Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid improves asthma
We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Read More
9
We aimed to understand how dietary intake of docosahexaenoic acid (DHA) relates to asthma in children. This investigation was based on a substantial group of 14,727 participants from the National Health and Nutrition Examination Survey (NHANES), which provided a comprehensive view of dietary habits and health outcomes over nearly two decades.
In our findings, we observed that asthma was reported in about 15.38% of the participants. Interestingly, we found a notable negative association between DHA intake and asthma prevalence. Specifically, children who consumed higher levels of DHA showed a lower likelihood of having asthma, with the odds especially favorable for boys, children aged 5 to 12 years, and those whose mothers smoked during pregnancy.
The data indicated that DHA, along with other omega-3 fatty acids like eicosapentaenoic acid (EPA), can play a protective role against childhood asthma. These findings suggest that encouraging a diet rich in these healthy fats could be beneficial in reducing asthma risk in young children, particularly among specific groups at greater risk.
In our findings, we observed that asthma was reported in about 15.38% of the participants. Interestingly, we found a notable negative association between DHA intake and asthma prevalence. Specifically, children who consumed higher levels of DHA showed a lower likelihood of having asthma, with the odds especially favorable for boys, children aged 5 to 12 years, and those whose mothers smoked during pregnancy.
The data indicated that DHA, along with other omega-3 fatty acids like eicosapentaenoic acid (EPA), can play a protective role against childhood asthma. These findings suggest that encouraging a diet rich in these healthy fats could be beneficial in reducing asthma risk in young children, particularly among specific groups at greater risk.
Read More
8
We aimed to understand the relationship between eicosapentaenoic acid, a type of n-3 polyunsaturated fatty acid, and its potential effects on asthma and other allergic conditions. Through analysis of blood samples taken from 940 children at age 8, we looked at how the proportions of eicosapentaenoic acid and other fatty acids might influence the development of asthma and allergic diseases by age 16.
Our findings were compelling. We observed that higher levels of eicosapentaenoic acid in the blood corresponded with a lower risk of asthma, nasal allergies, and general allergic sensitization when the children turned 16. Specifically, the data showed that for every increase in eicosapentaenoic acid, there was a notable decrease in the chances of developing asthma over the years. This suggests that maintaining higher levels of this fatty acid could potentially help in managing or even reducing the incidence of asthma in children.
Additionally, our study revealed that arachidonic acid, another fatty acid, also played a beneficial role, showing an association with remission from asthma and rhinitis between the ages of 8 and 16. These insights underscore the importance of certain fatty acids in the diet and their potential in shaping long-term health outcomes regarding allergic diseases.
Our findings were compelling. We observed that higher levels of eicosapentaenoic acid in the blood corresponded with a lower risk of asthma, nasal allergies, and general allergic sensitization when the children turned 16. Specifically, the data showed that for every increase in eicosapentaenoic acid, there was a notable decrease in the chances of developing asthma over the years. This suggests that maintaining higher levels of this fatty acid could potentially help in managing or even reducing the incidence of asthma in children.
Additionally, our study revealed that arachidonic acid, another fatty acid, also played a beneficial role, showing an association with remission from asthma and rhinitis between the ages of 8 and 16. These insights underscore the importance of certain fatty acids in the diet and their potential in shaping long-term health outcomes regarding allergic diseases.
Read More
Most Useful Reviews
9
Effective asthma treatment
It helps with asthma very effectively, especially when taken with zinc and magnesium.
Read More
7.5
Reduced coughs due to asthma
For coughs and asthma, this seems effective. I usually do not eat much fish, so I ordered it for the omega. I found it helps prevent sickness when I have a cold.
Read More
7.5
Helped granny's asthma
1 people found this helpful
Wonderfully helpful for my granny, who is 80 and has asthma. She started to feel better and less tired.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
- All Researches
9.5
DHA-derived lipid mediators aid asthma
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) in treating allergic asthma using a well-established ovalbumin (OVA) model in mice. The treatment comprised a mix of lipid mediators, including 17S-monohydroxy DHA, resolvin D5, and protectin DX. Through this investigation, we aimed to better understand how these components could alleviate asthma symptoms.
Our findings indicated that administering these lipid mediators significantly reduced key features of allergic asthma. We observed a decrease in inflammatory cell infiltration, particularly in eosinophils, and a drop in the levels of inflammation-related cytokines. Furthermore, treatment with the lipid mediators helped mitigate airway remodeling and oxidative stress, indicating a return to near-normal conditions for the mice.
Notably, the lipid mediators led to a remarkable drop in inflammatory markers such as interleukin-6 and tumor necrosis factor-α, signaling a positive response. We also witnessed an improvement in the lung's oxidative stress status, as shown by increased antioxidant activities and reduced harmful substances.
Collectively, our study suggests that lipid mediators from DHA could represent a promising therapeutic avenue for asthma treatment, particularly by protecting lung tissues from inflammation and oxidative damage.
Our findings indicated that administering these lipid mediators significantly reduced key features of allergic asthma. We observed a decrease in inflammatory cell infiltration, particularly in eosinophils, and a drop in the levels of inflammation-related cytokines. Furthermore, treatment with the lipid mediators helped mitigate airway remodeling and oxidative stress, indicating a return to near-normal conditions for the mice.
Notably, the lipid mediators led to a remarkable drop in inflammatory markers such as interleukin-6 and tumor necrosis factor-α, signaling a positive response. We also witnessed an improvement in the lung's oxidative stress status, as shown by increased antioxidant activities and reduced harmful substances.
Collectively, our study suggests that lipid mediators from DHA could represent a promising therapeutic avenue for asthma treatment, particularly by protecting lung tissues from inflammation and oxidative damage.
Read More
9
Eicosapentaenoic acid improves asthma
We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Read More
9
We set out to understand how eicosapentaenoic acid (EPA) might enhance the effects of mesenchymal stromal cell (MSC) therapy for allergic asthma. In our study, we used mice to create a model of severe allergic asthma by exposing them to house dust mite extracts. After the final exposure, we administered either unstimulated or EPA-stimulated MSCs to see how they impacted the mice's lung health and inflammation.
Our findings were quite promising. The mice that received EPA-stimulated MSCs showed notable improvements in their lung function and overall respiratory health compared to those treated with unstimulated MSCs. Specifically, we noticed a reduction in bronchoconstriction, less alveolar collapse, and decreased overall cell counts in the lungs, which is a sign of lower inflammation. Additionally, we saw an increase in beneficial markers such as IL-10 and changes in macrophage types, indicating a shift toward a more anti-inflammatory state.
This research underscores the potential of combining EPA with MSC therapy as a new approach for tackling allergic asthma. By enhancing the anti-inflammatory effects of MSCs, EPA might not only improve lung mechanics but also protect against further airway damage. Our work suggests that this strategy could be an exciting avenue for developing better treatments for asthma and potentially other inflammatory conditions.
Our findings were quite promising. The mice that received EPA-stimulated MSCs showed notable improvements in their lung function and overall respiratory health compared to those treated with unstimulated MSCs. Specifically, we noticed a reduction in bronchoconstriction, less alveolar collapse, and decreased overall cell counts in the lungs, which is a sign of lower inflammation. Additionally, we saw an increase in beneficial markers such as IL-10 and changes in macrophage types, indicating a shift toward a more anti-inflammatory state.
This research underscores the potential of combining EPA with MSC therapy as a new approach for tackling allergic asthma. By enhancing the anti-inflammatory effects of MSCs, EPA might not only improve lung mechanics but also protect against further airway damage. Our work suggests that this strategy could be an exciting avenue for developing better treatments for asthma and potentially other inflammatory conditions.
Read More
9
In our exploration of asthma treatment, we focused on sea cucumber extracts and their effects on allergic airway inflammation. Using a method that separated the extract into three distinct phases, we specifically looked at how the n-hexane phase—rich in fatty acids like eicosapentaenoic acid—could influence asthma symptoms in mice.
We observed that when mice with asthma were treated with this n-hexane phase, their symptoms improved. This phase not only elevated the expression of Il10, an important anti-inflammatory cytokine, but also reduced the presence of eosinophils and goblet cell hyperplasia around the airways. Remarkably, we found decreases in several Th2 and Th17-related cytokines, which are usually elevated during asthma attacks.
The increase in other markers, like TGF-β and IL-10, is particularly interesting, as these are associated with regulatory T cells, which help control inflammation. Our findings suggest that eicosapentaenoic acid, along with other components in the sea cucumber extract, plays a positive role in addressing asthma symptoms by modulating immune responses effectively.
We observed that when mice with asthma were treated with this n-hexane phase, their symptoms improved. This phase not only elevated the expression of Il10, an important anti-inflammatory cytokine, but also reduced the presence of eosinophils and goblet cell hyperplasia around the airways. Remarkably, we found decreases in several Th2 and Th17-related cytokines, which are usually elevated during asthma attacks.
The increase in other markers, like TGF-β and IL-10, is particularly interesting, as these are associated with regulatory T cells, which help control inflammation. Our findings suggest that eicosapentaenoic acid, along with other components in the sea cucumber extract, plays a positive role in addressing asthma symptoms by modulating immune responses effectively.
Read More
9
We aimed to understand how dietary intake of docosahexaenoic acid (DHA) relates to asthma in children. This investigation was based on a substantial group of 14,727 participants from the National Health and Nutrition Examination Survey (NHANES), which provided a comprehensive view of dietary habits and health outcomes over nearly two decades.
In our findings, we observed that asthma was reported in about 15.38% of the participants. Interestingly, we found a notable negative association between DHA intake and asthma prevalence. Specifically, children who consumed higher levels of DHA showed a lower likelihood of having asthma, with the odds especially favorable for boys, children aged 5 to 12 years, and those whose mothers smoked during pregnancy.
The data indicated that DHA, along with other omega-3 fatty acids like eicosapentaenoic acid (EPA), can play a protective role against childhood asthma. These findings suggest that encouraging a diet rich in these healthy fats could be beneficial in reducing asthma risk in young children, particularly among specific groups at greater risk.
In our findings, we observed that asthma was reported in about 15.38% of the participants. Interestingly, we found a notable negative association between DHA intake and asthma prevalence. Specifically, children who consumed higher levels of DHA showed a lower likelihood of having asthma, with the odds especially favorable for boys, children aged 5 to 12 years, and those whose mothers smoked during pregnancy.
The data indicated that DHA, along with other omega-3 fatty acids like eicosapentaenoic acid (EPA), can play a protective role against childhood asthma. These findings suggest that encouraging a diet rich in these healthy fats could be beneficial in reducing asthma risk in young children, particularly among specific groups at greater risk.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective asthma treatment
It helps with asthma very effectively, especially when taken with zinc and magnesium.
Read More
7.5
Reduced coughs due to asthma
For coughs and asthma, this seems effective. I usually do not eat much fish, so I ordered it for the omega. I found it helps prevent sickness when I have a cold.
Read More
7.5
Helped granny's asthma
1 people found this helpful
Wonderfully helpful for my granny, who is 80 and has asthma. She started to feel better and less tired.
Read More
Frequently Asked Questions
7.5
Helped granny's asthma
1 people found this helpful
Wonderfully helpful for my granny, who is 80 and has asthma. She started to feel better and less tired.
9
Effective asthma treatment
It helps with asthma very effectively, especially when taken with zinc and magnesium.
7.5
Reduced coughs due to asthma
For coughs and asthma, this seems effective. I usually do not eat much fish, so I ordered it for the omega. I found it helps prevent sickness when I have a cold.
7
Eicosapentaenoic acid and asthma
We examined the use of eicosapentaenoic acid (EPA) in infant formulas and its potential impact on asthma treatments in young children. Our analysis focused on data from a national study involving nearly 8,400 formula-fed infants.
Parents reported various health concerns, including asthma-related issues, as their children grew from 2 months to 5.5 years.
Interestingly, we found that while the consumption of formulas enriched with EPA, along with other beneficial fatty acids, was common, these enriched formulas did not show a significant overall benefit for reducing the incidence of infections or allergies. However, we did observe that infants consuming formulas with higher levels of EPA—specifically those with 3.2 mg or more per 100 kcal—tended to use asthma medications less frequently and had a lower risk of lower respiratory tract infections.
Our findings suggest that while not universally effective, higher EPA content in infant formula may play a role in supporting respiratory health in children with asthma.
Parents reported various health concerns, including asthma-related issues, as their children grew from 2 months to 5.5 years.
Interestingly, we found that while the consumption of formulas enriched with EPA, along with other beneficial fatty acids, was common, these enriched formulas did not show a significant overall benefit for reducing the incidence of infections or allergies. However, we did observe that infants consuming formulas with higher levels of EPA—specifically those with 3.2 mg or more per 100 kcal—tended to use asthma medications less frequently and had a lower risk of lower respiratory tract infections.
Our findings suggest that while not universally effective, higher EPA content in infant formula may play a role in supporting respiratory health in children with asthma.
4
We explored the connection between fatty acid profiles and the severity of equine asthma, an inflammatory condition affecting horses' lower airways. By analyzing samples of bronchoalveolar lavage fluid (BALF) from healthy horses and those with varying degrees of asthma severity, we aimed to uncover how specific fatty acids, particularly eicosapentaenoic acid (EPA), relate to inflammatory status.
Our findings highlighted distinct patterns in the fatty acid compositions among the different groups. While eicosapentaenoic acid levels increased in the extracellular vesicles of horses suffering from severe asthma, it was not clear whether this increase alone translated to any significant clinical benefit. All asthmatic horses exhibited elevated levels of dihomo-γ-linolenic acid, indicating a complex balance between pro-inflammatory and resolving actions of these fatty acids.
Through this study, we gained new insights into how fatty acid profiles vary with asthma severity, but the effectiveness of eicosapentaenoic acid treatment for asthma remains ambiguous. It appears that while EPA may have a role, other lipid mediators also significantly influence asthma pathology, complicating our understanding of its potential as a treatment option.
Our findings highlighted distinct patterns in the fatty acid compositions among the different groups. While eicosapentaenoic acid levels increased in the extracellular vesicles of horses suffering from severe asthma, it was not clear whether this increase alone translated to any significant clinical benefit. All asthmatic horses exhibited elevated levels of dihomo-γ-linolenic acid, indicating a complex balance between pro-inflammatory and resolving actions of these fatty acids.
Through this study, we gained new insights into how fatty acid profiles vary with asthma severity, but the effectiveness of eicosapentaenoic acid treatment for asthma remains ambiguous. It appears that while EPA may have a role, other lipid mediators also significantly influence asthma pathology, complicating our understanding of its potential as a treatment option.
8
We investigated how eicosapentaenoic acid (EPA), a type of long-chain polyunsaturated fatty acid, could influence asthma symptoms, particularly in children. This research delved into various studies that highlighted EPA's potential to impact immune responses, especially when combined with other fatty acids like arachidonic acid and docosahexaenoic acid (DHA).
While some findings suggested that supplementation with n-3 LCPUFAs, including EPA, could enhance immune maturation and reduce the risks of allergic diseases, the isolated effect of EPA specifically on asthma remains challenging to pinpoint. The studies indicated mixed results, noting certain benefits like reduced sensitization to allergens, but we found that the overall evidence regarding EPA's direct impact on asthma outcomes specifically is limited.
Therefore, although there are positive indications linking LCPUFAs to improved immune responses and potential reductions in asthma severity, the specific contribution of EPA alone could benefit from further examination. In essence, while EPA shows promise as part of a broader approach to managing asthma, the direct evidence of its effectiveness is not conclusively established.
While some findings suggested that supplementation with n-3 LCPUFAs, including EPA, could enhance immune maturation and reduce the risks of allergic diseases, the isolated effect of EPA specifically on asthma remains challenging to pinpoint. The studies indicated mixed results, noting certain benefits like reduced sensitization to allergens, but we found that the overall evidence regarding EPA's direct impact on asthma outcomes specifically is limited.
Therefore, although there are positive indications linking LCPUFAs to improved immune responses and potential reductions in asthma severity, the specific contribution of EPA alone could benefit from further examination. In essence, while EPA shows promise as part of a broader approach to managing asthma, the direct evidence of its effectiveness is not conclusively established.
7
We aimed to understand how dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both omega-3 fatty acids, affects the risk of developing asthma in children. Our study utilized data from the Avon Longitudinal Study of Parents and Children, specifically looking at the consumption of these fatty acids from fish at the age of 7.
Surprisingly, we did not find a direct overall association between higher intake of EPA and DHA and the incidence of asthma in the children studied, which included over 4,500 participants. However, a deeper dive into the data revealed an intriguing detail regarding genetics. Among those children carrying a specific genetic variant (the minor G allele), we observed a significant reduction in the odds of developing asthma linked to higher fish intake rich in these fatty acids.
This suggests that for certain children with this genetic makeup, consuming more EPA and DHA is indeed beneficial in lowering asthma risk. Unfortunately, this positive effect was not observed in children without this genetic variant. Our findings were also corroborated by research from another cohort in Sweden, adding more strength to the idea of a gene-nutrient interaction concerning asthma risk.
In conclusion, while EPA and DHA may not universally prevent asthma, they can potentially play a protective role for certain children based on their genetic profile.
Surprisingly, we did not find a direct overall association between higher intake of EPA and DHA and the incidence of asthma in the children studied, which included over 4,500 participants. However, a deeper dive into the data revealed an intriguing detail regarding genetics. Among those children carrying a specific genetic variant (the minor G allele), we observed a significant reduction in the odds of developing asthma linked to higher fish intake rich in these fatty acids.
This suggests that for certain children with this genetic makeup, consuming more EPA and DHA is indeed beneficial in lowering asthma risk. Unfortunately, this positive effect was not observed in children without this genetic variant. Our findings were also corroborated by research from another cohort in Sweden, adding more strength to the idea of a gene-nutrient interaction concerning asthma risk.
In conclusion, while EPA and DHA may not universally prevent asthma, they can potentially play a protective role for certain children based on their genetic profile.
8
We explored the effects of eicosapentaenoic acid (EPA) on asthma, focusing particularly on its ability to alleviate eosinophilic airway inflammation. Through a well-structured experiment, male C57BL6 mice were sensitized and challenged with ovalbumin, simulating allergic airway responses. After treating these mice with EPA, we measured various outcomes, including cell counts in bronchoalveolar lavage fluid and mRNA expressions in the lungs.
Our findings were encouraging! We observed that EPA not only reduced eosinophil accumulation in the airway but also lowered the expression of certain inflammatory mediators in the lungs. Moreover, when analyzing the metabolites of EPA, we identified 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE) as a significant player in these processes. This metabolite's production increased with EPA treatment and allergic inflammation.
Notably, administering 12-OH-17,18-EpETE directly into the bloodstream helped in decreasing airway eosinophilic inflammation by downregulating a specific inflammatory signal in the lungs. In our in vitro studies, this compound also inhibited the release of an inflammatory substance known as CCL11 from human airway cells that were stimulated by interleukin-4.
Overall, these results suggest that EPA has a favorable impact against asthma by converting into beneficial metabolites. Specifically, 12-OH-17,18-EpETE appears to be a promising therapeutic agent for asthma sufferers.
Our findings were encouraging! We observed that EPA not only reduced eosinophil accumulation in the airway but also lowered the expression of certain inflammatory mediators in the lungs. Moreover, when analyzing the metabolites of EPA, we identified 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE) as a significant player in these processes. This metabolite's production increased with EPA treatment and allergic inflammation.
Notably, administering 12-OH-17,18-EpETE directly into the bloodstream helped in decreasing airway eosinophilic inflammation by downregulating a specific inflammatory signal in the lungs. In our in vitro studies, this compound also inhibited the release of an inflammatory substance known as CCL11 from human airway cells that were stimulated by interleukin-4.
Overall, these results suggest that EPA has a favorable impact against asthma by converting into beneficial metabolites. Specifically, 12-OH-17,18-EpETE appears to be a promising therapeutic agent for asthma sufferers.
References
- Höglund N, Nieminen P, Mustonen AM, Käkelä R, Tollis S, et al. Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity. Sci Rep. 2023;13:9821. doi:10.1038/s41598-023-36697-x
- Olave CJ, Ivester KM, Couetil LL, Burgess J, Park JH, et al. Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial. J Vet Intern Med. 2023;37:338. doi:10.1111/jvim.16598
- Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. doi:10.1111/all.15137
- Talaei M, Sdona E, Calder PC, Jones LR, Emmett PM, et al. Intake of -3 polyunsaturated fatty acids in childhood, genotype and incident asthma. Eur Respir J. 2021;58. doi:10.1183/13993003.03633-2020
- Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. doi:10.3390/nu13010247
- Fussbroich D, Colas RA, Eickmeier O, Trischler J, Jerkic SP, et al. A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA. Mucosal Immunol. 2020;13:481. doi:10.1038/s41385-019-0245-2
- Stoodley I, Garg M, Scott H, Macdonald-Wicks L, Berthon B, et al. Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study. Nutrients. 2019;12. doi:10.3390/nu12010074
- Sordillo JE, Rifas-Shiman SL, Switkowski K, Coull B, Gibson H, et al. Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. J Allergy Clin Immunol. 2019;144:1534. doi:10.1016/j.jaci.2019.07.044
- Fussbroich D, Zimmermann K, Göpel A, Eickmeier O, Trischler J, et al. A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma. Lipids Health Dis. 2019;18:16. doi:10.1186/s12944-018-0947-6
- Abreu SC, Lopes-Pacheco M, da Silva AL, Xisto DG, de Oliveira TB, et al. Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma. Front Immunol. 2018;9:1147. doi:10.3389/fimmu.2018.01147
- Magnusson J, Ekström S, Kull I, Håkansson N, Nilsson S, et al. Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease. J Allergy Clin Immunol. 2018;142:510. doi:10.1016/j.jaci.2017.09.023
- Lee DI, Kang SA, Md A, Jeong UC, Jin F, et al. Sea Cucumber Lipid-Soluble Extra Fraction Prevents Ovalbumin-Induced Allergic Airway Inflammation. J Med Food. 2018;21:21. doi:10.1089/jmf.2017.3994
- Bian X, Sun B, Zheng P, Li N, Wu JL. Derivatization enhanced separation and sensitivity of long chain-free fatty acids: Application to asthma using targeted and non-targeted liquid chromatography-mass spectrometry approach. Anal Chim Acta. 2017;989:59. doi:10.1016/j.aca.2017.08.009
- Mochimaru T, Fukunaga K, Miyata J, Matsusaka M, Masaki K, et al. 12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs. Allergy. 2018;73:369. doi:10.1111/all.13297
- Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, et al. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med. 2016;375:2530. doi:10.1056/NEJMoa1503734
- Su Y, Choi HS, Kwon SK, Han Y, Cho SC, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress. Mol Med Rep. 2025;31. doi:10.3892/mmr.2025.13451
- Keenan K, Walton S, Mbayiwa K, Akande L, Cherian A, et al. Short Report: Exploring the Effect of Prenatal Fatty Acid Supplementation on Wheeze and Asthma in Black American Children. J Asthma Allergy. 2024;17:929. doi:10.2147/JAA.S474009
- Liu G, Ye H, Cheng Q, Zhao J, Ma C, et al. The association of polyunsaturated fatty acids and asthma: a cross-sectional study. J Health Popul Nutr. 2023;42:91. doi:10.1186/s41043-023-00435-w
- Heires AJ, Samuelson D, Villageliu D, Nordgren TM, Romberger DJ. Agricultural dust derived bacterial extracellular vesicle mediated inflammation is attenuated by DHA. Sci Rep. 2023;13:2767. doi:10.1038/s41598-023-29781-9
- Jia Y, Huang Y, Wang H, Jiang H. A dose-response meta-analysis of the association between the maternal omega-3 long-chain polyunsaturated fatty acids supplement and risk of asthma/wheeze in offspring. BMC Pediatr. 2022;22:422. doi:10.1186/s12887-022-03421-z
- Yu CX, Shi ZA, Ou GC, Chen XJ, Liu Q, et al. Maresin-2 alleviates allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome, Th2 type immune response and oxidative stress. Mol Immunol. 2022;146:78. doi:10.1016/j.molimm.2022.03.118
- Obara K, Inaba R, Kawakita M, De Dios Regadera M, Uetake T, et al. Docosahexaenoic Acid Selectively Suppresses U46619- and PGF-Induced Contractions in Guinea Pig Tracheal Smooth Muscles. Biol Pharm Bull. 2022;45:240. doi:10.1248/bpb.b21-00905
- Ulu A, Burr A, Heires AJ, Pavlik J, Larsen T, et al. A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts. J Nutr Biochem. 2021;97:108797. doi:10.1016/j.jnutbio.2021.108797
- Miyata J, Yokokura Y, Moro K, Arai H, Fukunaga K, et al. 12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice. Front Immunol. 2021;12:687192. doi:10.3389/fimmu.2021.687192
