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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
5,6-DiHETE alleviates diarrhea
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.
High relevance to diarrhea treatment
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
Read More
8
Fatty acids combat swine viruses
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress.
Significant antiviral effects noted
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Dietary ω3 fatty acids' benefits
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
Indicates potential for diarrhea treatment
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
Read More
Most Useful Reviews
2.5
Stomach issues
For some reason, I had a strong stomach reaction after starting the recommended dose, leading to diarrhoea. Upon halting the intake, the symptoms disappeared. It might be an intolerance to certain components, as I didn’t have this issue with regular fish oil.
Read More
9.5
Health improvements
Taking Omega-3 in tailored doses can lead to beneficial changes, such as reducing the risk of atherosclerosis and enhancing digestion. It may also normalise the menstrual cycle, improve sperm quality, and support heart health. Notably, Omega-3 may enhance cognitive skills and strengthen immunity, leading to better overall well-being and potentially alleviating issues like diarrhoea.
Read More
9.5
No diarrhoea
I was concerned that the iHerb brand of Omega-3 would upset my stomach and cause diarrhoea like others have, but I am pleased to say it didn't affect me negatively at all. I took it without experiencing any digestive issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
8
Fatty acids combat swine viruses
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress.
Significant antiviral effects noted
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.
These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Nutritional management in SAH patients
Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients.
Diarrhea findings inconclusive with EPA
We explored the effect of early enteral nutrition on patients who suffered a subarachnoid hemorrhage (SAH). In a retrospective study involving 245 patients, we compared two different liquid diets: one rich in high-protein whey peptide and the other containing eicosapentaenoic acid (EPA).
Our focus was on understanding how these diets impacted patients' health outcomes, especially regarding diarrhea. While we noticed that the high-protein whey peptide group had a lower rate of diarrhea (about 15.8%) compared to the EPA group (34.3%), we couldn’t isolate the effects of EPA specifically on gastrointestinal issues.
Overall, the study indicated that the choice of nutrients in enteral feeding could influence recovery and comfort for SAH patients. However, it’s important to note that the findings on eicosapentaenoic acid alone did not demonstrate any significant benefit regarding diarrhea in this context.
Our focus was on understanding how these diets impacted patients' health outcomes, especially regarding diarrhea. While we noticed that the high-protein whey peptide group had a lower rate of diarrhea (about 15.8%) compared to the EPA group (34.3%), we couldn’t isolate the effects of EPA specifically on gastrointestinal issues.
Overall, the study indicated that the choice of nutrients in enteral feeding could influence recovery and comfort for SAH patients. However, it’s important to note that the findings on eicosapentaenoic acid alone did not demonstrate any significant benefit regarding diarrhea in this context.
Read More
8
5,6-DiHETE alleviates diarrhea
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.
High relevance to diarrhea treatment
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
Read More
8
Fiber and EPA benefit GI health
Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial.
Limited isolated EPA impact
We conducted a randomized controlled trial to explore how a fiber, fish oil, and carotenoid-enriched tube feed formula might impact gastrointestinal (GI) health, particularly diarrhea, among hospitalized patients starting tube nutrition.
In this study, we compared the enriched formula to a standard, non-enriched tube feed. Daily records were kept on incidences of diarrhea and constipation based on stool frequency and consistency. After a week, we also measured levels of essential nutrients, including eicosapentaenoic acid (EPA), in the patients' plasma.
Our findings suggest that the nutrient-enriched formula may positively influence GI tolerance. We observed a reduced incidence of diarrhea among those receiving the enriched formula, along with a significant improvement in plasma levels of EPA, as well as DHA and carotenoids.
It’s important to note, however, that while the results point to benefits, the isolated effect of EPA on diarrhea couldn’t be definitively determined due to the combination of other treatments included in the formula.
Overall, this study showcases the potential advantages of using a specially formulated tube feed to support nutritional status and improve gastrointestinal outcomes for patients in need.
In this study, we compared the enriched formula to a standard, non-enriched tube feed. Daily records were kept on incidences of diarrhea and constipation based on stool frequency and consistency. After a week, we also measured levels of essential nutrients, including eicosapentaenoic acid (EPA), in the patients' plasma.
Our findings suggest that the nutrient-enriched formula may positively influence GI tolerance. We observed a reduced incidence of diarrhea among those receiving the enriched formula, along with a significant improvement in plasma levels of EPA, as well as DHA and carotenoids.
It’s important to note, however, that while the results point to benefits, the isolated effect of EPA on diarrhea couldn’t be definitively determined due to the combination of other treatments included in the formula.
Overall, this study showcases the potential advantages of using a specially formulated tube feed to support nutritional status and improve gastrointestinal outcomes for patients in need.
Read More
8
Dietary ω3 fatty acids' benefits
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
Indicates potential for diarrhea treatment
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.
Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.
While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
9.5
Health improvements
Taking Omega-3 in tailored doses can lead to beneficial changes, such as reducing the risk of atherosclerosis and enhancing digestion. It may also normalise the menstrual cycle, improve sperm quality, and support heart health. Notably, Omega-3 may enhance cognitive skills and strengthen immunity, leading to better overall well-being and potentially alleviating issues like diarrhoea.
Read More
9.5
No diarrhoea
I was concerned that the iHerb brand of Omega-3 would upset my stomach and cause diarrhoea like others have, but I am pleased to say it didn't affect me negatively at all. I took it without experiencing any digestive issues.
8.8
Reduced diarrhoea
I suspect I have a mild gluten intolerance as certain foods make me hungry. Although I didn't notice a change in my skin, Omega-3 fatty acids significantly reduced my diarrhoea when consuming flour-based foods. They have become essential for me, allowing me to manage my diet while avoiding flour as much as possible.
Read More
8.8
Initial diarrhoea
I experienced some diarrhoea initially, but my stomach and intestines improved over time. I'm hopeful that Omega-3 will work effectively for me in the long run.
2.5
Stomach issues
For some reason, I had a strong stomach reaction after starting the recommended dose, leading to diarrhoea. Upon halting the intake, the symptoms disappeared. It might be an intolerance to certain components, as I didn’t have this issue with regular fish oil.
