Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
Most Useful Reviews
9
Highly effective option
2 people found this helpful
Great budget option! Works well and is tasty! I usually experience slight nausea after taking zinc, but not with this product. I appreciate its rich composition: vitamin C, echinacea, zinc! It's an affordable solution for the first signs of illness. I wholeheartedly recommend this drug; it’s worthy of praise. All sick, recover quickly!
Read More
9
Family favourite
Highly recommend! During the growing season of diseases, my whole family enjoyed these, and they taste delightful, which is crucial for children. I’ve noted that they do not cause nausea.
Read More
9
Pleasant experience
C+zinc provides a pleasant taste without the metallic nausea or an unpleasant tongue sensation. I really enjoy the taste and suggest buying foaming tablets beforehand.
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
4
Zinc's tolerability in diarrhoea treatment
New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Read More
2
Vitamin C ineffective against nausea
The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.
We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.
While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.
Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.
Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Highly effective option
2 people found this helpful
Great budget option! Works well and is tasty! I usually experience slight nausea after taking zinc, but not with this product. I appreciate its rich composition: vitamin C, echinacea, zinc! It's an affordable solution for the first signs of illness. I wholeheartedly recommend this drug; it’s worthy of praise. All sick, recover quickly!
Read More
9
Family favourite
Highly recommend! During the growing season of diseases, my whole family enjoyed these, and they taste delightful, which is crucial for children. I’ve noted that they do not cause nausea.
Read More
9
Pleasant experience
C+zinc provides a pleasant taste without the metallic nausea or an unpleasant tongue sensation. I really enjoy the taste and suggest buying foaming tablets beforehand.
Read More
9
Digestive ease
I bought this supplement to boost my elderly parents' immune systems. They find it easy to digest, with no reported nausea. I'm eager to observe the results once the bottle is finished.
Read More
9
Effective choice
I purchased these vitamins for my children. They taste great and seem effective; we experienced minimal respiratory issues this autumn. I worried about zinc causing nausea for me, yet my children faced no such issues.
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Based on user reviews, many individuals have reported varying experiences regarding how long it takes to see results when taking this supplement for nausea. A common sentiment is that the product can relieve nausea quite quickly once ingested. One user noted using the supplement as soon as they felt nausea, dissolving it every four hours, indicating an immediate effect (Read Review). Another mentioned that it provided relief without the unpleasant metallic taste or nausea that other products caused, suggesting that users may experience effects relatively fast (Read Review).
Additionally, several reviewers shared that they felt confident using it for their families and observed that they faced minimal nausea, hinting that the supplement may be effective in providing comfort and relief during illness. For instance, one reviewer highlighted that their family members experienced no nausea when taking this specific supplement, which speaks to its overall pleasant effects (Read Review). However, the results may vary based on individual tolerance and timing of ingestion. For those looking for immediate support against feeling unwell, it seems this product can deliver positive results quite swiftly.
The scientific research surrounding various zinc supplements provides a mixed view on their effectiveness for treating nausea. One study involving zinc-infused packs demonstrated promising results, showing that patients who used zinc solution-impregnated gauze experienced significantly less severity of nausea following surgery compared to those using normal saline-impregnated gauze [4]. This suggests that zinc may alleviate nausea in specific post-operative contexts. However, another study on zinc acetate dihydrate indicated that while it was effective for various symptoms, it did not definitively highlight its effectiveness for nausea alone, with nausea reported in just 1.4% of patients [3].
Moreover, research on NPC-25, a newer form of zinc, found that participants reported fewer digestive issues, including nausea, compared to a standard treatment [2]. Conversely, a study on zinc tablets for children revealed a significant occurrence of nausea alongside other digestive symptoms [5]. In summary, while there is some evidence supporting zinc's potential benefits for nausea, particularly in certain settings, the results are not universally conclusive. Therefore, those considering zinc as a remedy for nausea should be aware of these varying findings.
Based on user reviews, many individuals have reported improvements in their symptoms, particularly concerning nausea associated with other zinc or elderberry products. Users frequently mention that this supplement is easier to digest and does not provoke the same nausea they encountered with previous brands. One user noted that while they used to experience slight nausea with zinc, this product did not elicit that response, making it a preferable choice (Read Review). Another reviewer remarked that they found the product's taste delightful, which encouraged their family to take it regularly without complaints of nausea, enhancing their willingness to use it during cold season (Read Review).
Moreover, parents reported positive outcomes for their children, with minimal respiratory issues and no nausea, which can often be a concern with supplements that include zinc. Users indicated that the product's formulation is well-received by both adults and children, showcasing its broad appeal as a solution for immune support while minimizing discomfort (Read Review). However, while many seem to enjoy benefits like these, individual results may vary depending on personal tolerance and dietary habits.
Based on user reviews, many individuals have found that combining this supplement with other dietary additions, such as zinc and elderberry, has allowed them to manage nausea more effectively. One user highlighted how they previously experienced nausea with zinc supplements but found this product to be a refreshing alternative, as it did not induce the same discomfort (Read Review). Similarly, another reviewer noted that during seasonal illnesses, their family enjoyed the product's taste and reported no nausea, making it a staple in their health routine (Read Review).
Additionally, parents remarked on improved tolerance for their children when using this supplement alongside other immune-boosting vitamins, such as zinc. They noted no nausea compared to previous products, which is particularly reassuring for families wary of the potential gastrointestinal side effects often associated with zinc (Read Review). Overall, the general sentiment is that this product serves as a synergistic aid when dealing with nausea while still providing the immune support that families seek during cold and flu season.
Based on user reviews, the right dose for Elderberry Sambucus while treating nausea seems to vary among individuals, with some users reporting that taking the product after meals can minimize the risk of nausea. One user indicated that dosing according to age was key, with children receiving one tablet and adults taking two daily, while ensuring to double the intake strictly after meals if ill to prevent nausea, particularly when zinc is involved Read Review. Others have highlighted that they did not experience nausea at all when using this product, suggesting a generally favorable tolerance among different age groups Read Review.
Additionally, users noted that some formulations include combinations with ingredients like vitamin C and zinc, which they found pleasant and effective without causing nausea, particularly when the tablets are consumed with food Read Review. Overall, for those wary of nausea, taking Elderberry Sambucus post-meal is a commonly endorsed strategy, providing both efficacy and comfort Read Review.
7.5
Lifesaver remedy
This product is my lifesaver at the first signs of a cold. I dissolve it every four hours upon feeling nausea or a sore throat. It’s now a regular purchase for me, and I recommend it wholeheartedly; I’m sure you’ll be as satisfied as I am.
9
Pleasant experience
C+zinc provides a pleasant taste without the metallic nausea or an unpleasant tongue sensation. I really enjoy the taste and suggest buying foaming tablets beforehand.
9
Family favourite
Highly recommend! During the growing season of diseases, my whole family enjoyed these, and they taste delightful, which is crucial for children. I’ve noted that they do not cause nausea.
9
Highly effective option
2 people found this helpful
Great budget option! Works well and is tasty! I usually experience slight nausea after taking zinc, but not with this product. I appreciate its rich composition: vitamin C, echinacea, zinc! It's an affordable solution for the first signs of illness. I wholeheartedly recommend this drug; it’s worthy of praise. All sick, recover quickly!
9
Effective choice
I purchased these vitamins for my children. They taste great and seem effective; we experienced minimal respiratory issues this autumn. I worried about zinc causing nausea for me, yet my children faced no such issues.
6
Highly effective remedy
My family is thrilled! Zinc, elderberry, and vitamin C are potent immunostimulants. For prevention, I give my children one tablet and adults two daily. Remarkably, we haven’t experienced a runny nose, though elderberry can cause nausea for some.
7.5
Convenient solution
These absorbable tablets are a convenient option, especially if I feel weak or foresee a sickness. They work effectively, but I advise taking them only after meals to avoid unpleasant taste and potential nausea.
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
7
Zinc treatment reduces nausea risk
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
4
Zinc's tolerability in diarrhoea treatment
New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
References
Foessleitner P, Rager L, Mikula F, Hager M, Granser S, et al. The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial. J Clin Med. 2024;13. doi:10.3390/jcm13175099
Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558
Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. doi:10.1691/ph.2024.3630
Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. doi:10.5812/aapm-127262
Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. doi:10.1111/jpc.15953