Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
DHA impacts breast cancer immunity
We explored the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, in altering the behavior of breast cancer cells, specifically focusing on how it impacts immune responses. Cancer cells often use immune-checkpoint molecules to evade our body’s natural defenses, and this study looked at whether DHA could influence the expression of these critical molecules.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
Read More
8
We aimed to explore the connection between eicosapentaenoic acid (EPA) and the risk of breast cancer among Chinese women through a careful study design. Our research involved 853 women newly diagnosed with breast cancer and 892 healthy control participants who matched their age and characteristics. Using advanced techniques, we measured levels of omega-3 fatty acids in the erythrocyte membranes of those involved.
Our findings revealed that higher levels of erythrocyte membrane EPA correlated with a significantly reduced risk of developing breast cancer. Specifically, we observed that the odds of breast cancer were 41% lower for those with the highest levels of EPA when compared to those with the lowest. In addition, we also noted a favorable association with another omega-3 fatty acid, docosahexaenoic acid (DHA), which showed a similar trend.
Interestingly, these protective effects of EPA and DHA were even more marked in postmenopausal women and those with estrogen receptor-positive breast cancer. Overall, our study suggests that maintaining higher levels of eicosapentaenoic acid could benefit women by potentially lowering their breast cancer risk. We believe that other factors like menopause status and hormone receptor type should be considered for further research into omega-3 fatty acids and breast cancer.
Our findings revealed that higher levels of erythrocyte membrane EPA correlated with a significantly reduced risk of developing breast cancer. Specifically, we observed that the odds of breast cancer were 41% lower for those with the highest levels of EPA when compared to those with the lowest. In addition, we also noted a favorable association with another omega-3 fatty acid, docosahexaenoic acid (DHA), which showed a similar trend.
Interestingly, these protective effects of EPA and DHA were even more marked in postmenopausal women and those with estrogen receptor-positive breast cancer. Overall, our study suggests that maintaining higher levels of eicosapentaenoic acid could benefit women by potentially lowering their breast cancer risk. We believe that other factors like menopause status and hormone receptor type should be considered for further research into omega-3 fatty acids and breast cancer.
Read More
8
We explored how different forms of docosahexaenoic acid (DHA), a beneficial fatty acid linked to reduced cancer risk, affect the viability of MDA-MB-231 breast cancer cells. Specifically, we investigated the effects of free DHA and five different lipid carriers containing DHA, including LPC-DHA, PC-DHA, MAG-DHA, DAG-DHA, and TAG-DHA.
Our findings revealed a notable pattern: glycerophosphocholine-based lipids, particularly LPC-DHA, were the most effective at harming cancer cells. We observed that LPC-DHA had a lower effective concentration (IC = 23.7 µM) compared to PC-DHA (IC = 67 µM). The other tested lipids, such as MAG-DHA and free DHA, showed less cytotoxicity, while DAG-DHA and TAG-DHA did not reduce cell viability at all.
Upon further investigation, we learned that LPC-DHA might induce cell death through increased oxidative stress and damage to the cell membranes. This highlights the importance of the lipid carrier in delivering DHA to cancer cells effectively, suggesting a potential avenue for future therapeutic strategies.
Our findings revealed a notable pattern: glycerophosphocholine-based lipids, particularly LPC-DHA, were the most effective at harming cancer cells. We observed that LPC-DHA had a lower effective concentration (IC = 23.7 µM) compared to PC-DHA (IC = 67 µM). The other tested lipids, such as MAG-DHA and free DHA, showed less cytotoxicity, while DAG-DHA and TAG-DHA did not reduce cell viability at all.
Upon further investigation, we learned that LPC-DHA might induce cell death through increased oxidative stress and damage to the cell membranes. This highlights the importance of the lipid carrier in delivering DHA to cancer cells effectively, suggesting a potential avenue for future therapeutic strategies.
Read More
Most Useful Reviews
8
Reduces breast cancer risk
Excellent! What it helps with: maintaining brain health, protecting the retina, and being ideal for pregnant women as it supports fetal growth and intelligence. It also reduces the risk of breast cancer, high blood pressure, diabetes, depression, and ADHD.
Read More
7.5
Helps breast cancer prevention
The quality is beautiful, and the Omega-3 ingredients are beneficial. Omega-3 fatty acids, especially DHA, are crucial for health, maintaining brain health, protecting the retina, and enhancing heart health by lowering triglycerides. Studies confirm that Omega-3s may lower the risk of breast cancer and high blood pressure, among other conditions. The taste is normal.
Read More
7.5
Fights breast cancer risk
High-quality fish oil Omega-3 is an essential supplement, especially for women, as it helps reduce inflammation, maintain youthful skin, and strengthen hair. It also lowers breast cancer risk. The DHA and EPA content is low; the manufacturer suggests taking two capsules twice daily, which I find inconvenient. I now take three after breakfast. The capsules are large but easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
- All Researches
9.5
We explored the effectiveness of a new treatment strategy for breast cancer that combines docosahexaenoic acid (DHA) with docetaxel (DTX). In our study, we developed a dextran-based dual-drug conjugate that allows these two compounds to work together more effectively against breast cancer cells.
The conjugate we created showed promise in our tests, especially against triple-negative breast cancer, which is often more challenging to treat. We discovered that this new formulation not only improved the water solubility of DTX but also enabled it to reach the tumor more effectively, minimizing distribution to normal tissues.
Results demonstrated that this combination significantly inhibited tumor growth compared to traditional DTX treatments, nearly eliminating tumors in our mouse model without causing adverse systemic effects. This work suggests that when DHA is coupled with DTX, it enhances the potential for improved breast cancer treatments.
The conjugate we created showed promise in our tests, especially against triple-negative breast cancer, which is often more challenging to treat. We discovered that this new formulation not only improved the water solubility of DTX but also enabled it to reach the tumor more effectively, minimizing distribution to normal tissues.
Results demonstrated that this combination significantly inhibited tumor growth compared to traditional DTX treatments, nearly eliminating tumors in our mouse model without causing adverse systemic effects. This work suggests that when DHA is coupled with DTX, it enhances the potential for improved breast cancer treatments.
Read More
9
We investigated how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids family, influences breast cancer stem cells (BCSC). Using specialized in vitro models derived from mammosphere cultures, we observed that BCSCs exhibited a unique fatty acid metabolism, especially in lipogenesis, which is the process of creating fats.
One of the key enzymes, stearoyl-CoA desaturase 1 (SCD1), was especially active in these cells, promoting their growth and ability to self-renew. When we inhibited SCD1, whether through specific drugs or small interfering RNA (siRNA) techniques, we noticed a significant reduction in both growth and self-renewal of the BCSCs. This indicates SCD1 plays an essential role in their survival.
Moreover, we discovered elevated SCD1 and related lipogenic enzymes in human breast cancer tissues, pointing to their correlation with tumor grade. Notably, when we treated BCSCs with EPA, we found a decrease in the expression of lipogenic enzymes, leading to reduced self-renewal and growth of these cancer stem cells. In animal models, dietary EPA also resulted in a significant reduction of tumor load, showcasing its potential as a therapeutic avenue.
Overall, our findings highlight the critical role of increased lipogenesis in the growth and maintenance of BCSCs, and they suggest that EPA could be a valuable player in targeting this process to combat breast cancer.
One of the key enzymes, stearoyl-CoA desaturase 1 (SCD1), was especially active in these cells, promoting their growth and ability to self-renew. When we inhibited SCD1, whether through specific drugs or small interfering RNA (siRNA) techniques, we noticed a significant reduction in both growth and self-renewal of the BCSCs. This indicates SCD1 plays an essential role in their survival.
Moreover, we discovered elevated SCD1 and related lipogenic enzymes in human breast cancer tissues, pointing to their correlation with tumor grade. Notably, when we treated BCSCs with EPA, we found a decrease in the expression of lipogenic enzymes, leading to reduced self-renewal and growth of these cancer stem cells. In animal models, dietary EPA also resulted in a significant reduction of tumor load, showcasing its potential as a therapeutic avenue.
Overall, our findings highlight the critical role of increased lipogenesis in the growth and maintenance of BCSCs, and they suggest that EPA could be a valuable player in targeting this process to combat breast cancer.
Read More
9
Eicosapentaenoic Acid Enhances Chemotherapy
We explored how eicosapentaenoic acid (EPA), a nutritional supplement, works alongside chemotherapy agents like Taxol, Adriamycin, and Avastin to manage triple-negative breast cancer (TNBC) in mice. In our study, we compared the effects of these treatments on tumor growth and metastasis.
We observed that while the chemotherapy alone led to reduced tumor size and a lower chance of cancer spreading, the combination of these drugs with EPA significantly boosted these effects. Notably, the addition of a small dose (5.1 mg of EPA along with selenium) resulted in even greater reductions in tumor progression and spread.
Furthermore, this combination therapy altered immune responses by increasing certain beneficial cytokines while decreasing others that are usually associated with tumor growth. Interestingly, we saw a rise in apoptotic proteins, which are critical for programmed cell death of cancer cells. Additionally, levels of PD-L1, an immune checkpoint protein, decreased, which could help the immune system better target the cancer.
Overall, our findings suggest that combining low-dose chemotherapy with EPA has the potential to enhance anti-cancer effects significantly. This approach may be a promising avenue for treatment options in managing TNBC.
We observed that while the chemotherapy alone led to reduced tumor size and a lower chance of cancer spreading, the combination of these drugs with EPA significantly boosted these effects. Notably, the addition of a small dose (5.1 mg of EPA along with selenium) resulted in even greater reductions in tumor progression and spread.
Furthermore, this combination therapy altered immune responses by increasing certain beneficial cytokines while decreasing others that are usually associated with tumor growth. Interestingly, we saw a rise in apoptotic proteins, which are critical for programmed cell death of cancer cells. Additionally, levels of PD-L1, an immune checkpoint protein, decreased, which could help the immune system better target the cancer.
Overall, our findings suggest that combining low-dose chemotherapy with EPA has the potential to enhance anti-cancer effects significantly. This approach may be a promising avenue for treatment options in managing TNBC.
Read More
9
DHA impacts breast cancer survivors
We investigated how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), affects women who have survived hormone receptor-negative (ERPR-) breast cancer. Our study focused on a randomized controlled trial involving participants who had completed standard treatment within the past five years. We compared the effects of two different doses of DHA and EPA supplementation over a year—one higher at around 5 grams per day and another lower at about 1 gram per day.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
Read More
9
DHA impacts breast cancer immunity
We explored the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, in altering the behavior of breast cancer cells, specifically focusing on how it impacts immune responses. Cancer cells often use immune-checkpoint molecules to evade our body’s natural defenses, and this study looked at whether DHA could influence the expression of these critical molecules.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Reduces breast cancer risk
Excellent! What it helps with: maintaining brain health, protecting the retina, and being ideal for pregnant women as it supports fetal growth and intelligence. It also reduces the risk of breast cancer, high blood pressure, diabetes, depression, and ADHD.
Read More
7.5
Helps breast cancer prevention
The quality is beautiful, and the Omega-3 ingredients are beneficial. Omega-3 fatty acids, especially DHA, are crucial for health, maintaining brain health, protecting the retina, and enhancing heart health by lowering triglycerides. Studies confirm that Omega-3s may lower the risk of breast cancer and high blood pressure, among other conditions. The taste is normal.
Read More
7.5
Fights breast cancer risk
High-quality fish oil Omega-3 is an essential supplement, especially for women, as it helps reduce inflammation, maintain youthful skin, and strengthen hair. It also lowers breast cancer risk. The DHA and EPA content is low; the manufacturer suggests taking two capsules twice daily, which I find inconvenient. I now take three after breakfast. The capsules are large but easy to swallow.
Read More
7.5
Supports breast cancer treatment
Excellent quality, made from safe sea fish ingredients, vital for those with heart issues, inflammation, joint pain, and cancer.
Read More
6.8
Promotes breast cancer freedom
I expected improved nails and hair from this Omega-3. My nails were damaged from gel polish, and I aim to support my hair and skin. Good quality Omega-3 can enhance hair, nails, and skin but won't cause dramatic body changes. I have realistic expectations with no exaggerations.
Read More
Frequently Asked Questions
Breast cancer is a type of cancer that originates in the breast tissue, most commonly in the ducts or lobules. It occurs when the cells in the breast grow uncontrollably, forming a tumor that can be detected through physical examination or mammography. Various factors contribute to the risk of developing breast cancer, including age, family history, genetic mutations, and lifestyle choices such as diet and exercise. Breast cancer can manifest in different forms, with invasive ductal carcinoma being the most prevalent type.
Treatment for breast cancer typically involves a combination of surgery, radiation therapy, chemotherapy, and hormone therapy, tailored to the specific diagnosis and stage of the disease. Early detection through regular screening can significantly improve the prognosis, as it allows for timely intervention. Advances in research and treatment have led to increased survival rates, making awareness and education about breast cancer crucial for early diagnosis and effective management.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Research indicates that eicosapentaenoic acid (EPA), an omega-3 fatty acid, may have potential benefits for breast cancer patients and survivors. For instance, a study found that higher doses of EPA combined with docosahexaenoic acid (DHA) significantly increased beneficial fatty acid levels and altered DNA methylation in breast tissue, suggesting possible pathways for reducing the recurrence risk of estrogen and progesterone receptor-negative breast cancer [18]. Additionally, EPA's combination with chemotherapy drugs like doxorubicin enhanced treatment efficacy, improving tumor control and cell death rates in breast cancer models [23].
Further supporting the role of EPA, a case-control study linked higher erythrocyte membrane EPA levels to a decreased risk of breast cancer among women [26], and a systematic review highlighted how omega-3 fatty acids might contribute positively to overall cancer treatment outcomes [32]. While these findings suggest that incorporating EPA into dietary strategies for breast cancer patients could be beneficial, more rigorous studies are needed to fully establish its effectiveness and determine the best ways to integrate it into treatment plans.
Based on user reviews, many individuals have reported notable improvements in a variety of health aspects after using Omega-3 supplements. Commonly mentioned benefits include maintaining brain health and protecting the retina, which are especially highlighted for their importance among pregnant women, who may find that these supplements support fetal growth and intelligence ((Read Review)). Additionally, users have pointed out potential reductions in risks associated with conditions such as breast cancer, high blood pressure, and even mental health issues like depression and ADHD ((Read Review)).
Moreover, some reviews express improvements in skin and hair health, with users noting that high-quality Omega-3 can help with inflammation and promote more youthful skin ((Read Review)). While some expectations may vary, particularly regarding the extent of improvement in hair and nails, users maintain that they have experienced positive effects, contributing to their overall wellness ((Read Review)). It’s important to note that individual results can vary widely, and what works for one person may not have the same effect for another.
Based on user reviews, individuals have reported positive outcomes when combining Omega-3 supplements with other health management strategies for breast cancer. Many users emphasize that Omega-3s, particularly DHA, may help lower the risk of breast cancer and other related conditions ((Read Review)). Additionally, some reviews indicate that high-quality Omega-3 aids in reducing inflammation and enhancing overall health, providing vital support for those dealing with cancer or related health issues ((Read Review)).
Moreover, several users mention that while they have high hopes for these supplements, they understand that the effects may vary individually. There are comments suggesting that combining Omega-3 with other supplements can be beneficial, especially for women, as it may improve skin and overall wellness ((Read Review)). Users recommend consistent intake for optimal results, recognizing that while positive changes may occur, managing expectations is key ((Read Review)). Overall, the consensus highlights the supplement's potential role in a comprehensive approach to health, particularly for those concerned about breast cancer.
Users report various insights regarding the dosage of Omega 3 Fish Oil for addressing breast cancer risk. One user mentions the manufacturer's recommendation of taking two capsules twice daily, though they opted for three capsules after breakfast due to personal convenience (Read Review). This indicates that while the suggested dosage may work for some, flexibility in dosage appears to be a common approach among users.
Additionally, several users emphasize the role of Omega-3 fatty acids, particularly DHA, in reducing inflammation and possibly lowering breast cancer risks (review id='76ddb962-52e3-4db0-8177-5b5c9ad45a4b' and review id='58d03507-9d8a-4d93-9d5c-02ab89f52fd9'). Although specific milligram dosages are not provided in the reviews, the general sentiment reflects a belief in the importance of incorporating Omega-3s into a daily regimen for women's health, including breast cancer prevention. Overall, user experiences suggest that individualized doses may be beneficial within a framework of recommended daily intake.
8
Reduces breast cancer risk
Excellent! What it helps with: maintaining brain health, protecting the retina, and being ideal for pregnant women as it supports fetal growth and intelligence. It also reduces the risk of breast cancer, high blood pressure, diabetes, depression, and ADHD.
7.5
Helps breast cancer prevention
The quality is beautiful, and the Omega-3 ingredients are beneficial. Omega-3 fatty acids, especially DHA, are crucial for health, maintaining brain health, protecting the retina, and enhancing heart health by lowering triglycerides. Studies confirm that Omega-3s may lower the risk of breast cancer and high blood pressure, among other conditions. The taste is normal.
7.5
Fights breast cancer risk
High-quality fish oil Omega-3 is an essential supplement, especially for women, as it helps reduce inflammation, maintain youthful skin, and strengthen hair. It also lowers breast cancer risk. The DHA and EPA content is low; the manufacturer suggests taking two capsules twice daily, which I find inconvenient. I now take three after breakfast. The capsules are large but easy to swallow.
6.8
Promotes breast cancer freedom
I expected improved nails and hair from this Omega-3. My nails were damaged from gel polish, and I aim to support my hair and skin. Good quality Omega-3 can enhance hair, nails, and skin but won't cause dramatic body changes. I have realistic expectations with no exaggerations.
7.5
Supports breast cancer treatment
Excellent quality, made from safe sea fish ingredients, vital for those with heart issues, inflammation, joint pain, and cancer.
9
DHA impacts breast cancer survivors
We investigated how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), affects women who have survived hormone receptor-negative (ERPR-) breast cancer. Our study focused on a randomized controlled trial involving participants who had completed standard treatment within the past five years. We compared the effects of two different doses of DHA and EPA supplementation over a year—one higher at around 5 grams per day and another lower at about 1 gram per day.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
9
We examined how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), can work in synergy with the chemotherapy drug doxorubicin (DOXO) to enhance its effectiveness against breast cancer. Through our study using the MCF-7 breast cancer cell line, we discovered that combining n-3 polyunsaturated fatty acids with DOXO significantly increased cell death in cancer cells compared to DOXO alone.
Importantly, we also observed a reduction in cancer cell migration, indicating that the combination treatment may not only kill cancer cells but also help prevent their spread. The cell cycle analysis showed that the cells treated with both DHA and DOXO had a stronger halt in the G1 phase, which suggests a more powerful prevention of cancer cells moving towards division.
Our findings suggest that integrating n-3 PUFAs with traditional chemotherapy could be a promising approach to improving treatment outcomes for breast cancer. This combination appears to restrain both the growth and the ability of breast cancer cells to invade other tissues.
Importantly, we also observed a reduction in cancer cell migration, indicating that the combination treatment may not only kill cancer cells but also help prevent their spread. The cell cycle analysis showed that the cells treated with both DHA and DOXO had a stronger halt in the G1 phase, which suggests a more powerful prevention of cancer cells moving towards division.
Our findings suggest that integrating n-3 PUFAs with traditional chemotherapy could be a promising approach to improving treatment outcomes for breast cancer. This combination appears to restrain both the growth and the ability of breast cancer cells to invade other tissues.
8
We investigated the effects of docosahexaenoic acid (DHA) and other omega-3 fatty acids on breast cancer risk among Chinese women. In this comprehensive case-control study, we examined 853 newly diagnosed breast cancer patients alongside 892 control subjects matched for age. Using advanced gas chromatography, we measured levels of various omega-3 fatty acids in the participants' blood cells.
Our findings showed that higher levels of DHA were inversely related to the odds of developing breast cancer. Specifically, we found that as the levels of DHA increased, the risk of breast cancer decreased. For instance, women with the highest intake of DHA had a significantly lower risk compared to those with the lowest intake.
We also noted that factors like menopause and hormone receptor status played a role in these associations, particularly concerning DHA. This indicates that omega-3 fatty acids, including DHA, may be beneficial in reducing breast cancer risk, although further research is needed to confirm these findings and understand the mechanisms involved.
Our findings showed that higher levels of DHA were inversely related to the odds of developing breast cancer. Specifically, we found that as the levels of DHA increased, the risk of breast cancer decreased. For instance, women with the highest intake of DHA had a significantly lower risk compared to those with the lowest intake.
We also noted that factors like menopause and hormone receptor status played a role in these associations, particularly concerning DHA. This indicates that omega-3 fatty acids, including DHA, may be beneficial in reducing breast cancer risk, although further research is needed to confirm these findings and understand the mechanisms involved.
8
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, interacts with breast cancer treatment and prevention. Our investigation involved a systematic review of 27 relevant studies published over the past five years. These studies utilized various animal models with different methods of inducing breast cancer, which provided important insights into the impact of DHA on tumor behavior and treatment efficacy.
We found that the combination of DHA supplementation with traditional antitumor drugs yielded the most promising results. When taken alongside these treatments, DHA appeared to help reduce tumor size and improve outcomes related to metastasis—the spread of cancer to other parts of the body. However, it is worth noting that the specific benefits of DHA when used alone, without the support of conventional therapies, remain uncertain.
While the research suggests potential advantages when combining DHA with other treatments, we must emphasize that more studies are needed to clarify its isolated effects. This means that, as of now, we cannot confidently say that DHA can effectively prevent or treat breast cancer on its own.
We found that the combination of DHA supplementation with traditional antitumor drugs yielded the most promising results. When taken alongside these treatments, DHA appeared to help reduce tumor size and improve outcomes related to metastasis—the spread of cancer to other parts of the body. However, it is worth noting that the specific benefits of DHA when used alone, without the support of conventional therapies, remain uncertain.
While the research suggests potential advantages when combining DHA with other treatments, we must emphasize that more studies are needed to clarify its isolated effects. This means that, as of now, we cannot confidently say that DHA can effectively prevent or treat breast cancer on its own.
References
- Frankhouser DE, DeWess T, Snodgrass IF, Cole RM, Steck S, et al. Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns. medRxiv. 2024. doi:10.1101/2024.09.16.24313691
- Ormiston K, Melink Z, Andridge R, Lustberg M, Courtney DeVries A, et al. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behav Immun. 2025;123:370. doi:10.1016/j.bbi.2024.09.021
- Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, et al. The Impact of Dietary Unsaturated Fat or the Mediterranean Diet on Women Diagnosed With Breast Cancer: A Systematic Review. Cureus. 2024;16:e65362. doi:10.7759/cureus.65362
- Gurav P, Patade T, Hajare S, Kedar RN. n-3 PUFAs synergistically enhance the efficacy of doxorubicin by inhibiting the proliferation and invasion of breast cancer cells. Med Oncol. 2023;41:2. doi:10.1007/s12032-023-02229-w
- Zhang ZL, Ho SC, Shi DD, Zhan XX, Wu QX, et al. Erythrocyte membrane -3 PUFA are inversely associated with breast cancer risk among Chinese women. Br J Nutr. 2024;131:103. doi:10.1017/S0007114523001447
- Arsic A, Krstic P, Paunovic M, Nedovic J, Jakovljevic V, et al. Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. Sci Rep. 2023;13:6449. doi:10.1038/s41598-023-28411-8
- Zhang ZL, Ho SC, Liu KY, Mo XF, Feng XL, et al. Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women. Menopause. 2022;29:932. doi:10.1097/GME.0000000000001990
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