Overview

SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Good
Based on 40 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg

Top Medical Research Studies

8
Myo-inositol enhances vitamin D effects
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.

Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).

This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
4
Inositol's impact on autoimmune thyroid
We set out to explore the effects of a combination of selenium and inositol on thyroid function and autoimmune characteristics in people with thyroid disorders. Through our systematic search spanning numerous databases, we reviewed studies published from 2007 to 2022, focusing on how these supplements influence thyroid health.

The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.

Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.

Most Useful Reviews

9
Significant improvement
144 people found this helpful
I really liked this supplement! I ordered it for my mother, who is 59 years old and suffers from frequent headaches and noise in her head due to atherosclerosis. With this supplement, she has experienced a significant improvement; her sleep has improved, and she feels much more cheerful! I wish I had found this product sooner. My mother takes DMAE in the morning and Choline in the evening. I have already ordered a second jar.
9
Health benefits
119 people found this helpful
I purchased this vitamin after a doctor's recommendation and found it to be very beneficial. I ordered it for my mother, who is 59 years old, and she has experienced significant improvement in her headaches related to atherosclerosis. She sleeps better and feels revitalised! I regret not discovering this product sooner. It has truly made a difference. I immediately ordered a second jar!
9
Improved sleep
52 people found this helpful
I ordered this supplement for my grandmother, who is 69. She suffers from frequent headaches and noise in her head due to atherosclerosis. After taking this, she reported significant improvement, having started to sleep better and feeling more invigorated! I am thrilled and only wish I had found this earlier. My grandmother takes it in the evening, and I have already ordered a second can.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
  • All Researches
Our exploration focused on how Myoinositol, often known as Myo, impacts autoimmune disorders, particularly autoimmune thyroiditis. We learned that Myo plays a crucial role in the body's thyroid function by aiding in the production of thyroid hormones and regulating iodine, which is essential in this process.

Interestingly, when Myo was combined with Selenium in treatment, patients with subclinical hypothyroidism showed significant decreases in thyroid-stimulating hormone (TSH) levels. Additionally, levels of antithyroid autoantibodies also dropped, which is promising for those battling autoimmune thyroid issues.

However, it is important to note that the study did not exclusively isolate the effect of Myoinositol, as the results were observed in conjunction with Selenium. Therefore, while the findings are encouraging, we cannot definitively claim that Myo alone yields the same benefits in managing autoimmune disorders.
8
Myo-inositol enhances vitamin D effects
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.

Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).

This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
4
Inositol's impact on autoimmune thyroid
We set out to explore the effects of a combination of selenium and inositol on thyroid function and autoimmune characteristics in people with thyroid disorders. Through our systematic search spanning numerous databases, we reviewed studies published from 2007 to 2022, focusing on how these supplements influence thyroid health.

The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.

Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
4
Myo-inositol shows inconclusive results
We explored the effects of myo-inositol as part of a treatment regimen for young women with Hashimoto's thyroiditis—an autoimmune disorder. This study primarily compared the sexual functioning and depressive symptoms of women who were untreated versus those receiving various supplements including vitamin D and selenomethionine alongside myo-inositol.

While all treatment groups showed improved sexual functioning and well-being compared to the untreated women, we observed that the greatest benefits came from those receiving vitamin D. Additionally, there were no significant differences in sexual functioning and depressive symptoms between the myo-inositol and selenomethionine treatment groups.

As a result, we must note that myo-inositol's isolated effect was not clearly determined in this study due to its combination with other treatments. Therefore, while myo-inositol is seen as part of a broader therapy, its specific influence on autoimmune disorders warrants further investigation.

User Reviews

USERS' SCORE
Good
Based on 40 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Significant improvement
144 people found this helpful
I really liked this supplement! I ordered it for my mother, who is 59 years old and suffers from frequent headaches and noise in her head due to atherosclerosis. With this supplement, she has experienced a significant improvement; her sleep has improved, and she feels much more cheerful! I wish I had found this product sooner. My mother takes DMAE in the morning and Choline in the evening. I have already ordered a second jar.
9
Health benefits
119 people found this helpful
I purchased this vitamin after a doctor's recommendation and found it to be very beneficial. I ordered it for my mother, who is 59 years old, and she has experienced significant improvement in her headaches related to atherosclerosis. She sleeps better and feels revitalised! I regret not discovering this product sooner. It has truly made a difference. I immediately ordered a second jar!
9
Improved sleep
52 people found this helpful
I ordered this supplement for my grandmother, who is 69. She suffers from frequent headaches and noise in her head due to atherosclerosis. After taking this, she reported significant improvement, having started to sleep better and feeling more invigorated! I am thrilled and only wish I had found this earlier. My grandmother takes it in the evening, and I have already ordered a second can.
7.5
Significant progress
3 people found this helpful
Great supplement! After methylprednisolone, my husband's cholesterol increased significantly, leading to a prescription for statins, which I wanted to avoid at his age (40). It seems that this increase is common for some people after the treatment. We decided to try this supplement. Not only did it normalise cholesterol, but it also proved beneficial for multiple sclerosis patients by aiding nerve impulse transmission. After a month, his total cholesterol dropped from 7.5 to 6.5, and low-density cholesterol from 5.4 to 4.7. Although still high, this progress is encouraging. He also sleeps better, is more focused, can work longer hours, and is less anxious. An excellent result! I plan on taking the supplement as well for my own nerves and well-being.
9
Calms nerves
1 people found this helpful
For two weeks of taking it, I have felt calmer and enjoyed excellent sleep; prior to this, I struggled with insomnia. Thanks to this miraculous supplement for my strong nerves!

Frequently Asked Questions

9
Reduced anxiety
4 people found this helpful
I started taking this supplement due to increased anxiety and poor sleep after my second caesarean. By the second week, I noticed I was sleeping better, thinking clearly, and no longer irritable. I’m extremely pleased and intend to order more as my body feels worn out during this winter season filled with holidays.
9
Calms nerves
1 people found this helpful
For two weeks of taking it, I have felt calmer and enjoyed excellent sleep; prior to this, I struggled with insomnia. Thanks to this miraculous supplement for my strong nerves!
7.5
Significant progress
3 people found this helpful
Great supplement! After methylprednisolone, my husband's cholesterol increased significantly, leading to a prescription for statins, which I wanted to avoid at his age (40). It seems that this increase is common for some people after the treatment. We decided to try this supplement. Not only did it normalise cholesterol, but it also proved beneficial for multiple sclerosis patients by aiding nerve impulse transmission. After a month, his total cholesterol dropped from 7.5 to 6.5, and low-density cholesterol from 5.4 to 4.7. Although still high, this progress is encouraging. He also sleeps better, is more focused, can work longer hours, and is less anxious. An excellent result! I plan on taking the supplement as well for my own nerves and well-being.
9
Significant improvement
144 people found this helpful
I really liked this supplement! I ordered it for my mother, who is 59 years old and suffers from frequent headaches and noise in her head due to atherosclerosis. With this supplement, she has experienced a significant improvement; her sleep has improved, and she feels much more cheerful! I wish I had found this product sooner. My mother takes DMAE in the morning and Choline in the evening. I have already ordered a second jar.
9
Health benefits
119 people found this helpful
I purchased this vitamin after a doctor's recommendation and found it to be very beneficial. I ordered it for my mother, who is 59 years old, and she has experienced significant improvement in her headaches related to atherosclerosis. She sleeps better and feels revitalised! I regret not discovering this product sooner. It has truly made a difference. I immediately ordered a second jar!
9
No more panic attacks
26 people found this helpful
I tend to experience panic attacks due to autonomic nervous system disorders. After switching to a supplement with choline, along with GABA and others, I haven’t had any attacks this year. I’m genuinely pleased that I can now live like a normal, healthy person, which I believe is due to this supplement.
9
Psoriasis improvement
1 people found this helpful
Good day. I purchased this to test, and I’ve been taking it for two weeks. I've noticed that my psoriatic plaques have started to disappear, and my skin looks clearer. I genuinely like it and will be ordering more!
7.5
Improved sleep quality
14 people found this helpful
I loved it! Choline and inositol pills belong to the vitamin B group. I took them alongside a vitamin B supplement for stress from 21 Century Company. The quality is excellent from Now Foods. Although the capsules have a slight plastic smell, it's not bothersome. With one pill a day after meals, the package lasts over 3 months. I suffer from sleep disorders and constant stress. After using this formula with a magnesium supplement, my sleep has improved, and I've felt more energetic. Despite still feeling a bit anxious, I’m happier than before. I'm early in the experiment but plan to continue and repurchase.
7.5
Insulin sensitivity improved
1 people found this helpful
I bought this for my mother-in-law, who has type 1 diabetes. To improve insulin sensitivity, her endocrinologist occasionally prescribes metformin. Now, she takes choline and inositol instead, consuming four capsules daily. She reports a positive effect on her insulin sensitivity, improved sleep, and overall well-being.
7.5
Improves irregular bleeding
1 people found this helpful
It assists in preparing for pregnancy and addresses irregular bleeding, which is why I ordered it. I take two in the evening and my sleep has improved. Thanks to this, I experienced relief from insomnia and a reduction in irregular bleeding.
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.

Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).

This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
4
Inositol's impact on autoimmune thyroid
We set out to explore the effects of a combination of selenium and inositol on thyroid function and autoimmune characteristics in people with thyroid disorders. Through our systematic search spanning numerous databases, we reviewed studies published from 2007 to 2022, focusing on how these supplements influence thyroid health.

The results were somewhat mixed. While our findings indicated a modest increase in levels of Triiodothyronine (T3) after using both supplements, this change was not statistically significant. However, we did observe a significant increase in Thyroxine (T4) levels and a notable decrease in Thyroid-stimulating hormone (TSH), which suggests potential positive outcomes. It's important to note that the levels of Anti-Thyroid Peroxidase Antibodies (TPOAb) did not show any significant change, and the overall improvements in T3 levels were not enough to substantiate a clear benefit.

Overall, our investigation reveals that adding inositol to selenium might not dramatically alter the thyroid's autoimmune activity. Still, the decrease in TSH and increase in T4 could hint at potential benefits that warrant further exploration. Given the limited number of studies in this area, more research will be essential to fully understand how inositol may affect autoimmune disorders related to thyroid health.
4
Myo-inositol shows inconclusive results
We explored the effects of myo-inositol as part of a treatment regimen for young women with Hashimoto's thyroiditis—an autoimmune disorder. This study primarily compared the sexual functioning and depressive symptoms of women who were untreated versus those receiving various supplements including vitamin D and selenomethionine alongside myo-inositol.

While all treatment groups showed improved sexual functioning and well-being compared to the untreated women, we observed that the greatest benefits came from those receiving vitamin D. Additionally, there were no significant differences in sexual functioning and depressive symptoms between the myo-inositol and selenomethionine treatment groups.

As a result, we must note that myo-inositol's isolated effect was not clearly determined in this study due to its combination with other treatments. Therefore, while myo-inositol is seen as part of a broader therapy, its specific influence on autoimmune disorders warrants further investigation.

References

  1. Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
  2. Yavari M, Akbari M, Ramezani Ahmadi A, Siavash Dastjerdi M, Hashemi MS. Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2024;19:269. doi:10.1080/17446651.2023.2295487
  3. Krysiak R, Kowalcze K, Szkróbka W, Okopień B. Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto's Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15122815
  4. Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
  5. Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730
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