' 
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Calories
<5
Total Carbohydrate
<1 g
<1%**
Total Sugars
0 g
†
Includes 0 g Added Sugars
0%**
Xylitol
<1 g
†
Vitamin C (as Ascorbic Acid)
100 mg
111%
Zinc (elemental) (from 15 mg Zinc Bisglycinate) (TRAACS™)
3 mg
27%
Elderberry (10:1 Concentrate)(Sambucus nigra) (Fruit)
150 mg
†
Top Medical Research Studies
9
Vitamin C improves heart perfusion
Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.
Highly relevant to the topic
We explored the impact of vitamin C on heart blood flow in patients undergoing a procedure called percutaneous coronary intervention (PCI) for stable angina. In our study, we enrolled 56 participants and divided them into two groups: one received a vitamin C infusion and the other a placebo.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Read More
9
Vitamin C enhances angina treatment
Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species.
Highly relevant to angina studies.
Our study looked into how vitamin C might help improve the health of blood vessels and insulin sensitivity in patients struggling with coronary spastic angina (CSA). We worked with 22 patients diagnosed with CSA and 20 control subjects, measuring how well their arteries could expand in response to blood flow—a process known as flow-mediated dilation.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
Read More
8
Vitamin C aids coronary spasm treatment
Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina.
Direct effect on spastic angina
We explored how vitamin C, known for its antioxidant properties, impacts abnormal blood vessel reactions in patients suffering from coronary spastic angina. In a well-structured study, responses of the left coronary arteries were measured in 32 patients before and during the infusion of vitamin C and compared to 34 control subjects who received saline.
Our results revealed that vitamin C significantly reduced the constriction of the arteries in patients experiencing spastic angina when given acetylcholine, a substance that normally causes blood vessels to widen. In contrast, the control group didn’t show any significant change in their artery reactions from vitamin C. This suggests that oxygen free radicals, which cause blood vessel dysfunction, could be a contributing factor to the abnormal coronary reactions observed in spasm patients.
Overall, this study indicates that vitamin C can play a beneficial role in improving blood flow in the coronary arteries of those with spastic angina, offering hope for managing this condition.
Our results revealed that vitamin C significantly reduced the constriction of the arteries in patients experiencing spastic angina when given acetylcholine, a substance that normally causes blood vessels to widen. In contrast, the control group didn’t show any significant change in their artery reactions from vitamin C. This suggests that oxygen free radicals, which cause blood vessel dysfunction, could be a contributing factor to the abnormal coronary reactions observed in spasm patients.
Overall, this study indicates that vitamin C can play a beneficial role in improving blood flow in the coronary arteries of those with spastic angina, offering hope for managing this condition.
Read More
Most Useful Reviews
8.3
Effective for angina
We frequently suffer from angina, so we bought it without much hope for results. After sucking four tablets a day, it improved the sore throat in four days! These pills have a long shelf life and are reasonably priced.
Read More
8.8
Good for angina
At the first symptoms of angina, this is a good working option.
Read More
8
Eases angina symptoms
Greetings from Ukraine! We use it when the first signs of a sore throat appear. A couple of days later, everything passes. It won't help with severe angina, but it eases the condition a bit. I always ensure to have them in my first aid kit and purse. A good product! I sincerely recommend it! Wishing everyone health and peace; I would be very grateful for a like!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.1
- All Researches
9
Vitamin C improves heart perfusion
Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.
Highly relevant to the topic
We explored the impact of vitamin C on heart blood flow in patients undergoing a procedure called percutaneous coronary intervention (PCI) for stable angina. In our study, we enrolled 56 participants and divided them into two groups: one received a vitamin C infusion and the other a placebo.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Read More
9
Vitamin C enhances coronary dilation
Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina.
Study focuses on vitamin C effects
We assessed how vitamin C influences coronary vasodilation in patients suffering from stable angina, a type of chest pain associated with reduced blood flow to the heart. In our study, we included 28 patients with coronary artery disease. They underwent a series of tests where they received intravenous infusions of vitamin C or normal saline in conjunction with L-arginine, a compound that helps expand blood vessels.
We observed that the infusion of L-arginine led to significant expansion of coronary arteries, with an increase in diameter by 4.87% in proximal segments and 6.33% in distal segments. Notably, when vitamin C was administered alongside L-arginine, the dilation was even more pronounced—8.68% for proximal segments and 13.07% for distal segments. This suggests that vitamin C enhances the effects of L-arginine.
While vitamin C alone resulted in a slight increase in coronary artery diameter, this change was not statistically significant. This indicates that although vitamin C can enhance the vasodilation effect of L-arginine, its direct impact on coronary artery diameters may not be as strong. Overall, our findings suggest that vitamin C may play a beneficial role in improving nitric oxide availability when used with L-arginine, potentially offering a more effective treatment strategy for patients with angina.
We observed that the infusion of L-arginine led to significant expansion of coronary arteries, with an increase in diameter by 4.87% in proximal segments and 6.33% in distal segments. Notably, when vitamin C was administered alongside L-arginine, the dilation was even more pronounced—8.68% for proximal segments and 13.07% for distal segments. This suggests that vitamin C enhances the effects of L-arginine.
While vitamin C alone resulted in a slight increase in coronary artery diameter, this change was not statistically significant. This indicates that although vitamin C can enhance the vasodilation effect of L-arginine, its direct impact on coronary artery diameters may not be as strong. Overall, our findings suggest that vitamin C may play a beneficial role in improving nitric oxide availability when used with L-arginine, potentially offering a more effective treatment strategy for patients with angina.
Read More
9
Effects of vitamins on angina
[Changes in the blood content of some vitamins in patients with ischemic heart disease].
Moderate relevance to vitamin C
We explored the impact of vitamins A and C on patients with different heart conditions, specifically those experiencing stable angina and those with post-infarction cardiosclerosis. Our study focused on 22 patients with stable exercise-induced angina and 28 patients with post-infarction cardiosclerosis who did not have circulation failure.
We observed that in patients with stable angina, the blood levels of vitamin C were higher, suggesting a potential role of this vitamin in managing their condition. Meanwhile, those with post-infarction cardiosclerosis exhibited increased vitamin A in their red blood cells and a rise in vitamin C in their blood plasma.
After successful antianginal therapy, we noted normalization of vitamin C levels in both the blood plasma and red blood cells, while vitamin A levels in red cells also returned to normal. However, it’s important to explain that while vitamin C showed increased levels, we cannot definitively attribute the improvement in angina symptoms solely to vitamin C, as successful antianginal therapy was also involved.
We observed that in patients with stable angina, the blood levels of vitamin C were higher, suggesting a potential role of this vitamin in managing their condition. Meanwhile, those with post-infarction cardiosclerosis exhibited increased vitamin A in their red blood cells and a rise in vitamin C in their blood plasma.
After successful antianginal therapy, we noted normalization of vitamin C levels in both the blood plasma and red blood cells, while vitamin A levels in red cells also returned to normal. However, it’s important to explain that while vitamin C showed increased levels, we cannot definitively attribute the improvement in angina symptoms solely to vitamin C, as successful antianginal therapy was also involved.
Read More
9
Vitamin C enhances angina treatment
[Use of ascorbic acid for raising clinical response to long-acting nitrates].
Moderately relevant interaction study
We explored how vitamin C, or ascorbic acid, can impact the treatment of angina, particularly in combination with nitroglycerine. Our observations revealed that when vitamin C was given, it significantly boosted the antianginal effects of nitroglycerine, a common medication used to relieve angina symptoms. This interaction helps to prevent heart muscle damage by reducing ischemic reactions during stress tests.
Through our analysis, we found that when we incubated vitamin C with nitric oxide donors and blood from patients already using long-acting nitroglycerine, gas bubbles identified as nitrogen oxide were released. This crucial finding points to the activation of internal nitric oxide donors by vitamin C, suggesting that it could enhance the effectiveness of nitrate therapy for patients suffering from angina.
In conclusion, taking vitamin C alongside traditional antianginal treatments like nitroglycerine appears to offer additional benefits, enhancing both the therapy's effectiveness and possibly improving patients’ quality of life. Our findings support the idea that incorporating vitamin C into angina treatment regimens might be a worthwhile consideration.
Through our analysis, we found that when we incubated vitamin C with nitric oxide donors and blood from patients already using long-acting nitroglycerine, gas bubbles identified as nitrogen oxide were released. This crucial finding points to the activation of internal nitric oxide donors by vitamin C, suggesting that it could enhance the effectiveness of nitrate therapy for patients suffering from angina.
In conclusion, taking vitamin C alongside traditional antianginal treatments like nitroglycerine appears to offer additional benefits, enhancing both the therapy's effectiveness and possibly improving patients’ quality of life. Our findings support the idea that incorporating vitamin C into angina treatment regimens might be a worthwhile consideration.
Read More
9
Vitamin C enhances angina treatment
Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species.
Highly relevant to angina studies.
Our study looked into how vitamin C might help improve the health of blood vessels and insulin sensitivity in patients struggling with coronary spastic angina (CSA). We worked with 22 patients diagnosed with CSA and 20 control subjects, measuring how well their arteries could expand in response to blood flow—a process known as flow-mediated dilation.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Effective for angina
We frequently suffer from angina, so we bought it without much hope for results. After sucking four tablets a day, it improved the sore throat in four days! These pills have a long shelf life and are reasonably priced.
8.8
Good for angina
At the first symptoms of angina, this is a good working option.
8
Eases angina symptoms
Greetings from Ukraine! We use it when the first signs of a sore throat appear. A couple of days later, everything passes. It won't help with severe angina, but it eases the condition a bit. I always ensure to have them in my first aid kit and purse. A good product! I sincerely recommend it! Wishing everyone health and peace; I would be very grateful for a like!
Read More
