We explored the impact of inulin on irritable bowel syndrome (IBS), particularly focusing on its effect for those suffering from constipation. IBS is a widespread issue that brings significant social and financial burdens.
Our investigation revealed that inulin appears to play a beneficial role in managing symptoms by influencing bowel movements and improving stool consistency. It does this by altering the gut microbiota, which is increasingly recognized as an important factor in gastrointestinal health.
However, while the positive outcomes of inulin for IBS patients with constipation seem promising, more large-scale, randomized clinical trials are necessary to strengthen this evidence. It’s essential to ensure the findings are backed by solid data so that patients can confidently consider inulin as a viable treatment option.
Read More
8
FODZYME aids in IBS symptom management
In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment.
We explored how a targeted supplement called FODZYME, which contains an enzyme that breaks down inulin, can influence the symptoms of irritable bowel syndrome (IBS). IBS can cause significant discomfort, and this supplement aims to alleviate some of that by reducing the amount of fermentable carbohydrates that can lead to gas production.
In our investigation, we used a sophisticated simulator that mimics the human digestive system to assess how effectively FODZYME breaks down inulin under realistic gastrointestinal conditions. The results indicated that FODZYME significantly reduces gas production while still promoting the production of beneficial short-chain fatty acids, which are good for gut health. This suggests that using this supplement could help manage IBS symptoms for those affected.
Overall, supplementing with FODZYME could lessen the impact of high-FODMAP foods on individuals with IBS. Our findings encourage further exploration of enzyme-based therapies in dietary management for IBS sufferers.
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4
Inulin's Effect on IBS Symptoms
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
We explored how inulin, a type of fermentable carbohydrate, influences the symptoms of irritable bowel syndrome (IBS) in individuals. In our study, we conducted a thorough 3-period, cross-over trial involving 29 patients diagnosed with IBS and 29 healthy control subjects. Each participant was given drinks containing specific carbohydrates—glucose, fructose, and inulin—on separate occasions, allowing us to observe their physical and symptomatic responses.
The results revealed that while IBS patients reported symptoms more frequently after consuming inulin compared to healthy individuals, there wasn’t a significant difference in gas production levels between the groups. This surprising find points to colonic hypersensitivity to distension as a likely cause of discomfort, rather than excessive gas buildup. In fact, patients with IBS reacted similarly to controls in terms of physiological changes after consuming fructose or inulin.
Ultimately, while we investigated the link between inulin and IBS symptoms, our study indicates that inulin may not provide a straightforward benefit. The key takeaway is that the hypersensitivity in the colon plays a critical role in the symptoms experienced by those with IBS, and inulin’s impact may not be as significant as previously thought.
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Most Useful Reviews
9
Effective against bowel issues
35 people found this helpful
In my experience with dietary supplements, inulin offered a remarkable outcome for my persistent bowel issues. After just a couple of days, I forgot about my belly discomfort. My mother uses a teaspoon daily for complete bowel normalisation. It’s surprisingly economical!
Read More
9
Improved intestinal health
12 people found this helpful
I've noticed increased effectiveness with probiotics! After taking Lactobifi each morning, my intestinal health has improved considerably. By incorporating prebiotics, the benefits have enhanced even further! My husband, who struggles with severe constipation, now experiences daily bowel movements. I plan to purchase a larger size this time. The product is almost tasteless, making it easy to add to coffee or protein. A great addition to my diet!
Read More
9
Excellent supplement
5 people found this helpful
It works undeniably well. One of my preferred supplements, it keeps my bowel functioning like clockwork.
We assessed the effectiveness of a non-alcoholic, fermented kombucha drink enriched with inulin and vitamins on individuals with constipation-predominant irritable bowel syndrome (IBS). This innovative study involved 40 participants who were randomly assigned to receive either the kombucha drink or plain water over a span of 10 days.
Our findings highlighted that those who consumed the kombucha drink experienced a notable increase in stool frequency—moving from an average of 0.60 to 0.85 bowel movements per day. Furthermore, the consistency of their stools improved significantly, indicating a shift from harder to softer stools, which benefits IBS sufferers.
Participants also reported feeling less discomfort related to incomplete bowel emptying after drinking the kombucha. In contrast, those in the control group did not experience such improvements, underscoring the potential benefits of inulin when combined with the unique properties of kombucha.
While the study revealed valuable insights into how a kombucha-based drink can enhance bowel health, it's essential to note that some symptoms did not show significant differences between groups—implying that while inulin may help, it is not a universal remedy for all IBS-related issues. Overall, our research suggests that kombucha enriched with inulin could be a promising supplement for those struggling with IBS symptoms, particularly constipation.
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9
Inulin improves IBS symptoms
[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
We explored the impact of a functional drink containing inulin, menthol, and pyridoxine on patients suffering from constipation-predominant irritable bowel syndrome (IBS-C). In our study, 49 participants, aged between 18 and 68 years and meeting the Rome III criteria, were divided into two groups. One group followed their standard diet plus two drinks a day for two weeks, while the control group maintained their usual diet without the drinks.
The results were promising. Those who consumed the functional drink experienced a notable improvement in bowel frequency and stool consistency, with an increase in daily bowel movements and a better Bristol stool scale score. Additionally, there was a significant reduction in abdominal pain, bloating, and the feeling of incomplete bowel emptying. Quality of life also received a boost, reflecting an enhanced well-being among participants.
However, we found that a significant number of participants reported experiencing heartburn after starting the treatment. This highlights the need for further adjustments in the drink’s formulation to mitigate these adverse effects. Overall, our findings suggest that a functional drink with inulin can improve various symptoms of IBS-C, while also making it clear that modifications may be necessary to address side effects like heartburn.
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9
Inulin improves IBS-C symptoms
[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study].
We conducted a study to see how a dry jelly concentrate, which contains inulin and other ingredients like curcumin and pyridoxine, could help people suffering from irritable bowel syndrome with constipation (IBS-C). Fifty patients who met the Rome III criteria for IBS-C were split into two groups. One group enjoyed a standard diet along with two jelly drinks each day for two weeks, while the control group stuck to just the standard diet.
After the treatment period, we noticed some significant improvements in the group consuming the jelly. Specifically, their stool frequency increased, and there were noticeable reductions in abdominal pain, bloating, and the feeling of incomplete bowel emptying. They also reported a better quality of life. For instance, stool frequency improved from about 0.6 times per day to 1.15 times, and their quality of life score rose significantly.
In contrast, the control group showed only minor improvements in abdominal pain and bloating. Moreover, our findings indicated that the jelly concentrate appeared to be safe, as we didn't observe any significant adverse effects during the study. In summary, our exploration suggests that inulin, along with other components in the jelly, can contribute positively to symptomatic relief for patients suffering from IBS-C.
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8
Potential benefits of synbiotics
Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study.
We looked into how a synbiotic treatment, which includes the prebiotic inulin, could help improve symptoms in Parkinson's disease (PD) patients experiencing constipation and related issues. The study involved patients with stable PD who qualified for constipation conditions based on specific criteria. They underwent 12 weeks of treatment with a product that combined both probiotics and inulin.
During our observations, we noted significant improvements in neurological assessments and behavioral symptoms after the treatment. Specifically, patients showed better scores across various tests that measure aspects like mood and autonomic function. Notably, their gastroenterological health also improved, with enhancements in bowel movement frequency and overall comfort.
Interestingly, while inulin was part of the treatment mix, the results highlight its role within the broader synbiotic approach. The study showcased an increase in beneficial gut bacteria after treatment, underscoring the potential of such therapies in managing non-motor symptoms associated with PD. However, it's essential to understand that we can't isolate the effects of inulin alone due to the combination with probiotics.
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8
Inulin impacts IBS-C symptoms positively
Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study.
We aimed to explore the effects of kombucha enriched with inulin and vitamins on females suffering from constipation-predominant irritable bowel syndrome (IBS-C). In a recent pilot study, 40 women were randomly divided into two groups: one group consumed 220 mL of the kombucha beverage each day, while the control group drank water for ten days.
Throughout the study, we evaluated stool frequency, using the Bristol stool scale, and assessed abdominal symptoms on specific days. Our findings indicated that short-term consumption of the kombucha drink resulted in increased stool frequency, improved bowel consistency, and less feeling of incomplete bowel emptying among participants.
The results suggest that adding inulin to kombucha might be beneficial for IBS-C symptoms, making this functional food an appealing dietary option. However, further large-scale studies will be essential to confirm these promising effects and better understand the role of inulin in IBS management.
In my experience with dietary supplements, inulin offered a remarkable outcome for my persistent bowel issues. After just a couple of days, I forgot about my belly discomfort. My mother uses a teaspoon daily for complete bowel normalisation. It’s surprisingly economical!
Read More
9
Improved intestinal health
12 people found this helpful
I've noticed increased effectiveness with probiotics! After taking Lactobifi each morning, my intestinal health has improved considerably. By incorporating prebiotics, the benefits have enhanced even further! My husband, who struggles with severe constipation, now experiences daily bowel movements. I plan to purchase a larger size this time. The product is almost tasteless, making it easy to add to coffee or protein. A great addition to my diet!
Read More
9
Excellent supplement
5 people found this helpful
It works undeniably well. One of my preferred supplements, it keeps my bowel functioning like clockwork.
Read More
9
Smooth bowel movements
4 people found this helpful
After three months of taking inulin, I experience smooth bowel movements twice daily. I often mix it with cut fruit in yogurt or add it to soup throughout the day and evening.
Read More
9
More frequent bowel movements
3 people found this helpful
It's truly wonderful for constipation - I absolutely love this! Since using it, I have nearly two bowel movements daily. Furthermore, it tastes delightful too.
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).
Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.
Prebiotic fiber inulin is a naturally occurring carbohydrate found in a variety of plants, particularly in roots and tubers such as chicory, garlic, leeks, and onions. As a soluble fiber, it is not digested in the small intestine but rather fermented by beneficial gut bacteria in the large intestine. This fermentation process helps promote the growth of beneficial bacteria, which can support gut health, improve digestion, and enhance the absorption of certain nutrients. Increasing dietary intake of prebiotic fibers like inulin can contribute to a healthier microbiome.
In addition to its benefits for gut health, inulin can also help to enhance feelings of fullness and reduce appetite, making it a popular ingredient in weight management products. It is often added to food and beverage items as a texturizer or sweetener because it offers a mildly sweet flavor without contributing significant calories. Given its numerous health benefits, inulin is frequently emphasized in discussions about dietary fiber and overall nutrition, making it a valuable component of a balanced diet.
Prebiotic fiber inulin has gained attention for its potential benefits in managing symptoms of Irritable Bowel Syndrome (IBS). As a soluble fiber, inulin serves as a food source for beneficial gut bacteria, promoting a healthy microbiome. Some research suggests that by improving gut health, inulin may help alleviate certain IBS symptoms, such as constipation and bloating. However, results can vary among individuals. While some people may experience positive effects, others might find that inulin can lead to increased gas or bloating, particularly if consumed in large quantities or if they are sensitive to fiber.
It's essential to approach the inclusion of inulin in your diet cautiously, especially if you're dealing with IBS. Gradually introducing inulin into your meals—found in foods like chicory root, garlic, leeks, and onions—might help your gut adjust more easily. As with any dietary change, it's advisable to consult with a healthcare professional, such as a registered dietitian, to tailor a plan that suits your specific needs and to monitor your symptoms effectively. Though inulin shows promise for some IBS sufferers, more extensive research is needed to fully understand its impact on this complex condition.
Based on user reviews, the time it typically takes to see results from taking a supplement for Irritable Bowel Syndrome, particularly inulin, varies considerably among individuals. Some users report experiencing significant improvements in their bowel function within just a few days. For instance, one user mentioned feeling cleansed and experiencing smooth bowel movements shortly after beginning the supplement, specifically after a few days of daily intake Read Review. In contrast, others have noted a longer timeline, such as upwards of two weeks, to see substantial effects on their constipation and overall bowel regularity Read Review.
While some users were delighted by immediate results, there are exceptions where individuals experienced discomfort or no improvement at all, which highlights that responses can be highly individualistic Read Review. Overall, while many report quick results within days to a couple of weeks, your personal experience may vary, and it may take some experimentation to find the right dosage and combination for your specific needs.
Based on current scientific research, inulin presents a mixed picture regarding its support as a supplement for managing Irritable Bowel Syndrome (IBS). While some studies highlight potential benefits, such as improved bowel frequency and reduced symptoms of constipation-predominant IBS (IBS-C) when combined with other ingredients (for instance, in a kombucha beverage enriched with inulin, it was observed that participants experienced better stool consistency and less discomfort) [4], the efficacy of inulin does not consistently translate into significant improvements across all IBS symptoms.
In several other investigations, researchers found that while inulin may positively influence gut health and modify gut microbiota, it did not show sufficiently strong evidence to be considered a standalone effective treatment for IBS [1][9]. Furthermore, concerns have been raised regarding inulin's potential to exacerbate gas production and gastrointestinal discomfort in sensitive individuals [8]. Therefore, while inulin could offer some symptomatic relief for specific IBS subsets, more comprehensive clinical trials are necessary to bolster our understanding of its role in dietary management for irritable bowel syndrome.
Based on user reviews, many individuals have reported notable improvements in their bowel symptoms after incorporating inulin into their routines. For instance, one user stated that within just a couple of days, their persistent belly discomfort vanished, while their mother experienced complete bowel normalization from a daily teaspoon of inulin Read Review. Another reviewer highlighted the transition from having bowel movements just twice a week to two per day after using the supplement, expressing that it has become a vital part of their diet Read Review. Furthermore, a long-term user reported achieving smooth bowel movements twice daily after consistent use of inulin for three months Read Review.
While many users have experienced quick and significant positive changes in their gut health, it's important to note that responses vary among individuals. A few users encountered adverse effects, such as increased gas or ineffectiveness, indicating that inulin may not be suitable for everyone Read Review. Overall, the anecdotal experiences suggest that while a substantial number find inulin beneficial for promoting regularity and reducing symptoms of constipation, others may need to explore alternative options based on their unique digestive responses.
Based on user reviews, many individuals have reported that combining inulin with other supplements, such as probiotics, has led to enhanced effectiveness in managing their Irritable Bowel Syndrome (IBS). For example, one reviewer noted that after incorporating probiotics into their routine alongside inulin, their intestinal health improved significantly, leading to daily bowel movements for both themselves and their husband, who had struggled with severe constipation Read Review. Another user also mentioned using inulin together with husk, which noticeably diminished the odour of stool and increased the frequency of bowel movements Read Review.
Other reviewers have found that inulin works well in conjunction with probiotics, stating that taking them together has brought about smoother bowel movements and diminished flatulence, enhancing overall digestive comfort Read Review. Furthermore, a reviewer reported positive results when taking inulin alongside a probiotic complex, indicating that this combination provided them with substantial improvements in their bowel function Read Review. Overall, while experiences vary, the combination of inulin with other digestive supplements appears to be a promising approach for many seeking relief from IBS symptoms.
According to user reviews, a teaspoon of Prebiotic Fiber Inulin appears to be a commonly reported effective dose for many individuals struggling with Irritable Bowel Syndrome (IBS) and constipation. Multiple users noted significant improvements in their bowel function after taking around one teaspoon daily. For instance, one user mentioned that after mixing a teaspoon into their morning protein shake, they experienced improved regularity and smoother bowel movements (Read Review). Another user experienced notable relief, resulting in nearly two bowel movements per day after using it consistently (Read Review).
However, it's important to note that some users reported varying responses. One individual experienced discomfort and flatulence instead of the desired results after trying the product (Read Review). Additionally, there were suggestions for newcomers to start with a lower dose or take breaks to assess tolerance, as one user recommended taking a day off after achieving initial success (Read Review). Overall, while many found success with a teaspoon daily, others indicated the need for personalization in dosage to avoid side effects.
9
Healthy lifestyle support
1 people found this helpful
After a few days of taking this prebiotic powder, just one spoon daily helped my bowel become very smooth, and I felt cleansed. I’m purchasing more to maintain this healthy lifestyle!
7.5
Fast constipation relief
5 people found this helpful
Since autumn, I’ve struggled with constipation. My tests were normal, so my doctor recommended taking Inulin along with the NOW bacteria complex. I found a great price and quickly noticed improvements. My bowel function enhanced substantially after two weeks! I will update my review later to see if the effects remain after I stop the medication.
0
No improvement noted
3 people found this helpful
I did not notice any improvement in my bowel movements and instead suffered from flatulence with a sulphurous smell and a feeling of fullness in my abdomen. It did not suit my constitution, so I discarded it after several attempts.
9
Effective against bowel issues
35 people found this helpful
In my experience with dietary supplements, inulin offered a remarkable outcome for my persistent bowel issues. After just a couple of days, I forgot about my belly discomfort. My mother uses a teaspoon daily for complete bowel normalisation. It’s surprisingly economical!
10
Must-have supplement
1 people found this helpful
An absolute must-have! Inulin is a water-soluble dietary fibre that significantly improved my bowel movements. I tend to be quite constipated, but this product has been the most effective I’ve tried. It's flavourless and mixes well with green juice or water. Since using it, I've been having two bowel movements a day instead of just two a week. It's a game-changer for me!
9
Smooth bowel movements
4 people found this helpful
After three months of taking inulin, I experience smooth bowel movements twice daily. I often mix it with cut fruit in yogurt or add it to soup throughout the day and evening.
9
Improved intestinal health
12 people found this helpful
I've noticed increased effectiveness with probiotics! After taking Lactobifi each morning, my intestinal health has improved considerably. By incorporating prebiotics, the benefits have enhanced even further! My husband, who struggles with severe constipation, now experiences daily bowel movements. I plan to purchase a larger size this time. The product is almost tasteless, making it easy to add to coffee or protein. A great addition to my diet!
9.5
Flatulence reduced
2 people found this helpful
For many years, I struggled with constipation, but using a combination of inulin and husk has notably improved my bowel movements. The odour of stool and flatulence has considerably diminished—this isn’t merely a placebo! Mixing a spoonful with yoghurt makes it easy to consume without any aversion.
9
Healthy stools
1 people found this helpful
In an effort to enhance my intestinal health, I began taking probiotics and this prebiotic. By adding a teaspoon to my morning and evening protein shakes, I've seen real improvement. Previously, my bowel movements were inconsistent, but this has resulted in healthier stools. I wish to maintain this routine.
9
More frequent bowel movements
3 people found this helpful
It's truly wonderful for constipation - I absolutely love this! Since using it, I have nearly two bowel movements daily. Furthermore, it tastes delightful too.
7.5
Effective bowel relief
364 people found this helpful
The result is quick, but I recommend taking a day off. I bought it to stimulate my bowels, and it worked well that day. I’ve now completed my course, and my body operates like clockwork. I wouldn’t describe it as sweet, just slightly so, which is a major plus for me. I tried diluting it with water and adding it to hot drinks like cocoa, and it had an effect. I've had intestinal issues all my life and tried many remedies; probiotics didn’t help, but Inulin proved effective. There’s a slight initial gas formation after the first intake, so starting on a Monday isn't ideal; the weekend is better.
8
Inulin impacts IBS-C symptoms positively
Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study.
We aimed to explore the effects of kombucha enriched with inulin and vitamins on females suffering from constipation-predominant irritable bowel syndrome (IBS-C). In a recent pilot study, 40 women were randomly divided into two groups: one group consumed 220 mL of the kombucha beverage each day, while the control group drank water for ten days.
Throughout the study, we evaluated stool frequency, using the Bristol stool scale, and assessed abdominal symptoms on specific days. Our findings indicated that short-term consumption of the kombucha drink resulted in increased stool frequency, improved bowel consistency, and less feeling of incomplete bowel emptying among participants.
The results suggest that adding inulin to kombucha might be beneficial for IBS-C symptoms, making this functional food an appealing dietary option. However, further large-scale studies will be essential to confirm these promising effects and better understand the role of inulin in IBS management.
7
Inulin's effects on gut health
Impact of low FODMAP sourdough bread on gut microbiota using an colonic fermentation model.
We investigated how inulin, a type of soluble fiber, impacts individuals with irritable bowel syndrome (IBS) by using specially prepared sourdough breads. In our study, we created various sourdough bread types, including those with reduced FODMAP content, using different strains of lactic acid bacteria and a control version made with traditional baker's yeast.
After preparing the breads, we conducted experiments to simulate digestion and colonic fermentation, measuring how these breads interacted with gut bacteria. We found that while the fermentation process shifted the gut microbiota composition, inulin specifically increased the abundance of beneficial bacteria compared to a control and a negative cellulose group.
However, we did not find significant overall differences in gut health indicators after fermentation with these breads. For instance, while acetic acid levels increased in the fermentation involving one type of sourdough, the study did not demonstrate substantial benefits of inulin on improving IBS symptoms specifically.
This suggests that while inulin can be beneficial for gut bacteria balance, its direct effectiveness in alleviating IBS is not yet definitively proven. The fermentation process and the type of bread may play roles that warrant further research to fully understand their impacts.
8
Inulin aids IBS-C symptom management
Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review).
We explored the impact of inulin on irritable bowel syndrome (IBS), particularly focusing on its effect for those suffering from constipation. IBS is a widespread issue that brings significant social and financial burdens.
Our investigation revealed that inulin appears to play a beneficial role in managing symptoms by influencing bowel movements and improving stool consistency. It does this by altering the gut microbiota, which is increasingly recognized as an important factor in gastrointestinal health.
However, while the positive outcomes of inulin for IBS patients with constipation seem promising, more large-scale, randomized clinical trials are necessary to strengthen this evidence. It’s essential to ensure the findings are backed by solid data so that patients can confidently consider inulin as a viable treatment option.
4
Effect of psyllium on inulin gas
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and fermentation studies.
We conducted a study to investigate whether adding psyllium to inulin could reduce gas production in patients with irritable bowel syndrome (IBS). Our research involved a rigorous randomized crossover trial with 19 participants. Each subject consumed a drink that contained either inulin, psyllium, both, or a placebo, and we measured breath hydrogen levels and used MRI to assess colonic gas over six hours.
We found that inulin alone caused a notable increase in colonic gas, while the combination of inulin and psyllium significantly reduced this gas production. However, it's important to note that while psyllium appeared to limit the gas associated with inulin intake, it did not directly inhibit fermentation. This means that while patients experienced less gas when both substances were taken together, the effect of inulin alone still triggered some gastrointestinal discomfort.
There's much to explore regarding how well patients with IBS can tolerate prebiotics like inulin when paired with psyllium. Our findings suggest that this combination may help improve their experience, but further investigation is needed to confirm these benefits.
References
Koc F, Arendt E, Coffey A, Ross RP, Stanton C. Impact of low FODMAP sourdough bread on gut microbiota using an colonic fermentation model. Front Microbiol. 2024;15:1496022. doi:10.3389/fmicb.2024.1496022
Andreozzi V, Cuoco S, Balestrieri M, Fierro F, Ferrara N, et al. Synbiotic supplementation may globally improve non-motor symptoms in patients with stable Parkinson's disease: results from an open label single-arm study. Sci Rep. 2024;14:23095. doi:10.1038/s41598-024-74400-w
Garvey SM, LeMoire A, Wang J, Lin L, Sharif B, et al. Safety and Tolerability of Microbial Inulinase Supplementation in Healthy Adults: A Randomized, Placebo-Controlled Trial. Gastro Hep Adv. 2024;3:920. doi:10.1016/j.gastha.2024.05.013
Isakov VA, Pilipenko VI, Vlasova AV, Kochetkova AA. Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of Constipation-Predominant Irritable Bowel Syndrome in Females: A Randomized Pilot Study. Curr Dev Nutr. 2023;7:102037. doi:10.1016/j.cdnut.2023.102037
Pilipenko VI, Isakov VA, Morozov SV, Vlasova AV, Kochetkova AA. [Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable bowel syndrome]. Vopr Pitan. 2022;91:95. doi:10.33029/0042-8833-2022-91-5-95-104
Ochoa KC, Samant S, Liu A, Duysburgh C, Marzorati M, et al. In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment. Gastro Hep Adv. 2023;2:283. doi:10.1016/j.gastha.2022.10.011
Bărboi OB, Chirilă I, Ciortescu I, Anton C, Drug VL. Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11082248
Gunn D, Abbas Z, Harris HC, Major G, Hoad C, et al. Psyllium reduces inulin-induced colonic gas production in IBS: MRI and fermentation studies. Gut. 2022;71:919. doi:10.1136/gutjnl-2021-324784
Bărboi OB, Ciortescu I, Chirilă I, Anton C, Drug V. Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review). Exp Ther Med. 2020;20:185. doi:10.3892/etm.2020.9315
Ahluwalia B, Magnusson MK, Böhn L, Störsrud S, Larsson F, et al. Randomized clinical trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2020;32:e13860. doi:10.1111/nmo.13860
Abhari K, Saadati S, Hosseini-Oskouiee F, Yari Z, Hosseini H, et al. Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management?. Eur J Nutr. 2020;59:2111. doi:10.1007/s00394-019-02060-y
Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. doi:10.5152/tjg.2016.16301
Major G, Pritchard S, Murray K, Alappadan JP, Hoad CL, et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome. Gastroenterology. 2017;152:124. doi:10.1053/j.gastro.2016.09.062
Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Using a multicomponent functional food in IBS patients with constipation a comparative controlled study]. Vopr Pitan. 2016;85:84.
Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. doi:10.3168/jds.2015-10743
Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]. Vopr Pitan. 2015;84:83.