Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
â€
Top Medical Research Studies
9
D-Pinitol shows promise in Alzheimer's
We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Read More
7
Our investigation focuses on the role of inositol supplementation in enhancing cognitive function in mice, particularly in the context of the ApoE2 genetic background, which is thought to provide some protective effects against Alzheimer's disease.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
Read More
Most Useful Reviews
9
Combats memory loss
Choline is crucial for human growth, development, and various bodily functions. Highest in dairy and meat, it assists nerve cells in communication. Recent studies suggest choline may combat Alzheimer's disease and improve memory. It also maintains cell structure and liver health, vital for a healthy nervous system and brain development.
Read More
9
Restores memory
Excellent! This supplement restores brain cells affected by stroke, dementia, and Alzheimer's. It effectively improves memory, and I highly recommend it.
Read More
7.5
Improves memory decline
Choline is vital for human growth, development, and maintaining healthy bodily functions. It is mainly found in dairy and meat, assisting nerve communication. Studies suggest that choline supplementation may help combat Alzheimer's disease and improve memory.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
D-Pinitol shows promise in Alzheimer's
We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Read More
7
Our investigation focuses on the role of inositol supplementation in enhancing cognitive function in mice, particularly in the context of the ApoE2 genetic background, which is thought to provide some protective effects against Alzheimer's disease.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Combats memory loss
Choline is crucial for human growth, development, and various bodily functions. Highest in dairy and meat, it assists nerve cells in communication. Recent studies suggest choline may combat Alzheimer's disease and improve memory. It also maintains cell structure and liver health, vital for a healthy nervous system and brain development.
Read More
9
Restores memory
Excellent! This supplement restores brain cells affected by stroke, dementia, and Alzheimer's. It effectively improves memory, and I highly recommend it.
Read More
7.5
Improves memory decline
Choline is vital for human growth, development, and maintaining healthy bodily functions. It is mainly found in dairy and meat, assisting nerve communication. Studies suggest that choline supplementation may help combat Alzheimer's disease and improve memory.
Read More
7.5
Supports brain function
Choline works with inositol to eliminate fat and cholesterol, entering brain cells to help transmit signals. This collaboration supports Alzheimer’s prevention and enhances memory. Inositol nourishes brain and nerve cells, breaking down fat effectively, thereby preventing accumulation-related diseases and aiding better sleep.
Read More
7.5
Memory aid
Currently in trial use. The packaging arrived in good condition, with no issues related to quality, origin, or ingredients. Choline, part of the B vitamin group, is essential for brain function, helping to reduce the occurrence of Alzheimer's and combat memory loss. It acts alongside inositol to eliminate fat and cholesterol, absorbed into the brain, facilitating nerve signals.
Read More
Frequently Asked Questions
9
Restores memory
Excellent! This supplement restores brain cells affected by stroke, dementia, and Alzheimer's. It effectively improves memory, and I highly recommend it.
6
Metabolism boost
Choline and myo-inositol are crucial vitamins that aid liver fat metabolism, prevent memory decline, and help avert cirrhosis and Alzheimer's disease.
7.5
Supports brain function
Choline works with inositol to eliminate fat and cholesterol, entering brain cells to help transmit signals. This collaboration supports Alzheimer’s prevention and enhances memory. Inositol nourishes brain and nerve cells, breaking down fat effectively, thereby preventing accumulation-related diseases and aiding better sleep.
7.5
Memory aid
Currently in trial use. The packaging arrived in good condition, with no issues related to quality, origin, or ingredients. Choline, part of the B vitamin group, is essential for brain function, helping to reduce the occurrence of Alzheimer's and combat memory loss. It acts alongside inositol to eliminate fat and cholesterol, absorbed into the brain, facilitating nerve signals.
9
Combats memory loss
Choline is crucial for human growth, development, and various bodily functions. Highest in dairy and meat, it assists nerve cells in communication. Recent studies suggest choline may combat Alzheimer's disease and improve memory. It also maintains cell structure and liver health, vital for a healthy nervous system and brain development.
7.5
Improves memory decline
Choline is vital for human growth, development, and maintaining healthy bodily functions. It is mainly found in dairy and meat, assisting nerve communication. Studies suggest that choline supplementation may help combat Alzheimer's disease and improve memory.
9
D-Pinitol shows promise in Alzheimer's
We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
7
Our investigation focuses on the role of inositol supplementation in enhancing cognitive function in mice, particularly in the context of the ApoE2 genetic background, which is thought to provide some protective effects against Alzheimer's disease.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
References
- Wang Y, Liu H, Ye Y, Fang W, Lin A, et al. ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner. Cell Commun Signal. 2025;23:112. doi:10.1186/s12964-025-02093-3
- Medina-Vera D, López-Gambero AJ, Verheul-Campos J, Navarro JA, Morelli L, et al. Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis. Nutrients. 2024;16. doi:10.3390/nu16234186
