We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Read More
8
DHA-derived protectins against influenza
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection.
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
Read More
7
DHA improves antibody response
B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection.
We investigated the effects of docosahexaenoic acid (DHA), an essential omega-3 fatty acid, on B cell activity during influenza infection, particularly in the context of obesity. Our focus was on understanding how obesity might impair the immune response, especially regarding B cell function.
The study revealed that in obese mice consuming a Western diet, the production of antibodies was significantly reduced compared to those not on the diet. However, when we added DHA to the diet, we observed improvements in antibody levels. This is important because higher DHA levels often correlate with better immune responses, potentially due to its ability to generate specialized pro-resolving lipid mediators, which enhance antibody production.
While the research showed promising results for DHA, it's worth noting that it does not seem to work directly on B cells. Instead, it appears to improve immunity through these mediators, which help bolster B cell function during influenza infections. This insight is valuable as it adds to our understanding of nutrition’s role in immune health, especially in individuals dealing with obesity.
Read More
Most Useful Reviews
7.5
Stress relief
1 people found this helpful
My husband and I fell ill with COVID-19. While recovering, we took vitamins and Omega-3. My husband’s headaches vanished, and his reaction to the weather improved. We now take two capsules each morning. I noticed increased physical activity, improved flexibility, and a reduction in post-illness stress. Omega-3 is known to support cardiovascular health, enhance mental well-being, and boost immunity during influenza and colds. It's essential for maintaining metabolic functions, stabilising cell membranes, and reducing inflammation. I highly recommend it for overall health.
Read More
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
Read More
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
Our study focused on understanding how 17-HDHA, a compound derived from docosahexaenoic acid (DHA), affects the immune response to influenza vaccination. We used both an OVA immunization model and a mouse model for influenza vaccination to investigate its potential benefits.
We found that when mice were immunized with either OVA plus 17-HDHA or H1N1-derived HA protein plus 17-HDHA, there was a notable increase in antibody titers. This means that the presence of 17-HDHA helped these mice produce more antibodies against the viruses involved. Additionally, the treatment boosted the number of antibody-secreting cells in vitro and in the bone marrow of the mice.
Importantly, the enhanced antibody production linked to 17-HDHA showed greater protective effects against live H1N1 influenza infection. This insight is particularly significant as it highlights a new connection between proresolution molecules and the adaptive immune response, suggesting exciting possibilities for developing new vaccine adjuvants.
Overall, our findings indicate that DHA-derived compounds like 17-HDHA could play a vital role in improving immune responses against influenza, a pressing global health challenge.
We examined the potential effects of eicosapentaenoic acid (EPA) on influenza infections, focusing on how the gut bacteria Clostridium butyricum contribute to this relationship. Our exploration revealed that when Clostridium butyricum is taken orally, it can bolster resistance to influenza by boosting levels of a signaling molecule called interferon-λ in the lungs.
This process is facilitated by gut-produced EPA, specifically a version called 18-hydroxy eicosapentaenoic acid (18-HEPE), which encourages the production of interferon-λ through a specific receptor pathway in lung cells. What's fascinating is that the presence of Clostridium butyricum also enhances the sensitivity of lung tissues to the benefits of EPA by increasing receptor levels that recognize the molecule.
Overall, this study sheds light on a gut-lung connection, offering new insights into potential treatments for viral infections like influenza. However, while we noticed positive outcomes with the involvement of Clostridium butyricum and EPA, arriving at the isolated effects of EPA on its own requires further examination.
Read More
8
Docosahexaenoic acid's antiviral effects
Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX.
We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Read More
8
DHA-derived protectins against influenza
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection.
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
Read More
7
DHA reduces lung inflammation
Docosahexaenoic Acid Controls Pulmonary Macrophage Lipid Raft Size and Inflammation.
We aimed to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects the organization of lipid rafts in alveolar macrophages and its potential role in reducing inflammation during influenza. To investigate this, we used MH-S cells, an alveolar macrophage line, and treated them with DHA, comparing the results to a vehicle control group.
Through various advanced techniques, we observed that DHA seems to drive sphingomyelin and cholesterol into larger lipid rafts, which may help lower inflammation signals in these immune cells. Additionally, in a murine model of influenza, we examined pulmonary inflammatory markers from mice that had been fed DHA, revealing its anti-inflammatory properties that could be beneficial in the context of lung health.
Overall, our findings suggest that targeting alveolar macrophages with DHA could provide a new avenue for managing inflammation linked to respiratory infections like influenza. While the results highlight DHA's potential, further research is necessary to fully understand its impact and mechanisms in clinical settings.
My husband and I fell ill with COVID-19. While recovering, we took vitamins and Omega-3. My husband’s headaches vanished, and his reaction to the weather improved. We now take two capsules each morning. I noticed increased physical activity, improved flexibility, and a reduction in post-illness stress. Omega-3 is known to support cardiovascular health, enhance mental well-being, and boost immunity during influenza and colds. It's essential for maintaining metabolic functions, stabilising cell membranes, and reducing inflammation. I highly recommend it for overall health.
Read More
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
Read More
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
Read More
7.5
Nervous system support
This supplement is often prescribed for preventing and treating cardiovascular diseases, including atherosclerosis. Taking Omega-3 during influenza and colds is an effective method to strengthen the nervous system, enhance immunity, and improve overall health. It also supports skin rejuvenation, both on the face and body.
Read More
Frequently Asked Questions
Influenza, commonly referred to as the flu, is a highly contagious viral infection that primarily affects the respiratory system. Caused by influenza viruses, it can lead to mild to severe illness and can result in hospitalization or even death, particularly in vulnerable populations such as the elderly, young children, and individuals with certain health conditions. Symptoms typically include fever, chills, cough, sore throat, body aches, headaches, and fatigue. It's important to note that while many people refer to common colds as the flu, the flu is generally more severe and lasts longer.
Preventing influenza is possible through vaccination, which is recommended annually as the viruses can change from year to year. Other preventive measures include practicing good hygiene, such as regular hand washing and avoiding close contact with infected individuals. If someone does contract the flu, antiviral medications may be prescribed by a healthcare provider, particularly if the treatment begins within the first few days of illness. Understanding the nature of influenza and the importance of preventive measures can help individuals protect themselves and their communities during flu season.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Based on user reviews, the timeframe for experiencing noticeable results from taking Omega-3 for influenza can vary. Some users report feeling an improvement in their overall health and immunity relatively quickly, although specific timelines are not consistently mentioned. One reviewer notes that after starting Omega-3, they observed a significant improvement in their parents’ immunity and a notable avoidance of illness, suggesting benefits might be seen within a few days to weeks of consistent use Read Review. Another user emphasizes that they felt enhanced energy levels and easier mornings after incorporating the supplement, indicating positive results may emerge promptly during the autumn-winter period Read Review.
Overall, while users report various positive outcomes such as reduced illness and enhanced health, there is no definitive timeline available in the reviews regarding how long it takes to see consistent results. Customers tend to agree that regular usage is key and that noticeable benefits, particularly against influenza, may be felt within days to weeks depending on individual health conditions and the severity of illness.
The research surrounding the use of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), offers some intriguing insights into their potential roles in combating influenza. One study highlights how the gut bacteria Clostridium butyricum, when paired with EPA, can enhance the immune response against influenza by increasing levels of interferon-λ in the lungs, suggesting a beneficial gut-lung connection that warrants further investigation [1]. Conversely, another study indicates a concerning trade-off where diets high in fish oil (rich in EPA) led to worse outcomes during influenza infections in mice, highlighting increased mortality and viral loads [2].
DHA, on the other hand, has shown promise in a range of contexts against influenza. Multiple studies indicate that DHA can boost antibody responses and reduce inflammation, potentially benefiting immune function [4], [8]. Compounds derived from DHA, like protectin DX (PDX), have also demonstrated effects in limiting influenza virus replication, presenting a possible therapeutic avenue [7]. However, while these findings are encouraging, they hint at a complex relationship between omega-3s and viral infections, underscoring the need for more research to clarify their roles in clinical applications against influenza.
Users have reported various improvements in their health symptoms after incorporating Omega-3 supplements into their routines. One reviewer noted that after taking Omega-3 while recovering from COVID-19, they experienced a reduction in headaches, improved flexibility, and increased physical activity, highlighting the supplement's potential in enhancing overall vitality and reducing post-illness stress Read Review. Another user emphasized feeling more energized and able to get up more easily in the morning during the autumn-winter period, suggesting that Omega-3 may help combat fatigue commonly associated with seasonal illnesses Read Review.
Additionally, users have reported noticeable improvements in immune function, with one user stating that their parents saw significant enhancements in immunity after starting Omega-3, allowing them to avoid illnesses altogether Read Review. Complementing these claims, another reviewer mentioned that Omega-3 is acknowledged for its role in bolstering the nervous system, enhancing immunity, and supporting overall health Read Review. While individual experiences can vary, these user anecdotes suggest that Omega-3 may offer beneficial effects for those looking to improve their health, particularly during flu season.
Users have shared their experiences about combining Omega-3 with other supplements to enhance their health during the influenza season. Many of them report positive outcomes when taking Omega-3 alongside vitamins, noting improvements in overall health and immunity. For instance, one user mentioned that while recovering from COVID-19, both she and her husband took Omega-3, resulting in reduced headaches and heightened physical activity, which illustrates its potential benefits in enhancing vitality and immune response Read Review. Another reviewer emphasized that incorporating Omega-3, particularly in the autumn-winter period, helped them feel more energized and ready to face the day Read Review.
Moreover, several users highlighted the role of Omega-3 in bolstering immunity against illnesses. A review pointed out that it significantly enhanced the immunity of the reviewer’s parents, allowing them to avoid sickness during flu season after starting the supplement Read Review. Overall, these user reports suggest that combining Omega-3 with other health supplements may provide synergistic benefits, particularly in supporting immune function and general well-being during influenza outbreaks, making it a recommended addition to anyone's health regimen in this context Read Review.
Based on user reviews, it appears that there isn't a universally stated "right dose" for Omega-3 Fish Oil specifically for treating influenza. However, many users indicate that they regularly take two capsules each morning as part of their health regimen, especially during the autumn-winter period when influenza is more prevalent. One user noted that they and their husband started taking this dose while recovering from COVID-19, which they found beneficial in improving their overall health and recovery (Read Review).
Others have also reported taking Omega-3 to support their immune system during flu season, with several noting significant improvements in their overall wellbeing, particularly in terms of recovery from respiratory illnesses (Read Review). While specific dosage recommendations are not detailed, users seem to agree on the consistency of taking Omega-3 daily as a preventive measure against influenza and to bolster immunity.
9
Enhanced immunity
Omega-3 is a commendable product I purchased for my parents to bolster their health against influenza and infections after the New Year. Since taking this, their immunity has significantly improved, and they’ve avoided illnesses. My wife and I have also decided to take Omega-3, especially as we feel weaker in spring. I wholeheartedly recommend it!
9
Boosts vitality
An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.
7.5
Stress relief
1 people found this helpful
My husband and I fell ill with COVID-19. While recovering, we took vitamins and Omega-3. My husband’s headaches vanished, and his reaction to the weather improved. We now take two capsules each morning. I noticed increased physical activity, improved flexibility, and a reduction in post-illness stress. Omega-3 is known to support cardiovascular health, enhance mental well-being, and boost immunity during influenza and colds. It's essential for maintaining metabolic functions, stabilising cell membranes, and reducing inflammation. I highly recommend it for overall health.
7.5
Nervous system support
This supplement is often prescribed for preventing and treating cardiovascular diseases, including atherosclerosis. Taking Omega-3 during influenza and colds is an effective method to strengthen the nervous system, enhance immunity, and improve overall health. It also supports skin rejuvenation, both on the face and body.
We examined the potential effects of eicosapentaenoic acid (EPA) on influenza infections, focusing on how the gut bacteria Clostridium butyricum contribute to this relationship. Our exploration revealed that when Clostridium butyricum is taken orally, it can bolster resistance to influenza by boosting levels of a signaling molecule called interferon-λ in the lungs.
This process is facilitated by gut-produced EPA, specifically a version called 18-hydroxy eicosapentaenoic acid (18-HEPE), which encourages the production of interferon-λ through a specific receptor pathway in lung cells. What's fascinating is that the presence of Clostridium butyricum also enhances the sensitivity of lung tissues to the benefits of EPA by increasing receptor levels that recognize the molecule.
Overall, this study sheds light on a gut-lung connection, offering new insights into potential treatments for viral infections like influenza. However, while we noticed positive outcomes with the involvement of Clostridium butyricum and EPA, arriving at the isolated effects of EPA on its own requires further examination.
2
Eicosapentaenoic acid impairs flu response
Fish oil-fed mice have impaired resistance to influenza infection.
We explored the effects of eicosapentaenoic acid, a key component of fish oil, on the immune response to influenza virus infections in mice. By feeding male C57BL/6 mice either a fish oil-rich diet or a control corn oil diet for two weeks, we sought to understand how such dietary choices might influence their resilience against the virus.
Our findings revealed a concerning trade-off. While the fish oil diet resulted in lower lung inflammation, it also significantly increased mortality rates, lung viral loads, and extended recovery times for the mice infected with the influenza virus. Notably, the fish oil-fed mice exhibited a 40% higher death rate and a 70% higher build-up of the virus in their lungs compared to those on the corn oil diet.
Additionally, we noted suppressed immune functions in the fish oil group, especially regarding splenic natural killer (NK) cell activity. Infected mice on the fish oil diet had fewer CD8+ T cells and showed reduced levels of key inflammatory markers, suggesting that the anti-inflammatory properties of eicosapentaenoic acid may impair the body’s immediate immune response necessary to fight off acute viral infections like influenza.
Overall, this study raises important questions about the balance between anti-inflammatory benefits during chronic conditions and the potential negative impact of fish oil on fighting off acute viral illnesses like the flu.
7
DHA's immune support for influenza
Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study.
We investigated whether docosahexaenoic acid (DHA), a type of long-chain n-3 polyunsaturated fatty acid, could influence the body's response to influenza in young children. In our research, we found that children exposed to higher levels of DHA tended to have increased IgG antibody levels against the influenza A virus. This suggests that DHA might play a supportive role in enhancing the immune response to this particular virus.
However, it is important to note that while we observed this positive association, the study did not isolate the effects of DHA specifically on influenza. This points to a more complex relationship between DHA and the various viral infections that children may encounter.
Furthermore, our findings indicate that while certain fatty acids, including DHA, can impact the immune response, the overall benefit of DHA in protecting against influenza requires further exploration. Understanding these dynamics can help parents make informed dietary choices for their children and highlight the potential importance of omega-3 fatty acids in early nutrition.
9
17-HDHA enhances influenza immunity
The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?
Our study focused on understanding how 17-HDHA, a compound derived from docosahexaenoic acid (DHA), affects the immune response to influenza vaccination. We used both an OVA immunization model and a mouse model for influenza vaccination to investigate its potential benefits.
We found that when mice were immunized with either OVA plus 17-HDHA or H1N1-derived HA protein plus 17-HDHA, there was a notable increase in antibody titers. This means that the presence of 17-HDHA helped these mice produce more antibodies against the viruses involved. Additionally, the treatment boosted the number of antibody-secreting cells in vitro and in the bone marrow of the mice.
Importantly, the enhanced antibody production linked to 17-HDHA showed greater protective effects against live H1N1 influenza infection. This insight is particularly significant as it highlights a new connection between proresolution molecules and the adaptive immune response, suggesting exciting possibilities for developing new vaccine adjuvants.
Overall, our findings indicate that DHA-derived compounds like 17-HDHA could play a vital role in improving immune responses against influenza, a pressing global health challenge.
8
DHA-derived protectins against influenza
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection.
We examined the role of protectins, specifically a compound derived from docosahexaenoic acid (DHA), in combating influenza virus infections. With recent strains of the virus developing resistance to antiviral treatments, we sought to explore alternative strategies to enhance recovery in severely affected individuals.
The research revealed that the isomer protectin D1 (PDX), derived from DHA, shows promising effects against flu by suppressing the replication of the virus. Rather than focusing on reducing inflammation, PDX works by inhibiting the nuclear export of viral mRNA, which is crucial for the virus to replicate effectively within cells.
We observed that the use of lipids as therapeutic agents to target viral pathogenesis might open up new avenues in influenza treatment. While this study signifies some advancement, it’s important to note that further investigation is required to fully realize the potential of DHA-derived protectins in clinical applications against influenza infections.
References
Hagihara M, Yamashita M, Ariyoshi T, Eguchi S, Minemura A, et al. Clostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation. Cell Rep. 2022;41:111755. 10.1016/j.celrep.2022.111755
Schwerbrock NM, Karlsson EA, Shi Q, Sheridan PA, Beck MA. Fish oil-fed mice have impaired resistance to influenza infection. J Nutr. 2009;139:1588. 10.3945/jn.109.108027
Pennington ER, Virk R, Bridges MD, Bathon BE, Beatty N, et al. Docosahexaenoic Acid Controls Pulmonary Macrophage Lipid Raft Size and Inflammation. J Nutr. 2024;154:1945. 10.1016/j.tjnut.2024.04.006
Hakola L, Oikarinen M, Niinistö S, Cuthbertson D, Lehtonen J, et al. Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study. Clin Nutr. 2022;41:2729. 10.1016/j.clnu.2022.10.017
Lagarde M, Guichardant M, Bernoud-Hubac N. Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX. Biochimie. 2020;179:281. 10.1016/j.biochi.2020.09.008
Kosaraju R, Guesdon W, Crouch MJ, Teague HL, Sullivan EM, et al. B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection. J Immunol. 2017;198:4738. 10.4049/jimmunol.1601031
Imai Y. Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection. Biochim Biophys Acta. 2015;1851:496. 10.1016/j.bbalip.2015.01.006
Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?. J Immunol. 2014;193:6031. 10.4049/jimmunol.1302795
Bassaganya-Riera J, Guri AJ, Noble AM, Reynolds KA, King J, et al. Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. Am J Clin Nutr. 2007;85:824.