Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
9
IP6 improves cholesterol levels
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
9
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
9
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Most Useful Reviews
9
Effective cholesterol reduction
13 people found this helpful
The supplement helped me lower my cholesterol. I took 2 capsules daily, and within a month and a half, my cholesterol dropped from 230 to 170.
9
Recommended for health
4 people found this helpful
This is the best product I have tried. It is excellent for those with insulin resistance or high cholesterol. I highly recommend it for its positive effects on health.
9
Normalised cholesterol
3 people found this helpful
This medication was taken by my mother to reduce her bad cholesterol (LDL). After two months, her cholesterol levels returned to normal. I recommend this complex to anyone with high cholesterol; don’t immediately resort to antiquities. Generally, this is sufficient. My dad also successfully lowered his cholesterol in the same way two years ago.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
- All Researches
9
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
9
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
9
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
9
IP6 improves cholesterol levels
We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.
8
Myo-inositol reduces cholesterol levels
We wanted to understand how myo-inositol (MI), a compound found in many foods, influences cholesterol levels and overall metabolic health in db/db mice, a commonly used model for type 2 diabetes. Our findings revealed that providing MI significantly reduced high cholesterol and triglyceride levels in these mice, making a noticeable impact on their lipid profiles.
In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.
Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.
Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
User Reviews
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective cholesterol reduction
13 people found this helpful
The supplement helped me lower my cholesterol. I took 2 capsules daily, and within a month and a half, my cholesterol dropped from 230 to 170.
9
Recommended for health
4 people found this helpful
This is the best product I have tried. It is excellent for those with insulin resistance or high cholesterol. I highly recommend it for its positive effects on health.
9
Normalised cholesterol
3 people found this helpful
This medication was taken by my mother to reduce her bad cholesterol (LDL). After two months, her cholesterol levels returned to normal. I recommend this complex to anyone with high cholesterol; don’t immediately resort to antiquities. Generally, this is sufficient. My dad also successfully lowered his cholesterol in the same way two years ago.
9
Normalised cholesterol
2 people found this helpful
I highly recommend this supplement for those needing to normalise cholesterol, alleviate intestinal issues, and enhance memory.
9
Cholesterol decrease
2 people found this helpful
It greatly helped to lower my cholesterol from the first course. The benefits are substantial; my cholesterol decreased. I've started the second course, and the composition is excellent, with well-selected ingredients. The neutral taste is agreeable since it’s in capsule form. I adhere to the instructions and appreciate the manufacturers for this product!
Frequently Asked Questions
9
Effective cholesterol reduction
13 people found this helpful
The supplement helped me lower my cholesterol. I took 2 capsules daily, and within a month and a half, my cholesterol dropped from 230 to 170.
9
Normalised cholesterol
3 people found this helpful
This medication was taken by my mother to reduce her bad cholesterol (LDL). After two months, her cholesterol levels returned to normal. I recommend this complex to anyone with high cholesterol; don’t immediately resort to antiquities. Generally, this is sufficient. My dad also successfully lowered his cholesterol in the same way two years ago.
0
No noticeable effect
1 people found this helpful
Unfortunately, this product did not work for me. After finishing the jar of choline and inositol, I noticed no changes at all. In fact, my cholesterol levels increased, showing no effect on my body.
9
Reduced triglycerides
1 people found this helpful
I had high triglycerides with no prescription option to lower them. After using this product twice daily, my triglycerides are now lower, and my cholesterol is around 135!
9
Recommended for health
4 people found this helpful
This is the best product I have tried. It is excellent for those with insulin resistance or high cholesterol. I highly recommend it for its positive effects on health.
7.5
Effective combination treatment
1 people found this helpful
Cholinergic antagonists block cholinergic receptors, impacting organ functions. I used this drug on Dr. Derek's advice to lower cholesterol and found it effective in conjunction with selimarin. I recommend taking one tablet daily.
6
Quality ingredients noted
Inositol has many benefits, and choline does too, but separately. This brand has high-quality ingredients, and while the effects are good, I believe they work better apart.
7.5
Enhances energy levels
5 people found this helpful
Choline and inositol are part of the B vitamins. These vitamins enhance each other's effects, aiding the liver in overcoming fatty hepatosis, returning cholesterol levels to normal, improving mental clarity, and enhancing efficiency. I recommend this to everyone; it’s exceptionally beneficial.
4
No improvement seen
After taking Choline & Inositol for over two years for my fatty liver, I saw no improvement at this dosage. I was advised to take over 5 grams for effectiveness, but I'm reluctant to experiment with such high dosages. I even noticed a fishy smell when using the bathroom, making the experience feel like a waste of money.
9
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
7
Inositol's cholesterol effects unclear
We explored the effects of combining metformin with two forms of inositol—myoinositol and D-chiro-inositol—on high cholesterol levels in women with polycystic ovary syndrome (PCOS). This study involved 72 participants who were randomly assigned to either metformin alone or the combination therapy for six months.
While we did observe significant improvements in other areas, such as cycle regularity and various hormonal levels, the specific impact of inositol on cholesterol was less clear. For instance, the combination therapy resulted in notable changes in average cholesterol and other metabolic parameters, but it’s important to highlight that the isolated effect of inositol on cholesterol was not explicitly measured.
Our findings suggest that while there are some benefits to this combined treatment, further research is necessary to fully understand how effective inositol alone might be on cholesterol management in women with PCOS.
While we did observe significant improvements in other areas, such as cycle regularity and various hormonal levels, the specific impact of inositol on cholesterol was less clear. For instance, the combination therapy resulted in notable changes in average cholesterol and other metabolic parameters, but it’s important to highlight that the isolated effect of inositol on cholesterol was not explicitly measured.
Our findings suggest that while there are some benefits to this combined treatment, further research is necessary to fully understand how effective inositol alone might be on cholesterol management in women with PCOS.
8
Myo-inositol reduces cholesterol levels
We wanted to understand how myo-inositol (MI), a compound found in many foods, influences cholesterol levels and overall metabolic health in db/db mice, a commonly used model for type 2 diabetes. Our findings revealed that providing MI significantly reduced high cholesterol and triglyceride levels in these mice, making a noticeable impact on their lipid profiles.
In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.
Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
In addition to lowering cholesterol levels, MI improved insulin resistance, suggesting it might offer a dual benefit for those struggling with metabolic disorders. Interestingly, while MI showed promising effects on cholesterol and glucose levels, it did not help with obesity in the treated mice.
Overall, our study highlights myo-inositol as a potential adjunct therapy for managing high cholesterol and related metabolic challenges in diabetes. These results indicate that incorporating this accessible compound into dietary strategies might benefit patients dealing with these issues.
8
Myo-inositol's limited cholesterol impact
We aimed to investigate how myo-inositol (MI) supplementation impacts metabolic parameters and specifically cholesterol levels in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In a controlled study with 92 participants, these individuals received treatment for eight weeks, divided among four groups—one receiving MI, another α-lipoic acid (ALA), a third group using propolis, and a control group.
Throughout the trial, we closely monitored the participants' cholesterol levels alongside other metabolic markers. Our results indicated that while HDL (good cholesterol) and LDL (bad cholesterol) levels improved in those taking myo-inositol, the differences compared to other groups were not statistically significant.
In essence, while we noted favorable trends in cholesterol levels, myo-inositol alone did not display a direct and substantial impact when compared to the other interventions tested. It’s important to approach these findings with a balanced perspective, recognizing the overall benefits of dietary recommendations alongside MI and the notable improvements in liver health linked to these treatments.
Throughout the trial, we closely monitored the participants' cholesterol levels alongside other metabolic markers. Our results indicated that while HDL (good cholesterol) and LDL (bad cholesterol) levels improved in those taking myo-inositol, the differences compared to other groups were not statistically significant.
In essence, while we noted favorable trends in cholesterol levels, myo-inositol alone did not display a direct and substantial impact when compared to the other interventions tested. It’s important to approach these findings with a balanced perspective, recognizing the overall benefits of dietary recommendations alongside MI and the notable improvements in liver health linked to these treatments.
References
- Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009
- Xu Y, Gong Y, Li S, Zhou Y, Ma Z, et al. Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass (). Aquac Nutr. 2024;2024:9944159. doi:10.1155/2024/9944159
- Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, et al. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024;16. doi:10.3390/nu16020249
- Nani A, Bertuzzi F, Meneghini E, Mion E, Pintaudi B. Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. J Clin Med. 2023;12. doi:10.3390/jcm12247650
- Tutunchi H, Arefhosseini S, Ebrahimi-Mameghani M. Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial. Clin Nutr ESPEN. 2023;54:412. doi:10.1016/j.clnesp.2023.02.016
- Yang Q, Zhang Y, Li L, Li J, Li Y, et al. D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition. Food Funct. 2022;13:7192. doi:10.1039/d2fo00869f
- Bahadur A, Arora H, Ravi AK, Naithani M, Bahurupi Y, et al. Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Cureus. 2021;13:e15510. doi:10.7759/cureus.15510
- Derosa G, D'Angelo A, Vanelli A, Maffioli P. An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes Metab Syndr Obes. 2020;13:653. doi:10.2147/DMSO.S232791
- Choi MS, Lee MK, Jung UJ, Kim HJ, Do GM, et al. Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet. Mol Nutr Food Res. 2009;53:751. doi:10.1002/mnfr.200800241
- Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. doi:10.1016/j.nutres.2008.07.003
