Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Most Useful Reviews
9
Liver function support
14 people found this helpful
I've used this product for ten years following a scan revealing fatty layers in my liver, an early indication of severe liver disease. After extensive research, I discovered that choline bitartrate and inositol both help diminish fatty liver deposits. I continued taking them while maintaining my regular lifestyle, and subsequent tests have shown excellent liver health.
9
Energy boost felt
5 people found this helpful
Liver Support! It's great for my nervous system! I love complex preparations that solve multiple issues. A gastroenterologist recommended choline to restore liver function and prevent stone formation. I needed this support, as I don’t eat the healthiest diet. Moreover, it has a mild impact on my nervous system. Inositol helps regulate blood sugar, crucial as insulin resistance risk rises with age. Since taking this, the heaviness in my right side has dissipated, and I feel lighter, calm, and energetic. I'm relieved that I made a good choice.
9
ALT levels reduced
1 people found this helpful
I purchased this drug to lower ALT in the blood, as inositol can restore damaged liver cells affected by antibiotics and fatty hepatosis. After a month of use, I had a blood test revealing my ALT dropped from 120 to 45, which is nearly within the normal range.
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
User Reviews
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver function support
14 people found this helpful
I've used this product for ten years following a scan revealing fatty layers in my liver, an early indication of severe liver disease. After extensive research, I discovered that choline bitartrate and inositol both help diminish fatty liver deposits. I continued taking them while maintaining my regular lifestyle, and subsequent tests have shown excellent liver health.
9
Energy boost felt
5 people found this helpful
Liver Support! It's great for my nervous system! I love complex preparations that solve multiple issues. A gastroenterologist recommended choline to restore liver function and prevent stone formation. I needed this support, as I don’t eat the healthiest diet. Moreover, it has a mild impact on my nervous system. Inositol helps regulate blood sugar, crucial as insulin resistance risk rises with age. Since taking this, the heaviness in my right side has dissipated, and I feel lighter, calm, and energetic. I'm relieved that I made a good choice.
9
ALT levels reduced
1 people found this helpful
I purchased this drug to lower ALT in the blood, as inositol can restore damaged liver cells affected by antibiotics and fatty hepatosis. After a month of use, I had a blood test revealing my ALT dropped from 120 to 45, which is nearly within the normal range.
7.5
Calming effect
75 people found this helpful
After nearly three months of consistent intake, I've had no gastrointestinal side effects. My experience with choline has been positive; it induces a calming sensation that eases my stress while helping regulate bodily functions effectively. I've noticed improvements in my body's natural cycles without adverse effects, making it a beneficial supplement.
6
Improved health
11 people found this helpful
I completed my course, primarily for the emulsifying action of choline, which helps discharge triglycerides from blood vessels. I noticed better clarity in thought, and it has become an essential supplement for managing my saliva and improving visibility during depressive episodes. I'm taking it with my husband, who has also felt the benefits.
Frequently Asked Questions
9
ALT levels reduced
1 people found this helpful
I purchased this drug to lower ALT in the blood, as inositol can restore damaged liver cells affected by antibiotics and fatty hepatosis. After a month of use, I had a blood test revealing my ALT dropped from 120 to 45, which is nearly within the normal range.
7.5
Calming effect
75 people found this helpful
After nearly three months of consistent intake, I've had no gastrointestinal side effects. My experience with choline has been positive; it induces a calming sensation that eases my stress while helping regulate bodily functions effectively. I've noticed improvements in my body's natural cycles without adverse effects, making it a beneficial supplement.
2
No changes noticed
I started taking this to control high cholesterol. I haven't seen any noticeable changes yet, so I'm continuing with it. I won't know the results until my next blood test during my health check, so I will provide an update if there are any changes then.
9
Liver function support
14 people found this helpful
I've used this product for ten years following a scan revealing fatty layers in my liver, an early indication of severe liver disease. After extensive research, I discovered that choline bitartrate and inositol both help diminish fatty liver deposits. I continued taking them while maintaining my regular lifestyle, and subsequent tests have shown excellent liver health.
9
Energy boost felt
5 people found this helpful
Liver Support! It's great for my nervous system! I love complex preparations that solve multiple issues. A gastroenterologist recommended choline to restore liver function and prevent stone formation. I needed this support, as I don’t eat the healthiest diet. Moreover, it has a mild impact on my nervous system. Inositol helps regulate blood sugar, crucial as insulin resistance risk rises with age. Since taking this, the heaviness in my right side has dissipated, and I feel lighter, calm, and energetic. I'm relieved that I made a good choice.
7.5
Overall wellbeing
5 people found this helpful
Life-changing—it took just one bottle of two capsules daily for noticeable improvements in my mood and brain function. I feel more energetic, and my PMS symptoms have significantly reduced. This is essential for anyone with PCOS. I've lost weight and curbed unhealthy cravings while hoping my blood test shows better cholesterol levels soon.
0
Dangerous side effects
11 people found this helpful
This product proved dangerous for me. While taking it alongside Now L-methionine, my blood pressure fell too low. I struggled to maintain my balance upon waking, fearing I would fall or faint. It's a perilous liver detoxifier.
7.5
Blood sugar control
7 people found this helpful
I genuinely believe this supplement aids my cognitive functions and helps regulate my blood sugar. It's invaluable for managing my PCOS without weight gain. Combined with fish oil, it contributes significantly to overcoming my long-standing depression. I highly recommend it.
7.5
Improved blood flow
1 people found this helpful
Bright mind! Clear mind. Choline normalises fat metabolism and aids in weight reduction. Inositol activates lipid metabolism, making it vital for athletes. Also, inositol helps maintain blood vessel elasticity, thinning blood and preventing blood clot formation in the body.
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
References
- Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, et al. A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. J Thromb Haemost. 2019;17:2110. doi:10.1111/jth.14606
