Zinc treatment reduces nausea riskRandomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
Moderate relevance to nausea aspect
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
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We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
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Zinc affects post-op nausea minimallyComparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
Relevant but limited impact
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
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Zinc's tolerability in diarrhoea treatmentNew formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
Explores nausea related to zinc
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
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Vitamin C ineffective against nauseaThe Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.
Vitamin C's isolated effects unclear
We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.
While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.
Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.
Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.
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