We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
Stopped nasal allergy
2 people found this helpful
I initially bought this product for vitamin C supplementation as I have nasal allergies. After taking 1 pill, I was amazed that I stopped begging from it. I take 1 pill every day when I wake up, and my nose feels much better.
Read More
9
Helped respiratory allergy
1 people found this helpful
It was fantastic for me and my daughter! I had a respiratory allergy for 3 weeks, and this sambucus helped me recover! My daughter also had her allergy issues.
Read More
9
Excellent for allergies
This is an excellent product. It helped me significantly. The composition and quality are good, and it did not result in any allergies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Pleuran and Vitamin C aid asthma
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
I initially bought this product for vitamin C supplementation as I have nasal allergies. After taking 1 pill, I was amazed that I stopped begging from it. I take 1 pill every day when I wake up, and my nose feels much better.
Read More
9
Helped respiratory allergy
1 people found this helpful
It was fantastic for me and my daughter! I had a respiratory allergy for 3 weeks, and this sambucus helped me recover! My daughter also had her allergy issues.
Read More
9
Excellent for allergies
This is an excellent product. It helped me significantly. The composition and quality are good, and it did not result in any allergies.
Read More
9
No allergy reactions
At the first sign of a cold, we drink this ourselves and give it to our child. The taste is sour-berry, and although my child is allergic, this product did not cause any allergic reactions.
Read More
9
Allergy on hands vanished
We completed a full course, and during the cold, we never got sick. The allergy on my hands completely disappeared after using this. We will definitely purchase more.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
While elderberry (Sambucus) is often heralded for its immune-boosting properties and its potential to alleviate cold and flu symptoms, its effectiveness in managing allergies is less clear. Some proponents suggest that the anti-inflammatory properties of elderberry may provide relief from symptoms typical of allergies, such as congestion and sinus pressure. However, scientific research specifically targeting elderberry's efficacy in treating allergic reactions is limited and largely anecdotal.
If you're considering elderberry as a natural remedy for allergies, it's important to approach it with realistic expectations. Consulting with a healthcare professional is advisable, especially if you are already on allergy medications, as elderberry could potentially interact with other treatments. Overall, while elderberry may contribute to general wellness and support immune function, relying on it as a primary solution for allergies may not be the most effective approach. Finding a comprehensive strategy that includes conventional allergy treatments may yield better results.
Based on user reviews, the time it takes to see positive results from this supplement for allergy relief can vary significantly. Some users report experiencing immediate benefits; for instance, one reviewer noted that they felt much better after just one day of taking the product for their nasal allergies Read Review. Others, however, mention a longer experience before noticing substantial improvements, with reports suggesting effective relief emerging after a few weeksRead Review.
Interestingly, there are also instances where users have not experienced immediate changes, as one individual who took the supplement for five days noted no noticeable effect on their sore throat Read Review. This suggests that while some users may find relief quickly, others might need a more extended period to experience benefits. Overall, if you are considering this supplement for allergies, it may be prudent to allow yourself at least a week or two to assess its effectiveness.
The supplemental use of zinc has shown encouraging signs in the management of various allergic conditions, particularly allergic rhinitis and atopic dermatitis. Research indicates that zinc, when combined with quail egg-based supplements, significantly improves symptoms associated with allergic rhinitis, such as nasal congestion and sneezing. The results from a systematic review emphasized that this combination not only provided symptom relief but also potentially reduced reliance on standard allergy medications, making it an appealing alternative for those affected ([2]). Moreover, another study found that zinc treatment might alleviate allergic rhinitis symptoms by lowering the total calcium influx associated with allergic responses, indicating an important role for this mineral in allergy management ([4]).
Furthermore, studies focusing on the relationship between zinc levels and atopic dermatitis have revealed that individuals suffering from this condition often exhibit lower zinc levels in their bloodstream compared to non-affected individuals. Zinc supplementation was associated with a reduction in inflammation markers and improvement in skin lesions in model systems ([8]). Despite the promising evidence, it’s essential to note that more research is encouraged to fully establish the effectiveness of zinc in allergy management and determine the optimal dosages and formulations([7]).
Based on user reviews, many individuals have reported significant improvements in their allergy symptoms after using this supplement. For example, one user noted that after just one pill, their nasal allergy symptoms improved dramatically, allowing them to breathe easier Read Review. Another reviewer shared a positive experience, stating that both they and their daughter saw notable recovery from their respiratory allergies within three weeks of use Read Review.
Moreover, several users mentioned that the product not only alleviated allergy symptoms but also played a role in strengthening their immune system. One user highlighted that their frequent nasal allergies improved, and they felt more resilient against colds Read Review. While these accounts are promising, it is important to note that individual responses can vary. For instance, one user did not find the product effective for their sore throat, reporting no improvement even after five days of use Read Review. This variance underscores the necessity of personalized experiences when it comes to supplements for allergy relief.
Based on user reviews, combining this supplement with other supplements for handling allergies seems to produce positive results for many. Several users have reported significant relief from their allergy symptoms, indicating that they have effectively used this product alongside other remedies or supplements. For instance, one reviewer reported that after they started taking this supplement for their nasal allergies, they experienced effectively reduced symptoms after just one day Read Review. Another user shared that both they and their daughter experienced notable recovery from respiratory allergies while using it Read Review. This suggests that those seeking comprehensive allergy relief might benefit from incorporating this supplement into a broader regimen.
Furthermore, some users mentioned that the supplement aided in enhancing their overall immunity, which could be crucial during allergy seasons. One individual highlighted not only the alleviation of their nasal allergies but also an improved resilience against colds Read Review. This potential synergy underscores the possibility that while users might feel inclined to combine this with other supplements, personal experiences can differ significantly. It's vital for consumers to monitor their responses when integrating multiple supplements Read Review.
Users report varied experiences with Elderberry Sambucus for treating allergies, largely indicating satisfaction with its effects. Many recommend a daily dose of 1 pill or lozenge, as they found it effective in managing their allergy symptoms. For instance, one user noted that taking 1 pill each morning helped alleviate their nasal allergies significantly, stating, "After taking 1 pill, I was amazed that I stopped begging from it" Read Review. Another user emphasized giving 1 lozenge to both their child and themselves, asserting that they felt improvement "immediately" Read Review.
Several reviews suggest that the product is safe, even for those who are typically prone to allergies. For example, one user shared their surprise at the lack of allergic reactions after consumption, even with a known sensitivity Read Review. Overall, while users report positive outcomes with daily dosing, particularly at the onset of allergy symptoms or as prevention, they also note the importance of monitoring individual reactions, especially for children, as some mentioned potential sensitivities to herbal ingredients Read Review.
9
Stopped nasal allergy
2 people found this helpful
I initially bought this product for vitamin C supplementation as I have nasal allergies. After taking 1 pill, I was amazed that I stopped begging from it. I take 1 pill every day when I wake up, and my nose feels much better.
9
Helped respiratory allergy
1 people found this helpful
It was fantastic for me and my daughter! I had a respiratory allergy for 3 weeks, and this sambucus helped me recover! My daughter also had her allergy issues.
6
No allergies relief
I appreciated that there are no unnecessary additives and that xylitol is used instead of sugar, which is pleasing as I experienced no allergies. However, I found they did not particularly assist with my sore throat. After taking them for 5 days, I noticed no effect whatsoever.
7.5
Strong immunity boost
Good! My frequent nasal allergies and colds have improved, and these helped strengthen my immunity!
7
Useful for colds
I recently purchased this product and give it to my child and myself, as the quality and ingredients suit us. Health needs maintenance during seasonal colds. I take it for ages 6 and 35, but herbs in the composition may cause allergies. It helps to avoid cold issues, and improvement is felt immediately. Very useful, and the packaging is sealed. I give 1 lozenge, and the taste is fine; my child enjoys chewing it.
9
No allergy reactions
At the first sign of a cold, we drink this ourselves and give it to our child. The taste is sour-berry, and although my child is allergic, this product did not cause any allergic reactions.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
8
Zinc gluconate helps atopic dermatitis
Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation.
We investigated how zinc affects atopic dermatitis (AD), a chronic skin condition linked to immune responses. Our analysis revealed that individuals with AD had significantly lower levels of zinc in their bloodstream compared to those without the condition. This connection led us to examine how zinc could potentially ease the symptoms associated with AD.
Through our research, we noticed that AD skin showed increased levels of a specific protein called CXCL10. This protein is known to be involved in inflammatory responses, and we found that its levels were inversely related to zinc levels in the serum. When we treated keratinocytes, the cells that make up the skin, with zinc gluconate, we observed a reduction in CXCL10 release, suggesting it may help manage inflammation associated with AD.
Moreover, in a mouse model mimicking AD, zinc gluconate therapy significantly reduced the severity of skin lesions and serum IgE levels—an indicator of allergic responses. The therapy also decreased skin thickness and CXCL10 production, showcasing its promise as a treatment option for managing atopic dermatitis.
Overall, our findings illustrate that zinc gluconate can be beneficial in reducing inflammation and symptoms in individuals with AD by modulating the immune response through specific cellular mechanisms.
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
References
Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. doi:10.1038/s41598-025-91830-2
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129