Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 11 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
8
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
9
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Most Useful Reviews
9
Restored normal breathing
220 people found this helpful
After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, with one nostril often blocked. However, my nose eventually began to breathe! I could finally perceive all the scents while walking down the street—the aroma of grass and flowers. At home, I even detected the smell of shower gel! What a joy it is to breathe normally! Thank you!!
9
Restored sense of smell
1 people found this helpful
After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, one nostril often blocked. But my nose finally began to breathe! I could once again enjoy the scents while strolling, like grass and flowers, and even detected the scent of shower gel at home! What happiness it is to breathe normally! Thank you! I advise those with similar issues to seek help!
7.5
Family health boost
I took this for my mother, and everything was fine. I also give it to my children, and I drink it myself during colds. I recommend it!
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
- All Researches
9
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
9
We explored how myo-inositol oxygenase (MIOX), an important enzyme, might help alfalfa, a type of forage crop, adapt to challenging cold conditions. The study identified ten MsMIOX genes in the alfalfa genome, which were found distributed across three chromosomes.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
Through analysis, we noted that these genes exhibited similarities in structure and conserved features, hinting at a functional role important for the plant's survival under stress.
Our qRT-PCR tests showed that different MsMIOX genes could be triggered by cold and other abiotic stress factors like drought and salinity. Notably, the activity of MIOX in alfalfa significantly increased under these harsh conditions.
By overexpressing the MsMIOX2 gene in yeast, we found that it notably enhanced resistance to cold stresses. Additionally, when MsMIOX2 was overexpressed in alfalfa’s hairy roots, it reduced reactive oxygen species and improved the plant's resilience against cold.
This study provides valuable insights into how inositol plays a part in helping alfalfa thrive even in cold weather, presenting a candidate for future efforts to enhance the plant’s stress tolerance.
9
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
8
We examined how inositol, a key component in the production of raffinose, plays a role in helping sugar beet plants withstand cold stress. In the study, researchers identified the vacuolar inositol transporter BvINT1;1, which seems to be critical for the synthesis of raffinose under chilly conditions.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
When plants were exposed to cold, BvINT1;1 was found to be highly active, ensuring adequate inositol was available for raffinose production. Interestingly, sugar beet mutants that lacked functional BvINT1;1 not only had higher levels of inositol but also lower amounts of raffinose when subjected to cold stress.
This reduction in raffinose was significant because raffinose can help neutralize harmful reactive oxygen species (ROS), which accumulate when plants are stressed. As a result, these mutants showed increased expression of genes related to ROS, pointing out a potential risk for them during cold weather.
Overall, our findings suggest that the transporter BvINT1;1 is not just about moving inositol; it plays a vital role in boosting the plant's cold resilience by facilitating raffinose biosynthesis and maintaining balance against oxidative stress.
8
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restored normal breathing
220 people found this helpful
After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, with one nostril often blocked. However, my nose eventually began to breathe! I could finally perceive all the scents while walking down the street—the aroma of grass and flowers. At home, I even detected the smell of shower gel! What a joy it is to breathe normally! Thank you!!
9
Restored sense of smell
1 people found this helpful
After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, one nostril often blocked. But my nose finally began to breathe! I could once again enjoy the scents while strolling, like grass and flowers, and even detected the scent of shower gel at home! What happiness it is to breathe normally! Thank you! I advise those with similar issues to seek help!
7.5
Family health boost
I took this for my mother, and everything was fine. I also give it to my children, and I drink it myself during colds. I recommend it!
7.5
Reduced cold susceptibility
After taking the supplement for a while, the effect is clear: I'm not as prone to catching a cold anymore. My face feels smoother too. The packaging is excellent, the quality is high, and the ingredient list is very clean.
7.5
Reduced cold frequency
57 people found this helpful
I have been taking the NOW Foods Choline and Inositol supplement for about a month. I've noticed it invigorates and boosts my performance. After starting the supplement, I have more energy and concentration, managing mentally demanding work better. I've also experienced fewer colds, and my chronic fatigue syndrome has improved, along with better liver health and cholesterol levels. My sleep has normalised as well. I find this supplement effective and recommend consulting a doctor before usage.
Frequently Asked Questions
7.5
Reduced cold frequency
57 people found this helpful
I have been taking the NOW Foods Choline and Inositol supplement for about a month. I've noticed it invigorates and boosts my performance. After starting the supplement, I have more energy and concentration, managing mentally demanding work better. I've also experienced fewer colds, and my chronic fatigue syndrome has improved, along with better liver health and cholesterol levels. My sleep has normalised as well. I find this supplement effective and recommend consulting a doctor before usage.
9
Improved immunity
My self-esteem has improved, and my immune system feels stronger. I recovered from the cold quite easily. Admittedly, I do take several other B vitamins.
7.5
Effective liver support
I've been taking the NOW Foods Choline and Inositol supplement for a month. I have observed more energy and better concentration. It helps noticeably reduce colds and fatigue while improving my overall well-being and liver health. My cholesterol levels and liver fat have also improved. Sleep has normalised, making me very satisfied. Consultation with a doctor is advisable, but I suggest it to others as well!
6
Quality vitamin supplement
I've been taking the NOW Foods Choline & Inositol supplement for about a month. It's invigorating and enhances performance. After starting it, I've gained more energy and focus, leading to fewer colds. My chronic fatigue has improved, as well as my overall health and liver function. I recommend checking with a doctor, but I find this supplement excellent! The capsules are small and easy to consume without any taste.
9
Restored normal breathing
220 people found this helpful
After frequent colds, my sense of smell decreased—it didn't vanish, merely dulled, with one nostril often blocked. However, my nose eventually began to breathe! I could finally perceive all the scents while walking down the street—the aroma of grass and flowers. At home, I even detected the smell of shower gel! What a joy it is to breathe normally! Thank you!!
7.5
Recommended supplements
My sister encouraged me to take numerous supplements when I had a cold, and the effect was quite evident. I will definitely purchase it again.
9
We explored the effects of myo-inositol and corn steep liquor (CSL) on cucumber and tomato seedlings, particularly focusing on their ability to withstand cold temperatures. Through our research, we found that applying these substances led to noticeable improvements in seedling growth during low-temperature stress.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
Our treatments not only increased the levels of photosynthetic pigments, enhancing photosynthesis, but also reduced harmful compounds like malondialdehyde (MDA) and electrolyte leakage. This suggests that the combination of inositol and CSL helps to protect plant cells under stress.
Additionally, we confirmed these findings by analyzing the expression of important genes that relate to cold tolerance in cucumbers. The most effective mix we identified was 0.6 mL L of CSL together with 72 mg L of myo-inositol. Overall, this study gives us valuable insights into how we can use inositol and maize leachate to foster early growth in crops and improve their resilience against cold weather.
8
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
8
We delved into the fascinating world of white water lilies and their remarkable ability to withstand cold temperatures. This study aimed to understand how certain compounds, particularly myo-inositol, contribute to the plant's cold resilience.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
Through a comprehensive examination, we learned that the water lily effectively copes with winter by entering a state called ecodormancy. During this time, the plant reallocates resources and enhances its defenses against cold stress.
One of our key findings was the significance of myo-inositol. This compound helps bolster the plant’s cold tolerance, although it works alongside various other factors. It plays a role in regulating metabolic activities, especially in relation to amino acids, which are crucial for overcoming chilly conditions.
Although our study highlighted the importance of myo-inositol, it did not isolate its effects from other treatments, which limits our understanding of its specific impact. Nevertheless, the insights we gained about the water lily’s adaptive strategies provide valuable information for future agricultural practices in cold climates.
9
We explored how low red to far-red light ratios influence cold tolerance in tomato plants. The focus was on two key proteins, SlFHY3 and SlHY5, which play a role in increasing the accumulation of myo-inositol, a compound linked with cold resistance.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
Our findings revealed that when tomato plants experienced low light ratios, it encouraged the production of SlFHY3 under cold stress. Knocking out this gene led to lower myo-inositol levels and made the plants more vulnerable to cold, while overexpressing it had the opposite effect.
Moreover, we found that SlFHY3 works closely with SlHY5 to boost writing activity for a particular gene involved in myo-inositol synthesis. This interaction is crucial, as it significantly enhances both myo-inositol levels and the plants' ability to withstand cold conditions. Without these proteins or the inositol synthesis gene, the cold resistance we observed was diminished.
Ultimately, our study shines a light on the important relationship between light signals, inositol accumulation, and cold tolerance in tomatoes, unveiling how plants manage environmental stress.
References
- Berg J, Rodrigues CM, Scheid C, Pirrotte Y, Picco C, et al. The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet. Plant Cell Environ. 2025. doi:10.1111/pce.15367
- Sun S, Zhang X, Wang C, Yu Q, Yang H, et al. Combined application of myo-inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato. Physiol Plant. 2024;176:e14422. doi:10.1111/ppl.14422
- Qiu P, Liu T, Xu Y, Ye C, Zhang R, et al. Multi-omic dissection of the cold resistance traits of white water lily. Hortic Res. 2024;11:uhae093. doi:10.1093/hr/uhae093
- Guo W, Yu D, Zhang R, Zhao W, Zhang L, et al. Genome-wide identification of the myo-inositol oxygenase gene family in alfalfa (Medicago sativa L.) and expression analysis under abiotic stress. Plant Physiol Biochem. 2023;200:107787. doi:10.1016/j.plaphy.2023.107787
- Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. doi:10.3389/fpls.2022.775692
- Wang F, Wang X, Zhang Y, Yan J, Ahammed GJ, et al. SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. New Phytol. 2022;233:2127. doi:10.1111/nph.17934
