' 
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g
†
Top Medical Research Studies
9
Inulin alleviates ulcerative colitis
An inulin-type fructan CP-A from alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics.
High relevance to ulcerative colitis
We investigated how inulin-type fructan CP-A, a key component found in certain polysaccharides, influences ulcerative colitis (UC), an inflammatory disease marked by symptoms like abdominal pain, diarrhea, and bloody stools. To conduct this research, we used a rat model treated with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to simulate UC and an in vitro model with colonic epithelial cells exposed to lipopolysaccharides (LPS) to better understand the cellular response.
Through our experiments, we discovered that CP-A significantly lessens colonic injuries and reduces markers associated with inflammation, such as interleukin-8 and tumor necrosis factor-alpha. Furthermore, we observed improvements in levels of protective substances like interleukin-10 and transforming growth factor-beta after treatment with CP-A. In our in vitro tests, CP-A effectively lowered nitric oxide and interleukin-1 beta production following LPS stimulation, indicating a reduction in inflammatory responses.
Our metabolic analysis revealed a connection between CP-A therapy and the mammalian target of rapamycin (mTOR) signaling pathway. Both in vivo and in vitro validations suggested that this pathway plays a critical role in CP-A's ability to alleviate UC by inhibiting inflammation-related signaling mechanisms. These findings can pave the way for new treatment approaches for patients suffering from ulcerative colitis, suggesting that inulin-type fructan CP-A holds therapeutic promise in managing and potentially improving this challenging condition.
Through our experiments, we discovered that CP-A significantly lessens colonic injuries and reduces markers associated with inflammation, such as interleukin-8 and tumor necrosis factor-alpha. Furthermore, we observed improvements in levels of protective substances like interleukin-10 and transforming growth factor-beta after treatment with CP-A. In our in vitro tests, CP-A effectively lowered nitric oxide and interleukin-1 beta production following LPS stimulation, indicating a reduction in inflammatory responses.
Our metabolic analysis revealed a connection between CP-A therapy and the mammalian target of rapamycin (mTOR) signaling pathway. Both in vivo and in vitro validations suggested that this pathway plays a critical role in CP-A's ability to alleviate UC by inhibiting inflammation-related signaling mechanisms. These findings can pave the way for new treatment approaches for patients suffering from ulcerative colitis, suggesting that inulin-type fructan CP-A holds therapeutic promise in managing and potentially improving this challenging condition.
Read More
9
Inulin shows anti-ulcer activity
Inulin-rich fractions from Vernonia kotschyana roots have anti-ulcer activity.
High relevance for ulcer treatment
We evaluated the effects of inulin-rich water extracts from the roots of Vernonia kotschyana on ulcers. This plant is traditionally used in Mali to treat conditions like gastritis and gastric ulcers, where it’s sold under the name Gastrosedal.
To understand the potential of inulin in preventing ulcer formation, we administered two types of extracts to mice before exposing them to a harmful substance that induces gastric lesions. Notably, we measured the extent of ulcer formation, which allowed us to ascertain the extracts' effectiveness.
Our findings indicated that both the extracts, containing 98% inulin for Vk50-I and 83% inulin for Vk100-I, significantly reduced gastric lesions. Importantly, we did not observe any adverse effects or immunomodulating activities from these extracts.
Overall, it appears that inulin plays an important role in the anti-ulcer activity of Gastrosedal and might support overall gastrointestinal health as well.
To understand the potential of inulin in preventing ulcer formation, we administered two types of extracts to mice before exposing them to a harmful substance that induces gastric lesions. Notably, we measured the extent of ulcer formation, which allowed us to ascertain the extracts' effectiveness.
Our findings indicated that both the extracts, containing 98% inulin for Vk50-I and 83% inulin for Vk100-I, significantly reduced gastric lesions. Importantly, we did not observe any adverse effects or immunomodulating activities from these extracts.
Overall, it appears that inulin plays an important role in the anti-ulcer activity of Gastrosedal and might support overall gastrointestinal health as well.
Read More
8
Inulin improves ulcerative colitis
Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels.
Highly relevant study findings
We set out to determine whether inulin-type fructans could assist with symptoms of ulcerative colitis (UC) and if their benefits might be linked to changes in gut bacteria. In our study, 25 patients with mild to moderately active UC participated, receiving either 7.5 grams or 15 grams of oligofructose-enriched inulin daily for nine weeks. We carefully monitored the patients' symptoms, as measured by the total Mayo score, endoscopic activity, and the presence of calprotectin in their feces.
Interestingly, we found that a higher dose of fructans—a daily amount of 15 grams—significantly reduced colitis symptoms. About 77% of patients in this group showed a noticeable clinical response, compared to just 33% in the low-dose group. We also observed that the high-dose fructans led to increased production of butyrate, a beneficial short-chain fatty acid, which correlated negatively with disease severity. This suggests that higher butyrate levels may contribute to symptom relief.
Our findings indicate that while inulin-type fructans alter gut microbiota metabolism beneficially, the changes in the composition of gut bacteria themselves weren’t directly linked to improvements in disease scores. This means that the positive effects of these prebiotics could be more about how they enhance gut health rather than merely changing which bacteria are present. Overall, our pilot study provides a strong basis for further research into using inulin-type fructans as a supportive treatment for patients with active ulcerative colitis.
Interestingly, we found that a higher dose of fructans—a daily amount of 15 grams—significantly reduced colitis symptoms. About 77% of patients in this group showed a noticeable clinical response, compared to just 33% in the low-dose group. We also observed that the high-dose fructans led to increased production of butyrate, a beneficial short-chain fatty acid, which correlated negatively with disease severity. This suggests that higher butyrate levels may contribute to symptom relief.
Our findings indicate that while inulin-type fructans alter gut microbiota metabolism beneficially, the changes in the composition of gut bacteria themselves weren’t directly linked to improvements in disease scores. This means that the positive effects of these prebiotics could be more about how they enhance gut health rather than merely changing which bacteria are present. Overall, our pilot study provides a strong basis for further research into using inulin-type fructans as a supportive treatment for patients with active ulcerative colitis.
Read More
Most Useful Reviews
8.8
Excellent for ulcers
This is a great product for burning sensations in the stomach, especially after consuming spicy food. It has effectively alleviated my discomfort and performed its job well.
Read More
8
Long-term remission
This product is excellent value compared to its competitors. I use inulin as part of a pre and probiotic regimen that has kept my severe ulcerative colitis in remission for seven years. The NOW brand offers the best value!
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.6
9
Inulin's role in gut recovery
Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria.
Combination treatment explored
We embarked on a fascinating exploration to understand how inulin might affect tummy troubles, particularly in relation to ulcers. Our study involved testing a specific group of beneficial bacteria along with inulin in mouse models that symbolize human gut health. This bacterial consortium, known as SC-4, was selected due to its low abundance yet significant potential in promoting gut health. These bacteria, typically found in healthy human guts, were evaluated for their ability to help recover from colitis induced by Dextran Sodium Sulfate (DSS).
During our research, we observed that inulin, a type of dietary fiber, worked hand-in-hand with SC-4 to boost health benefits in the mice. When combined, this duo increased the thickness of mucin in the gut, which serves as a protective barrier. This combination also significantly aided in recovery from DSS-induced colitis and improved the diversity of gut microbial communities, steering them closer to healthier compositions.
Importantly, our findings suggest that while inulin alone has promising properties, its effects were notably enhanced when paired with SC-4. This cooperative interaction points to a combined approach that may be worth exploring further for managing gut health issues in humans, especially those related to inflammatory bowel diseases.
During our research, we observed that inulin, a type of dietary fiber, worked hand-in-hand with SC-4 to boost health benefits in the mice. When combined, this duo increased the thickness of mucin in the gut, which serves as a protective barrier. This combination also significantly aided in recovery from DSS-induced colitis and improved the diversity of gut microbial communities, steering them closer to healthier compositions.
Importantly, our findings suggest that while inulin alone has promising properties, its effects were notably enhanced when paired with SC-4. This cooperative interaction points to a combined approach that may be worth exploring further for managing gut health issues in humans, especially those related to inflammatory bowel diseases.
Read More
9
Inulin mitigates ulcerative colitis
Synbiotic of and Inulin Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice.
Moderate relevance due to combination
We explored the effects of a synbiotic, combining inulin and another substance, on ulcerative colitis induced by dextran sulfate sodium (DSS) in a mouse model. The main goal was to see if this combination could ease the symptoms of colitis, which is a significant digestive system disorder affecting many individuals.
The results were promising. The synbiotic helped reduce body weight loss and improved the disease activity index, which indicates a decrease in colitis severity. We also noted an increase in antioxidant activity and a reduction in inflammation within the mice.
Histopathological analyses showed that the synbiotic effectively reversed colonic damage, particularly the loss of goblet cells, which are essential for a healthy gut lining. Additionally, inflammatory markers like IL-1β, TNF-α, and IL-6 in the serum were significantly reduced after treatment. Overall, this suggests that the combination of inulin with the other component offers both preventive and therapeutic benefits against DSS-induced colitis in mice.
The results were promising. The synbiotic helped reduce body weight loss and improved the disease activity index, which indicates a decrease in colitis severity. We also noted an increase in antioxidant activity and a reduction in inflammation within the mice.
Histopathological analyses showed that the synbiotic effectively reversed colonic damage, particularly the loss of goblet cells, which are essential for a healthy gut lining. Additionally, inflammatory markers like IL-1β, TNF-α, and IL-6 in the serum were significantly reduced after treatment. Overall, this suggests that the combination of inulin with the other component offers both preventive and therapeutic benefits against DSS-induced colitis in mice.
Read More
9
Inulin alleviates ulcerative colitis
An inulin-type fructan CP-A from alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics.
High relevance to ulcerative colitis
We investigated how inulin-type fructan CP-A, a key component found in certain polysaccharides, influences ulcerative colitis (UC), an inflammatory disease marked by symptoms like abdominal pain, diarrhea, and bloody stools. To conduct this research, we used a rat model treated with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to simulate UC and an in vitro model with colonic epithelial cells exposed to lipopolysaccharides (LPS) to better understand the cellular response.
Through our experiments, we discovered that CP-A significantly lessens colonic injuries and reduces markers associated with inflammation, such as interleukin-8 and tumor necrosis factor-alpha. Furthermore, we observed improvements in levels of protective substances like interleukin-10 and transforming growth factor-beta after treatment with CP-A. In our in vitro tests, CP-A effectively lowered nitric oxide and interleukin-1 beta production following LPS stimulation, indicating a reduction in inflammatory responses.
Our metabolic analysis revealed a connection between CP-A therapy and the mammalian target of rapamycin (mTOR) signaling pathway. Both in vivo and in vitro validations suggested that this pathway plays a critical role in CP-A's ability to alleviate UC by inhibiting inflammation-related signaling mechanisms. These findings can pave the way for new treatment approaches for patients suffering from ulcerative colitis, suggesting that inulin-type fructan CP-A holds therapeutic promise in managing and potentially improving this challenging condition.
Through our experiments, we discovered that CP-A significantly lessens colonic injuries and reduces markers associated with inflammation, such as interleukin-8 and tumor necrosis factor-alpha. Furthermore, we observed improvements in levels of protective substances like interleukin-10 and transforming growth factor-beta after treatment with CP-A. In our in vitro tests, CP-A effectively lowered nitric oxide and interleukin-1 beta production following LPS stimulation, indicating a reduction in inflammatory responses.
Our metabolic analysis revealed a connection between CP-A therapy and the mammalian target of rapamycin (mTOR) signaling pathway. Both in vivo and in vitro validations suggested that this pathway plays a critical role in CP-A's ability to alleviate UC by inhibiting inflammation-related signaling mechanisms. These findings can pave the way for new treatment approaches for patients suffering from ulcerative colitis, suggesting that inulin-type fructan CP-A holds therapeutic promise in managing and potentially improving this challenging condition.
Read More
9
Inulin enhances 5-ASA delivery
Application of inulin/Eudragit RS in 5-ASA pellet coating with tuned, sustained-release feature in an animal model of ulcerative colitis.
Study highlights inulin's role
We utilized a 3 factorial design to investigate how inulin, when combined with Eudragit RS, can fine-tune the release of 5-aminosalicylic acid (5-ASA) for treating inflammatory bowel disease (IBD), specifically ulcerative colitis.
Our focus was on achieving optimal delivery of 5-ASA pellets throughout the small and large intestine. We experimented with different ratios of inulin and Eudragit RS, along with varying coating levels, while monitoring drug release at different pH levels. In our results, the combination of 18% inulin and 82% Eudragit RS at a 16% coating level proved to be our best option.
The coated pellets demonstrated a significantly better therapeutic outcome compared to uncoated pellets and the brand Pentasa. This was evident in terms of the colitis activity index (CAI) and the levels of certain tissue enzymes in the colon. Our findings suggest that the inulin and Eudragit RS combination not only facilitated a controlled release of 5-ASA but showed a response to microbial degradation, which may enhance its effectiveness against ulcerative colitis.
Our focus was on achieving optimal delivery of 5-ASA pellets throughout the small and large intestine. We experimented with different ratios of inulin and Eudragit RS, along with varying coating levels, while monitoring drug release at different pH levels. In our results, the combination of 18% inulin and 82% Eudragit RS at a 16% coating level proved to be our best option.
The coated pellets demonstrated a significantly better therapeutic outcome compared to uncoated pellets and the brand Pentasa. This was evident in terms of the colitis activity index (CAI) and the levels of certain tissue enzymes in the colon. Our findings suggest that the inulin and Eudragit RS combination not only facilitated a controlled release of 5-ASA but showed a response to microbial degradation, which may enhance its effectiveness against ulcerative colitis.
Read More
9
Inulin boosts probiotic therapy effects
Study of the alleviation effects of a combination of Lactobacillus rhamnosus and inulin on mice with colitis.
Combination treatment complicates findings
We set out to explore how inulin, when combined with the probiotic Lactobacillus rhamnosus, impacts ulcerative colitis (UC) in a mouse model. In our study, mice were given a solution containing dextran sodium sulfate (DSS) to induce colitis, and then treated with different interventions over the following 28 days. These interventions included antibiotics, Lactobacillus rhamnosus alone, inulin alone, and the combination of both inulin and Lactobacillus rhamnosus.
Our findings revealed that while we did observe some positive changes in the mice treated with the combination therapy, it was challenging to pinpoint the specific effects of inulin on its own. The combination therapy helped to reduce inflammation, improve some indicators of health, and positively affected the intestinal flora by increasing the abundance of beneficial bacteria. However, it's important to note that we cannot entirely isolate the benefits attributed solely to inulin since it was always administered alongside Lactobacillus rhamnosus.
Overall, our study underscores the potential of using prebiotics like inulin to enhance probiotic therapy in managing ulcerative colitis, even though further research is necessary to fully understand the specific role of inulin alone in treating ulcers.
Our findings revealed that while we did observe some positive changes in the mice treated with the combination therapy, it was challenging to pinpoint the specific effects of inulin on its own. The combination therapy helped to reduce inflammation, improve some indicators of health, and positively affected the intestinal flora by increasing the abundance of beneficial bacteria. However, it's important to note that we cannot entirely isolate the benefits attributed solely to inulin since it was always administered alongside Lactobacillus rhamnosus.
Overall, our study underscores the potential of using prebiotics like inulin to enhance probiotic therapy in managing ulcerative colitis, even though further research is necessary to fully understand the specific role of inulin alone in treating ulcers.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Excellent for ulcers
This is a great product for burning sensations in the stomach, especially after consuming spicy food. It has effectively alleviated my discomfort and performed its job well.
8
Long-term remission
This product is excellent value compared to its competitors. I use inulin as part of a pre and probiotic regimen that has kept my severe ulcerative colitis in remission for seven years. The NOW brand offers the best value!
