Curcumin Phytosome(Turmeric Rhizome Extract (curcuma longa)/Phosphatidyl Choline Complex) (Meriva® Turmeric Phytosome)(Standardized to min. 18% Curcuminoids - 90 mg)
500 mg
**
Top Medical Research Studies
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Read More
9
Curcumin enhances blood clot resolution
Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.
We explored the potential benefits of curcumin, the active compound in turmeric, in helping to resolve blood clots, particularly in cases of deep venous thrombosis (DVT). The study investigated whether curcumin could support the natural process of venous thrombi resolution, a crucial aspect of managing DVT.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Read More
9
Tetrahydrocurcumin reduces blood clotting
Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth.
We explored the effects of tetrahydrocurcumin (THC), a major metabolite of turmeric's active compound, curcumin, on blood clot formation and platelet behavior. Our focus was on how THC influences platelet granule secretion and thrombus growth, crucial factors in atherothrombosis.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
Read More
Most Useful Reviews
7.5
Liver benefits
2 people found this helpful
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
Read More
7.5
Improves joint mobility
1 people found this helpful
"Curcumin phytosome, derived from enhanced turmeric root extract, has a tonic and antioxidant effect. It improves blood composition and reduces viscosity, lowering the risk of blood clots. My mother, who has diabetes, finds it suitable. While I cannot assess its effect immediately, it has improved her joint mobility."
Read More
8.5
Effective anti-inflammatory
"Curcumin is a fantastic supplement, an excellent anti-inflammatory that promotes blood thinning."
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Read More
9
Tetrahydrocurcumin reduces blood clotting
Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth.
We explored the effects of tetrahydrocurcumin (THC), a major metabolite of turmeric's active compound, curcumin, on blood clot formation and platelet behavior. Our focus was on how THC influences platelet granule secretion and thrombus growth, crucial factors in atherothrombosis.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
Read More
9
Curcumin enhances blood clot resolution
Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.
We explored the potential benefits of curcumin, the active compound in turmeric, in helping to resolve blood clots, particularly in cases of deep venous thrombosis (DVT). The study investigated whether curcumin could support the natural process of venous thrombi resolution, a crucial aspect of managing DVT.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
Read More
8
Curcumin's role in clot prevention
The regulatory role of curcumin on platelet functions.
We explored how curcumin, the active component found in turmeric, can influence blood clotting. This powerful phytochemical has been traditionally used as a spice and herbal remedy for its various health benefits, especially in Asian cultures. Recent studies highlighted curcumin's potential effects on platelet function, hinting at its promise in treating conditions like thrombosis and inflammatory diseases.
Our investigation shows that curcumin might help improve platelet dysfunction, a condition that could lead to cardiovascular disease. Through several studies, we've observed that curcumin demonstrates antiplatelet activity, meaning it can help prevent excessive clotting. As we sift through the evidence, it becomes clear that curcumin serves as a fascinating candidate for addressing issues related to blood clotting.
While the data is promising, it is essential to acknowledge that more comprehensive and controlled trials are necessary to confirm these findings fully. However, the results we've examined suggest curcumin could be a valuable ally in maintaining healthy platelet function and potentially reducing the risk of clots.
Read More
8
Curcumin's role in clotting
Curcumin, hemostasis, thrombosis, and coagulation.
The study we reviewed delves into the effectiveness of curcumin, a compound derived from turmeric, on blood clotting processes. It highlights that curcumin is well-known for its safe, non-toxic properties and has been used in various alternative medicine practices.
We discovered that curcumin exhibits several beneficial effects on cardiovascular health, particularly in terms of managing hemostasis and coagulation. The research indicates that curcumin may possess anti-inflammatory and antithrombotic properties, which could positively influence how platelets behave during clot formation.
The findings suggest that curcumin could play a role in the prevention of cardiovascular diseases related to blood clotting. This opens up interesting possibilities for using turmeric as a natural approach to support heart health.
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
Read More
7.5
Improves joint mobility
1 people found this helpful
"Curcumin phytosome, derived from enhanced turmeric root extract, has a tonic and antioxidant effect. It improves blood composition and reduces viscosity, lowering the risk of blood clots. My mother, who has diabetes, finds it suitable. While I cannot assess its effect immediately, it has improved her joint mobility."
Read More
8.5
Effective anti-inflammatory
"Curcumin is a fantastic supplement, an excellent anti-inflammatory that promotes blood thinning."
Read More
9
Thrombosis prevention
"For information - curcumin is excellent against thrombosis and does not affect blood formula; there is no bleeding from it."
Read More
8
Regulates blood sugar
"This bioavailable form really regulates blood sugar and relieves inflammation in arthritis with prolonged use."
Read More
Frequently Asked Questions
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Turmeric curcumin is a natural compound derived from the root of the turmeric plant (Curcuma longa), a spice commonly used in cooking, particularly within Indian cuisine. Curcumin is the primary active ingredient in turmeric, known for its bright yellow color and various health benefits. It boasts strong anti-inflammatory and antioxidant properties, which have made it popular in both culinary practices and dietary supplements. Many people incorporate turmeric curcumin into their diets in order to support overall health, alleviate joint pain, and bolster immune function.
In recent years, turmeric curcumin has gained attention in the wellness community, leading to the production of numerous supplements that isolate this powerful compound. When considering turmeric curcumin supplements, it's essential to note that curcumin is poorly absorbed by the body on its own, so many products include added black pepper extract (piperine) to enhance absorption. As the potential health benefits and culinary uses of turmeric curcumin continue to be explored, a growing number of consumers are incorporating it into their lifestyles for its perceived benefits. However, as with any supplement, it's advisable to consult with a healthcare professional before starting a new regimen.
Turmeric, particularly its active compound curcumin, has been widely studied for its potential health benefits, including anti-inflammatory and antioxidant properties. While some research suggests that curcumin may have effects on blood circulation and could potentially help in reducing the risk of blood clot formation, the evidence is not definitive. Several studies indicate that curcumin can inhibit platelet activation and reduce the aggregation of platelets, which are crucial factors in blood clotting. However, these effects are generally observed in controlled laboratory settings rather than in large-scale clinical trials on humans.
If you're considering using turmeric or curcumin supplements for blood clot prevention or treatment, it is vital to consult with a healthcare professional. They can provide guidance tailored to your specific health needs and conditions, particularly if you are currently on blood-thinning medications or have existing health issues related to blood coagulation. It's essential to approach the use of turmeric and its compounds as a complementary strategy, rather than a substitute for conventional medical treatments.
Based on user reviews, the timeline for seeing results from curcumin phytosome supplements, particularly for blood clot-related concerns, can vary. Some users have noted improvements in blood composition and reduced viscosity over time, although specific timeframes are not consistently detailed. For instance, a reviewer mentions that while they cannot assess the immediate effects, they have observed improvements in joint mobility after prolonged use Read Review. This suggests that while you may not see immediate benefits, consistent use over several weeks may lead to positive outcomes.
Additionally, other reviews highlight curcumin's anti-inflammatory properties and its role in promoting blood thinning, which could indicate that its effects may be more pronounced with regular consumption over time Read Review. However, it is essential to remember that individual responses to supplements can differ widely, so results may depend on various factors, including diet, lifestyle, and the underlying condition being addressed.
Curcumin, the active compound in turmeric, has garnered attention for its potential benefits in managing blood clotting. Research indicates that curcumin can inhibit platelet aggregation, which is crucial in forming blood clots. A study showed that curcumin significantly suppressed platelet aggregation when triggered by amyloid peptides related to Alzheimer's disease, suggesting a targeted approach to managing clotting responses in specific contexts [1]. Furthermore, another investigation emphasized its antiplatelet activity, indicating it could prevent excessive clotting—something particularly beneficial for cardiovascular health [5].
Additionally, tetrahydrocurcumin (THC), a metabolite of curcumin, demonstrated promising effects on reducing clot formation in laboratory settings and animal models, indicating its potential as a safer alternative for managing blood clots without increasing bleeding time [2]. Other studies have also highlighted curcumin’s role in promoting angiogenesis, which aids in the resolution of blood clots, particularly in cases of deep venous thrombosis [3]. Overall, while the existing research is promising, further comprehensive studies are needed to conclusively establish curcumin and turmeric's role in managing blood clot conditions.
Users report a variety of symptom improvements associated with curcumin phytosome supplements, particularly highlighting their potential health benefits. Many users have noted enhanced liver function, intestinal health, and respiratory support as a result of the supplement's superior absorption capabilities, which can be attributed to its formulation with PhosphatidylCholine Read Review. Additionally, individuals have experienced benefits such as improved blood composition and viscosity reduction, potentially lowering the risk of blood clots Read Review.
Moreover, users have shared personal anecdotes regarding joint mobility improvements and anti-inflammatory effects linked to consistent use of curcumin. For instance, one reviewer emphasized the supplement's effectiveness in relieving arthritis symptoms and regulating blood sugar over time Read Review. However, it's essential to note that individual results can vary significantly depending on factors such as underlying health conditions and lifestyle choices.
Users report positive experiences when combining curcumin phytosome supplements with other supplements for managing blood coagulation concerns. Many highlight that curcumin not only provides anti-inflammatory benefits but also promotes blood thinning, potentially contributing to improved blood composition and lower viscosity, thus reducing the risk of blood clots Read Review. Additionally, a user noted the effectiveness of curcumin against thrombosis without causing bleeding, suggesting a safe profile for those wary of blood thinning remedies Read Review.
Moreover, users have shared that the superior absorption of curcumin phytosome, due to its formulation with PhosphatidylCholine, enhances its efficacy, potentially allowing it to work synergistically with other supplements aimed at improving overall vascular health Read Review. However, individual responses can vary, and some users emphasize the need for a careful approach when integrating multiple supplements, underscoring the importance of monitoring how the body reacts over time for optimal benefits.
Based on user reviews, there is a noted effectiveness of Turmeric Curcumin, particularly in its phytosome form, for treating blood clot issues. Users report that Curcumin phytosome significantly improves blood composition while also reducing blood viscosity, which may lower the risk of blood clots Read Review. Additionally, it has been highlighted that curcumin acts as a fantastic anti-inflammatory agent that promotes blood thinning Read Review.
Moreover, users have suggested that curcumin is effective against thrombosis without negatively impacting overall blood formula, indicating it does not cause bleeding Read Review. However, specifics regarding the exact right dose for treating blood clots were not detailed in the reviews provided. It seems that while users find Curcumin beneficial, more targeted dosage information would be needed for definitive recommendations.
7.5
Improves joint mobility
1 people found this helpful
"Curcumin phytosome, derived from enhanced turmeric root extract, has a tonic and antioxidant effect. It improves blood composition and reduces viscosity, lowering the risk of blood clots. My mother, who has diabetes, finds it suitable. While I cannot assess its effect immediately, it has improved her joint mobility."
8.5
Effective anti-inflammatory
"Curcumin is a fantastic supplement, an excellent anti-inflammatory that promotes blood thinning."
7.5
Liver benefits
2 people found this helpful
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
8
Regulates blood sugar
"This bioavailable form really regulates blood sugar and relieves inflammation in arthritis with prolonged use."
9
Thrombosis prevention
"For information - curcumin is excellent against thrombosis and does not affect blood formula; there is no bleeding from it."
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
8
Curcumin's role in clot prevention
The regulatory role of curcumin on platelet functions.
We explored how curcumin, the active component found in turmeric, can influence blood clotting. This powerful phytochemical has been traditionally used as a spice and herbal remedy for its various health benefits, especially in Asian cultures. Recent studies highlighted curcumin's potential effects on platelet function, hinting at its promise in treating conditions like thrombosis and inflammatory diseases.
Our investigation shows that curcumin might help improve platelet dysfunction, a condition that could lead to cardiovascular disease. Through several studies, we've observed that curcumin demonstrates antiplatelet activity, meaning it can help prevent excessive clotting. As we sift through the evidence, it becomes clear that curcumin serves as a fascinating candidate for addressing issues related to blood clotting.
While the data is promising, it is essential to acknowledge that more comprehensive and controlled trials are necessary to confirm these findings fully. However, the results we've examined suggest curcumin could be a valuable ally in maintaining healthy platelet function and potentially reducing the risk of clots.
9
Tetrahydrocurcumin reduces blood clotting
Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth.
We explored the effects of tetrahydrocurcumin (THC), a major metabolite of turmeric's active compound, curcumin, on blood clot formation and platelet behavior. Our focus was on how THC influences platelet granule secretion and thrombus growth, crucial factors in atherothrombosis.
In laboratory settings, we observed that THC significantly reduced the release of substances that promote clot formation, such as CD62P and CD63, as well as platelet factor 4 and adenosine triphosphate. The mechanism behind this involves THC downregulating specific pathways that trigger the activation of enzymes involved in thromboxane A2 (TxA) production—a key player in platelet activation and clotting.
When tested in mice with induced thrombosis, THC showed potent inhibitory effects on clot formation without increasing bleeding time, suggesting it could be a safer alternative to other treatments. Interestingly, we found that THC worked effectively alongside aspirin, a common blood thinner, without diminishing its effects.
Overall, our findings suggest that tetrahydrocurcumin has promising potential as a cardioprotective agent, particularly in managing blood clot risks.
9
Curcumin enhances blood clot resolution
Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.
We explored the potential benefits of curcumin, the active compound in turmeric, in helping to resolve blood clots, particularly in cases of deep venous thrombosis (DVT). The study investigated whether curcumin could support the natural process of venous thrombi resolution, a crucial aspect of managing DVT.
Using various laboratory techniques, including immunofluorescence staining and microarray analysis, we assessed how curcumin affects angiogenesis—the creation of new blood vessels—that is essential for thrombus resolution. We found that curcumin significantly enhances the therapeutic angiogenesis process, aiding in the recovery of affected tissues.
Interestingly, we also observed that curcumin led to a decrease in the expression of a specific microRNA, miR-499, which is connected to the regulation of a protein known as PTEN. This suggests a mechanism whereby curcumin promotes healing by modulating important signaling pathways involved in blood vessel formation and repair.
Overall, our findings indicate that curcumin could be an effective natural treatment for enhancing the body's ability to resolve blood clots through promoting therapeutic angiogenesis. This discovery opens new avenues for DVT treatment strategies that could be more effective than traditional methods.
References
Rustichelli S, Lanni C, Zarà M, Guidetti GF, Torti M, et al. Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients. Nutrients. 2024;16. doi:10.3390/nu16244419
Li W, Ma Y, Zhang C, Chen B, Zhang X, et al. Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth. Thromb Haemost. 2022;122:739. doi:10.1055/s-0041-1735192
Wang T, Guan R, Xia F, Du J, Xu L. Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499. Microvasc Res. 2021;136:104148. doi:10.1016/j.mvr.2021.104148
Song S, Gu LY, Xu JG, Cui XB, DU SL, et al. [UFLC-Q-TOF-MS fingerprints of rhizome of Curcuma phaeocaulis and its vinegar processed products and inhibitory effect on thrombosis]. Zhongguo Zhong Yao Za Zhi. 2019;44:2511. doi:10.19540/j.cnki.cjcmm.20190321.310
Tabeshpour J, Hashemzaei M, Sahebkar A. The regulatory role of curcumin on platelet functions. J Cell Biochem. 2018;119:8713. doi:10.1002/jcb.27192
Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. J Cell Physiol. 2018;233:4497. doi:10.1002/jcp.26249
Singh V, Jain M, Misra A, Khanna V, Prakash P, et al. Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat. Indian J Med Res. 2015;141:823. doi:10.4103/0971-5916.160719