intake, which is often a challenge for arthritis patients. However, while the system showed favorable drug release characteristics, the specific impact of inulin alone on arthritis symptoms wasn’t distinctly isolated in this study, marking an area for future research.
Overall, our findings highlight a potential advancement in how we can administer arthritis treatments more effectively, while also emphasizing the need for further exploration of inulin’s direct effects on arthritis conditions.
Read More
8
Dietary intervention for arthritis
Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4 T cell reconstitution.
Moderate relevance due to diet context
Our investigation focused on understanding how inulin and pectin, found in high-fiber diets, can impact rheumatoid arthritis (RA). We designed our study to observe collagen-induced arthritis (CIA) models, where mice were fed a diet rich in these fibers.
Through our research, we discovered that this high-fiber diet significantly reduces arthritis symptoms in the CIA mice. One notable finding was how it helps in balancing specific immune cells, known as Th17 and Treg cells, which are crucial in autoimmune responses.
We also noted that the dietary change positively affected gut bacteria, encouraging an increase in butyrate levels in the feces. This beneficial short-chain fatty acid was instrumental in mimicking the high-fiber diet’s effects when added directly to the drinking water of the mice.
Overall, our findings suggest that both dietary inulin and pectin may play a role in improving arthritis conditions by enhancing gut microbiome health and influencing immune cell behavior. It's an interesting avenue for dietary intervention in managing RA that could pave the way for future research.
Through our research, we discovered that this high-fiber diet significantly reduces arthritis symptoms in the CIA mice. One notable finding was how it helps in balancing specific immune cells, known as Th17 and Treg cells, which are crucial in autoimmune responses.
We also noted that the dietary change positively affected gut bacteria, encouraging an increase in butyrate levels in the feces. This beneficial short-chain fatty acid was instrumental in mimicking the high-fiber diet’s effects when added directly to the drinking water of the mice.
Overall, our findings suggest that both dietary inulin and pectin may play a role in improving arthritis conditions by enhancing gut microbiome health and influencing immune cell behavior. It's an interesting avenue for dietary intervention in managing RA that could pave the way for future research.
Read More
8
Inulin may aid arthritis treatment
The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats.
Inulin's effect on arthritis unclear
We explored the effects of inulin, a prebiotic, on the prevention and progression of rheumatoid arthritis (RA) using an experimental model with rats. Our study involved 48 healthy male Wistar rats divided into six groups, including a control group and various treatment groups receiving either inulin, a probiotic called Bacillus coagulans, a combination of both, or indomethacin, a traditional anti-inflammatory medication.
On day 14, arthritis was induced in the rats, allowing us to examine how different treatments influenced arthritis symptoms and related biochemical markers. We measured paw thickness and assessed key biochemical indicators associated with inflammation over time. While we did observe that both inulin and Bacillus coagulans could improve some arthritis-related measures, it is important to note that we couldn't isolate the specific effects of inulin. This means we can't definitively conclude how much of the improvement was due solely to inulin, as it was always combined with the probiotic.
Overall, our findings suggest potential benefits from using Bacillus coagulans and inulin in managing RA symptoms. However, further research is needed to fully understand inulin's independent effects on arthritis.
On day 14, arthritis was induced in the rats, allowing us to examine how different treatments influenced arthritis symptoms and related biochemical markers. We measured paw thickness and assessed key biochemical indicators associated with inflammation over time. While we did observe that both inulin and Bacillus coagulans could improve some arthritis-related measures, it is important to note that we couldn't isolate the specific effects of inulin. This means we can't definitively conclude how much of the improvement was due solely to inulin, as it was always combined with the probiotic.
Overall, our findings suggest potential benefits from using Bacillus coagulans and inulin in managing RA symptoms. However, further research is needed to fully understand inulin's independent effects on arthritis.
Read More
7
Inulin improves knee osteoarthritis
Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial.
High relevance to arthritis management
We examined the potential benefits of inulin, a type of prebiotic fiber, for improving the physical function and overall well-being of adults with knee osteoarthritis and obesity. Over six months, 54 participants, mostly women, were randomly assigned to take either inulin or a placebo while undergoing several performance tests, alongside monitoring their pain levels, body composition, gut health, and metabolic markers.
Our findings revealed several encouraging results. Those who received inulin showed greater improvements in certain physical performance tests compared to those taking the placebo. Notably, we observed a reduction in trunk fat among the inulin group, and there was a trend suggesting they experienced less knee pain as well. Interestingly, the gut microbiota analysis highlighted changes in beneficial bacteria, particularly an increase in Bifidobacterium, which was linked to better physical performance.
The changes in serum metabolites further underscored the positive effects of inulin, with enhancements in certain metabolic processes. While these results are promising and suggest that prebiotics could offer a new avenue for managing knee osteoarthritis in individuals with obesity, more extensive trials are necessary to confirm these findings. Overall, this study strengthens the case for considering dietary fibers, like inulin, in arthritis treatment strategies.
Our findings revealed several encouraging results. Those who received inulin showed greater improvements in certain physical performance tests compared to those taking the placebo. Notably, we observed a reduction in trunk fat among the inulin group, and there was a trend suggesting they experienced less knee pain as well. Interestingly, the gut microbiota analysis highlighted changes in beneficial bacteria, particularly an increase in Bifidobacterium, which was linked to better physical performance.
The changes in serum metabolites further underscored the positive effects of inulin, with enhancements in certain metabolic processes. While these results are promising and suggest that prebiotics could offer a new avenue for managing knee osteoarthritis in individuals with obesity, more extensive trials are necessary to confirm these findings. Overall, this study strengthens the case for considering dietary fibers, like inulin, in arthritis treatment strategies.
Read More
4
Inulin's effects on knee OA
Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial.
Direct investigation of inulin
We embarked on an investigation to see how inulin, a type of dietary fiber known for its prebiotic benefits, might affect knee osteoarthritis (OA) in adults who also struggle with obesity. This double-blind, placebo-controlled trial included 60 participants with a body mass index (BMI) over 30 and diagnosed with knee OA. They were divided into two groups—one receiving inulin supplementation and the other a calorie-matched placebo—for a duration of six months.
Throughout the study, we assessed participants on various fronts, including knee function, pain levels, quality of life, and changes in gut microbiota. By examining these factors over time, we aimed to uncover whether inulin could help improve not only joint function but also reduce inflammation linked to obesity.
Our findings, while still underway, hold promise. If successful, this research could introduce a simple yet effective intervention for managing knee OA, potentially delaying or even eliminating the need for joint replacement surgeries. This could lead to enhanced quality of life for many suffering from these intertwined health issues.
Throughout the study, we assessed participants on various fronts, including knee function, pain levels, quality of life, and changes in gut microbiota. By examining these factors over time, we aimed to uncover whether inulin could help improve not only joint function but also reduce inflammation linked to obesity.
Our findings, while still underway, hold promise. If successful, this research could introduce a simple yet effective intervention for managing knee OA, potentially delaying or even eliminating the need for joint replacement surgeries. This could lead to enhanced quality of life for many suffering from these intertwined health issues.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
10
Knee relief
Excellent osteoarthritis treatment. This pretty much cured my knee osteoarthritis—evidence suggests FOS is very effective—so I can't recommend it highly enough. It also tastes pleasant and is affordable! For effectiveness, take at least 10g (4 tsp) daily; there may be some gas initially, so start slowly.
Read More
