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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Curcumin Phytosome(Turmeric Rhizome Extract (curcuma longa)/Phosphatidyl Choline Complex) (Meriva® Turmeric Phytosome)(Standardized to min. 18% Curcuminoids - 90 mg)
500 mg
**
The product is found useful for the following medical conditions
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.8
10
Pain relief achieved
Most Useful Review
Excellent! I received it yesterday and immediately took one capsule. The results were surprising; after months of battling leg cramps due to plantar fascia inflammation, the pain has significantly diminished! I can now walk comfortably. I bought curcumin to improve my metabolism and regulate insulin resistance. I hope for further health improvements. It truly is a magical remedy for pain relief!
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.7
9
Curcumin improves rheumatoid arthritis symptoms
The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.
Most Relevant Research
We conducted a clinical trial to explore how curcumin, a compound found in turmeric, affects women with rheumatoid arthritis (RA). Over the course of eight weeks, 48 participants took either a daily curcumin capsule or a placebo. This double-blind, placebo-controlled design ensured that neither the participants nor the researchers knew who was receiving the actual treatment, which adds credibility to our findings.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
9.5
Miraculous joint relief
Most Useful Review
A tool that truly works! I ordered this product to maintain joint health, and I was pleased to feel its effects surprisingly quickly. Joint pain decreased, and I noticed an unexpected boost in my energy and mood. This remedy has become essential for me, as I now feel revitalised and energetic.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 24 Reviews
8.7
9.5
Turmeric-Boswellia improves back pain
The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial.
Most Relevant Research
We investigated how a turmeric and Boswellia formulation, known as Rhuleave-K, helps manage low back pain related to poor posture. This study involved 52 participants, equally divided by gender, who had been experiencing discomfort for at least two to three weeks.
Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.
We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.
Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.
We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.
8.8
Improved family health
Most Useful Review
Although I didn't notice a significant personal benefit from this product, it's made a stark difference for my family. My dad has been able to play squash regularly without pain, and I continue to order it for my parents because of the benefits they've experienced.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
Curcumin inhibits platelet activation
Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.
Most Relevant Research
We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.
Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.
Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.
8.8
Liver benefits
Most Useful Review
"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 44 Reviews
8.7
9.5
Pain relief noted
Most Useful Review
Fantastic supplement for arthritis sufferers! I suffer from Rheumatoid arthritis in my wrists, knees, and back. After taking Curcumin, my life has become much more manageable with significantly less bone pain. I now feel nearly pain-free. This supplement energises me and motivates me to exercise, but caution is needed – too much activity can lead to acute pain. Thanks to iHerb for great prices and fresh supplements.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
USERS' SCORE
Good
Based on 32 Reviews
8.7
9
Curcumin alleviates knee osteoarthritis pain
An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study.
Most Relevant Research
In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
9.5
Significant pain relief
Most Useful Review
Curcumin has greatly improved my rheumatoid arthritis symptoms in my wrists, knees, and back. I no longer rely on painkillers, and I feel near pain-free. This supplement energises me, but I advise exercising with caution to avoid overdoing it. iHerb offers great prices and fresh products.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 13 Reviews
8.7
9
Turmeric shows promise for NAFLD
"Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial".
Most Relevant Research
In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.
The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.
Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.
9.5
Effective for liver inflammation
Most Useful Review
I purchased this for my dog, who had liver inflammation. Despite curcumin's low bio-availability in turmeric form, giving him 1 gm/day for ten days lowered his ALT levels significantly. It shows great promise as an anti-inflammatory, and I appreciate the efforts of Indena, the manufacturer.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.7
2
Curcumin shows no allergy test effects
Curcumin does not significantly affect immediate skin tests.
Most Relevant Research
We focused on how turmeric, specifically curcumin, might influence allergies. Our study involved 34 participants who were allergic to certain antigens. To assess the effect of curcumin, we randomly assigned participants to receive either curcumin or a placebo for one week, all while keeping the study double-blind to eliminate bias.
After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.
The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.
After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.
The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.
9.5
Alleviates joint pain
Most Useful Review
This anti-inflammatory supplement is fantastic! I’m allergic to aspirin and many NSAIDs induce hives. After three weeks, my joint pain has significantly decreased. I’ve had no allergic reactions and my doctor recommends turmeric. It’s been a beneficial addition to my wellness routine.
Cancer details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Keeps cat alive
Most Useful Review
My cat loves this! After being diagnosed with nasal lymphoma, this has helped keep him alive. His symptoms, including sneezing and nasal mucous, have improved significantly. The vet suggested radiation or chemotherapy, but I’ve solely used curcumin for his treatment. Despite previously using another brand, I switched to this one, which is highly rated by ConsumerLab. I mix half a capsule daily with his wet food, and he enjoys it. I am incredibly grateful that this has kept my little friend alive.
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Curcumin protects heart cells effectively
Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.
Most Relevant Research
We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.
Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.
Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.
9.5
Strong antioxidant properties
Most Useful Review
I recommend this supplement wholeheartedly, regardless of existing health issues. It is an excellent antioxidant and high-quality product for combating inflammation. The benefits extend to fighting cancer as well. The packaging is commendable; this is suitable for adults of all ages.
Alzheimer details
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Curcumin derivative shows Alzheimer's promise
New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.
Most Relevant Research
We examined the potential of a curcumin derivative, known as Derivative 27, to treat Alzheimer's disease (AD). Curcumin, a compound found in turmeric, has previously been recognized for its ability to interfere with amyloid-β (Aβ) peptide aggregates, a hallmark of AD. The study focused on enhancing curcumin's effectiveness at lower doses, aiming to make treatment more accessible for patients.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.
In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.
Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.
9.5
Curcumin slows memory loss
Most Useful Review
Not only is this Curcumin highly rated, but my Nurse-Practitioner recommended this brand. It was suggested to help slow my husband's memory loss progress. Curcumin, derived from turmeric in curry powder, is shown to decrease beta-amyloid brain plaques associated with Alzheimer's disease and delay neuronal decline.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 30 Reviews
8.5
9
Curcumin reduces osteoarthritis severity
Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.
Most Relevant Research
We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.
We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.
9.5
Pain relief
Most Useful Review
Fantastic supplement for arthritis sufferers! I have rheumatoid arthritis in my wrists and knees. I've taken Jarrow and Now brands Curcumin for months, which has significantly reduced my pain and flare-ups. I recently tried the Bio form of Curcumin, and it felt miraculous. Post-taking, I experienced a surge in energy, but beware of overdoing it as I did. Thanks iHerb for the great prices and fresh supplements.
High Cholesterol details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.5
USERS' SCORE
Good
Based on 9 Reviews
8.5
8
Turmeric improves cholesterol levels
Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Most Relevant Research
We aimed to understand how turmeric, specifically its active compound curcumin, affects cholesterol levels in the body. After searching several online databases and analyzing 64 randomized clinical trials, we found that turmeric supplementation can lead to noticeable improvements in key cholesterol metrics.
Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.
Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.
Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.
Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.
8.3
Metabolic syndrome support
Most Useful Review
Curcumin lowers bad cholesterol, slows blood clot formation, and blocks inflammatory substances. Turmeric is excellent for reducing metabolic syndrome and preventing atherosclerosis.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Nano-curcumin reduces IL-17 levels
The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.
Most Relevant Research
We conducted a study to explore how nano-curcumin, a special formulation of turmeric, influences the balance of immune proteins associated with migraines. By randomly assigning forty participants with episodic migraines to receive either an 80 mg dose of nano-curcumin or a placebo for two months, we ensured that our findings would be robust and reliable.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.
The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.
Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.
9.5
Significant pain reduction
Most Useful Review
This high-quality curcumin capsule is excellent. I only need one a day, even with moderate to severe ME/CFS. It remarkably reduces my overall pain, including the intensity of my migraines, improves cognitive function, and alleviates autonomic problems. It's fantastic, and much cheaper here than elsewhere.
